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Lactoxira
Lactoxira
New
Lactoxira
The first psychobiotic formulation for fighting depression
  • Based on the latest advances in neuro-science.
  • Acts deep-down to counter mood problems (depression, demotivation, ‘the blues’)..
  • Supports a healthy microbiota and optimal ‘microbiota-brain’ communication.
  • Contains eight probiotic strains supported by clinical trials..
  • Also contains prebiotics to ‘nourish’ the probiotics.
see review

Availability : Limited quantity

Quantity : 60 DR Caps™ 56.00 €
(63.96 US$)
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The formulation of Lactoxira draws on the very latest advances in neurobiology : we now know that the microorganisms that populate our digestive tract communicate with the brain (via neurotransmitter synthesis and the indirect release of cell-signalling substances) and that they influence our mood, thoughts and behaviour.
This major discovery is revolutionising the way we treat those suffering from low mood, depression, and mood disorders who generally have a highly-compromised microbiome.

Who is Lactoxira aimed at?

The probiotic formulation Lactoxira is aimed at anyone prone to problems with mood and motivation:

  • those subject to episodes of chronic, temporary, persistent or seasonal depression; ;
  • those who’ve lost interest in activities they previously enjoyed;
  • those who recurrently suffer from low mood for no apparent reason;
  • those who often have negative thoughts or low self-regard (“I’m such a loser”, “I hate myself”, “I don’t belong here”…);
  • those trying to overcome difficult experiences;
  • those who need to recharge and who find it hard to get motivated in the morning;
  • those who’ve lost their zest for life;
  • those who are often moody (gloomy, irritable or sad).

Lactoxira is also for anyone with a lifestyle that doesn’t support a healthy mental state (smoking, stress, excess alcohol consumption, lack of physical activity, lack of sleep, antibiotic treatment, nutritional deficiencies, particularly in vitamins D, B6, B12 and B9, ageing …).

Lactoxira’s effects on mood and psychological state.

What are Lactoxira’s effects on mood and psychological state?

Probiotics are living microorganisms that can have a positive effect on our gut flora (1). They are associated with numerous improvements to health (relating to gastrointestinal problems (2), particularly irritable bowel syndrome (3-4), as well as to their ability to lower blood pressure (5) and reduce the risk of eczema (6)), but it seems their therapeutic potential offers even greater promise.

Over the last few years, a number of studies have revealed the huge potential of probiotics for improving mood disorders and fighting depression (7). Scientists now understand that depressive disorders are in fact psycho-neuro-immunological disorders and that probiotic treatment can bring improvements. Two mechanisms of action have been discovered:

Constant, two-way communication with the brain

This is one of the most striking discoveries of recent years: bacteria in the gut are able to communicate with the brain via the vagus nerve (referred to as the microbiome-gut-brain axis (8)). Even more amazingly, they can produce neurotransmitters identical to those found in the brain (9). Several strains of Lactobacilli and Bifidobacteria secrete the inhibitory neurotransmitter GABA (10), production of which is significantly reduced in people with depression and anxiety (11). Other species of bacteria produce acetylcholine (a neurotransmitter involved in memory, concentration and mood (12)) and serotonin (a tryptophan metabolite involved in regulating mood (13)).

These discoveries explain why gut flora is now considered to be a virtual endocrine organ, capable of influencing the central nervous system through the microbiome-gut-brain axis (14-15). Studies have shown that the use of probiotics increases levels of certain neurotransmitters in the frontal cortex, thus reducing symptoms of depression (16).

Control of systemic inflammation

The second mechanism of action of psychobiotics is based on their ability to reduce levels of inflammation . Scientists had observed that depressed individuals had a number of abnormally high inflammatory markers (17-19), but they had not made the link with their gut flora. We now know that probiotics act against inflammation by impeding the growth of pathogenic bacteria in the small intestine, strengthening the intestinal barrier, reducing bacterial translocation and decreasing the number of inflammatory cytokines and toxins circulating in the body.

Probiotics thus improve mood disorders as a result of their multiple effects against inflammation (2-23). These psychological benefits have indeed been confirmed by two randomised, controlled clinical trials (24-25).

