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Welcome Shop by health concern Brain nutrition Bacopa Monnieri + Gingko Biloba
Bacopa Monnieri + Gingko Biloba
Brain nutrition Customer reviews
38.70 €(43.43 US$) Limited quantity
Description
Gingko Biloba extract with high content of active principles
  • Standardised to 24% ginkgo flavonglycosides and 6% terpene lactones (ginkgolides A, B et C, bilobalides).
  • Supports healthy blood flow (microcirculation, cerebral and peripheral blood supply, capillary resistance, vasodilation).
  • Helps to maintain cognitive function and improve performance.
  • Sourced from a tree with famously resilient defence systems.
Extract of Bacopa monnieri leaf (5% bacosides)
  • Helps improve memory, learning capacity and information-processing.
  • Supports central nervous system function (general tonic).
  • Has a positive effect on the hippocampus.
  • Has been used for over 3000 years in Ayurvedic medicine.
  • Is standardised to provide at least 50% bacosides.
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Inspired by the sacred practices of Ayurveda, Bacopa monnieri 100 mg is a nootropic supplement, made from Bacopa leaves and standardised to 50% bacosides (the chemical compounds responsible for its nootropic effects).

It helps improve memory, learning capacity and information-processing, while at the same time supporting the whole central nervous system in functioning properly. It is often combined with Ginkgo biloba, another ‘gold-standard’ of Ayurvedic medicine.

Who should take Bacopa Monnieri 100 mg?

Bacopa monnieri 100 mg is aimed at many groups of people:

  • Those over 50 who want to combat cognitive decline.
  • Those who frequently experience recall problems and feel as if they’re losing their memory.
  • Those wishing to boost their cognitive function.
  • Those looking for a natural-source, traditionally-used nootropic.
  • Those with a parent, brother or sister affected by serious cognitive decline.

What benefits does Bacopa Monnieri 100 mg offer?

According to ancient Ayurvedic writings, Bacopa monnieri was recommended for various conditions of the central nervous system and mind: attention deficit, memory problems, chronic stress, decline in cognitive performance … It was used to stimulate awareness and help maintain an alert mind.

Today, research is beginning to confirm such anecdotal use. Many studies, including clinical trials, suggest that extracts of Bacopa monnieri help to improve certain cognitive functions and maintain memory(1-3) (retrieval of information (4-5), learning capacity, associative memory (6), visual memory, work memory etc.).

As is the case for almost all Ayurvedic plants, scientists have discovered mechanisms of action that support the claims made for this nootropic.

Bacopa monnieri’s mechanisms of action

Bacopa monnieri primarily encourages the formation of synapses (7-9), the junctions between two neurons which ensure that information is transmitted and neural circuits are maintained. All our cognitive abilities depend on these circuits: if they become weak or disappear, our performance declines. How does Bacopa monnieri do this? By triggering the production of several molecules central to healthy synaptic function: glutamate and neutrophins such as BDNF and NGF (10-12). These molecules are crucial for initiating the process (13-14). They support the creation of neural circuits (an essential stage in learning), help to maintain existing circuits (vital for preserving memories) and are involved in a cascade of neuromolecular events that support cognitive performance.

Recent double-blind trials showed improvements in cognitive function following supplementation (15-16). Standardised extracts of Bacopa containing at least 50% bacosides (the compounds responsible for the previously-mentioned effects) have also produced positive effects on short-term memory in healthy individuals (17-20).

5 good reasons to choose Bacopa Monnieri 100 mg from SuperSmart

When deciding which Bacopa monnieri supplement to buy, be sure to keep in mind the advantages offered by our product:

  1. Bacopa leaves were traditionally pressed to extract the juice which was then dried into a powder and made into a very sweet syrup in order to mask the bitter taste of the Bacopa.
    Though 100% inspired by this ancient practice, Bacopa Monnieri 100 mg is a product with neither sugar nor bitterness.
  2. Bacopa Monnieri 100 mg is a leaf extract which contains all the naturally-occurring compounds. It’s important to remember this as many cheaper supplements are made from the plant’s roots or stems.
  3. Each vegetarian capsule contains 100 mg of Bacopa monnieri extract standardised to provide at least 50% bacosides (the maximum available, with supplements generally offering between 20% and 50%).
  4. In India, Bacopa is currently recognised by medical authorities as a valid treatment for several types of mental and intellectual dysfunction.
  5. Bacopa Monnieri 100 mg contains no chemical bulking agents: just Bacopa monnieri leaves, acacia fibre and rice flour.

