SuperSmart's beta-(1.3/1.6)-glucan contains Wellmune WGP®, a natural substance found in the cell walls of a baker's yeast (Saccaromyces cerevisiae), which is obtained using an exclusive proprietary process giving an exceptionally pure product.
Different types of glucan can be isolated from almost all forms of yeast. SuperSmart's beta-(1.3/1.6)-glucan (containing at least 75% beta-(1.3/1.6)-glucan) is the most widely-studied most biologically effective.
Clinical studies have shown that beta-(1.3/1.6)-glucan boosts immune response by activating key cells in the immune system, including macrophages and neutrophils, enabling them to act more quickly in recognising and destroying harmful foreign cells. Research in human and animal cell cultures suggests it can stimulate various aspects of immune function, such as phagocytosis or interleukin production.
The first studies showing beta-glucan's effect on the immune system were conducted in the 1940s. By the end of the Eighties, its precise mode of action had been established: it activates specific receptors located on the surface of macrophages, releasing a cascade of events which produce an entire arsenal of immune defence weapons.
The first human study involved cases of advanced HIV infection. Administration of beta-(1.3/1.6)-glucan resulted in an increase in serum IL-1 and IL-2 cytokines and interferon, even in subjects with severe immune deficiency.
Other studies have indicated that beta-(1.3/1.6)-glucan:
- significantly reduced mortality from infection complications in patients suffering from severe trauma;
- reduced the amount of antibiotics and antiviral drugs needed to stop infection in animals subjected to various bacteria;
- totally protected rats from the harmful effects of exposure to lethal doses of radiation - acting to defend macrophages from free radical attack, thus enabling them to function properly, even in an irradiated body;
- reduced, over a 6-week period, LDL cholesterol levels in hypercholesterolaemic subjects;
In particular, clinical studies have shown that administering beta-(1.3/1.6)-glucan (Wellmune WGP®):
- to severely stressed subjects, over four weeks, led to a clear improvement in their general health. It increased their energy by 42%, reduced fatigue by 38%, and tension by 19%.
- to marathon runners, boosted their immune system to the extent that they had 66% fewer respiratory system infections. These findings highlight beta-(1.3/1.6)-glucan's ability to counteract immunodepression caused by intensive exercise.
Take one vegetarian capsule a day 30 minutes before a meal, or as advised by your therapist. As it takes around 5 days for beta 1.3/1.6 glucan to have an effect on the immune system, daily supplementation is recommended.
Organic MycoComplex is an exceptional formulation containing extracts of seven medicinal mushrooms (Inonotus obliquus, Trametes versicolor, Cordyceps militaris, Ganoderma lucidum, Agaricus brasiliensis, Lentinula edodes and Grifola frondosa), with a guaranteed concentration of at least 30% polysaccharides and 0.7% triterpenes.
“Mushrooms are miniature pharmaceutical factories, and of the thousands of mushroom species in nature, our ancestors and modern scientists have identified several dozen that have a unique combination of talents that improve our health“, Paul Stamets, leading American mycologist and member of the editorial board of The International Journal of Medicinal Mushrooms.
SuperSmart has chosen seven of these species for its brand-new nutritional formulation which offers exceptional benefits. Produced using an enzyme mixture and the latest advances in microbiology, Organic MycoComplex optimises the activity and bioavailability of the best mushroom species available in the field of nutritional supplementation. So you can be among the first to benefit from some of the most promising medicines of the future ...
Who is Organic MycoComplex designed for?
This formulation is primarily for people suffering from fatigue, whatever the cause. It is also for those who:
- wish to benefit from the ‘super-tonic’ and protective effects of mushrooms;
- want to protect their body using natural substances;
- are lacking in energy;
- are suffering from various types of pain;
- have intestinal disorders;
- are receiving intensive anti-cancer treatment;
- have a fragile immune system.
What is in Organic MycoComplex ?
Organic MycoComplex contains extracts of seven different organically-grown mushrooms.
Maitake (Grifola frondosa).
Prior to its cultivation in 1979, maitake was known as the dancing mushroom because it’s said that those who found it growing wild danced with joy at their discovery. It is a highly-valued mushroom which contains a number of polysaccharides. Among its properties, scientists have shown that it’s able to:
- lower blood glucose levels (1-2);
- reduce blood pressure;
- reduce blood cholesterol levels;
- stimulate activity of certain immune cells (3).
