What is hyaluronic acid?
Over the past few years, hyaluronic acid has received significant attention from both the medical press and the cosmetics sector. It’s a polysaccharide macromolecule from the glycosaminoglycan family which is abundant in the skin and synovial fluid (the viscous fluid surrounding our joints). Under normal conditions, the human body contains around 12g.
It’s produced by cells called chondrocytes and synoviocytes to increase the viscosity of synovial fluid, which improves lubrication of the joints. It also helps maintain good hydration in the skin by capturing water and retaining it in the skin’s deeper layers (1). In some cases, it also reduces the concentration of inflammatory mediators and activity of immune cells.
The viscosity of the gel depends on the chain length of the hyaluronic acid. The higher its molecular weight, the greater the molecule’s capacity for absorbing water. Therefore, with a molecular weight of 1.2 million Daltons, Hyaluronic Acid 150 mg is one of the best sodium hyaluronate supplements available.
How is hyaluronic acid produced?
Hyaluronic acid is obtained in two different ways:
- by extraction from rooster combs, after which it is crushed, chemically treated and purified;
- by bacterial fermentation: strands of hyaluronic acid are produced from innocuous bacteria.
Hyaluronic Acid 150 mg is made using the second of these methods. It is therefore 100% suitable for vegetarians and vegans and offers guaranteed, controlled optimal purity.
The human body is itself able to produce hyaluronic acid via a mechanism discovered around 20 years ago by Professor Paul Weigel and his team. Synthesis occurs at the inner side of plasma membranes and is a fast, effective and unique process.
What are hyaluronic acid’s properties?
Hyaluronic acid is present in the form of sodium hyaluronate (also called hyaluronan) in the synovial fluid surrounding joints. It usually has a molecular weight of more than 1 million Daltons and under normal conditions, is highly concentrated. As a result of its specific structure and considerable size, it can retain enormous amounts of water (up to 1000 times its own weight), and all the nutrients and hydrophilic substances that go with it. It is solely responsible for the viscosity and elasticity of synovial fluid.
In certain disease states, both the concentration and molecular weight of sodium hyaluronate decrease, contributing to an increase in inflammatory processes and adverse effects on cartilage (2).
Is high molecular weight hyaluronic acid well-absorbed?
It was long believed that when taken orally, hyaluronic acid had no real clinical benefit because of its particularly high molecular weight. In fact, the bioavailability of orally-administered hyaluronic acid is well-documented (3).
Animal studies, which were somewhat late in investigating this question, have shown that when administered orally, part of the hyaluronic acid molecules are perfectly capable of reaching the bloodstream and various body tissues. This discovery concurs with the recorded effects of hyaluronic acid supplementation in horses and other animals (4-6) as well as in humans (7-8).
It’s believed that these molecules cross the gut wall via micro-particles (9-10) and that part of them reaches peripheral tissues such as the skin and joints without any difficulty. The transport of hyaluronic acid in the body is, in any case, a completely normal physiological process (11-12).
It’s therefore entirely appropriate that hyaluronic acid should be available in dietary supplement form (13-15). Supplements represent an alternative to the HA injections given by health professionals and recommended by the European League against Rheumatism (EULAR).
Why is it better to take high molecular weight hyaluronic acid?
Studies show that low molecular weight hyaluronic acid molecules have a completely different function in the body: they can activate cascades of molecular events which trigger the release of inflammatory cytokines. Following trauma, enzymes break the hyaluronic acid up into multiple molecules of lower molecular weight which have a pro-inflammatory effect.
These effects are not seen with large hyaluronic acid molecules, which supports the belief that they are not broken down by digestive enzymes before crossing the intestinal barrier.
What other measures can be combined with taking Hyaluronic Acid 150mg?
Alongside supplementation with hyaluronic acid, the following steps are highly recommended:
- gradually increase the time you spend exercising every day;
- avoid making too many repetitive movements or putting too much strain on painful joints;
- consider physiotherapy or phytotherapy for reducing pain. For example, the boswellic acid in the natural supplement Super Boswellia helps to reduce joint pain and inflammation
Should hyaluronic acid capsules be taken every day?
The life of a hyaluronic acid molecule is relatively short, ranging from 12 hours to a few days. It’s thought that a third of the body’s total hyaluronic acid composition is renewed each day under normal circumstances. A daily dose of two 150mg capsules is therefore recommended.
This dose is not associated with any adverse side-effects, whether taken for short periods (two weeks) or indeed for up to 12 months.
Dr. Nahon’s view
The huge advantage of this method is that it offers an alternative to painful and sometimes dreaded injections. Oral administration of hyaluronic acid is simple and safe and produces the same results as those demonstrated in recent scientific studies.