Are probiotics effective at treating depression?
“A combination of several strains of probiotic (Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum) slightly reduced symptoms of depression and anxiety.” L’AAFP (https://www.aafp.org/afp/2018/0315/od2.html)

What is Lactoxira comprised of?

The formulation Lactoxira contains the most widely-studied probiotic strains in relation to mental health and mood disorders. It is based on the latest meta-analysis which reviewed 25 animal studies and 15 clinical trials (26):

  • Bifidobacterius longum (present in the human gastrointestinal tract, it reduces symptoms of depression).
  • Lactobacillus plantarum (present in certain fermented, cabbage-based foods, it offers neuroprotection and combats inflammatory processes).
  • Bifidobacterium bifidum
  • Bifidobacterium lactis
  • Lactobacillus lactis
  • Lactobacillus casei (present in the gut and oral mucous membranes, it increases concentrations of tryptophan, serotonin, and dopamine, producing a significant improvement in mood in those with depression).
  • Lactobacillus brevis (reduces symptoms of anxiety).
  • Lactobacillus salivarius (the most active of all).

Some of these strains are able to withstand stomach acids (if they weren’t, there would be no benefit to eating yogurts or drinking kefir), but to maximise their chances of survival and ensure the formulation is as effective as possible, the delivery method chosen by SuperSmart is gastro-resistant capsules which release the probiotics at the site where they need to act – the gut. The number of living microorganisms that arrive there intact determines their impact. This is also why each dose of Lactoxira contains more than 100 billion bacteria (CFU).

To enhance its efficacy still further, prebiotics have been added to the Lactoxira formulation. These natural compounds, which are indigestible by humans, support the growth of probiotics and make it easier for them to colonise the digestive system.

Five good reasons to take Lactoxira

There are many reasons for taking probiotics to improve psychological health, but if we limit ourselves to five, they are as follows:

  1. According to the WHO, depression is a leading factor in morbidity and disability worldwide: the number of victims has been growing steadily for decades.
  2. Medication is not very effective at treating chronic depression (results are acceptable in only 30% of cases (27)), the rate of relapse is very high (around 50%) and there are numerous side-effects.
  3. Microorganisms in the gut are able to produce neurotransmitters that are identical to those synthesised in the brain. They are sent to the brain via the vagus nerve. .
  4. Modern lifestyles have led to a dramatic fall in numbers of beneficial microorganisms, which probably explains the sharp increase in auto-immune diseases and depression.
  5. Psychobiotics not only benefit psychological health, they also deliver the positive effects associated with probiotics: a reduction in inflammation markers, improvements in digestive problems, enhanced digestion…

How did scientists identify this new property?

It had been suspected for decades that microbiota played an important role in determining mood (as far back as 1863, Ludwig Andreas Feuerback was asserting that ‘we are what we eat’), but it had not been proven scientifically.

In studies conducted on laboratory animals, scientists first succeeded in modifying the behaviour of selected species by adding probiotics to their food: they observed that certain types of probiotic made the animals more aggressive while others had soothing effects. These early findings encouraged researchers to test their theories in humans suffering from anxiety, depression or the effects of chronic stress – with convincing results. Thus after several clinical trials, it was possible to isolate all the strains shown to be most active in this area, so that they could be combined in a cutting-edge probiotic formulation.

How can you make Lactoxira even more effective?

If you want to maximise the effects of Lactoxira, here are some measures to adopt alongside your supplementation.

1) Improve your diet throughout the supplementation period (28). The main thing is to gradually increase your intake of dietary fibre: the higher it is, the lower the risk of depression (29). Dietary fibre is only digestible by beneficial bacteria: consuming more of it therefore gives them an advantage over pathogenic organisms. It’s found in almost all fresh fruits and vegetables as well as in whole grains.

In addition, a number of studies have demonstrated an inversely-proportional link between consumption of foods rich in omega-3 fatty acids and depression (30). Some scientists thus advise those with depression to increase their weekly consumption of oily fish or to take omega-3 fatty acid supplements (1-4g a day of EPA/DHA) (31-32).

Finally, it’s important to increase your intake of B group vitamins (especially folic acid). Vitamin B deficiency is common in those with depression (33-35). These nutrients play an important role in the synthesis of neurotransmitters which influence mood (particularly serotonin and dopamine).

