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Agmatine Sulfate 250 mg
Agmatine Sulfate 250 mg


Agmatine Sulfate 250 mg

Agmatine nutritional supplement

  • For reducing stress.
  • Anti-depressant effects.
  • Can be used as a sports supplement.

    Availability : is available

    Quantity : 120 Veg. Caps 41.00 €26.65 €*
    (31.88 US$)
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    Best if used before 02/27/2018

    +Certificate of Analysis

    Agmatine (N-4-aminobutylguanidine) is a biogenic amine commonly found in certain foods (plant-based foods, fish, meat …) which is formed by the decomposition of proteins. It is present in almost all body tissues.

    ¤ It is synthesized and stored:
      • in brain cells, in synaptic vesicles, for binding to adrenoreceptors;
      • in spinal cord cells, acting in particular as metabolic support for the nervous system.
    ¤ Already present in Nitric Oxide Formula, agmatine is actually a by-product of arginine created by a process of decarboxylation. The enzyme that enables the conversion of arginine into agmatine in the stomach or intestine has not yet been confirmed. It is also thought the diet provides an independent, exogenous source of agmatine and that it is absorbed via a specific transporter.

    An essential role in nitric oxide production

    ¤ Nitric oxide (NO) is a gaseous molecule released by the body to relax the smooth muscle that surrounds blood vessels. When blood vessels contract, blood flow decreases and when they relax, blood flows more freely. Thus by dilating blood vessels, nitric oxide maintains stable blood pressure.

    ¤ NO is also active in pulmonary smooth muscle, improving oxygen flow to the lungs and reducing breathlessness. Finally, it can improve the quality of erections.

    ¤ As we age, however, our bodies produce less and less NO, increasing the potential for a number of diseases.

    ¤ Agmatine stimulates the release of nitric oxide by inhibiting potential NO-destructive enzymes and helps raise NO levels in the endothelial tissue surrounding blood vessels. It therefore helps prevent vein constriction and plays an important role in lowering blood pressure.

    It improves stress management

    ¤ Exposure to chronic stress upsets the hypothalamo-hypophyseal-adrenal axis, and may even cause mild depression. Agmatine is released in response to various stimuli of stress in order to maintain homeostasis.

    ¤ One study evaluated how agmatine supplementation influenced the harmful effects of chronic stress. It showed that taking agmatine led to an improvement in motivation - through the regulation of corticosterone levels and the prevention of weight fluctuations - that was comparable to fluoxetine, a selective serotonin reuptake inhibitor (SSRI). The study clearly demonstrated a positive effect for agmatine supplementation in the management of stress.

    A perfect supplement for sports enthusiasts

    ¤ Agmatine not only increases blood flow to muscles, via nitric oxide production, but also stimulates the release of LH and GH (growth hormone), making it a valuable pre-training substance for athletes. It increases stamina and improves performance, and reduces body fat mass.

    It relieves pain and improves quality of life in cases of lumbar disc hernation

    Double-blind studies conducted at the Orthopedics Department of the Tel Aviv Sourasky Medical Center highlighted agmatine’s efficacy in herniated lumbar disc-associated radiculopathy. The daily dose administered ranged from 1.3g to 3.5g over a period of 10 to 21 days. The results clearly showed that agmatine sulfate provided effective pain relief, and in particular, improved the quality of life of 70.8% of patients suffering from herniated lumbar disc-associated radiculopathy.

    Other indications :
      • it combats oxidative stress, an important factor in aging ;
      • it is neuro-protective and participates in spatial learning and memory processing as a potential new neurotransmitter;
      • it supports the release of catecholamines ;
      • iti promotes the release of insulin, reduces glycaemia and calcium absorption in pancreatic cells ;
      • it offers benefits for type 1 diabetics in reducing the accumulation of collagen in diabetic nephropathy ;
      • it may have a role as a cancer-preventive agent, due to modulation of polyamines such as spermine or spermidine which are involved in cellular growth.
    Absence of toxicity

    ¤ Clinical trials suggest that short-term (21 days), high oral doses of agmatine sulphate are effective and most importantly, safe. A long-term pilot study has also demonstrated the safety of agmatine sulphate supplementation.
    Daily dose : 4 capsules
    Number of doses per pack : 30
    Amount per dose
    Agmatine sulfate 1 000 mg
    Other ingredients: microcrystalline cellulose, magnesium stearate, silicon dioxide

    Adults. Take 2 to 4 capsules a day.
    Each capsule contains 250 mg of agmatine sulfate.

    Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet. Keep out of childrens' reach. Store away from direct light, heat and humidity. As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
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