Telomeres Maintenance Formula
Extends lifespan by preventing shortening of telomeres.
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Promising new studies are beginning to support the use of certain nutrients and phytonutrients for maintaining telomeres.
Telomeres are the fine, protective tips found at the end of our chromosomes. With each cell division, the DNA in chromosomes has to be replicated, but at the same time, the telomeres shorten and so the life of the cell is reduced. Indeed, telomere shortening is directly linked to cell aging and development of the many diseases that accompany advancing age.
Telomerase is an enzyme that can lengthen the shortest telomeres. Recent studies show that it is not so much those of average length, but the shortest telomeres that telomerase affects. It is actually the percentage of short telomeres that is the best indicator of senescence, and even prevalence of mortality. Cycloastragenol and astragaloside IV have been shown to stimulate telomerase and thus extend the length of the shortest telomeres - which represents a significant advance – but they unfortunately have little or no effect on average-length telomeres.
Is there any way we can compensate for this telomere shortening? Researchers have identified a number of substances likely to be of benefit, some of them significantly so. Telomeres Maintenance Formula combines these substances, all of which have been scientifically tested and found to have genuine, consistent and confirmed effects.
¤ Magnesium ascorbyl-phosphate is a rare and stable form of vitamin C which is able to penetrate into cells. In vitro studies have shown that introducing it into human vascular endothelial cells prevents up to 62% of telomere shortening, via suppression of intracellular oxidative stress, whereas the natural form of vitamin C, ascorbic acid, has no effect. In addition, this form of vitamin C prevents the cell from widening, a valuable indicator of cell senescence.
¤ L-carnosine (beta-alanine-L-histidine), a natural di-peptide recognised for its anti-glycation and antioxidant properties, has also been shown in culture – particularly in lung fibroblasts - to counteract telomere damage and shortening by around 32%, and substantially lengthen lifespan.
¤ Extract of Terminalia chebula fruit, standardised to 30% tannins, has demonstrated cyto-protective effects against oxidative stress (particularly UVB-associated oxidative damage), as well as inhibitory effects on cell aging, in a study conducted at the College of Pharmacy of Chungnam University, Korea. The lifespan of treated cells was extended by 40% compared with the non-treated controls.
¤ Extract of green tea standardised in polyphenols, especially EGCG, is recognised for its ability to lengthen human telomeres. A large-scale Chine study carried out at the University of Hong Kong, involving over 2000 subjects aged 65 and over, showed that consuming at least 700ml/day of green tea led to an average lengthening in telomeres of over 46%, which equates to an extension in human lifespan of five years.
¤ Tocomax®, a standardised extract of palm fruit oil, provides 11% d-gamma tocotrienols. Tocotrienols are vitamin E isomers that boost the action of tocopherols. An in vitro study has demonstrated the protective effect of d-gamma tocotrienol against oxidative stress and its potential to produce significant increases in telomere length by modulating telomerase activity. In this study, cells were exposed for 24 hours to gamma tocotrienol, before and/or after two hour exposure to hydrogen peroxide. At the doses used in this study, the telomere length of treated cells was over 16% longer than controls.
¤ Extract of purslane 10:1 (Portulaca oleracea) was investigated in a study on three-month old mice given sub-cutaneous injections of the extract for a two-week period at doses of 2.5mg/kg a day. The results highlighted several benefits in purslane-treated mice, as compared with controls: improvements in learning and memorising, neuro-protective effects, increased SOD levels and in particular, an increase of over 27% in the activity of telomerase and telomeres of brain cells, after just two weeks’ supplementation. In vivo administration of purslane produced a slowing down in telomere shortening of between 24 and 57%, after only two weeks’ use.
¤ It was not technically possible to include Omega 3 fatty acids in this formulation, as these are better absorbed in an oil form, but their efficacy in maintaining telomeres is well-supported and we recommend taking them as well.
Taking the dose suggested of two capsules per 24 hours, this formulation represents the only real ‘insurance’ currently available against telomere shortening. We recommend taking it alongside cycloastragenol and astragaloside IV as it complements and boosts the effect.
adults. Take two capsules a day, after a meal.
Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet. Keep out of childrens' reach. Store away from direct light, heat and humidity. As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.