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Welcome Shop by health concern Anti-ageing Dragonhead Extract + Natural Rapalogs
Dragonhead Extract + Natural Rapalogs
Anti-ageing Customer reviews
66.50 €(74.65 US$) is available
Description
Natural extender of life expectancy
  • Formulated to significantly extend life expectancy in mammals.
  • May help inhibit the (mTor) signalling pathway responsible for aging.
Anti-aging dragonhead extract that mimics the effects of calorie restriction
  • Produced from the leaves of the dragonhead plant (the most active part).
  • Helps replicate the effects of calorie restriction and increases longevity.
  • Helps improve the skin’s appearance (hydration, elasticity and density) and supports its regeneration.
  • Organic raw material.
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Dragonhead Extract + Natural Rapalogs
Dragonhead Extract + Natural RapalogsDragonhead Extract + Natural RapalogsDragonhead Extract + Natural Rapalogs

DragonHead Extract is a supplement made from the dragonhead plant (Dracocephalum moldavica), sometimes called ‘Moldavian Melissa’, which is traditionally used in Uighur medicine for combatting the aging process.

With its unique mode of action and high content in flavonoid glucuronides, it mimics the effects of calorie restriction, an action that significantly slows down the aging process. In the short term, it produces benefits for the skin, while in the long term, it promotes longevity.

It has a similar action to that of the exceptional anti-aging product Nicotinamide mononucleotide.

What benefits are offered by DragonHead Extract?

Aqueous extract of Dracocephalum moldavica is distinct in being able to mimic calorie restriction, and as a result, may be able to push back the limits of human life expectancy and reduce the risk of age-related diseases.

What exactly is calorie restriction and how does it affect aging?

Calorie restriction is simply limiting one’s food intake to the minimum necessary. Until very recently, it was the only method known to increase longevity whilst improving general health (3-5).

Calorie restriction activates a cell protein called AMPK (6-7) which itself triggers the expression of a family of genes called sirtuins (8-9-20). These genes slow down the aging process by acting on a number of cell mechanisms, such as DNA repair, resistance to oxidative stress and cell death. Studies also show that sirtuin activation increases insulin sensitivity and lipolysis, reduces levels of inflammation and plays a preventive role in neurodegenerative problems.

But just how many of us would be prepared to make such a huge sacrifice? A lifetime of drastically reduced calorie consumption in order to increase one’s life expectancy holds little appeal for most people (even if, in the past, such diets were undoubtedly responsible for the incredibly long life expectancy enjoyed by Japan’s Okinawa islanders).

Anti-aging dragonhead extract that mimics the effects of calorie restriction

Fortunately, researchers recently succeeded in isolating natural compounds capable of reproducing the beneficial effects of calorie restriction, with dragonhead emerging as one of the most impressive resources. When humans and other animals are given extract of dragonhead, its flavonoid glucuronides activate AMPK in exactly the same way as calorie restriction. This brings about the same increase in activation of sirtuins, the genes that slow down aging. This results in both general benefits and cellular ones, with effects ranging from a decrease in metabolic waste products, to a reduction in fat mass. Accordingly, one laboratory study showed that the compounds in DragonHead Extract led to an increase of 400% in AMPK activity, and of 300% in FOXO transcription factors which activate the sirtuin family. Perhaps most surprising is that the beneficial effects of this molecule are even observed in cases of overeating (which is common in Western countries).

With dragonhead’s ability to mimic calorie restriction, it’s therefore possible to have your cake (maximum life expectancy), and eat it too (normal calorie intake) and even have a cherry on top (a slim figure).

Additional benefits of DragonHead Extract

Through a domino effect, DragonHead Extract’s activation of sirtuins produces other health benefits too:

  • It improves the circulation(1).
  • It helps you slim down.
  • It supports regeneration of the skin and improves a number of visible markers (elasticity, density, hydration …). One study examined 32 women in their fifties with sun-damaged skin. Following daily administration of 200mg of DragonHead Extract for eight weeks, dermal imaging showed a 14% improvement in hydration, a 7% improvement in elasticity and an approximate 3% increase in skin density (2).

What exactly is Moldavian dragonhead?

It’s a plant that has recently been rediscovered and positively exploited for its high content in glucuronic flavonoids, the compounds responsible for its many properties. It is indigenous to central Asia where it plays a prominent part in Uighur medicine.

What is in DragonHead Extract?

DragonHead Extract is produced from the aerial parts of Moldavian dragonhead which contain most of the active substances. The use of high-quality aqueous extraction produces an extract packed with active compounds such as flavonoids, terpenoids, steroids, glycosides and volatile components. Of all these ingredients, it is the flavonoids which are the most active. Several studies have shown the most important flavonoids to be tilianin, luteolin-7-O-glucuronides, apigenin and rosmarinic acid (15-17). But as in all plant extracts, it is really the synergy between the components which is key.