2) Adopt a healthier lifestyle during the supplementation period. Take the opportunity to go to bed earlier to improve the quality of your sleep. It’s also a good moment to undertake new projects, reach out to loved ones and acknowledge your fears.

3) Discover the benefits of massage. Several studies (36-37) have shown that massage helps improve mood and sleep by releasing additional serotonin and dopamine.

4) Significantly increase your level of physical activity. Being active is vital for mental well-being. The metabolic changes it induces enhance brain function, and particularly mood (38-39). To feel the benefits, you need to be physically active for around 30 minutes a day, five days a week. If you’re already managing to do this, you could increase the intensity or duration of your activities.

Lactoxira can also be combined with other dietary supplements such as SAM-e, a natural molecule that plays a key role in metabolising neurotransmitters, or St. John’s Wort, as long you use it in a well-controlled manner (it’s a plant that interacts with many drugs and substances).

Drawing on the very latest scientific research, Lactoxira provides the means to do what would have previously been unthinkable: improve an individual’s psychological state by improving their microbiota composition and optimising their gut-brain communication.

See also:
Probiotics: the latest gut-related discoveries herald a genuine revolution

Written: October 2018

Bibliography

Cepeda, M. S., Katz, E. G., & Blacketer, C. (2017). Microbiome-Gut-Brain Axis: Probiotics and Their Association With Depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 29(1), 39–44. doi:10.1176/appi.neuropsych.15120410

França, K., & Lotti, T. (2017). The gut-brain connection and the use of probiotics for the treatment of depression, anxiety and obsessive-compulsive disorders in dermatology. Dermatologic Therapy, 30(5), e12506. doi:10.1111/dth.12506

