"mTOR" or mammalian target of rapamycin refers to an enzyme from the serine/threonine protein kinase family encoded by the mTOR gene. It is found in humans as well as worms, mice, flies and yeasts. It regulates the growth, proliferation, motility and survival of cells.
¤ Cell senescence seems to be the driving force behind ageing, both in terms of loss of cell-replication potential as well as mTOR signalling pathways inducing “too much growth”. Successfully inhibiting mTOR signalling pathways has been shown to produce increased lifespan in worms, flies, yeasts and even mice if accompanied by calorie restriction.
¤ Rapamycin is a molecule produced naturally by the mycelial bacterium Streptomyces hygroscopicus, which was discovered on Easter Island in 1975. Also known as Sirolimus, it is an immunosuppressant drug used in orthodox medicine to prevent rejection following organ transplantation. Rapamycin inhibits the mTOR signalling pathway and studies show it can significantly extend lifespan in mammals, even when taken in later life, with increases in life expectancy for males and females of between 9% and 14% respectively.
¤ Other studies have identified its anti-diabetic properties (types I and II), as well as benefits for age-related cognitive decline, with increases in memory and learning capacity, and in particular, decreases in certain proteins seen in neurodegenerative diseases such as Alzheimer’s.
¤ In pre-clinical trials, Rapamycin analogues or “Rapalogs”, in particular inhibitors of the complex mTORC1, have shown measurable efficacy against certain cancers.
¤ Recent scientific findings suggest that, at precise concentrations, a number of completely natural substances can also inhibit mTOR; Natural Rapalogs contains a combination of these substances.
¤ Meriva® is a patented curcumin formulation (derived from Curcuma longa) combined with soy phospholipids to increase its bioavailability beyond that of classic standardised curcumin extracts. This key curcuma ingredient has emerged as a natural mTOR inhibitor and exhibits anti-tumour properties in a variety of cancer cell lines via modification of a number of oncogenic pathways.
Green tea extract standardised to 70% EGCG
¤ Studies have confirmed the inhibitory role of certain components of green tea (Camellia sinensis) on mTORC1 and mTORC2. Specifically, a study conducted by GlaxoSmithKline in Collegeville, Pennsylvania, showed that EGCg (epigallocatechin-3-gallate) acted as a double inhibitor, both of the P13K (phosphoinositide-3-kinase) pathway and the mTOR signalling pathway.
¤ Research has established that transresveratrol, a polyphenol compound and calorie restriction mimetic, also inhibits the mTOR signalling pathway. Studies show that this pathway is activated by oxidised LDL-cholesterol lipoproteins in smooth muscle cells. Resveratrol can, however, block the phosphorylation and activation of the P13K and mTOR pathways. This activity is independent of resveratrol’s antioxidant effect and its activation of AMPK and clearly identifies a new property for resveratrol that may add to this polyphenol’s overall anti-atherogenic capacities.
Another article reported that at relatively high doses, resveratrol inhibits mTOR and cell senescence, while contributing to cell apoptosis.
¤ This flavonoid, extracted from the small tree Rhus succedanea, sends an activating signal to anti-aging gene carrier cells, ensuring DNA and neuron protection, particularly during periods of oxidative stress.
¤ Fisetin also has a stabilising effect on resveratrol by preventing its metabolic breakdown and thus supports its function of inhibiting the mTOR signalling pathway. Fisetin has also been shown to exhibit anti-tumour and anti-angiogenic activity.
Salicin extracted from white willow
¤ This highly active compound, extracted from white willow bark (Salix alba) gave rise to the isolation of the acetylsalicylic acid molecule (aspirin®) by the chemist Felix Hoffman. It has been shown that taking a baby aspirin (81 mg) a day cuts the risk of developing cancer by at least 25%. Salicin possesses all the activity of aspirin® including its mTOR inhibitory effect. Although not as fast-acting as aspirin®, its effect is less irritating and it has longer-lasting efficacy.