Active compounds: primarily the polysaccharides beta 1-6-glucans, alpha-glucans and MZF (Maitake Z-fraction) (4). Studies have shown that these compounds encourage maturation of dendritic cells and help activate various cell effectors such as macrophages, Natural Killer cells, T lymphocytes, interleukin-1 and superoxide anion (5). Other studies have demonstrated a blood glucose-lowering effect: by acting on insulin receptors, alpha-glucan polysaccharides may increase insulin sensitivity in cells and improve insulin resistance in peripheral tissues. They also act against tumours by upregulating expression of a pro-apoptosis gene (BAK-1) (6).
Attention: The extracts do not all have the same proportion of active principles nor the same concentration. This product should not be taken alongside anti-diabetes medication.
Reishi (Ganoderma lucidum).
This ‘mushroom of immortality’ has enjoyed exceptional renown in Asia for more than 2000 years. There are references to it in the oldest written Chinese pharmacopoeia (dating back to 56BC) and it was probably being used by Asian populations for thousands of years before then.
It’s very rarely found growing wild, but cultivation became possible after the 1970s under highly specific laboratory conditions. This was truly liberating given the significance of its therapeutic properties, which include the ability to:
- lower blood cholesterol levels;
- stimulate certain immune cells (7);
- reduce inflammation (8);
- increase antioxidant capacity (9);
- protect the liver;
- combat cell proliferation(10-13);
- boost the body as a whole and maintain optimal health.
Active compounds: these are primarily beta-glucan polysaccharides and triterpenes. The latter reduce the expression of metalloproteins and prevent cell proliferation by suppressing the expression of Vascular Endothelial Growth Factor (VEGF) and upregulating the expression of connexin 43 (14).
Attention: In traditional Chinese medicine, only the flesh of the mushroom is used (ie, the cap and the stalk) but several supplement manufacturers use the mycelium, a less expensive part of the mushroom which does not offer the same benefits.
Shiitake (Lentinula edodes).
Used for over 2000 years for its medicinal properties, shiitake is probably the most widely-studied mushroom for its anti-cancer virtues. It helps to:
- reduce levels of LDL cholesterol transporters (15);
- boost the immune system against cancer and infections (16);
- promote healthy arteries.
Active compounds: Its properties come from two compounds in particular, lentinan (1-3 beta-D-glucan) (17) and eritadenine. These compounds do not have a direct cytotoxic effect on tumours but they modify the body’s biological response. Increases have thus been observed in secretion of interleukin (IL-2) and additional activation of macrophages.
Royal sun mushroom (Agaricus brasiliensis).
Native to Brazil, but also widely-found in Asia, the royal sun mushroom is highly valued for its delicious, almond-flavoured flesh. It also offers significant benefits:
- it improves quality of life for cancer sufferers (18-20);
- it supports liver function (21 ;
- it improves insulin resistance (22-24);
- it reduces blood glucose levels;
- it reduces blood cholesterol levels (25) ;
- it has an oestrogen-like effect.
Active compounds: brefeldin A, ergosterol (the primary constituent), blazeispirol A (produced by fermentation of the mushroom), agaritine and polysaccharides. These compounds activate a number of molecular cascades that lead to apoptosis, the programmed death of abnormal cells. They also play a role both in activating NK cells, normal cell signalling and supporting damaged blood vessels (26).
Chaga (Inonotus obliquus).
Unlikely as it might seem, this increasingly popular mushroom is nothing more than a parasite of the birch tree. Yet behind this inauspicious exterior lies a powerful health-boosting mushroom with a delicate flavour. With blood glucose-lowering properties, it has been used for centuries in Asia and Russia to calm inflammation and optimise digestion. Interest in chaga intensified dramatically when in 2011, a team of scientists from Queensland University of Technology discovered that in certain cases, it could reverse tumours in rodents, with no apparent side effects. Researchers are currently investigating its potential to:
- boost antioxidant capacity (27);
- reduce inflammation and fatigue (28);
- relieve pain (29);
- stimulate the immune system (30);
- slow down the progress of cancer (31-32).
Active compounds: inotodiols (triterpenoids), oxalic acid, gallic acid, protocatechuic acid and p-hydroxybenzoic acid. Terpenoids are responsible for the anti-diabetes effects by inhibiting alpha-glucosidase, while the anti-fatigue effects come more from polysaccharides which increase glycogen in the muscles and liver, while reducing levels of nitrogen in urea and restoring those of endogenous antioxidants (glutathione, superoxide dismutase) (33). Its pain-relieving properties are due to inhibition of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Last but not least, its anti-proliferative properties are the result of modulated expression of caspase apoptosis-triggers by lignin derivatives.