Notes

  1. World Health Association: Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Geneva, Switzerland, World Health Association
  2. Ritchie ML, Romanuk TN: A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 2012; 7:e34938
  3. McFarland LV: Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006; 101:812–822
  4. Hoveyda N, Heneghan C, Mahtani KR, et al: A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 2009; 9:15
  5. Khalesi S, Sun J, Buys N, et al: Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension 2014; 64:897–903
  6. Cuello-Garcia CA, Brozek JL, Fiocchi A, et al: Probiotics for the _ prevention of allergy: A systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol 2015; 136:952–961
  7. Bravo JA, Forsythe P, Chew MV, et al: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011; 108:16050–16055
  8. Dash S, Clarke G, Berk M, et al: The gut microbiome and diet in psychiatry: focus on depression. Curr Opin Psychiatry 2015; 28:1–6
  9. Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016, October). Effect of probiotics on central nervous system functions in animals and humans: A systematic review. Journal of Neurogastroenterology and Motility, 22(4), 589–605. doi:10.5056/jnm16018
  10. Dinan TG, Stanton C, Cryan JF (2013) Psychobiotics: a novel class of psychotropic. Biol Psychiatry 74(10):720–726
  11. Schousboe A, Waagepetersen HS (2007) GABA: homeostatic and pharmacological aspects. In: Tepper JM, Abercrombie ED, Bolam JP (eds) GABA and the basal ganglia: from molecules to systems, vol 9–19. Elsevier Science B, Amsterdam
  12. Roshchina VV (2010) Evolutionary considerations of neurotransmitters in microbial, plant, and animal cells. In: Lyte M, Freestone PPE (eds) Microbial endocrinology: interkingdom signaling in infectious disease and health. Springer, New York, pp 17–52
  13. Collins SM, Bercik P (2009) The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136:2003–2014
  14. Bested AC, Logan AC, Selhub EM: Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances, part II: contemporary contextual research. Gut Pathog 2013; 5:3–3
  15. Logan AC, Katzman M: Major depressive disorder: probiotics may be an adjuvant therapy. Med Hypotheses 2005; 64:533– 538
  16. Desbonnet L., Garrett L., Clarke G., Bienenstock J., Dinan T.G. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J. Psychiatr. Res. 2008;43:164–174. doi: 10.1016/j.jpsychires.2008.03.009.
  17. Wium-Andersen MK, Ørsted DD, Nielsen SF, et al: Elevated C-reactive protein levels, psychological distress, and depression in 73,131 individuals. JAMA Psychiatry 2013; 70:176–184
  18. Cepeda MS, Makadia R: Depression is associated with high levels of C reactive protein and low levels of exhaled nitric oxide: results from the 2007–2012 National Health and Nutrition Examination Surveys. J Clin Psychiatry (Epub ahead of print, June 21, 2016)
  19. Berk M, Williams LJ, Jacka FN, et al: So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 2013; 11:200
  20. Maes M, Kubera M, Leunis JC et al (2013) In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes. Acta Psychiatr Scand 127(5):344–354
  21. Clarke G, Grenham S, Scully P et al (2013) The microbiome-gutbrain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18(6):666–673
  22. Tillisch K, Labus J, Kilpatrick L, et al: Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013; 144:1394–1401
  23. Mayer EA, Knight R, Mazmanian SK, et al: Gut microbes and the brain: paradigm shift in neuroscience. J Neurosci 2014; 34:15490– 15496
  24. Steenbergen L, Sellaro R, van Hemert S, et al: A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 2015; 48: 258–264
  25. Messaoudi M, Lalonde R, Violle N, et al: Assessment of psychotropiclike properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011; 105:755–764
  26. Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016, October). Effect of probiotics on central nervous system functions in animals and humans: A systematic review. Journal of Neurogastroenterology and Motility, 22(4), 589–605. doi:10.5056/jnm16018
  27. Perovic B, Jovanovic M, Miljkovic B, Vezmar S (2010) Getting the balance right: established and emerging therapies for major depressive disorders. Nuropsychiatr Dis Treat 7(6):343–364
  28. Evrensel A., Ceylan M.E. The Gut-Brain Axis: The Missing Link in Depression. Clin. Psychopharmacol. Neurosci. 2015;13:239–244. doi: 10.9758/cpn.2015.13.3.239.
  29. Lai JS, Hiles S, Bisquera A, et al: A systematic review and metaanalysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr 2014; 99:181–197
  30. Hibbeln JR. Fish consumption and major depression. Lancet. 1998;351(9110):1213. Lettre; Texte intégral
  31. Jacka EN, Pasco JA, et al. Dietary omega-3 fatty acids and depression in a community sample.Nutr Neurosci. 2004 Apr;7(2):101-6.
  32. Mamalakis G, Tornaritis M, Kafatos A. Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002;67(5):311-318.
  33. Tolmunen T, Hintikka J, et al. Dietary folate and the risk of depression in Finnish middle-aged men. A prospective follow-up study. Psychother Psychosom. 2004 Nov-Dec;73(6):334-9.
  34. Papakostas GI, Petersen T, et al. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol. 2005 Dec;8(4):523-8. Erratum in: Int J Neuropsychopharmacol. 2005 Dec;8(4):528.
  35. Papakostas GI, Petersen T, et al. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol. 2005 Dec;8(4):523-8. Epub 2005 May 9. Erratum in : Int J Neuropsychopharmacol. 2005 Dec;8(4):528.
  36. Hou WH, Chiang PT, et al. Treatment effects of massage therapy in depressed people: a meta-analysis. J Clin Psychiatry. 2010 Mar 23.
  37. Field T, Hernandez-Reif M, et al. Cortisol decreases and serotonin and dopamine increase following massage therapy. Int J Neurosci. 2005;115(10):1397-413.
  38. Brosse AL, Sheets ES, et al. Exercise and the treatment of clinical depression in adults: recent findings and future directions. Sports Med. 2002;32(12):741-60. Review
  39. Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001 Mar 31;322(7289):763-7.
Daily dose: 2 capsules
Number of doses per pack: 30
Amount per dose
Lactobacillus salivarius 28 x 109CFU
Lactobacillus plantarum 12 x 109CFU
Lactobacillus casei 12 x 109CFU
Lactobacillus brevi 12 x 109CFU
Lactobacillus lactis 12 x 109CFU
Bifidobacterium bifidum 12 x 109CFU
Bifidobacterium longum 11 x 109CFU
Bifidobacterium lactis 11 x 109CFU
Other ingredients: acacia gum, rice bran.


 
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