Additional measures to make Bacopa Monnieri even more effective

There are two types of intervention for improving aspects of cognition: taking nootropics such as Bacopa monnieri and brain training(21-23). A large number of studies show that brain training reduces age-related cognitive decline (24-27), and some suggest it is even more effective when combined with Bacopa monnieri supplementation.

The theory behind this potential synergy is quite simple.
Brain training reactivates neural circuits that were previously under-exploited or were in decline (28-30). As we age, many neural circuits disappear or become weaker in areas of the brain important for cognition and memory, such as the hippocampus, the striatum and the prefrontal cortex (31-32). When brain training is practiced frequently, it repeatedly reactivates these circuits and improves the connection between the neurons of which they’re composed (33). As a result, it helps boost or reorganise them more effectively. This reinforcement involves several molecules mentioned earlier in this article: glutamate, BDNF and TGF. Molecules whose production is promoted by Bacopa.

In other words, brain training is the stimulus which signals to the body that it’s time to boost its neural circuits. Bacopa is the supplier, providing the elements it needs in order to do so.

It’s therefore highly recommended that alongside supplementation with Bacopa monnieri, brain training, such as puzzles, brain-teasers and a range of cognitive tasks, is practised regularly. The aim of this combined approach is to counteract the cognitive losses that lead to decline. It needs to be maintained for at least 12 weeks to be effective.

Bacopa monnieri can also be combined with Ginkgo biloba supplements to increase blood supply to the brain and help maintain cognitive function.

If you’re interested in other natural Ayurvedic products, you may wish to consider:

Are there any precautions to be taken or interactions to be aware of?

As a precautionary measure, Bacopa monnieri is not recommended for women who are pregnant or breastfeeding.
Bacopa monnieri can in theory increase the effects of phenothiazine, a neuroleptic drug.

Updated: 30/01/2019

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place .

