From its name, you would probably think oxaloacetate was a chemical or pharmaceutical but it is actually neither.
- Oxaloacetic acid, or oxaloacetate in its ionic form, is a dicarboxylic acid and an intermediate in the Krebs cycle. It is produced by dehydrogenation of malic acid, a reaction catalysed by the enzyme malate dehydrogenase.
- Oxaloacetate is a natural, biological substance comprising metabolites that are present in every cell of the body. These metabolites are directly involved in mitochondrial energy production.
- The components of oxaloacetic acid are found particularly in oranges and apples, although oxaloacetate is extremely unstable and does not last more than a day at room temperature. However, a complex process has just been developed that has enabled it to be thermally stabilised and thus made available for use in supplements.
- Recent biological studies have highlighted oxaloacetate's exceptional properties. Experiments have shown it to:
- increase lifespan in mice by over a quarter ;
- improve scores in endurance tests ;
- significantly boost antioxidant status ;
- regulate blood sugar levels ;
- combat denaturation of nucleic acids in the mitochondria ;
- protect pancreatic, neural and retinal tissues
- Even more significantly, oxaloacetate mimics and reproduces the recognised benefits of calorie restriction without the necessary reduction in calorie intake. In this sense, it is similar to the formulation Resveratrol Synergy, although it works via different mechanisms.
- This is one of those rare products that can increase lifespan, as confirmed by research on male mice which are known to have a shorter lifespan than females.
- This research showed that at the 50% mortality mark, oxaloacetate increased average lifespan by around 25% compared to a control group. The residual lifespan, ie, the lifespan remaining once oxaloacetate had been added to the diet, measured more than 39% as compared to the control group.
- In addition to these remarkable results, it was also reported that mice given oxaloacetate had minimal inflammation symptoms and a lower tendency to age-related curvature of the spine ; furthermore, bone density was higher than in the control group.
- Further studies have shown that oxaloacetate's activity is not restricted to mice. Research on Drosophila melanogaster (the common fruit fly) has demonstrated an average increase in lifespan of 20% following the addition of oxaloacetate to food. Similar results were also obtained with the roundworm C. elegans.
- Calorie restriction (by between 30% and 50%) has been widely shown to extend lifespan in mammals, including primates. It has a beneficial effect on most biological markers and delays the development of degenerative diseases. In humans, calorie restriction reduces the risk of atherosclerosis, peaks in fasting blood sugar, blood pressure, triglycerides and cholesterol.
- Being able to offer the equivalent of calorie restriction in a nutritional supplement is a major advance in combatting age-related degenerative diseases.
Oxaloacetate is an important calorie restriction mimetic that produces a number of beneficial changes in gene expression. It is also one of the only supplements that research has shown can genuinely extend lifespan in animals. Larger-scale human studies are now underway as part of the US National Institute on Aging's “Interventions Testing Programme”.