Attention : Its use is contra-indicated in type 1 diabetics, those with coagulation disorders and those who have had a transplant.
Organic MycoComplex also contains extracts of polyporus versicolor, and cordyceps (effective at stimulating poor sexual function and restoring energy (34)), as well as selenium, prebiotic fructo-oligosaccharides and an extract of ginseng, the essential plant-source aid for stimulating the immune system and fighting fatigue.
What are the benefits of taking Organic MycoComplex?
Europeans and North Americans tend to be wary of mushrooms because of their potential toxicity. But they are missing out. East Asian populations have always regarded them as an essential part of their pharmacopoeia, while the scientific community continues to link them to an increasing number of therapeutic benefits. It now seems that mushrooms’ range of activity is huge: they are in a therapeutic class of their own, with an almost unrivalled wealth of nutritional virtues.
Organic MycoComplex addresses several areas of health:
Gut health. Mushrooms contain a large amount of insoluble dietary fibre which increases the weight and volume of stools, facilitating their elimination from the body and preventing constipation. They also contain non-digestible sugars which nourish ‘friendly’ bacteria in the gut and bowel, helping to strengthen the intestinal barrier and reduce systemic inflammation.
The field of oncology . Two types of compound are responsible for the anti-tumour properties of mushrooms: polysaccharides and lectins. Polysaccharides are long chains of simple sugars. They induce production of cytokines such as interferon or IL-2 which activate the proliferation of a number of immune cells and boost the destruction of foreign elements. Lectins are carbohydrate-binding proteins which induce apoptosis in abnormal cells including tumour cells.
The field of cardiology . As a result of its various ganoderma, coumarin and polysaccharide compounds, mushrooms help lower cholesterol and triglyceride levels, two factors associated with cardiovascular problems.
The immune system . This is mushrooms’ ‘strongest suit’. Most of them have properties that strengthen weakened immune systems, particularly as a result of radiotherapy or infections. The polysaccharide compounds increase numbers of macrophages, NK cells and cytotoxic T lymphocytes.
Activity against free radicals . Mushrooms have certain antioxidant properties and thus help combat the oxidative stress involved in many health problems. When the body is exposed to high levels of free radicals, normal detoxification processes are unable to function properly which leads to a state of pathological imbalance.
Stress. Like ginseng and ashwagandha, mushrooms are considered to be adaptogens, helping to restore and balance various parameters associated with stress. They act rather like spark plugs, improving the body’s adaptation to stress and acting as an energy potentiator of the adrenal system
Did you know?
Mushrooms, which are known scientifically as Eumycetes, are phylogenetically closer to us than to plants.
Five reasons to choose Organic MycoComplex
- Mushrooms are hard to identify and keep fresh
. We would all like to benefit from the medicinal properties of mushrooms, but these days, it’s a risky practice: knowledge is no longer being handed down from one generation to the next and it’s easy to confuse an edible species with a poisonous one. In addition, many mushrooms decompose rapidly after being picked and produce mycotoxins which cause botulism. If they’re consumed after being stored in unsuitable conditions (they should be hermetically sealed and kept refrigerated below 4°C), it can result in serious food poisoning with no detectable changes in their appearance, taste or smell.
- Encapsulating them ensures maximum efficacy
Mushrooms contain many health-beneficial compounds but they also have a high water content which dilutes these compounds. When dehydrated and encapsulated, the mushrooms are converted into dry matter which is exceptionally concentrated in active principles.
Loose powder is more economical but once opened, it quickly oxidises which makes it less effective over time. In contrast, capsules offer stable active principles and are precisely dosed. They’re easy to use, practical and safe.
- One of the most promising areas of medicine
Metabolically rich, mushrooms offer huge pharmacological potential, with considerable research being conducted in this field. The areas of medicine in which they’re used are growing all the time: antibiotic therapy, cardiology, haematology, oncology, parasitology …
- A formulation with guaranteed active principles
Organic Mycocomplex is produced from the carpophores in mushrooms, the part with the highest therapeutic value. Many manufacturers use mycelium for their dietary supplements, but this underground part is composed of strands and is much lower in beneficial substances.
- Natural, organic excipients
Organic Mycocomplex capsules are free from lactose, gluten, gelatine, soya, flavourings, pesticides, fungicides, artificial colours, allergens, GMO substances and animal products. The mushrooms used are grown in line with organic farming specifications. Their cellular compounds, including polysaccharides and triterpenes, are extracted using a unique enzymatic formula which initiates fermentation of chitin walls. Solvents are then added, primarily water, but also alcohol when appropriate.