References

  1. S. Aguiar and T. Borowski, Neuropharmacological review of the nootropic herb Bacopa monnieri, Rejuvenation Res 16 (2013), pp. 313-326.
  2. M.P. Pase, J. Kean, J. Sarris, C. Neale, A.B. Scholey and C. Stough, The cognitiveenhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials, J Altern Complement Med 18 (2012), pp. 647-652.
  3. Russo and F. Borrelli, Bacopa monniera, a reputed nootropic plant: an overview, Phytomedicine 12 (2005), pp. 305-317.
  4. H.C. Barbhaiya, R.P. Desai, K. Pravina, et al., Efficacy and tolerability of BacoMind on memory improvement in elderly participants - a double blind placebo controlled study, J Pharmacol Toxicol 3 (2008), pp. 425-434.
  5. C. Stough, J. Lloyd, J. Clarke, et al., The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects, Psychopharmacology (Berl) 156 (2001), pp. 481-484.
  6. S. Roodenrys, D. Booth, S. Bulzomi, A. Phipps, C. Micallef and J. Smoker, Chronic effects of Brahmi (Bacopa monnieri) on human memory, Neuropsychopharmacology 27 (2002), pp. 279-281.
  7. S.R. Ingole, S.K. Rajput and S.S. Sharma, Cognition enhancers: current strategies and future perspectives, CRIPS 9 (2008), pp. 42-48.
  8. P. Semwal, T. Kapoor, P. Anthwal, B. Sati and A. Thapliyal, Herbal extract as potential modulator and drug for synaptic plasticity and neurodegenerative disorders, Int J Pham Sci Rev Res 25 (2014), pp. 69-79.
  9. C. Stough and M.P. Pase, Improving cognition in the elderly with nutritional supplements, Curr Dir Psychol Sci 24 (2015), pp. 177-183.
  10. J. Preethi, H.K. Singh, P.D. Charles and K.E. Rajan, Participation of microRNA 124- CREB pathway: a parallel memory enhancing mechanism of standardised extract of Bacopa monniera (BESEB CDRI-08), Neurochem Res 37 (2012), pp. 2167-2177.
  11. H. Priyanka, P. Bala, S. Ankisettipalle and S. Thyagarajan, Bacopa monnieri and lDeprenyl Differentially Enhance the Activities of Antioxidant Enzymes and the Expression of Tyrosine Hydroxylase and Nerve Growth Factor via ERK 1/2 and NF- [kappa]B Pathways in the Spleen of Female Wistar Rats, Neurochemical Research 38 (2013), pp. 141-152.
  12. M.K. Saraf, A. Anand and S. Prabhakar, Scopolamine induced amnesia is reversed by Bacopa monniera through participation of kinase-CREB pathway, Neurochem Res 35 (2010), pp. 279-287.
  13. M.P. Mattson, R.B. Lee, M.E. Adams, P.B. Guthrie and S.B. Kater, Interactions between Entorhinal Axons and Target Hippocampal Neurons: A Role for Glutamate in the Development of Hippocampal Circuitry, Neuron 1 (1988), pp. 865-876.
  14. Schmid, S. Hallermann, R. Kittel, et al., Activity-dependent site-specific changes of glutamate receptor composition in vivo, Nat. Neurosci. 11 (2008), pp. 659-666.
  15. M.P. Pase, J. Kean, J. Sarris, C. Neale, A.B. Scholey and C. Stough, The cognitiveenhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials, J Altern Complement Med 18 (2012), pp. 647-652.
  16. C. Neale, D. Camfield, J. Reay, C. Stough and A. Scholey, Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes, Br J Clin Pharmacol 75 (2013), pp. 728-737.
  17. Stough C, Lloyd J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
  18. Roodenrys S, Booth D, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory.Neuropsychopharmacology. 2002 Aug;27(2):279-81.
  19. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Stough C, Downey LA, et al. Phytother Res. 2008 Dec;22(12):1629-34.
  20. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Calabrese C, Gregory WL, et al. J Altern Complement Med. 2008 Jul;14(6):707-13.
  21. C. Hertzog, A.F. Kramer, R.S. Wilson and U. Lindenberger, Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced?, Psychol. Sci. Public Interest 9 (2008), pp. 1-65.
  22. S. Rabipour and A. Raz, Training the brain: fact and fad in cognitive and behavioral remediation, Brain Cogn 79 (2012), pp. 159-179.
  23. Zangara and K.A. Wesnes, Herbal Cognitive Enhancers: New Developments and Challenges for Therapeutic Applications In: M.K. Thakur and S.I.S. Rattan, Editors, Brain Aging and Therapeutic Interventions, Springer Netherlands (2012), pp. 267- 289.
  24. J. Reijnders, C. van Heugten and M. van Boxtel, Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review, Ageing Res Rev 12 (2013), pp. 263-275.
  25. M.E. Kelly, D. Loughrey, B.A. Lawlor, I.H. Robertson, C. Walsh and S. Brennan, The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis, Ageing Res Rev 15 (2014), pp. 28-43.
  26. A.M. Kueider, J.M. Parisi, A.L. Gross and G.W. Rebok, Computerized cognitive training with older adults: a systematic review, PLoS One 7 (2012), p. e40588.
  27. M. Martin, L. Clare, A.M. Altgassen, M.H. Cameron and F. Zehnder, Cognitionbased interventions for healthy older people and people with mild cognitive impairment, Cochrane Database Syst Rev (2011), p. CD006220.
  28. J.A. Anguera, J. Boccanfuso, J.L. Rintoul, et al., Video game training enhances cognitive control in older adults, Nature 501 (2013), pp. 97-101.
  29. K.I. Erickson, S.J. Colcombe, R. Wadhwa, et al., Training-induced plasticity in older adults: effects of training on hemispheric asymmetry, Neurobiol Aging 28 (2007), pp. 272-283.
  30. S. Heinzel, R.C. Lorenz, W.R. Brockhaus, et al., Working memory load-dependent brain response predicts behavioral training gains in older adults, J Neurosci 34 (2014), pp. 1224-1233.
  31. D.L. Dickstein, C.M. Weaver, J.I. Luebke and P.R. Hof, Dendritic spine changes associated with normal aging, Neuroscience 251 (2013), pp. 21-32.
  32. T. Hedden, Imaging Cognition in the Aging Human Brain In: D.R. Riddle, Editor, Brain Aging: Models, Methods, and Mechanisms, CRC Press, Boca Raton (FL) (2007).
  33. K.I. Erickson, S.J. Colcombe, R. Wadhwa, et al., Training-induced plasticity in older adults: effects of training on hemispheric asymmetry, Neurobiol Aging 28 (2007), pp. 272-283.
Daily serving: 6 capsules
Number of servings per bottle: 16
Quantity per serving
Bacopa monnieri (leaf extract standardised to provide 50% baccosides) 600 mg
Other ingredients: Acacia gum, rice flour.

Each vegetarian capsule contains 100 mg Bacopa monnieri extract standardised to provide at least 50% baccosides.
Take one or two capsules, one to three times a day, as required or as advised by your therapist.