It’s worth noting that there is no difference between men and women in terms of the treatment’s activity.
This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the directions for use, the recommended daily dose and the ‘use-by’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of reach of young children. Store in a cool, dry place
- Davies DV, Palfrey AJ. Visco-elastic properties of some pathological human synovial fluids. Ann Rheum Dis 1969;28(2):194.
- Wright V, Dowson D. Lubrication and cartilage. J Anat 1976;121(Pt 1): 107e18.
- Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53(3):523e37.
- Pierce, S. W. Efficacy of orally administered sodium hyaluronate gel in the racing thoroughbred. In Hyaluronan 2003 Proceedings. Chapter 6 Musculoskelatal System: Balazs, E. A., Hascall, V. C., Eds.; Matrix Biology Institute: Cleveland, OH, 2004; pp 1-4
- Bergin, B. J.; Pierce, S. W.; Bramlage, L. R.; Stromberg, A. Oral hyaluronan gel reduces post operative tarsocrural effusion in the yearling Thoroughbred. Equine Vet. J. 2006, 38, 375–378.
- Martinez-Puig, D.; Carmona, J. U.; Arguelles, D.; Deulofeu, R.; Ubia, A.; Prades, M. Oral hyaluronic acid administration improves osteochondrosis clinical symptoms and slightly increses intraarticular concentration of hyaluronic acid in a horse model: a pilot survey. Osteoarthritis Cartilage 2007, 15, C62-C63(abstract 96).
- Kalman, D. S.; Heimer, M.; Valdeon, A.; Schwartz, H.; Sheldon, E. Effect of a natural extract of chickencombs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized doubleblind placebo-controlled trial. Nutr. J. 2008, 7 (3), 1–9.
- Bucci, L. R.; Sheldon, E.; Schwartz, H.; Pachon, J.; Kalman, D.; Mederos, M.; Pezzullo, J. C.; Beer, C. Comparison between glucosamine with chondroitin sulfate and glucosamine with chondroitin sulfate and hyaluronate for symptoms of knee osteoarthritis. Osteoarthritis Cartilage 2005, 13, S99.
- Florence, A. T.; Jani, P. U. Oral uptake of microparticles across the gastrointestinal mucosa. In Drug Targeting and DeliVery: Concepts in Dosage Form Design; Junginger, H. E., Ed.; Ellis Horwood: New York, NY, 1992; pp 113-128
- Thanos, C. G.; Yip, K. P.; Mathiowitz, E. Intestinal uptake of polymer microspheres in the rabbit studied with confocal microscopy. J. Bioact. Compat. Polym. 2004, 19, 247–266
- Liu, N. Metabolism of macromolecules in tissue. Lymphat. Res. Biol. 2003, 1 (1), 67–70
- Liu, N. Trafficking of hyaluronan in the interstitium and its possible implications. Lymphology 2004, 37 (1), 6–14.
- Balogh L, Polyak A et al. Absorption, Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs. J. Agric. Food Chem., Vol. 56, No. 22, 2008
- Ricci M, Micheloni GM et al. Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis. Musculoskelet Surg. 2017 Apr;101(1):45-49. doi: 10.1007/s12306-016-0428-x. Epub 2016 Sep 28.
- Panuccio E, Memeo A, Richetta S. [Evaluation of the combined treatment of oral viscosupplementation with hyaluronic acid intra-articular injection on symptomatic knee osteoarthritis]. Clin Ter. 2015;166(5):e321-6. doi: 10.7417/T.2015.1886.
|Daily dose: 2 capsules
Number of doses per pack: 30
|High molecular weight sodium hyaluronate
||300 mg |
| Other ingredients: acacia gum, rice flour. |
adults. Take 2 capsules a day.
Each vegetarian capsule contains 150 mg of high molecular weight sodium hyaluronate.
Super Boswellia is a 100% naturalBoswellia Serrata supplement for improving comfort of the joints. Its enrichment with active principles (20% AKBA) and superior absorption make it one of the best supplements on the market, along with Joint Support Formula.
Who is Super Boswellia aimed at?
Super Boswellia is designed for several groups of people:
- those suffering from joint pain or stiffness;
- those experiencing discomfort in particular joints;
- those with inflammation (in the joints or elsewhere) ;
- those affected by decreasing flexibility in certain joints.
What is Boswellia serrata?
Boswellia serrata is a tree indigenous to India, the Middle East and Africa which belongs to the Burseraceare family. The resin it produces is one of the most popular natural health products available today, especially with those plagued by joint problems.
An oleo-gum resin known as ‘olibanum’ or ‘incense’ is produced by resin-secretory structures in the tree, and tapped from incisions made on its trunk. This resin solidifies on contact with air and releases a pleasant scent when burned. It is teardrop-shaped, around 2cm in diameter, amber-brown in colour with a very brittle consistency.
