Ornithine alpha ketoglutarate (OKG) is a compound that combines two molecules of the amino acid ornithine with one molecule of alpha ketoglutaric acid, an important component in the Krebs cycle. As a precursor of growth hormone, ornithine is twice as effective as arginine. OKG supplementation increases production of GH (growth hormone) and of IGF-1, an active, easy-to-measure derivative of GH.
OKG has been used to promote growth in children of abnormally small stature (Monkorzel, Goulet et al., Growth retardation in children receiving long term total parenteral nutrition: effects of ornithin alpha ketoglutarate, Am J Clin Nutr, 60(3): 408-13.1974 Sep).
OKG also slows down loss of muscle mass in hospitalized patients and accelerates healing of serious burns (de Bandt, Coudray-Lucas et al, a randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients, J Nutr, 128(3):563-9 1998 Mar)
OKG increases protein synthesis and protects against muscular catabolism and is therefore particularly beneficial to sports enthusiasts and anyone wishing to promote their production of growth hormone.
Other studies show that OKG is particularly active in the mechanisms of ammonia detoxification: it combines with the ammonia produced during muscular exercise and thus improves recovery, helping to prevent cramps and stiffness.
OKG is also an effective inhibitor of protein glycation (the process in which sugar molecules bond to proteins by cross-linking': these non-functional structures accelerate the ageing process).
Take from 3 to 10 tablets per day, in one or two doses according to your therapist advise.
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet. Keep out of childrens' reach. Store away from direct light, heat and humidity. As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.