Specific products
Natural Pain Relief 400 mg
Natural Pain Relief 400 mg
Natural Pain Relief 400 mg
Natural Pain Relief, an all-round, natural analgesic
  • formulated from palmitoylethanolamide (PEA);
  • anti-inflammatory and analgesic properties;
  • used for relieving neuropathic and inflammatory pain.

Quantity : 60 Veg. Caps. 48.00 €
(55.91 US$)
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Powerful and natural active principle

Our dietary supplement Natural Pain Relief is the result of many years’ research into palmitoylethanolamide. More commonly-known as PEA, this compound’s considerable therapeutic potential has made it the subject of numerous scientific studies. The anti-inflammatory and analgesic properties of this fatty acid amide have been known for decades but it was in 1990 that its therapeutic benefits were properly recognised by the scientific community as a result of the work of Italian Nobel Laureate Rita Levi-Montalcini. This famous neurologist demonstrated PEA’s efficacy in treating some types of neuropathic pain. Further research then led to the development of PEA-based nutritional supplements. These products have been available since 2010 in the form of powder or capsules and have made quite an impact in the Netherlands where they are offered as a new kind of natural pain relief.

Natural Pain Relief, a natural analgesic

Our new product, Natural Pain Relief, offers all the anti-inflammatory and analgesic properties of palmitoylethanolamide (PEA). The effects of this compound are significant given that pain can be common and varied. It can take the form of acute pain which is temporary in nature, or chronic pain that persists over a long period of time. Scientists also categorise pain by its origin: inflammatory pain which involves the immune system, neuropathic pain which is associated with the nervous system, and a mixture of the two – both inflammatory and neuropathic. A number of treatments have been developed to relieve such pain and it is within this context that PEA has been identified as natural solution to pain that is inflammatory, neuropathic or a mixture of the two. PEA has the advantage of being a natural molecule, found, for example, in eggs and milk.

Anti-inflammatory and analgesic properties of PEA

It is PEA’s particular mechanism of action which is responsible for its exceptional properties. According to some scientists, this fatty acid amide works by binding to a specific cell receptor called PPAR-alpha. This receptor activates peroxisomes - cell organelles involved in the regulation of pain and inflammation genes. By binding to the PPAR-alpha receptor, PEA reduces peripheral sensitivity induced by both neural and non-neural cells. In other words, PEA’s action reduces the sensation of pain in a number of situations. In this context, encouraging results have already been obtained in the management of diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, back pain, sciatica, pelvic pain and multiple sclerosis.

Natural Pain Relief, an optimal PEA formulation

Natural Pain Relief has been developed from a high quality, patented PEA formulation called OptiPEA©. This pain relief supplement is in capsule form with a suggested dose of three capsules a day, although this dosage can be adapted to your needs and the advice of your therapist. It should be noted that taking this supplement may not produce instant pain relief. Several days’ supplementation may be necessary to obtain the desired results. You may also be interested in our other formulations aimed at relieving joint pain: OptiMSM® and Joint Support Formula.
Daily dose: 3 capsules
Number of doses per pack: 20

per dose

OptiPEA©(Palmitoylethanolamide) 1 200 mg
Other ingredients : microcrystalline cellulose, magnesium stearate.
OptiPEA©, Innexus Nutraceuticals, Holland.

adults. Take 3 capsules a day.
Each capsule contains 400 mg of OptiPEA©.

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet. Keep out of childrens' reach. Store away from direct light, heat and humidity. As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.
See some of our customer reviews
"Now I don’t think about the pain any more – it’s like it’s disappeared."
Dominique H., 64, France
Following surgery for breast cancer in January 2009 at the age of 56, I had to have chemotherapy and radiotherapy which seriously weakened my bones. It left me unable to move about normally and I had to find a seat every 5-10 minutes to sit down and rest. On top of that, severe joint pain and stiffness meant that the simplest of everyday movements, such as climbing the stairs, were difficult. To relieve the pain, I was prescribed a codeine painkiller (Tramadol 200mg twice a day) which I’ve now been taking for two years, plus injections three times a year. While this gave me some relief, the side-effects were disabling (dizziness, falls ...). I’ve been a Supersmart customer for several years now and wanted to try their new product, ‘Natural Pain Relief’, described as a natural painkiller with no side-effects. I’ve now been taking this product for around one month and have stopped thinking about the pain – it’s as if it’s disappeared …. I’ve gradually reduced the drugs prescribed by my doctor and now I don’t take them at all. I go walking, stairs are no longer a challenge. I’m even surprising myself by dancing – something I haven’t been able to do for a long time. I didn’t even realise... I think it’s a very good product, thank you.
"Today, I no longer suffer the pain that used to be my constant companion."
Steve J., 33, UK
I’ve suffered from chronic lower back pain since I was a teenager but refused to take painkillers because of their effects on the liver and kidneys. One day, I saw Natural Pain Relief on the Supersmart website and decided to try it, albeit with reservations. To be perfectly honest, I felt no benefit the first week I used it, but then … a miracle happened.  Now, I no longer suffer the pain that used to be my constant companion. I’m back to normal, I walk without dragging my feet, I’ve begun to go jogging again and play team sports such as badminton. Natural Pain Relief quite simply changed my life. Thank you from the bottom of my heart.
"I can walk more easily and sleep much better."
Jurgen B., 58, Germany
I’ve suffered with back pain for 15 years. I did a lot of hiking from a very young age but I had to give it up … I was having to stop every five minutes to rest. At least twice a year, I put my back out and have to stay in bed for several days to recover. My doctor prescribed strong painkillers but the effects tended to diminish over time plus they caused dizziness. 

I half-heartedly tried Natural Pain Relief at the suggestion of my naturopath. To start with I felt no different, but after a week, my back pain began to subside and now it’s completely bearable. Walking is easier now and I’m sleeping much better.


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