Pharmacological studies have demonstrated the biological activity of this exceptional synergy: researchers have observed antioxidant, anti-hypoxic, immune-modulatory, anti-microbial, and vasodilatory properties (the latter accounting for its traditional use in treating heart and blood pressure problems (18-19).

How should DragonHead Extract be taken?

The recommended dose is two 100mg capsules a day, to be taken in between meals.

Other anti-aging supplements available from our catalogue include:

  1. Nicotinamide Riboside 125 mg;
  2. Longevity Nutrients, an enhanced formulation for promoting longevity;
  3. Natural Dopamine Support 400 mg, a wild green oat extract;
  4. Natural Rapalogs, a natural ‘rapalog’ formulation for slowing down aging;
  5. PQQ & Q10, a synergistic formulation for fighting cognitive impairment (PQQ and co-enzyme Q10).

Written : March 2019.

Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

References

  1. Maimaitiyiming D, Hu G, Aikemu A. The treatment of Uygur medicine Dracocephalum moldavica L on chronic mountain sickness rat model. Pharmacoqnosy Magazine. 2014;10:477–82.
  2. DracoBelle™ Nu Key to skin’s beauty by mimicking caloric restriction, [https://haanspecialingredients.nl/framework/files/35/uploads/Brochure_DracoBelle_Nu_.pdf]
  3. Leanne M. Redman, Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il'yasova, Eric Ravussin. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.02.019
  4. Heilbronn LK, de Jonge L, Frisard MI, DeLany JP, LarsonMeyer DE, Rood J, Nguyen T, Martin CK, Volaufova J, Most MM, Greenway FL, Smith SR, Deutsch WA, Williamson DA, Ravussin E (2006) Effect of 6-month calorie restriction on biomarkers of longevity, metabolic AGE (2011) 33:15–31 29 adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. J Am Med Assoc 295 (21):2482–2482
  5. Blanc S, Schoeller D, Kemnitz J, Weindruch R, Colman R, Newton W, Wink K, Baum S, Ramsey J (2003) Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction. J Clin Endocrinol Metab 88(1):16–23
  6. Greer EL, Oskoui PR, Banko MR, et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007 ; 282 : 30107–30119.
  7. Greer EL, Dowlatshahi D, Banko MR, et al. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 2007 ; 17 : 1646–1656.
  8. Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004 ; 303 : 2011–2015. [CrossRef] [PubMed] [Google Scholar]
  9. Motta MC, Divecha N, Lemieux M, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004 ; 116 : 551–563.
  10. Hwangbo DS, Gershman B, Tu MP, et al. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004 ; 429 : 562–566.
  11. Giannakou ME, Goss M, Junger MA, et al. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004 ; 305 : 361.
  12. Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 2001 ; 11 : 1975–1980.
  13. Willcox BJ, Donlon TA, He Q, et al. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 2008 ; 105 : 13987–13992
  14. Flachsbart F, Caliebe A, Kleindorp R, et al. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 2009 ; 106 : 2700–2705.
  15. Jiang W, He CH, Xing JG. Preparation technology of Dracocephalum moldevica total flavonoids pellets and its release mechanism. Chinese Traditional and Herbal Drugs. 2013;44:26–29.
  16. González-Trujano ME, Ponce-Muñoz H, Hidalgo-Figueroa S. Depressant effects of Agastache Mexicana methanol extract and one of major metabolites tilianin. Asian Pacific Journal of Tropical Medicine. 2015;8:185–90.
  17. Yang, L. N., Xing, J. G., He, C. H., Wu, T., The phenolic compounds from Dracocephalum moldavica L. Biochem. Syst. Ecol. 2014, 54, 19–22.
  18. Zeng, Q., Jin, H. Z., Qin, J. J., Fu, J. J., Hu, X. J., Liu, J. H., Yan, L., Chen, M., Zhang, W. D., Chemical constituents of plants from the genus Dracocephalum. Chem. Biodiv. 2010, 7, 1911–1929.
  19. Dastmalchi, K., Dorman, H. D., Laakso, I., Hiltunen, Raimo., Chemical composition and antioxidative activity of Moldavian balm (Dracocephalum moldavica L.) Food Sci. Technol. Int. 2007, 40, 1655– 1663.
  20. Michan S, Sinclair D. Sirtuins in mammals : Insights into their biological function. Biochem J 2007;404:1-13
  21. Bordone L, Cohen D, Robinson, et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007;6:759-67
Daily dose: 2 capsules
Number of doses per pack: 30
Amount per dose
DracoBelle™ (extract of dragonhead leaf - Dracocephalum moldavica) 200 mg
Other ingredients: white rice flour, acacia gum.

Each capsule contains 100mg of DracoBelle™. DracoBelle™, Mibelle, Switzerland.
Take 2 capsules a day.
"mTOR" or mammalian target of rapamycin refers to an enzyme from the serine/threonine protein kinase family encoded by the mTOR gene. It is found in humans as well as worms, mice, flies and yeasts. It regulates the growth, proliferation, motility and survival of cells.