Ginkgo biloba 25mg is an exceptional supplement formulated from one of the oldest species of tree on Earth. Now one of the world’s most widely-used supplements , Ginkgo biloba boasts numerous scientifically-supported benefitsfor the circulation and for cognitive function.

The supplement offered by SuperSmart differs from other such products in that it has a very high content of active principles: 24% ginkgo flavonglycosides and 6% terpene lactones (ginkgolides A, B et C, bilobalides). Unlike many average products on the market, this supplement is composed exclusively of natural ingredients (natural extract of Ginkgo biloba, rice flour and acacia fibre).

Who is Ginkgo Biloba 60mg aimed at?

A truly exceptional species, Ginkgo biloba can improve daily life for all sorts of people.

Nonetheless, it is especially recommended for those at higher risk of cognitive decline and circulation problems:

  • those aged over 50, particularly women;
  • those who suffer with circulation problems;
  • those who are not very physically active;
  • those with raised cholesterol levels;
  • those who smoke;
  • those with hypertension;
  • those who are overweight;
  • those with a parent, brother or sister affected by significant cognitive decline.

What are the benefits offered by Ginkgo biloba?

Therapeutic use of Ginkgo biloba among Asian populations dates back thousands of years: it is actually one of traditional Chinese medicine’s most important plants.

Substantiating the experiences of these forebears, more than 200 studies conducted over the course of the 20th century have confirmed the effects of ginkgo biloba on circulation and brain function (1).

A positive effect on circulation

There are many compounds responsible for this effect, the most important of which are without doubt the flavonoids. These antioxidants are recognised for acting at all levels of the circulatory system (2). Ginkgo biloba contains a large number of them such as kaempferol, quercetol and luteolin, grouped together under the name ginkgo flavonglycosides. Once ingested, they help:

  • relax capillary resistance;
  • increase blood flow to the brain;
  • combat platelet activating factor which promotes blood viscosity and inflammation of blood vessels (3-4);
  • act as ‘flak-jackets’ against oxidising agents circulating in the blood that damage blood vessels (5-6);
  • improve the fat and carbohydrate metabolism implicated in inflammation of blood vessel walls (7);
  • improve the circulation (8-9).

Benefits for cognitive decline

Research shows that Ginkgo biloba is able to optimise cognitive function while at the same time slowing down cerebral ageing. Its high content of terpene lactones (primarily bilobalides) means it is able to protect mitochondrial barriers from oxidising elements (10-11), which helps increase energy production (fewer ‘leaks’). It also consolidates neural circuits which ensures the preservation of our memories and the optimisation of our cognitive faculties. (14).

In addition to its effect on mitochondrial function, Ginkgo biloba extract also contributes to several physiological improvements in cognitive health:

  • increased serotonin in synapses which boosts activity in the hippocampus, a memory-integrating structure in the brain;
  • stronger expression of the genes that control synaptic growth in neurons (15) ;
  • deactivation of NF-kB, a pro-inflammatory molecule implicated in neuro death.
  • Two recent meta-analyses identified studies highlighting these effects on the brain and confirmed ginkgo’s efficacy for improving daily life and problems with cognitive function (difficulty concentrating, changes in memory, confusion, low cognitive efficiency ...) (16).

5 good reasons to choose SuperSmart’s Ginkgo Biloba 60mg

  1. It’s an exceptionally high-quality product with a high content in active principles: 24% ginkgo flavonglycosides and 6% terpene lactones (ginkgolides A, B and C, bilobalides).
  2. the excipients used are 100% natural (acacia and rice flour).
  3. Ginkgo biloba is an extremely hardy species : it has adapted to all the climate changes that have taken place over the last 150 million years or more, making it a genuine ‘living fossil’. In 1945, four ginkgo biloba trees survived the nuclear bomb at Hiroshima despite being located less than 3 kilometres from the impact. A feat which is testimony to their incredible resilience.
  4. The lifespan of the Ginkgo biloba is extraordinary: the oldest specimens are 4000 years old and 40 metres tall. This longevity is attributed to the remarkable combination of micronutrients found in the tree’s cells which enables it to resist disease, parasites, pollutants, heat, insects and even ageing itself.
  5. It’s one of the most clinically-tested natural substances for improving the circulation and optimising cognitive function. .

