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Welcome Shop by health concern Brain nutrition Lion's Mane + Huperzine A
Lion's Mane + Huperzine A
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Lion's Mane + Huperzine A
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70.00 €(75.77 US$) in stock
Huperzine-A
Huperzine-A is a natural alkaloid extract of Huperzia serrata.
  • Improves cognitive performance.
  • May help with age-related memory disorders.
  • Studies show significant improvements in memory, concentration and learning capacity.
Lion's Mane
New design!
Lion's Mane is a nootropic mushroom extract with powerful regenerating properties.
  • Contributes to neuron growth and survival (neurotrophic effects).
  • Obtained by dual-extraction (water decoction and alcohol) for maximum preservation of the mushroom’s active principles.
  • Guaranteed to contain 30% β-glucan polysaccharides and content in hericenones.
  • 100% natural and safe excipients.
Please note: this label has recently changed its graphic design, but rest assured: the composition of the product has remained strictly the same.
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Huperzia serrata green leaves

Huperzine-A is a natural alkaloid extract of Huperzia serrata, a Chinese plant. It has been used for centuries in traditional Chinese medicine for treating senile dementia. You can now enjoy its benefits in a supplement form with vegetarian capsules, available to buy in Supersmart's online catalogue.

What is Huperzine-A?

Just like certain drugs, huperzine-A inhibits the enzyme acetylcholinesterase which breaks down acetylcholine, a neurotransmitter essential for optimal cognitive function. The amount of acetylcholine available in the brain is therefore greater. Unlike drugs, huperzine-A:

  • Does not create dependency and is therefore suitable for long-term use.
  • It has longer-lasting action.
  • Is absorbed faster.
  • Crosses the blood-brain barrier quickly.
  • Has few or no side-effects.
  • Does not produce liver toxicity.

What are the benefits of Huperzine-A supplementation?

Huperzine-A's unique properties make it a potential treatment for many age-related cognitive deficits, now available in vegetarian capsules. Healthy individuals may buy this supplement for preventive purposes, choosing to take a reduced dose or to improve their cognitive performance. Huperzine was isolated for the first time in 1948 by Chinese scientists.

  • The majority of clinical studies have been conducted in China where huperzine now has drug status and is used to treat Alzheimer's disease and other age-related memory disorders.
  • In the United States, researchers from the University of Georgetown announced a new clinical trial in June 2006, involving 150 patients with mild to moderate Alzheimer's disease, to test the efficacy of huperzine-A. Taking huperzine-A leads to significant improvements in memory, concentration and learning capacity.
  • Research has also shown that huperzine-A substantially reduced abnormally high radical activity both in the brains of elderly animals as well as in the blood of Alzheimer's patients.
  • In monkeys, it reversed scopolamine-induced amnesia suggesting that it may have benefits for cognitive problems of Alzheimer's patients or those with other cognitive disorders.
CompositionHuperzine-A
Daily serving: 2 capsules
Number of servings per bottle : 60

Quantity
per serving

Huperzia serrata extract 10 mg
standardised to 1% Huperzine-A 100 mcg
Other ingredients: Acacia gum, rice bran.

Each vegetarian capsule contains 5 mg of Huperzia serrata extract standardised to 1% huperzine-A.
Directions for useHuperzine-A
Take one vegetarian capsules morning and evening or as advised by your therapist.
Lion’s Mane mushroom next to branch

Hericium erinaceus, also known as Lion’s Mane, is an edible mushroom which has been used for centuries in traditional Chinese medicine. It is rich in exceptional compounds such as β-glucans, polysaccharides associated with lowering blood cholesterol, as well as hericenones which support neuron function.

Hericium erinaceus, the champion of neuroprotection

In China, where it originated, it’s called "hóu tóu gū" and in Japan, "yamabushitake". A highly unusual mushroom that resembles a long white beard or lion’s mane, its use in Chinese medicine dates back to the Han dynasty, 200 years BC, a period when it was already considered to have extraordinary medicinal properties.

In recent years, as interest in traditional remedies has grown, a number of scientific studies have confirmed its traditionally-recognised therapeutic benefits and have highlighted a remarkable physiological property: Lion’s Mane protects, optimises and repairs the nervous system.

Neurotrophic and nootropic effects of Lion’s Mane

The most exciting potential offered by H. erinaceus relates to neuron activity. Studies show that extracts of Hericium erinaceus mushrooms are able to increase the production of nerve growth factor (NGF) (6), a neuropeptide known for its key role in neuron growth and survival (7-9), particularly in the part of the brain responsible for memory-processing called the hippocampus. This effect is due to the properties of hericenones of which Lion’s Mane has a guaranteed content.

NGF is a protein involved in regulating the growth, proliferation and survival of central and peripheral neurons. It plays a role in numerous mechanisms:

  • The ability of neurons to bind to each other and form synapses.
  • Maintaining neuron populations over time.
  • Axonal growth (a key stage in neural circuit assembly which is important for final neuron size).
  • Optimum efficacy of mitochondria (the ‘powerhouses’ where energy conversion takes place) in neurons (34-35).
  • Axonal regeneration or sprouting processes following trauma (recovery of damaged nerve tissue).
  • Increase in specific activity of enzymes involved in synthesis of catecholamines and of substance P in sensory neurons.
  • Improving myelinisation of nerve fibres (30-32).

NGF is a peptide produced by a large number of cells such as those of the immune system, but production declines with age and in the presence of certain disease states. Unfortunately, NGF cannot be used in a treatment or preventative capacity as it is unable to cross the blood-brain barrier. We therefore have to rely on natural compounds with a lower molecular weight (which can cross this barrier) that promote NGF synthesis within the body. That’s exactly what the hericenones in Lion’s Mane do.

Several studies have demonstrated the effects of H. erinaceus on mental efficacy in people with cognitive problems (33) and its use in dementia, cognitive dysfunction and memory problems (10). It seems that it acts primarily as a nootropic and that it’s necessary to take a supplement in order to maintain the effect.

Other properties of Lion’s Mane

1) Cardioprotective effects. As indicated by traditional Chinese medicine, H. erinaceus offers benefits for cardiovascular health. Its lipid-lowering effect is due to the action of the polymers it produces. When administered orally, these natural compounds are able to reduce blood levels of LDL-cholesterol and triglycerides, and increase those of HDL-cholesterol. It’s thought that polymers may also play a role in modulating the expression of a gene involved in lipid metabolism (5).

2) Antioxidant effects. Oxidative stress plays a key role in many pathologies including cardiovascular and neurodegenerative diseases (12). Oxidative stress is the result of an imbalance in pro-oxidative and antioxidant agents but can be inhibited, thus helping to prevent irreparable damage to the body, by consuming plenty of antioxidant-rich foods or by taking supplements. Extract of Hericium erinaceus is one such supplement, as it can neutralise free radicals and prevent cell membrane peroxidation (13), a process involved in ageing. These effects are due to its phenolic compounds (14) and polysaccharides (15).

3) Support for stomach health. Several years ago, a study demonstrated the benefits of Hericium erinaceus in relieving stomach ache (16), an effect believed to be related to its saponin content.

CompositionLion's Mane
Daily dose: 3 capsules
Number of doses per pack: 30

Amount
per dose

Extract of Lion’s Mane (Hericium erinaceus) 8:1 standardised to 30% polysaccharides 1500 mg
Other ingredients: Acacia gum, rice flour.
Directions for useLion's Mane
Adults. Take 3 capsules per day before meals.
Each capsule contains 500 mg

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