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Berberine 500 mg
Berberine 500 mg
Berberine 500 mg

Berberine (Berberis vulgaris extract)

  • Helps reduce blood glucose levels in people with type 2 diabetes.
  • May help improve lipid profiles (hyperlipidemia).

Availability : is available

Quantity : 60 tablets 32.00 €
(37.76 US$)
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Chinese and ayurvedic medicine utilise a number of plants that are still relatively unknown in Western medicine. One such plant is Berberis vulgaris, or European barberry, the berries of which contain a powerful plant alkaloid called berberine. Traditionally used for its immune-stimulant, anti-fungal, and anti-bacterial properties, and its ability to control intestinal disorders, this substance has emerged as a new means of treating type II diabetes and pre-diabetic conditions, incidence of which has been growing rapidly for some years.

¤ Berberine’s mechanism of action essentially relates to the regulation of AMPK-Adenosine Monophosphate activated Protein Kinase. This is a fundamental and ubiquitous enzyme which is involved in normalising energy metabolism and regulating food intake and sensitivity of tissues to insulin. Thus it plays a key role in certain metabolic diseases such as diabetes and its complications, insulin-resistance and obesity.

¤ In activating AMPK, berberine works at several levels :
    • by improving sensitivity to insulin, it facilitates intracellular glucose transport, enhancing the body’s use of both sugar and insulin and thus reducing blood glucose levels ;
    • by stimulating fatty acid metabolism in the mitochondria, it reduces levels of circulating lipids in the blood: triglycerides and LDL-cholesterol ;
    • by promoting extraction of glucose transporters from the circulation, it results in measurable reductions in blood sugar levels;
    • and finally, by increasing production of GLUT4, a glucose transporter present only in muscles and fat cells, it leads to significant improvements in insulin sensitivity.
¤ Such is the extent of berberine’s properties, it can be compared with metformin, a drug widely-used to treat type II diabetes and excess weight associated with glucose metabolism. Furthermore, the most representative studies focus on the efficacy of berberine versus metformin in patients with type II diabetes, whether or not associated with dyslipidaemia.

¤ With properties traditionally-recognised as beneficial to immunity, cardiovascular and intestinal health, berberine also appears to be an excellent, easy to use and well-tolerated nutritional supplement for treating type II diabetes in its early stages, or as an adjuvant therapy.

¤ Research on berberine suggests the recommended daily amount to be between 1,000 and 1,500 mg a day, spread over two or three doses, taken before the three main meals of the day.

¤ In order to benefit fully from berberine supplementation, it should be taken for at least three months, as its optimal activity is only apparent after two weeks’ regular use.

¤ Apart from a few reported cases of mild, temporary constipation immediately after beginning supplementation, berberine is completely free of side-effects.

¤ To summarise, the four main benefits from berberine supplementation are :
    • significant reductions in glycaemia ;
    • decreased levels of glycated haemoglobin (HbA1c) ;
    • rebalancing of circulating levels of insulin ;
    • lower triglycerides, LDL-cholesterol and total blood cholesterol.
Daily dose : 2 tablets
Number of doses per box : 30
Amount per dose
Berberine (from 1040 mg Berberis vulgaris extract standardised to 97 % berberine) 1 000 mg
Other ingredients : magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hydroxypropyl methyl cellulose, glycerol.


Adults. Take 2 tablets a day. Each tablet contains 500 mg berberine.

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet. Keep out of childrens' reach. Store away from direct light, heat and humidity. As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
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