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Hyaluronic Acid supplement is a high molecular weight sodium hyaluronate, that brings benefits for both improving lubrication of the joints and helping to maintain good hydration in the skin.
What is hyaluronic acid?
Over the past few years, hyaluronic acid has received significant attention from both the medical press and the cosmetics sector. It’s a polysaccharide macromolecule from the glycosaminoglycan family which is abundant in the skin and synovial fluid (the viscous fluid surrounding our joints). Under normal conditions, the human body contains around 12g.
It’s produced by cells called chondrocytes and synoviocytes to increase the viscosity of synovial fluid, which improves the lubrication of the joints. It also helps maintain good hydration in the skin by capturing water and retaining it in the skin’s deeper layers (1). In some cases, it also reduces the concentration of inflammatory mediators and the activity of immune cells.
The viscosity of the gel depends on the chain length of the hyaluronic acid. The higher its molecular weight, the greater the molecule’s capacity for absorbing water. Therefore, with a molecular weight of 1.2 million Daltons, Hyaluronic Acid 150 mg is one of the best sodium hyaluronate supplements available.
What are hyaluronic acid’s properties?
Hyaluronic acid is present in the form of sodium hyaluronate (also called hyaluronan) in the synovial fluid surrounding joints. It usually has a molecular weight of more than 1 million Daltons and under normal conditions, is highly concentrated. As a result of its specific structure and considerable size, it can retain enormous amounts of water (up to 1000 times its own weight), and all the nutrients and hydrophilic substances that go with it. It is solely responsible for the viscosity and elasticity of synovial fluid.
In certain disease states, both the concentration and molecular weight of sodium hyaluronate decrease, contributing to an increase in inflammatory processes and adverse effects on cartilage (2).
Why is it better to take high molecular weight hyaluronic acid?
Studies show that low molecular weight hyaluronic acid molecules have a completely different function in the body: they can activate cascades of molecular events which trigger the release of inflammatory cytokines. Following trauma, enzymes break the hyaluronic acid up into multiple molecules of lower molecular weight which have a pro-inflammatory effect.
These effects are not seen with large hyaluronic acid molecules, which supports the belief that they are not broken down by digestive enzymes before crossing the intestinal barrier.
CompositionHyaluronic Acid
Daily dose: 2 capsules
Number of doses per pack: 30 |
Amount per dose |
High molecular weight sodium hyaluronate
| 300 mg |
Other ingredients: acacia gum, rice flour. |
Directions for useHyaluronic Acid
adults. Take 2 capsules a day.
Each vegetarian capsule contains 150 mg of high molecular weight sodium hyaluronate.
PEA is an ultra-innovative supplement based on palmitoylethanolamide, a bioactive fatty acid produced naturally by animal and plant cells.
Palmitoylethanolamide (PEA) has been attracting widespread attention in the scientific community following the Nobel Prize-winning work of Dr Rita Levi-Montalcini. Taken for a period of several months, it aims to restore the body’s natural biochemical balance.
What is in the supplement PEA?
PEA is formulated from a proprietary source of palmitoylethanolamide (PEA) (OptiPEA®) which offers unrivalled purity.
This is an important advantage because palmitoylethanolamide is usually taken for several months if not years: taking a poor quality supplement (of which there are plenty on the market) will invariably cause adverse effects in the long term.
Palmitoylethanolamide in the human body
The vast majority of our cells are able to produce palmitoylethanolamide on demand, primarily when they are damaged or threatened.
When they need it, they remove certain fatty acids from their membranes and convert them into palmitoylethanolamide with the help of precursors called N-acylphosphatidylethanolamines (NAPEs). The reverse pathway is equally simple: using an enzyme called ‘fatty acid amide hydrolase’ (FAAH), the PEA is broken down by cells and the fatty acids reintegrated into cell membranes.
Cells use this process to rebalance biological processes that have been disrupted, such as over-activation of glial cells (2).
Note : this paragraph does not deal with the effects of exogenous palmitoylethanolamide.
Four good reasons to try PEA
- As PEA is not very soluble in water, it has quite low bioavailability. To maximise it, you need to choose a micronised supplement - in other words, one that contains very fine particles, which is obviously the case with our PEA.
- As PEA supplements are taken for very long periods, it’s important to opt for the highest quality product possible.
- Most PEA supplements are made from palm oil grown in conditions that involve deforestation and adversely affect biodiversity. The PEA in our supplement has been extracted from RSPO-certified (Roundtable on Sustainable Palm Oil) palm oil, in accordance with strict sustainable development criteria.
- PEA is a compound that has played a key role in evolutionary history, since almost all animals still produce it today. Its properties have been known for decades but it was the work of Dr Rita Levi-Montalcini which made it possible to understand its precise role in the body. Indeed, this work earned her the Nobel Prize in Medicine in the 1990s.
Note : this product should not be used to replace a varied, balanced diet or healthy lifestyle. Follow the advice on use, the recommended daily dose and the use-by date. Not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of young children’s reach. Store in a cool, dry place.
Updated : February 2019
CompositionPEA
Daily dose: 3 capsules
Number of doses per pack: 20 |
Amount per dose |
OptiPEA©(Palmitoylethanolamide) |
1 200 mg |
Other ingredients :Acacia gum, rice bran. OptiPEA©, Innexus Nutraceuticals, Holland. |
Directions for usePEA
adults. Take 3 capsules a day.
Each capsule contains 400 mg of OptiPEA©.