Rich in anti-aging actives designed to prevent and minimise the appearance of wrinkles (Matrixyl®, hibiscus seed extract, Syn®-Ake - which stimulates production of sirtuin-1...), restore skin hydration (sodium hyaluronate, ceramides), and protect against oxidative stress (coenzyme Q10, vitamin E, pomegranate extract ...), Advanced Anti-Aging Cream offers intensive protection while reducing existing signs of aging. Fine lines and wrinkles are gradually smoothed out and skin hydration is restored, leading to noticeable improvements in facial appearance.

Actives ingredients: 4% of a myrtle extract which stimulates cell longevity: • increases production of sirt1, a longevity-related protein. It restores expression of sirt1 in senescent fibroblasts; • improves cell-to-cell communication; • blocks glycation of collagen, an irreversible process which leads to tissue rigidity ; applied to the skin twice a day for 28 days, it was shown to reduce the number of wrinkles by 16%, total wrinkle surface area by 33% and length of wrinkles by 25%. After 55 days’ use, these reductions had increased to 30%, 39% and 36% respectively. 3% Matrixyl®, an innovative, anti-wrinkle pentapeptide more effective against wrinkles than vitamin C or retinol (and without the latter’s irritation side-effects) : : • stimulating fibroblast synthesis of collagen and proteo-aminoglycans ; • applied to the face twice a day, it reduced wrinkle depth by 21.8%, wrinkle volume by 24.4%, wrinkle surface area by 49.3% and skin roughness by 13.5%. 1% sodium hyaluronate essential for skin hydration: • when applied to the skin, it forms a non-occlusive, moisturising and softening film • it can bind to - and retain in the dermis - huge amounts of water - up to 1000 times its weight 3% type 3 ceramides, essential to the skin’s barrier function • involved in the process of desquamation and vital for skin hydration : when applied to the skin, they repair the damaged skin barrier and improve hydration ; • inhibit the activity of free radicals, elastase and collagenase, protecting the skin and restricting damage to structural proteins. 0.01 % CoQ10 provides antioxidant protection and protects against photoaging. 0.5 % alpha-tocopherol, a form of vitamin E, the major lipid-soluble antioxidant protector 1 % Aloe vera juice, moisturising and soothing.

Advanced Anti-Aging Cream, with clinically-demonstrated anti-wrinkle efficacy In a 28-day study of 22 women aged 45-63, twice-daily use of Smart Skin Advanced Anti-Aging Cream produced a significant anti-wrinkle effect, characterised by an average decrease of : • 10% in the number of medium wrinkles ; • 30% in the number of deep wrinkles ; • 6 % in the depth of the deep wrinkles ; • 20% in the total wrinkle surface area. These results demonstrate that Advanced Anti-Aging Cream is highly effective against wrinkles. It should also be noted that tests with anti-aging creams rarely produce positive results against all four of these criteria and in a majority of participants. In addition, a reduction in the appearance of wrinkles was observed in terms of crow’s feet, nasolabial folds, frown lines, forehead wrinkles and lines around the lips. Skin was softer, smoother, firmer, younger-looking, more hydrated and supple. The skin around the eyes appeared smoother and facial features appeared lifted. Those who used Advanced Anti-Aging Cream said it helped combat the signs of aging and had an anti-wrinkle effect. 95 % said they would like to continue using it.

In addition, Advanced Anti-Aging Cream contains 1 % oligopeptides extracted from hibiscus seed which naturally smoothes out expression lines : • significantly reduces the facial muscle contractions that lead to expression lines (Botox-like effect) ; • provides antioxidant protection and increases levels of reduced glutathione in fibroblasts ; • applied twice a day for three weeks reduced depth of expression lines by 26 %. 1 % Syn®-Ake, a synthetic tripeptide which resulted from research into snake venom, reduces facial muscle contraction (Botox-like effect) : • applied twice a day for 28 days, it was shown to reduce expression lines by 52 %. 0.1 % pomegranate extract stimulates renewal of skin cells and provides antioxidant protection. 0.01 % biotin, a B vitamin essential for cell renewal