It is held in particular esteem by the world’s principal traditional systems of medicine. In Ayurvedic medicine, it is known as ‘Salaï Guggul’ or ‘Shallaki Guggul’ (1).
Super Boswellia is formulated to contain up to 20% AKBA, a much higher than normal level. It is made from the Boswellia serrata tree, as this is the richest source of AKBA (2). Extract of Boswellia serrata generally consists of 5-10% essential oil (including primarily α-pinene, α-thuyene, myrcene and sabinene), and also importantly, four boswellic acids including AKBA and KBA, the tree’s major active principles.
Where does Boswellia serrata come from? How is Super Boswellia made?
The Boswellia serrata tree grows mainly in the dry regions of India, tropical Africa and the southern Arabian peninsula (Yemen, Oman). In summer or autumn, a few months after deep incisions have been made in the tree’s bark, the oleoresin gum is collected. Once it has solidified in the open air, it is scraped off as amber-coloured teardrops and the collected resin is then made into a dry extract and produced in vegetarian capsule form. Trees from the Boswellia species cannot go on producing good quality resin indefinitely: after three consecutive years of harvesting, they must be allowed to ‘rest’ for a few years.
Super Boswellia is produced by the Laila Impex Research Centre, in India, an establishment recognised by the country’s Department of Scientific and Industrial Research (DSIR) and affiliated to a number of university programmes.
What are Boswellia serrata’s mechanisms of action?
Boswellia serrata was used by the Persians, Greeks, Romans, Indians, Chinese and other civilisations for ‘purifying the soul of the departed’ during ceremonial rituals, as well as for its medicinal properties. Ayurvedic texts credit its use with a wide range of benefits, especially improving joint health (3).
These benefits are due to the two ingredients mentioned above, KBA and AKBA. A number of in vitro studies show that KBA and AKBA inhibit 5-lipoxygenase (5-LO), an enzyme which plays a role in inflammation and thus joint discomfort. AKBA is potentially the more effective of the two because of its acetyl group which gives it greater affinity with 5-LO. Other mechanisms of action are also under investigation (TNF, IL-1, MMP3…).
Frequently-asked questions from internet-users
How does Super Boswellia compare with other such supplements?
Super Boswellia has been specifically enriched with AKBA, the boswellic acid with the most pronounced effect on 5-LO. While many supplements are produced from other Boswellia species such as Boswellia carterii, Boswellia frereana and Boswellia bhau-dajiana, Super Boswellia is made from Boswellia serrata, the richest source of boswellic acid.
What’s more, it has been shown to be better absorbed (by around 52%) than other extracts on the market.
Why is the boswellia not grown in Europe?
It is not possible to harvest from boswellia grown in Europe because the overly-humid conditions produce a coating on the resin which makes its extraction very difficult and causes the resin to be impermeable to solvents.
Do the incisions made on the trunk cause serious damage to the tree?
Boswellia is a robust tree which can easily withstand the cuts made to the bark when harvesting the resin. Having said that, it has to be allowed to rest for several years after three consecutive years of harvesting.
What is the preferred dose?
The suggested daily dose is one 100g capsule, to be taken with the most substantial meal of the day.
With which other supplements can Super Boswellia be combined?
While the bioavailability of boswellic acid is relatively low, it can be significantly increased by combining it with lipids. Eating food that’s high in fat (the healthy kind, of course) will thus increase the absorption of Super Boswellia, which is why it’s advisable to take it with a meal.
Turmeric/curcuma supplements such as Natural Curcuma and Super Curcuma also help reduce inflammation and combining them with boswellia is likely to have a synergistic effect. There are two other supplements worth mentioning here: Smart joints creamUC II® 10 mg, a undenatured type II collagen supplement.
This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.
- Sharma S, Thawani V et al. Pharmacokinetic study of 11-keto β-Boswellic acid. Phytomedicine. 2004 ;11(2) :255-260.
- Abdel-Tawab M, Werz O et al. Boswellia serrata : an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. Juin 2011 ;50(6) :349-369.
- Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent : an overview. Indian J Pharm Sci. 2011 ;73(3) :255-261.
- Bannuru RR, Osani MC, Al-Eid F, Wang C. Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2018 Mar 10. pii: S0049-0172(18)30002-7. doi: 10.1016/j.semarthrit.2018.03.001
|Daily dose : 1 capsules
Nombre de doses par boîte : 60
|Amount per dose
[Extract of Boswellia serrata standardised to 20 % 3-0-acetyl-11-keto-beta-boswellic acid (AKBA)]
| Other ingredients :Acacia gum, rice flour.
AprèsFlex™, PL Thomas, USA.
Adults. Take one capsule a day.