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Welcome Shop by health concern Sleep CBD+Melatonin + Pharma GABA
CBD+Melatonin + Pharma GABA
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CBD+Melatonin + Pharma GABA
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PharmaGABA®
Natural GABA (gamma-aminobutyric acid) supplement
  • Central nervous system (CNS) neurotransmitter.
  • Produced naturally from Lactobacillus hilgardii.
  • Quality and safety recognised by a US Food and Drug Administration (FDA) expert panel.
CBD + Melatonin
CBD + Melatonin is a powerful synergy for deep, natural sleep.
  • Helps reduce the time it takes to fall asleep.
  • Improves sleep quality.
  • Promotes physical and mental relaxation.
  • Helps naturally restore a healthy sleep-wake cycle.
  • Perfect for reducing the effects of jet lag.
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FINDER Hans
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Es hilft einfach auf eine sanfte und nebenwirkungsfreie Art und Weise beim Ein- und Durchschlafen.
Cannabidiol molecule structure

CBD and melatonin are natural substances that have long been recognised for re-establishing restorative sleep and promoting relaxation. Now for the first time, SuperSmart is combining them in an exceptional formulation available to buy in vegetarian capsules, probably the best alternative to sleeping tablets for re-establishing restorative sleep naturally and durably.

Who is CBD + Melatonin aimed at?

This highly innovative formulation is for anyone affected by the following:

  • Repeated problems with falling asleep at conventional times.
  • Difficulty getting up in the morning.
  • Waking frequently in the night.
  • Waking up too early in the morning.
  • Feeling tired on waking.
  • Feeling anxious about going to bed.
  • Chronic lack of sleep that impacts on daily life.
  • Insomnia.
  • Muscle or joint pain on waking or at bedtime.
  • Jet lag.

It is suitable for men and women of all ages. It’s particularly good for anyone with an unhealthy lifestyle, or who spends too much time in front of a screen, who works in an office or who has low levels of physical activity.

Why melatonin?

Melatonin is a hormone derived from serotonin, which is secreted by the pineal gland, primarily during the hours of darkness. Often referred to as the ‘sleep hormone’, it is crucial for regulating our circadian rhythms, particularly the sleep/wake cycle. It signals to the body where it is in the day/night cycle and promotes sleepiness at appropriate times.

Unfortunately, production of this hormone is nowadays significantly impaired by artificial light. At the end of the day, when the retina senses the decrease in light levels, a neural signal is sent to stimulate the production of melatonin and the start of the sleep process. Exposure to artificial light during these key hours thus has a deeply negative effect: melatonin secretion falls dramatically, only to resume later, causing an untimely peak in its production which results in fatigue and sleepiness in the morning (1). This is exacerbated by exposure to the blue light emitted by screens.

Melatonin production also declines with age, due to calcification of the pineal gland (2) and decreased melatonin receptor sensitivity. Indeed, studies have shown that after the age of 60, the deep and REM (or paradoxical) phases of sleep decline sharply and night-time waking increases.

Taking an external source of melatonin before bed is a recognised natural solution to correcting impaired melatonin secretion. Its effects have been demonstrated in people with and without sleep problems (3-4). Unlike drugs, it works without disrupting the different stages of sleep and causes no residual effects the following morning.

Various studies show that to obtain maximum efficacy, you need to take melatonin for a minimum of 3-4 days. However, use of this hormone at low doses (as is the case here) should not be prolonged indefinitely, 4 weeks at most, by which time things will be back to normal.

Why add CBD?

CBD does not induce sleep per se, but it helps promote relaxation, vasodilation and pain relief. It is a phytocannabinoid molecule found in hemp (Cannabis sativa) along with the well-known psychotropic substance tetrahydrocannabinol (THC). But unlike THC, CBD has no psychoactive effect – it will not get you ‘high’.

CBD is very similar to the endocannabinoid messengers produced by the body to trigger various responses (pain modulation (6-7), reduction in spontaneous locomotion (8-9), relaxation, hypothermia… (10)). Such is its similarity, it is (to varying degrees) able to bind to the same receptors and trigger the same sort of chain reactions. These receptors are primarily found on cell surfaces in the brain, central nervous system and immune system tissues.

What are the main elements of the chain reaction triggered?