Many experts agree that mushrooms currently represent one of the most promising areas of medicine, and that their huge potential is only just starting to be scientifically evaluated. With its exceptional range of benefits, Organic MycoComplex has more than earned its place in the SuperSmart catalogue.
Written: December 2018
- Konno S, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients.Diabet Med 2001 Dec;18(12):1010
- Hong L, Xun M, Wutong W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. Pharm Pharmacol. 2007 Apr;59(4):575-82
- Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa(Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21
- Masuda Y, Ito K, Konishi M, Nanba H. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother. 2010 Oct;59(10):1531-41.
- Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull 1987;35:262-70.
- Soares R, Meireles M, Rocha A, et al. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.J Med Food. 2011 Jun;14(6):563-72.
- Chen HS, Tsai YF, Lin S, et al. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem. Nov 1 2004;12(21):5595-5601.
- Joseph S, Sabulal B, George V, Antony KR, Janardhanan KK. Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum. Acta Pharm. 2011 Sep 1;61(3):335-42.
- Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. Feb 2004;91(2):263-269.
- Hsu MJ, Lee SS, Lin WW. Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. J Leukoc Biol. Jul 2002;72(1):207-216.
- Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. Mar 17 1997;70(6):699-705.
- Sun LX, Li WD, Lin ZB, et al. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell Physiol Biochem. 2014;33(2):289-299.
- Jin X, Ruiz Beguerie J, Sze DM, et al. Ganoderma lucidum (Reishi mushroom) for cancer treatment.Cochrane Database Syst Rev. Apr 05 2016;4:Cd007731.
- Ko KK, Murthee KG, Koh TH, et al. Reishi (lingzhi) ingestion mistaken for persistent Clonorchis infection. Pathology. Oct 2014;46(6):576-578.
- Yang H, Hwang I, Kim S, et al. Lentinus edodes promotes fat removal in hypercholesterolemic mice.Exp Ther Med. Dec 2013;6(6):1409-1413.
- Israilides C, Kletsas D, Arapoglou D, et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Phytomedicine 2008.
- Oba K, Kobayashi M, Matsui T, et al. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer. Anticancer Res. Jul 2009;29(7):2739-2745.
- Ohno S, Sumiyoshi Y, Hashine K, Shirato A, Kyo S, Inoue M. Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract.Complement Ther Med. 2013 Oct;21(5):460-7.
- Kimura Y, Kido T, Takaku T, et al. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. Sep 2004;95(9):758-764.
- Lee YL, Kim HJ, Lee MS, et al. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Exp Anim. Oct 2003;52(5):371-375.
- Hsu CH, Hwang KC, Chiang YH, et al. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med. Apr 2008;14(3):299-301.
- Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol. May 1998;157(2):259-266.
- Swanston-Flatt SK, Day C, Flatt PR, et al. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res. Feb 1989;10(2):69-73.
- Kim YW, Kim KH, Choi HJ, et al. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett. Apr 2005;27(7):483-487.
- Liu Y, Fukuwatari Y, Okumura K, et al. Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers. Evid Based Complement Alternat Med. Jun 2008;5(2):205-219.
- Dong S, Furutani Y, Suto Y, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Microbiol Res. Oct 17 2011.
- Giridharan VV, Thandavarayan RA, Konishi T. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom. Food Funct. Jun 2011;2(6):320-327.
- Mishra SK, Kang JH, Kim DK, et al. Orally administered aqueous extract of Inonotus obliquusameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice. J Ethnopharmacol. Sep 28 2012;143(2):524-532.
- Park YM, Won JH, Kim YH, et al. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol. Oct 3 2005;101(1-3):120-128.
- Ko SK, Jin M, Pyo MY. Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice. J Ethnopharmacol. Oct 11 2011;137(3):1077-1082.
- Ning X, Luo Q, Li C, et al. Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells. Int J Med Mushrooms. 2014;16(1):29-36.
- Ham SS, Kim SH, Moon SY, et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res. Jan 10 2009;672(1):55-59.
- Glamoclija J, Ciric A, Nikolic M, et al. Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”. J Ethnopharmacol. Mar 13 2015;162:323-332.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part I. J Altern Complement Med. 1998 Winter;4(4):429-57. Review.
adults. Take 3 capsules a day.
This product should not be taken alongside diabetes medication. Its use is contra-indicated in type 1 diabetics, those with coagulation disorders and those who have had a transplant.