- Extracted from the mycelium of shiitake mushroom.
- Patented supplement produced in Japan using a proprietary liquid culturing process.
- Rich in easily absorbed alpha-glucan polysaccharides.
AHCC is a dietary supplement containing shiitake mushroom. It comes in 500mg capsules and is made in Sapporo, Japan, by the excellent Amino Up laboratory, and distributed by SuperSmart.
Of the thousands of mushrooms found in nature, twelve have caught the attention of the scientific community because of their unique combination of health benefits. Shiitake, which has featured in certain natural pharmacopoeia for thousands of years, is one of them.
Mushrooms, particularly shiitake, help to normalise several of the body’s functions:
These properties are due to shiitake’s exceptionally rich nutritional value. In addition to its high content of lentinan and eritadenine, which act on innate and adaptive immune responses (1), shiitake contains AHCC, rich in partly acetylated alpha-1,4 glucan polysaccharides. AHCC is the subject of intensive research (2-11).
AHCC is produced from the mushroom’s mycelium, cultured in a liquid medium using a proprietary method, under the strictest health controls.
The resulting dietary supplement consists of 10% alpha-1,4 glucans, a type of polysaccharide not normally found in mushrooms, which is derived only through this proprietary manufacturing process.
Daily dose: 2 capsules Number of doses per pack: 30 |
Amount per dose |
AHCC® (extract of shiitake mycelium (Lentinus edodes) standardised to 10% alpha glucans) | 1000 mg |
Other ingredients : Acacia gum *AHCC© is a registered trademark of Amino Up Co., Ltd., Japan. |
Each capsule contains 500 mg of shiitake mushroom mycelium (Lentinus edodes).
Adults. Take two capsules a day. Each capsule contains 500mg of AHCC® (extracted from the mycelia of Shiitake (Lentinus edodes) standardised to 10% alpha glucans).
Caution: do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used to replace a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat and humidity. As with all nutritional supplements, consult a health professional before taking if you are pregnant, breastfeeding or suffer from a health problem.
Senolytic Complex is a completely new ‘senolytic’ formulation for fighting the ageing process, based on the very latest discoveries in anti-ageing medicine, now available to buy at Supersmart. The term ‘senolytic’, recently coined by the scientific community, describes the ability to eliminate senescent cells (ie, aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of ageing. Since there was previously no way of preventing or slowing down this process, Senolytic Complex constitutes a truly revolutionary treatment.
The formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin (in a form 20 times more bioavailable than standard quercetin), theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s really setting the scientific community alight.
Senolytic Complex is for anyone over 40, whether as a course of treatment, or as long-term supplementation, to eliminate senescent cells and prevent their reappearance.
It is particularly recommended for the following groups of people:
In 2014, researchers achieved a major advance in the fight against ageing. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed ‘senescent’, these zombie-like cells (1) are deformed and unable to divide, and are distributed throughout the body’s tissues. Though no longer functioning normally, they are not eliminated and thus accumulate pathologically.
These cells are rare in young people but increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin (2-3).
Unfortunately, senescent cells do not just take over, they also impede the activity of neighbouring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment (4-7). These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighbouring healthy cells (8)!
Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of ageing (9) and the development of age-related health problems. Even a small amount of these cells is enough to wreak havoc in tissues(10) and induce the onset of many age-related problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases (11), sarcopenia, cataracts, insulin resistance, vascular hypo-reactivity (12) (13) ...
These cells normally destroy themselves in a process called apoptosis, in order to avoid damaging the body. However, this mechanism does not always work in which case the senescent cells continue to parasitize the body and cause chaos all around them (14).
Fortunately, researchers have identified several compounds that are specifically capable of repairing this defective mechanism and bringing about the self-destruction of these senescent cells. These extraordinary compounds are called ‘senolytics’.
The first study to identify senolytics was published in 2015 in the well-known scientific journal Aging Cell (15). Quercetin, a natural flavonol compound, combined with an anti-cancer drug, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. In just five weeks, this combination resulted in a significant reduction in mortality and physical deterioration.
Dozens of studies have since identified natural compounds with the same properties (16-17). This has led to the development of a revolutionary new therapy, senolytic treatment, which is able to selectively destroy senescent cells and thus reduce the severity of age-related diseases, increase resilience and longevity, and delay the effects of ageing.
The treatment is essentially a massive ‘spring clean’, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against ageing.
The very latest research shows that a formulation such as this can produce powerful rejuvenating effects, improve the condition of those affected by age-related health problems, slow down the ageing process and extend lifespan. Exceptional benefits which place this dietary supplement right at the top of anti-ageing nutrition and which should come as welcome news for many people…
Daily dose: 3 capsules Number of doses per pack: 30 |
Amount per dose |
Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardised to 40% lecithin and 40% quercetin) | 400 mg |
Bromelain 2000 GDU/g | 200 mg |
Vitamin C (Ester C®) | 100 mg* |
Fisetin from Rhus succedanea stem | 100 mg |
Extract of decaffeinated black tea leaves | 300 mg |
Nicotinamide mononucleotide | 10 mg |
Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C Quercefit®, Indena, Italy. Ester C®, Ester C Company. |
Attention: fisetin should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants (30).
Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.
A number of proteins and amino acids are being studied for their potential effects on human longevity. Here we take a look at 3 key anti-ageing proteins and the various ways they can be used to help ‘hold back time’.
Mitochondria (the cells’ power plants) deteriorate with age but you can help take care of yours and slow down the ageing process with our tips and natural remedies.
Does a dietary supplement past its expiry date necessarily have to be thrown away? Read on for the answers.