  • Reduction in the inflammatory response (pain relief) (11-13).
  • Triggering of vasodilation (14).
  • Decreased intensity and impact of symptoms associated with anxiety or chronic stress (15-16) (with stress being a common cause of sleep problems).
  • Effect on other brain receptors, particularly serotonin, a neurotransmitter that controls mood and sleep.
  • Reduction in reactive oxygen species (ROS) and lipid peroxidation (17).

It’s an important element of the formulation as a lack of sleep is very often linked to stress.

How is CBD produced?

The CBD in this formulation is extracted from the leaves of Cannabis sativa, using supercritical carbon dioxide (sCO₂). This is an alternative mode of extraction to the organochlorine solvents normally used in such processes, but which are potentially harmful to the environment. Very eco-friendly, sCO₂ both ensures the final product is free from solvent residues and helps maintain the chemical integrity of the heat-sensitive molecules. It is odourless, colourless, non-toxic and non-inflammable and is completely safe for our health and our environment.

Five good reasons to take CBD + Melatonin

  1. CBD perfectly complements the effects of melatonin: one deals with the hormonal disruption caused by environmental factors, while the other tackles anxiety and stress, which are recognised factors in insomnia.
  2. Scientific studies show that melatonin’s mechanism of action is radically different from that of benzodiazepines. Unlike sleeping pills which enforce drowsiness and disrupt cognitive performance and the architecture of sleep, melatonin induces a form of ‘calm sleep’ (18-19).
  3. Western populations generally get less sleep than they need to stay on top form (20).
  4. Good quality sleep is essential for long-term health, as it has an effect on cognitive faculties, rebuilding damaged cells, neural synapse plasticity, the immune defences, tissue repair, efficacy of endogenous antioxidants, mental health, and maintenance of muscle and bone tissue.
  5. CBD and melatonin offer numerous other health benefits, particularly antioxidant, immune-stimulant and anti-inflammatory effects.
CompositionCBD + Melatonin
Daily dose: 1 capsule
Number of doses per pack: 60
Amount per dose
Cannabidiol (CBD) extracted from non-psychotropic hemp leaf standardised to 17% CBD 5 mg
Melatonin 1,5 mg
Other ingredients: acacia gum, rice flour.
Directions for useCBD + Melatonin
For adults only. Take 1 capsule 30 minutes before bed.
Relaxed young woman with eyes closed, leaning against the wall

PharmaGABA® 125mg is a dietary supplement containing GABA (gamma-aminobutyric acid) for inner relaxation. It’s a neurotransmitter which helps to inhibit the central nervous system which has been produced naturally by the fermentation process of Lactobacillus hilgardii.

Is PharmaGABA well-absorbed? Is it natural?

GABA has been available in supplement form for several decades. However, this new form of GABA is much more effective. Once ingested, it is easily absorbed by the body.

PharmaGABA is produced naturally through fermentation of Lactobacillus hilgardii, a beneficial bacteria used for fermenting vegetables in the traditional Korean dish kimchi. The vast majority of GABA supplements are produced synthetically from pyrrolidinone.

Which foods contain GABA?

GABA is a metabolic product specific to microorganisms and so is not found in fresh foods but in fermented ones, such as kefir, kimchi, miso, sauerkraut, tempeh and yogurt.

What other substances can be combined with GABA supplementation?

Some studies (1) suggest that flavonoids (such as those found in plants and cutting-edge supplements like Grapefruit Extract 99% naringin) may enhance GABA’s efficacy.

Combining PharmaGABA with adaptogen plant extracts such as Super Ashwagandha and Rhodiola rosea also makes sense.

Is there a link between GABA and glutamate?

Glutamate, an ionised form of glutamic acid, is one of the most important neurotransmitters of the central nervous system and is a precursor of GABA. Metabolism of GABA and glutamate are thus closely related. However, unlike GABA, glutamate contributes to prolonged neuronal excitation.

CompositionPharmaGABA®
Daily serving: 1 capsule
Number of servings per bottle: 60
Quantity per serving
GABA (gamma aminobutyric acid) (from 125 mg of PharmaGABA® standardised to 80% GABA) 100 mg
Other ingredients: Acacia gum
Directions for usePharmaGABA®
adults. Take 1 capsule a day.

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CBD+Melatonin + Pharma GABA
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