With its exceptional formulation, the complex Natural Rapalogs offers the benefits of five natural inhibitors of the mTOR signalling pathway. In addition to this potent natural complex, other natural anti-ageing supplements may also be of interest. The product , for example, has been formulated to provide a range of anti-ageing nutrients with antioxidant, anti-inflammatory and anti-infection effects. Similarly, the powerful contains three plant extracts with active principles that reactivate a key enzyme of metabolism called AMPK. Discover too the supplement (NMN), an innovative formulation based on the latest advances in anti-ageing medicine.
|Daily dose : 3 capsules
Number of doses per pack : 30
|Amount per dose
|Meriva® (soy phospholipids, extracted from Curcuma longa)A
|Green tea extract standardised to 70% EGCg
| Polygonum cuspidatum extract standardised to 50% trans-resveratrol
| Rhus Succedanea extract standardised to 98% fisetin
|White willow extract standardised to 25% salicin
| Other ingredients: Acacia gum, white rice flour
Meriva®, Indena, Italy.
Directions for useNatural Rapalogs
Adults. Take one capsule with every meal.
Do not take if allergic to aspirin.
Finding a way of stopping the ageing process has been the stuff of dreams for generations. But now it’s on the way to becoming reality as Australian and American scientists believe they’ve found a way of not just ‘pausing’ the ageing process but ‘rewinding’ it!
Nicotinamide mononucleotide (NMN) is a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis. This new compound should not, however, be confused with nicotinamide riboside (NR) and other substances already on the market even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than NR.
Experiment brings hope for counteracting the ageing process
An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases (cancer and type 2 diabetes).
When Professor Sinclair and his colleagues injected this rare substance into two year-old mice, they observed, after just one week’s treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals. According to Dr Nigel Turner, a pharmacologist at the University of New South Wales,: “It’s like a 60 year-old being similar to a 20 year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
Re-establishing communication between the mitochondria and cell nucleus
The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery - their nuclei shrink and ageing becomes inevitable.
For Professor David Sinclair, “The ageing process can be compared to a married couple - when they’re young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solved the problem”.
This scientist therefore sees the decline in mitochondrial function and communication as a reversible process! He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age - until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.
In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.
The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN’s ability to activate all seven of the SIRT genes involved in extending longevity.
He believes nicotinamide mononucleotide could be a new class of ‘superdrug’ capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, and extending life expectancy to 150 years!
What is NAD+?
Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply. However, levels decline with age - the NAD+ in an older person’s cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased.
In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes.
Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome.
All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.
Specific benefits for type 2 diabetes
NMN not only helps prolong life expectancy but has also shown promise in treating type 2 diabetes. This degenerative disease is directly linked to over-consumption of fat and calories which overwhelm adaptive metabolic pathways. Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels. It enhanced insulin sensitivity in the liver, restored impaired gene expression related to oxidative stress, inflammatory response and the circadian rhythm by activating SIRT1.
At a conference on the biology of ageing organised by the Ellison Medical Foundation, Dr Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to be able to improve the activity of orexin, a brain hormone which enhances cells’ sensitivity to insulin and prevents increases in body fat. However sirtuins alone are not enough - cellular NAD+ must also be present for these beneficial processes to work. The problem is, levels of NAD+ decline both with age and as a result of a high-fat diet.
The good news, according to Dr Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.
In addition to this innovative formulation, you may also be interested in other anti-ageing supplements that offer effective and long-lasting protection from the effects of ageing. The potent , for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature ageing. You can also benefit from the optimised formulation which combines a selection of natural anti-ageing nutrients.
In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.
CompositionNicotinamide Mononucleotide 125 mg
|Daily serving: 1 capsule
Number of servings per box: 30
|Amount per dose
|Other ingredients: Acacia gum
Directions for useNicotinamide Mononucleotide 125 mg
Adults. Take 1 capsule a day. Each capsule contains 125 mg of nicotinamide mononucleotide.