While there are very many powerful antioxidants, we have chosen those with the utmost potency, the efficacy of which has been widely studied. According to researchers, these multi-beneficial antioxidants have various mechanisms of action. For example, resveratrol, which is included in its bioactive form, appears to act by stimulating mitochondria, the cells’ powerhouses, as well as by blocking certain inflammatory factors. Quercetin, which is recognised for its anti-inflammatory effect, may inhibit the NF-kappaβ pathway, a protein that plays a fundamental role in the inflammatory process. Finally, pterostilbene may offer benefits in regulating the genes involved in the development of atherosclerosis, diabetes, and inflammation.

In addition to their antioxidant power, the compounds in Resveratrol Synergy may positively influence fat and carbohydrate metabolism and thus offer another anti-ageing effect. In the absence of adequate measures, long term disruption to this metabolism can eventually manifest in metabolic syndrome. This is a collection of symptoms that can foreshadow the development of problems such as cardiovascular disease and type 2 diabetes. Further studies are ongoing to confirm this protective effect which could help prevent premature ageing of certain cells.

Our anti-ageing supplement has been formulated to provide a concentrate of antioxidants and is offered in vegetarian capsules at a dose of two capsules a day. To fully benefit from their effects, supplements should be taken for at least a month, though this can be adjusted in line with your needs and the advice of your therapist. You may also be interested in other products available to buy at Supersmart with anti-ageing properties such as Astragaloside IV.

Buy Resveratrol Synergy to benefit from its antioxidant power.

Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-ageing compounds of interest (vitamin C, nicotinamide mononucleotide and bromelain).

Fisetin, the most powerful senolytic.

Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants (18) found in small amounts in strawberries, mangos and certain plants. Of all the flavonoids tested, it was shown to be the most effective at reducing senescent cells (19).

It helps extend longevity (20-21) and reduce markers of senescence in humans. Its hydrophobic nature means it penetrates cells easily via cell membranes (22) and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its specific abilities is to reduce the fraction of senescent cells in the immune system (T lymphocytes and NK cells), thus increasing its beneficial effect, since immune cells are important for clearing out senescent cells (23). In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and also offers anti-hyperlipidaemia effects (24).

It is supplied at a dose of 100mg a day (an average 0.4mg a day is consumed from the diet (25)).

For more information on fisetin and its senolytic properties, see: Fisetin is a senotherapeutic that extends health and lifespan.

Quercetin and theaflavin, two other major senolytic compounds

Since senescent cells use different mechanisms to resist programmed cell death (26-27), it’s important that other senolytic compounds are included in the formulation. Quercetin and theaflavin have been selected as two natural senolytics highlighted in the research.

Like fisetin, quercetin is also a member of the flavonoid family. It is extracted from Styphnolobium japonicum, the ‘Japanese pagoda tree’ or ‘honey tree’, and is delivered in a phytosome form which maximises its absorption into the bloodstream. It is recognised as being a benchmark senolytic, in combination with theaflavin, a polyphenol from black tea.

Bromelain, NMN and vitamin C

Senolytic Complex is enhanced by the addition of anti-ageing substances that work in symbiosis, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.

Senolytic Complex can either be used as an annual or quarterly treatment (28), or taken continuously, according to your needs. The capsules should be taken at mealtimes.

Senolytic treatment (senotherapy) can be undertaken as a three-step programme:

1. Eliminate senescent cells from your body (even a partial cleansing appears to bring benefits (29)) with the aid of Senolytic Complex.
2. Prevent the development of new senescent cells by improving your lifestyle, protecting yourself against the factors that cause cellular ageing, and strengthening both your DNA repair systems (with the aid of DNA Repair) and antioxidant systems (with the aid of Resveratrol synergy). With its vitamin C and bromelain, Senolytic Complex plays an active role in preventing the reappearance of senescent cells. A number of mechanisms are responsible for their development but two appear to be dominant: high inflammation levels and oxidative stress.
3. Stimulate and boost the immune system so that it too can help clear out senescent cells (with the aid of an immunostimulant mushroom extract).