A powerful and original nutrient, CBD 25mg is emerging as an important natural painkiller: it is aimed at anyone who is exhausted by pain and the impact it has on their everyday life. It is similar to CBD Oil 6% but has a much higher concentration of active principles (25mg vs 5mg for CBD Oil).
Its main applications are for:
- severe or intractable pain;
- acute and chronic pain;
- muscle and joint pain;
- headache and migraine, particularly those caused by stress and sleep problems;
- neuropathic and fibromyalgia pain;
- sleep problems caused by pain of various sorts.
What is CBD?
Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp ((Cannabis sativa) alongside the well-known psychotropic substance tetrahydrocannabinol (THC). However, unlike THC, CBD does not have any narcotic properties.
It is a natural compound which mimics the action of endocannabinoid messengers produced by the body. Like them, it is able to bind to specific receptors (CB1 and CB2) located on external cell membranes, and trigger various cellular responses such as restricting synaptic transmission, relieving pain and reducing spontaneous locomotion (1). Just like endogenous cannabinoids, CBD thus inhibits the transmission of small diameter nociceptive fibres (which are involved in the pain process) and reduces the release of neurotransmitters like substance P, responsible for transmitting pain .
Unlike THC, which has a strong affinity for CB1 receptors, CBD binds more to CB2 receptors. These are found on the surface of cells of the central nervous system and in particular in immune system tissues where they are involved in modulating memory, emotions and pain (chronic, inflammatory or neuropathic) (2-3).
What are the effects of CBD 25mg ?
What are the effects of CBD 25mg on pain?
The binding of CBD to CB2 receptors, and the modulation of serotonin receptors triggers a cascade of molecular reactions, the main effects of which are:
A reduction in the inflammatory response . The modulation of receptors leads to both a rise in BDNF (a protein that promotes growth and differentiation of new nerve cells), and a reduction in microglial cells and pro-inflammatory mediators (4-5).
Stimulation of vasodilation. (6-7).
A decrease in sensitivity to pain. CBD promotes activation of PPARs, proteins that act as a transcription factor for certain genes involved in pain transmission.
A neuro-protective effect . CBD helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation. (8).
An analgesic effect (by reducing the transmission of nociceptive fibres).
An anxiolytic effect. . Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several disorders such as stress and anxiety.
An improvement in sleep (9).
What’s the right CBD dose for optimal efficacy?
This depends on several factors:
- the concentration of the CBD;
- a person’s weight;
- individual biological factors;
- the severity of the initial problem or symptoms.
For someone with a bodyweight of 70kg, and where the product is standardised to 17% CBD, the optimal dose would be 25mg, although this can be gradually increased to 50mg depending on the results obtained (though this higher dose should not be exceeded). CBD can also be vaporised but the most stable and consistent mode of administration is expertly-dosed, oral capsules.
“Over a lifetime, our body’s physiology changes, as does the number and distribution of receptors in the endocannabinoid system which are directly responsible for interactions with CBD. The optimal dose will therefore change depending on the individual and age“Nick Jikomes, PhD, neuro-physician.
How is CBD 25mg produced?
CBD 25mg is obtained by plant extraction using supercritical carbon dioxide (sCO₂). This is an alternative mode of extraction to the organochlorine solvents normally used in such processes but which are potentially harmful to the environment. Very eco-friendly, sCO₂ both ensures the final product is free from solvent residues and helps maintain the chemical integrity of the heat-sensitive molecules. It is odourless, colourless, non-toxic and non-inflammable and is completely safe for our health and our environment.
Does CBD 25mg produce any side-effects?
Unlike the drug cannabis which usually contains around 15% THC, the form used in this product has none. It therefore has no psychotropic effects and has an excellent safety profile in humans.
Once ingested, CBD is rapidly distributed around the body. It is lipophilic and thus quickly crosses the blood-brain barrier to reach brain tissues. It has no effect on heart rate, blood pressure or body temperature. CBD’s half-life is around 9 hours after which it is excreted in a metabolised form in urine.
To date, no public health problem has been associated with the nutritional use of CBD.
This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place
Written : November 2018.
- Venance L, Maldonado R, Manzoni O. Le système endocannabinoïde central. Med Sci (Paris) 2004 ; 20 : 45-53.
- Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: A clinical review. JAMA. 2015;313:2474–83
- Rog DJ, Nurmikko TJ, Friede T, Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology. 2005;65:812–9
- Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34:13–25
- Wang Q, Shao F, Wang W. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Front Mol Neurosci. 2015;8:49
- Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther. 2000;294:27–32.
- Schultes RE. Hallucinogens of Plant Origin.Science. 1969;163:245–54.
- Castillo A, Tolóna MR, Fernández-Ruizb, J, Romeroa J, Martinez-Orgadoa J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis. 2010;37:434–40.
- Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. Br J Clin Pharmacol. 2011; 72(5):735-44
|Daily dose: 1 capsule
Number of doses per pack: 30
|Amount per dose
| Cannabidiol (CBD) extracted from non-psychotropic hemp leaf standardised to 17% CBD
|Other ingredients: Acacia gum, rice flour.
adults. Take 1 capsule a day.
This supplement contains no psychotropic substances.
The dietary supplement Joint Support Formula
has been specially formulated to optimise joint health, drawing on a wide body of scientific research.
In particular, it incorporates glucosamine and chondroitin, two natural-source substances which several meta-analyses have confirmed to be effective at relieving the symptoms of arthritis1-5
Glucosamine and chondroitin: the two stars of natural arthritis therapy
Despite what you might think, glucosamine
is not a molecule created entirely by the pharmaceutical industry: it is naturally produced by the body from glutamine and glucose. It plays a fundamental role in maintaining the integrity of the joints, particularly cartilage. We now know that when this process of producing glucosamine goes awry, cartilage degenerates and arthritis develops.