Additional steps you can take to enhance the efficacy of Ginkgo biloba supplementation

In order to deliver the benefits of Ginkgo biloba, our supplement is offered at a suggested dose of three capsules a day, to be taken with meals. While it can be adjusted in line with your needs and the advice of your therapist, this dose corresponds to the recommendations of Commission E (an independent scientific advisory board), the WHO and the IQWIG (an independent agency responsible for assessing the quality and efficiency of ingredients, amongst others). As ginkgo’s effects take a little while to be fully appreciated, it is advisable to continue supplementation for at least two to three months.

To enhance its efficacy, you can also adopt the following measures throughout the supplementation period:

1) Eat as much fresh fruit and vegetables as possible and consider taking a multivitamin supplement. Restoring optimal nutritional status in antioxidant micronutrients is essential for combatting cognitive decline and circulation problems.

2) Start taking exercise again, or if you’re already doing so, gradually increase its intensity. This will increase neurogenesis - the production of new neurons – and improve the volume of blood in the brain, resulting in improved cognitive performance. It will also promote compression of the muscles adjacent to veins, facilitating venous return.

3) Ensure you drink more water than usual (to prevent dehydration) and do deep breathing exercises several times during the day.

An age-old witness to the history of the world and humankind, Ginkgo biloba has managed to withstand all the challenges it has faced over time because of its unique richness in micronutrients. SuperSmart has harnessed the best of this remarkable tree to produce a 100% natural supplement.

Updated 30/08/2018

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place

Références

  1. Singh B, Kaur P, Gopichand, et al. Biology and chemistry of Ginkgo biloba. Fitoterapia. 2008;79(6):401–18.
  2. Hertog MG, Feskens EJ, Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet. 1997;349(9053):699.
  3. Tzeng SH, Ko WC, Ko FN, et al. Inhibition of platelet aggregation by some flavonoids. Thromb Res 1991; 64(1): 91-100.
  4. Smith PF, Maclennan K, Darlington CL. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J Ethnopharmacol. 1996;50(3):131–9.
  5. Ou HC, Lee WJ, Lee IT, et al. Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells. J Appl Physiol 2009; 106(5): 1674-85.
  6. Pierre SV, Lesnik P, Moreau M, et al. The standardized Ginkgo biloba extract Egb-761 protects vascular endothelium exposed to oxidized low density lipoproteins. Cell Mol Biol 2008; 54(Suppl 1): 1032-42.
  7. Fiorentino TV, Prioletta A, Zuo P, et al. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des 2013; 19(32): 5695-703.
  8. Tsai TN, Lin WS, Wu CH, et al. Activation of Kruppel-like factor 2 with Ginkgo biloba extract induces eNOS expression and increases no production in cultured human umbilical endothelial cells. Acta Cardiol Sin 2014; 30(3): 215-22.
  9. Kubota Y, Tanaka N, Umegaki K, et al. Ginkgo biloba extractinduced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci 2001; 69(20): 2327-36.
  10. Abdel-Kader R, Hauptmann S, Keil U, et al. Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res. 2007;56(6):493–502.
  11. Eckert A, Keil U, Kressmann S, et al. Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress. Pharmacopsychiatry. 2003;36(Suppl 1):S15–23.
  12. Janssens D, Michiels C, Delaive E, et al. Protection of hypoxiainduced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem Pharmacol. 1995;50(7):991–9.
  13. Janssens D, Remacle J, Drieu K, et al. Protection of mitochondrial respiration activity by bilobalide. Biochem Pharmacol. 1999;58(1):109–19.
  14. Tchantchou F, Lacor PN, Cao Z, et al. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis. 2009;18(4):787–98.
  15. Rimbach G, Wolffram S, Watanabe C, et al. Effect of Ginkgo biloba (EGb 761) on differential gene expression. Pharmacopsychiatry. 2003;36(Suppl 1):S95–9.
  16. Ahlemeyer B, Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci. 2003;60(9):1779–92.
Daily serving: 3 capsules
Number of servings per bottle : 30

Quantity
per serving

Ginkgoflavonglycosides (extracted from 180 mg of Ginkgo biloba standardised to contain 24% ginkgoflavon-glycosides 43.2 mg
Terpene lactones (extracted from 180 mg of Ginkgo biloba standardised to contain 6% terpene lactones) 10.8 mg
Ginkgolide A (extracted from 180 mg of Ginkgo biloba standardised to contain 1.5% ginkgolide A) 2.7 mg
Ginkgolide B (extracted from 180 mg of Ginkgo biloba standardised to contain 1.2% of ginkgolide B) 2.16 mg
Other ingredients: Acacia gum, rice bran.

Each vegetarian capsule contains 60 mg of Ginkgo biloba extract.
Take 2 to 3 capsules a day during the meal.
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