¤ Cell senescence seems to be the driving force behind ageing, both in terms of loss of cell-replication potential as well as mTOR signalling pathways inducing “too much growth”. Successfully inhibiting mTOR signalling pathways has been shown to produce increased lifespan in worms, flies, yeasts and even mice if accompanied by calorie restriction.

¤ Rapamycin is a molecule produced naturally by the mycelial bacterium Streptomyces hygroscopicus, which was discovered on Easter Island in 1975. Also known as Sirolimus, it is an immunosuppressant drug used in orthodox medicine to prevent rejection following organ transplantation. Rapamycin inhibits the mTOR signalling pathway and studies show it can significantly extend lifespan in mammals, even when taken in later life, with increases in life expectancy for males and females of between 9% and 14% respectively.

¤ Other studies have identified its anti-diabetic properties (types I and II), as well as benefits for age-related cognitive decline, with increases in memory and learning capacity, and in particular, decreases in certain proteins seen in neurodegenerative diseases such as Alzheimer’s.

¤ In pre-clinical trials, Rapamycin analogues or “Rapalogs”, in particular inhibitors of the complex mTORC1, have shown measurable efficacy against certain cancers.

¤ Recent scientific findings suggest that, at precise concentrations, a number of completely natural substances can also inhibit mTOR; Natural Rapalogs contains a combination of these substances.

Curcumin

¤ Meriva® is a patented curcumin formulation (derived from Curcuma longa) combined with soy phospholipids to increase its bioavailability beyond that of classic standardised curcumin extracts. This key curcuma ingredient has emerged as a natural mTOR inhibitor and exhibits anti-tumour properties in a variety of cancer cell lines via modification of a number of oncogenic pathways.

Green tea extract standardised to 70% EGCG

¤ Studies have confirmed the inhibitory role of certain components of green tea (Camellia sinensis) on mTORC1 and mTORC2. Specifically, a study conducted by GlaxoSmithKline in Collegeville, Pennsylvania, showed that EGCg (epigallocatechin-3-gallate) acted as a double inhibitor, both of the P13K (phosphoinositide-3-kinase) pathway and the mTOR signalling pathway.

Resveratrol

¤ Research has established that transresveratrol, a polyphenol compound and calorie restriction mimetic, also inhibits the mTOR signalling pathway. Studies show that this pathway is activated by oxidised LDL-cholesterol lipoproteins in smooth muscle cells. Resveratrol can, however, block the phosphorylation and activation of the P13K and mTOR pathways. This activity is independent of resveratrol’s antioxidant effect and its activation of AMPK and clearly identifies a new property for resveratrol that may add to this polyphenol’s overall anti-atherogenic capacities.
Another article reported that at relatively high doses, resveratrol inhibits mTOR and cell senescence, while contributing to cell apoptosis.

Fisetin

¤ This flavonoid, extracted from the small tree Rhus succedanea, sends an activating signal to anti-aging gene carrier cells, ensuring DNA and neuron protection, particularly during periods of oxidative stress.
¤ Fisetin also has a stabilising effect on resveratrol by preventing its metabolic breakdown and thus supports its function of inhibiting the mTOR signalling pathway. Fisetin has also been shown to exhibit anti-tumour and anti-angiogenic activity.

Salicin extracted from white willow

¤ This highly active compound, extracted from white willow bark (Salix alba) gave rise to the isolation of the acetylsalicylic acid molecule (aspirin®) by the chemist Felix Hoffman. It has been shown that taking a baby aspirin (81 mg) a day cuts the risk of developing cancer by at least 25%. Salicin possesses all the activity of aspirin® including its mTOR inhibitory effect. Although not as fast-acting as aspirin®, its effect is less irritating and it has longer-lasting efficacy.

With its exceptional formulation, the complex Natural Rapalogs offers the benefits of five natural inhibitors of the mTOR signalling pathway. In addition to this potent natural complex, other natural anti-ageing supplements may also be of interest. The product Longevity Nutrients, for example, has been formulated to provide a range of anti-ageing nutrients with antioxidant, anti-inflammatory and anti-infection effects. Similarly, the powerful AMPK Booster contains three plant extracts with active principles that reactivate a key enzyme of metabolism called AMPK. Discover too the supplement Nicotinamide Mononucleotide (NMN), an innovative formulation based on the latest advances in anti-ageing medicine.

Daily dose : 3 capsules
Number of doses per pack : 30
Amount per dose
Meriva® (soy phospholipids, extracted from Curcuma longa)A 500 mg
Green tea extract standardised to 70% EGCg 340 mg
Polygonum cuspidatum extract standardised to 50% trans-resveratrol 400 mg
Rhus Succedanea extract standardised to 98% fisetin 10 mg
White willow extract standardised to 25% salicin 300 mg
Other ingredients: microcrystalline cellulose, magnesium stearate, silicon dioxide
Meriva®, Indena, Italy.
Adults. Take one capsule with every meal.
Do not take if allergic to aspirin.
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Dragonhead Extract + Natural Rapalogs
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