That is why it is one of the most widely-studied natural substances in relation to arthritis: thousands of studies have been published on the subject with the vast majority of meta-analyses confirming its efficacy for the relief of arthritis1-5
. Some of them even suggest it can help inhibit development of the disease, unlike NSAID-type painkillers which tend to aggravate the process. It’s not for nothing then that the Osteoarthritis Research Society International
(OARSI) counts glucosamine among the treatments it considers potentially helpful to arthritis sufferers.
It is included in Joint Support Formula
in the form of glucosamine sulphate (the form most highly-rated by studies) from marine sources (the shells of certain crustaceans).
A close second to glucosamine is chondroitin
, another molecule naturally produced by the body with well-documented efficacy6-9
. It’s an essential constituent of cartilage which helps ensure it retains water and maintains the elasticity, firmness and suppleness of the joints. Like glucosamine, it is recognised for relieving the pain of arthritis: it’s thought to help fight inflammation and promote the reconstruction of cartilage by inhibiting hyaluronidase, the enzyme which destroys it, and osteoclasts, cells that contribute to loss of bone substance.
The chondroitin in Joint Support Formula
, is of marine origin whereas the majority of supplements use bovine or porcine cartilage. As absorption rates are somewhat low, supplements that contain less than 800mg per daily dose should be avoided (Joint Support Formula
contains 1200 mg).
Hyaluronic acid, boron and MSM: active principles of major interest
Joint Support Formula
hyaluronic acid may also offer benefits for joint health. Its ability to bind and retain more than 500 times its weight in water is particularly interesting as it may enable it to play a cushioning and lubricating role in cartilage and thus potentially reduce friction between bones. This mechanism is clearly one of the most credible explanations for its apparent analgesic effect.
The formulation also contains boron
(2.5 mg per dose), a trace element involved in a number of physiological processes including bone development and calcium metabolism. While the scientific consensus is not total, a number of researchers have shown incidence of arthritis to be higher among people consuming less than 1mg of boron a day. Evidence also suggests that arthritis sufferers always have lower boron levels (in the bones and synovial fluid) than healthy individuals. These two associations have led some scientists to recommend the consumption of 3-6mg of boron a day (found in small quantities in nuts, pulses, fruit and vegetables) for preventing and treating arthritis.
The last of the three active principles included in Joint Support Formula
is methylsulfonylmethane (MSM)
, a sulfur-containing compound found in very small amounts in a number of foods (fruits and vegetables, seaweed, seafood and meat). For some time, MSM too has been thought to reduce the pain of arthritis (by promoting joint comfort), with a number of studies demonstrating its efficacy, at least in the short-term11
. Several books have been written about this supplement but the theories advanced to explain its effects remain unproven: the most plausible is based on its high content of sulphur-containing compounds.
Vitamin C, silica and manganese: the final touches
To top it off, the creators of Joint Support Formula
have thought to include three extra compounds: vitamin C
the antioxidant and anti-inflammatory effects of which are well-established, manganese
, an essential nutrient for bone formation, and silicon
, a chemical element found in certain plants (in this case, Bambusa vulgaris
) which may have a positive effect on those suffering from joint problems.
This is therefore a formulation that combines a selection of ingredients which are among the most widely-studied or which offer potential in improving the health of the joints. Used for relieving pain, it offers a credible alternative to NSAIDs, the side-effects of which are increasingly apparent. It is aimed at individuals with joint problems, particular those with arthritis: the dose can be adjusted according to the degree of pain felt, but should not exceed three tablets a day.
Other innovative formulations are also available for relieving joint pain. One such supplement contains bone morphogenetic proteins which are involved in joint and bone regeneration, while the formulation UC-II®
offers the only patented form of undenatured type II collagen. There’s also an improved form of methylsulfonylmethane (MSM)
, one of the most extensively-studied molecules in the area of joint health.
1. Towheed TE, Maxwell L, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002946. Review.
2. Richy F, Bruyere O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. 2003 Jul 14;163(13):1514-22.
3. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. Bruyère O, Burlet N, et al. BMC Musculoskelet Disord. 2008 Dec 16;9:165.
4. Dietary supplements for osteoarthritis. Gregory PJ, Sperry M, Wilson AF. Am Fam Physician. 2008 Jan 15;77(2):177-84. Review
5. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Black C, Clar C, Henderson R et al. Health Technol Assess. 2009 Nov;13(52):1-148. Review.
6. Richy F, Bruyere O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. 2003 Jul 14;163(13):1514-22.
7. Uebelhart D. Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage. 2008;16 Suppl 3:S19-21. Review.
8. Lamari FN. The potential of chondroitin sulfate as a therapeutic agent. Connect Tissue Res. 2008;49(3):289-92. Review.
9. Monfort J, Martel-Pelletier J, Pelletier JP. Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin. 2008 May;24(5):1303-8. Review.
10. Newnham RE. Essentiality of boron for healthy bones and joints.Environ Health Perspect 1994 Nov;102 Suppl 7:83-5.
11. Xie Q, Shi R, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27; 7:31.
Daily dose : 3 tablets
Number of doses per box: 30
Amount per dose
Glucosamine sulphate (marine origin)
|| 1 500 mg
|Chondroitin sulphate (marine origin)
|| 1 200 mg
|| 500 mg
|| 80 mg
|Boron (calcium fructoborate)
|| 2,5 mg
|| 60 mg
Manganese sulphate (providing 0.66 mg elemental manganese)
|| 2 mg
Silicon (from 40 mg Bambusa vulgaris extract 75 % silicium)
|| 30 mg
Other ingredients : Acacia gum.
Take three tablets a day.
Caution : do not take if allergic to fish or shellfish.