Daily 3® composition is regularly updated in order to push back the boundaries of excellence even further and incorporate the latest scientific advances.

What’s been added 

For the first time, we have added nicotinamide riboside.

The addition of nicotinamide riboside to Daily 3® (10mg per daily dose) is a major development given this compound’s reputation within the scientific community. It’s a highly promising anti-ageing substance which is only just starting to be available to the public. Once ingested, it crosses the intestinal barrier with ease, where it is converted into an essential coenzyme called NAD (nicotinamide adenine dinucleotide), production of which declines with age. It’s clear that NAD helps fight against ageing by increasing the level of sirtuins, the ‘longevity proteins’ involved in many physiological mechanisms.

The amount of BioPQQ® has been doubled and that of lycopene increased (from 2 to 5 mg).

Studies show that PQQ stimulates the growth of new mitochondria, the organelles responsible for cellular energy production, as well as that of nerve growth factor (NGF) (5-6). One clinical study demonstrated that 8 weeks’ supplementation with PQQ led to improvements in mood, fatigue, and sleep quality (7). In this new version of Daily 3®, Supersmart has increased PQQ levels to 10mg in line with the dose used in most of these studies.

The amount of magnesium has been doubled.

A recent study showed that one in two of us has inadequate magnesium levels (8). This is a growing trend due to rapid changes in dietary habits, greater stress levels (9), increasingly common disruption of the acid-base balance, and the rising incidence of diseases like diabetes (10) and metabolic syndrome. And the consequences of such inadequacy are far from trivial: nerve and muscle hyperexcitability, cramps, tingling, hypersensitivity to stress, insomnia, increased heart rate, more frequent migraines, emotional over-sensitivity, fatigue, muscle pain...

In light of this, Supersmart has doubled the amount of magnesium, taking the total daily dose to 80 mg.

What’s been improved

Resveratrol has been replaced by pterostilbene.

Daily 3® now features pterostilbene, a nutrient from the same family as resveratrol but with much better bioavailability (80% for pterostilbene as against 20% for resveratrol).

It now contains a better form of vitamin B6.

Scientists have recently demonstrated that the active form of vitamin B6 in the body is pyridoxal-5-phosphate. Pyridoxine has therefore been replaced by this more bioavailable form.

The amount of vitamin K1 has been reduced (from 140 µg to 100 µg) but vitamin K2 has been added (75 µg).

There are two main forms of vitamin K: phytomenadione (K1) and menaquinone (K2).The most recent studies suggest that vitamin K1 acts more directly on coagulation, while K2 works on the calcification of soft tissue. It therefore makes sense to offer both forms in our formulation.

What’s been reduced or removed

The amount of vitamin A is now lower.

As recent studies have shown that the risk of vitamin A deficiency in developed countries is now low, Supersmart has reduced the amount of this vitamin in order to make room for other beneficial nutrients. It’s important to stress that the previous version never presented any risk of ‘over-dosing’, as beta-carotene is only converted into vitamin A when the body needs it.

Total tocopherols and gamma tocopherols have been removed.

Some meta-analyses have questioned the wisdom of regular supplementation with vitamin E at doses above 400IU a day (11). For those with very low starting levels of oxidative stress, it could actually present a slight health risk. While such conclusions remain the subject of debate, Supersmart has chosen to remove the synthetic tocopherols from Daily 3® and to retain only the natural vitamin E and tocotrienols, which according to the scientific literature, are more active (12).

Molybdene, selenium and zinc have all been reduced.

We’ve chosen to reduce the amount of these three trace elements and bring them in line with recommended daily amounts since the latest studies have shown no benefit in exceeding these levels. We have, of course, retained the same exceptional forms which offer optimal bioavailability: molybdene citrate, selenomethionine (obtained naturally) and zinc gluconate.

• An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases.
• When Professor Sinclair and his colleagues injected this rare substance into two-year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals.
• According to Dr Nigel Turner, a pharmacologist at the University of New South Wales, “It's like a 60-year-old being similar to a 20-year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
• In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.
• The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity.
• In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.

1. To extend your life expectancy. As you’re no doubt aware, healthy life expectancy or ‘healthspan’, has stopped rising in Western countries. Many physiological mechanisms become less efficient with age, such as absorption of nutrients through the digestive wall, production of endogenous antioxidants, and efficacy of the immune system, neurotransmission, and circulation. Relatively quickly, this degeneration leads to the development of age-related diseases and makes the body more fragile. The composition of Daily 3® has been developed to combat the decline in these functions and compensate for their loss of efficacy.
2. To allow your body to realise its full potential and help you feel great. Even if you eat a balanced, organic diet, you’ll almost certainly still be lacking in several micronutrients. The nutrient and mineral content of our food has been in constant decline since the last century and our fruit and vegetable intake is generally far from ideal (13). Researchers have estimated the loss in calcium, iron, vitamin B12 and vitamin C to be in the region of 30% in 50 years. This is due to misuse of pesticides, soil depletion, the preference for more resistant, but less nutritious, varieties, eating foods that spend days in transit before being stored, and modern lifestyles. Daily 3® allows you to compensate for these losses: within just a few days, you’ll notice you have significantly renewed energy. 
3. To combat the relentless attack on your body from the pollution, harmful substances and stress that cause disease. In the West, we’re facing an epidemic of ‘new’ disorders and health problems, such as diabetes and obesity, as well as auto-immune and neurodegenerative diseases. These are all linked, either directly or indirectly, to our unhealthy new dietary model, increasingly sedentary lifestyles and raised stress levels, all of which increase our requirements for many nutrients, particularly antioxidant compounds and vitamins. With its high content of exceptional antioxidants and vitamins in optimal forms, Daily 3® helps the body combat these attacks and reduces the risk of disease.

Take three capsules a day, one with each of your three main meals: it’s never been easier to maintain good health.

Note: if you’d like more information on basic supplementation and the benefits of taking a daily multivitamin supplement, why not download our eBook The practical guide to nutritional supplements.