Maintaining a correct level of homocysteine is an essential element in a healthy cardiovascular system
¤ Indeed, it has been shown that elevated homocysteine damages internal artery walls and other cells when it is converted into toxic metabolites.
¤ A normal homocysteine level is considered to be less than 10-12 mmol per litre of blood but levels are generally found to be higher when tested and can often exceed the acceptable upper limit of 15 mmol/l. In order to make it harmless, homocysteine must be metabolised through one of two pathways: methylation and transulfuration.
¤ The methylation pathway requires the enzyme methylenetetrahydrofolate reductase (vitamin B9) and vitamin B12 in its methylated form (methylcobalamine), In the kidneys and liver, it is also methylated via demethylation of the enzyme betaine-homocysteine methyltransferase. This mechanism results in the trimethyl glycine present in the formulation.
¤ Transulfuration requires the enzyme cytathionine synthase and vitamin B6 (pyridoxine 5 phosphate); this is the process which enables cysteine to be used in the synthesis of proteins and cellular glutathione.
¤ Catalase, a major enzyme and cell protector, is also a powerful detoxifier as it reduces levels of circulating hydrogen peroxide molecules (H202 oxygenated water). It also acts as a protective antioxidant enzyme - supplementing catalase intake increases mitochondrial and cytoplasm stores. Supplementation has been shown to help extend lifespan in mice by around 20%, because of its ability to strengthen muscle tissue, in particular, cardiac muscle.
¤ This combination of synergistic ingredients can help improve:
- congestive heart failure ;
- migraine attacks (vitamin B complex) ;
- macular degeneration, both wet and dry forms ;
- noise-related hearing loss (by acting on nerve endings).
Preventing increases in homocysteine levels is therefore a simple, reliable, safe and effective way of protecting your health from a silent risk factor that's often ignored but is nonetheless prevalent in both men and women.