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CBD Oil 6 % is a supplement with non-psychotropic hemp oil standardised to 6.4% CBD, to provide an anti-inflammatory effect which helps with pain relief.
How does CBD work? What are its benefits?
The CB1 and CB2 receptors to which endocannabinoids and phytocannabinoids bind are not randomly located in the body. They’re primarily found on the surface of cells of the human brain, central nervous system and immune system tissues. The hippocampus (particularly the dentate gyrus) as well as the Globus pallidus which controls movements (5) have a very high concentration of CB1 receptors, whereas immune tissue has a higher density of CB2 receptors (6). Their specific siting suggests that cannabinoids are involved in modulating memory, emotion, pain (chronic, inflammatory and neuropathic) (7-8) and movements (9-10).
CBD binds more to CB2 receptors, and THC to CB1 receptors. When CBD binds to its receptors, it triggers a chain reaction which results in a decrease in the release of neurotransmitters.
The binding of CBD to CB2 receptors appears primarily to reduce the inflammatory response. This involves multiple cellular targets and leads to a rise in BDNF (a protein that encourages the growth and differentiation of new neurons), a reduction in microglial cells and a fall in pro-inflammatory mediators (11-13). It is this anti-inflammatory effect which makes CBD so useful for pain relief.
CBD thus helps lower the production of inflammatory cytokines, maintain cerebral circulation during ischaemic events and reduce neuroinflammation (14). It also helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation (15). In addition, it helps to activate PPARs (16), proteins that act as transcription factors of certain genes involved in inflammation and pain transmission.
Several studies have shown it to have additional benefits: it promotes vasodilation (17-18) and helps reduce reactive oxygen species (ROS) as well as lipid peroxidation (19-21). CBD is also involved in modulating receptors outside of the endocannabinoid system. For example, serotonin receptors also appear to play a part in CBD’s benefits and therapeutic properties.
CBD can reduce the intensity and impact of symptoms associated with chronic anxiety and stress (22-23). Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several psychiatric disorders. According to one study, a single dose of CBD administered orally to healthy volunteers altered resting activity in the limbic and paralimbic regions of the brain (24-25).
Research has also shown a potential reduction in memory associated with a traumatic experience.
The use of CBD oil for pain or anxiety is currently enjoying sustained popularity. Though media attention has played a substantial part in this, it is CBD’s properties and benefits, which are now well-documented, which are largely responsible for its success. Following is a summary of the properties variously demonstrated by in vitro, animal and clinical studies (26):
- Pain relief.
- An effect on receptors in the brain, particularly serotonin, a neurotransmitter that regulates mood and social behaviour.
- Anti-inflammatory potential against cytokines.
- Neuroprotective benefits.
- Anxiolytic and stress-fighting properties.
- Anti-addiction benefits.
- An effect on certain stress responses.
Buy CBD Oil 6% for pain relief.
CompositionCBD Oil 6 %
Daily dose: 2 softgels
Number of doses per pack: 15 |
Amount per dose |
Cannabidiol (CBD)
from 156.25mg of non-psychotropic hemp oil standardised to 6.4% CBD |
10mg |
No RDA established. Other ingredients: organic olive oil. |
Directions for useCBD Oil 6 %
Adults. Take 2 softgels a day. Each softgel contains 78.125mg of hemp oil standardised to 6.4% cannabidiol (CBD), ie, 5mg of CBD.
This supplement contains no psychotropic substances.
PEA is an ultra-innovative supplement based on palmitoylethanolamide, a bioactive fatty acid produced naturally by animal and plant cells.
Palmitoylethanolamide (PEA) has been attracting widespread attention in the scientific community following the Nobel Prize-winning work of Dr Rita Levi-Montalcini. Taken for a period of several months, it aims to restore the body’s natural biochemical balance.
What is in the supplement PEA?
PEA is formulated from a proprietary source of palmitoylethanolamide (PEA) (OptiPEA®) which offers unrivalled purity.
This is an important advantage because palmitoylethanolamide is usually taken for several months if not years: taking a poor quality supplement (of which there are plenty on the market) will invariably cause adverse effects in the long term.
Palmitoylethanolamide in the human body
The vast majority of our cells are able to produce palmitoylethanolamide on demand, primarily when they are damaged or threatened.
When they need it, they remove certain fatty acids from their membranes and convert them into palmitoylethanolamide with the help of precursors called N-acylphosphatidylethanolamines (NAPEs). The reverse pathway is equally simple: using an enzyme called ‘fatty acid amide hydrolase’ (FAAH), the PEA is broken down by cells and the fatty acids reintegrated into cell membranes.
Cells use this process to rebalance biological processes that have been disrupted, such as over-activation of glial cells (2).
Note : this paragraph does not deal with the effects of exogenous palmitoylethanolamide.
Four good reasons to try PEA
- As PEA is not very soluble in water, it has quite low bioavailability. To maximise it, you need to choose a micronised supplement - in other words, one that contains very fine particles, which is obviously the case with our PEA.
- As PEA supplements are taken for very long periods, it’s important to opt for the highest quality product possible.
- Most PEA supplements are made from palm oil grown in conditions that involve deforestation and adversely affect biodiversity. The PEA in our supplement has been extracted from RSPO-certified (Roundtable on Sustainable Palm Oil) palm oil, in accordance with strict sustainable development criteria.
- PEA is a compound that has played a key role in evolutionary history, since almost all animals still produce it today. Its properties have been known for decades but it was the work of Dr Rita Levi-Montalcini which made it possible to understand its precise role in the body. Indeed, this work earned her the Nobel Prize in Medicine in the 1990s.
Note : this product should not be used to replace a varied, balanced diet or healthy lifestyle. Follow the advice on use, the recommended daily dose and the use-by date. Not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of young children’s reach. Store in a cool, dry place.
Updated : February 2019
CompositionPEA
Daily dose: 3 capsules
Number of doses per pack: 20 |
Amount per dose |
OptiPEA©(Palmitoylethanolamide) |
1 200 mg |
Other ingredients :Acacia gum, rice bran. OptiPEA©, Innexus Nutraceuticals, Holland. |
Directions for usePEA
adults. Take 3 capsules a day.
Each capsule contains 400 mg of OptiPEA©.