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Welcome Shop by health concern Heart & Circulation Willow Bark Extract + Ubiquinol
Willow Bark Extract + Ubiquinol
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Willow Bark Extract + Ubiquinol
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103.00 €(111.48 US$) in stock
Ubiquinol™
New design!
Ubiquinol™ is a reduced form of Co-enzyme Q10.
  • Key nutrient for protecting the heart, brain and red blood cells.
  • Its heart-protective effects may offer benefits for fighting hypertension.
  • Offers important benefits for protecting the body and thus delaying the ageing process.
Please note: this label has recently changed its graphic design, but rest assured: the composition of the product has remained strictly the same.
Willow Bark Extract
Willow Bark Extract is a ‘plant-based’ aspirin for relieving pain and reducing the risk of cardiovascular events
  • Helps provide lasting relief from chronic pain and headaches without causing side-effects.
  • Standardised to 15% salicin, but also contains many other natural synergistic anti-inflammatories: flavonoids, polyphenols, flavanones, proanthocyanidins …
  • Produced exclusively from white willow bark.
  • Lowers the risk of cardiovascular events (natural anti-coagulant).
  • Supports general health and strengthens and stimulates the body.
  • Essential element of supplementation for anyone over 45.
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Stethoscope around a red wood heart with a white cross

Ubiquinol™ is the reduced form of coenzyme Q10, also known as CoQ10, ubiquinone or simply Q10. Coenzyme Q10 is recognised as a powerful antioxidant and is used in the formulation of many anti-ageing creams. Extensively studied, it has also demonstrated protective benefits for certain of the body’s vital organs, and the prevention of some diseases. As a consequence, CoQ10 is also available to buy as a dietary supplement from the Supersmart catalogue. While coenzyme Q10 may be more widely known than Ubiquinol™, the latter also offers important benefits for protecting the body and thus delaying the ageing process. Scientific studies suggest too that Ubiquinol™ may be more absorbable, stable and resistant to oxidation than coenzyme Q10.

What are the health benefits associated with Ubiquinol™?

Like coenzyme Q10, Ubiquinol™ has been widely studied for its therapeutic potential. Research shows that Ubiquinol™ shares many of CoQ10’s properties and is thus often regarded as a key nutrient for health, helping to protect vital organs such as the heart and brain. It may also have a protective effect on red blood cells which are responsible for transporting oxygen around the body. While we do not yet fully understand how Ubiquinol™ works, it is thought to act via a number of mechanisms of action:

  • Acting as a neuro-protector to defend the brain against oxidative stress.
  • Supporting energy metabolism, helping to provide sufficient energy to muscles and tissues.
  • Acting positively on mitochondria, the cells’ energy powerhouses.
  • Modulating respiratory enzymes.
  • Helping reduce fatigue during intensive exercise.
  • Protecting the heart and helping to maintain cardiovascular health.
  • Protecting and maintaining numbers of red blood cells.
  • Boosting the effects of nutrients including vitamin C, the tocotrienols and carotenoids such as astaxanthin.

What do studies say about Ubiquinol™?

In a general sense, Ubiquinol™ appears to have a positive effect on how the body and its cells function. Given its protective effects, scientists have investigated Ubiquinol™’s therapeutic potential.

  • While studies are still ongoing, Ubiquinol™ has been identified as helping to delay the ageing process and thus prevent the development of associated diseases such as age-related macular degeneration (AMD).
  • Its neuroprotective effects in the brain may also help prevent or combat neurodegenerative diseases such as Huntington’s and Parkinson’s disease.
  • Similarly, Ubiquinol™’s heart-protective effects may offer benefits for the prevention and treatment of hypertension.
  • Finally, research has indicated a positive effect for this nutrient against migraines.

Further studies are underway to expand our understanding of Ubiquinol™’s therapeutic properties. Based on this scientific research, our product provides an optimal intake of Ubiquinol™, in the form of 100mg vegetarian capsules, with a suggested dose of one to two capsules a day.

CompositionUbiquinol™
Daily dose : 2 softgels
Number of doses per pack : 30
Amount per dose
Kaneka Ubiquinol™ 200 mg
Other ingredients : rapeseed oil, polyglycerol esters of fatty acids, beeswax, soy lecithin.
Q+® , Kaneka Ubiquinol and the quality seal™ are registered or pending trademarks of Kaneka Corp.
Directions for useUbiquinol™
Adults. Take one or two softgels a day with a meal containing fat (butter or cheese) but avoid consuming fibre at the same time.
Each softgel contains 100 mg ubiquinol. Warning : contains soy lecithin.
Person grabbing wrist next to willow bark

Willow Bark Extract is an analgesic and cardioprotective supplement made from white willow bark. It’s a gentler, safer and longer-lasting alternative to the drug aspirin. Over the past few months, it has been attracting extraordinary interest for its clinically proven synergistic power, naturally high salicin content and durable effects on chronic pain and circulation.

What’s the reason for this phenomenal rise in interest in white willow extract?

The use of willow bark for medicinal purposes spans centuries and civilisations. From Imperial China to First Nation America, Ancient Greece to medieval Europe, willow bark has been widely used to soothe pain and bring down fever (1).

In 1828, Pierre-Joseph Leroux, a French pharmacist, thought he had identified the active substance behind these effects: salicin. It was quickly discovered that this substance was converted in the body into salicylic acid, a compound with clear analgesic and antipyretic properties. There then followed a frantic race to be the first laboratory to synthesise the molecule. It was a German chemist working for the Bayer group who succeeded in doing so, producing for the first time a derivative of salicylic acid (acetylsalicylic acid) without using willow bark. Named ‘aspirin’, the drug would go on to enjoy rapid success, consigning willow bark to oblivion … for almost 120 years.

But for some time now, white willow extract has been experiencing a surprising and extraordinary comeback. Why so? In actual fact, Pierre-Joseph Leroux had made a mistake. While salicin is indeed an active compound in willow bark, it is by no means the only one! There are dozens of other natural molecules that act synergistically and complement the effect of salicin (2-3): proanthocyanidins (extensively metabolised by our gut flora), anti-inflammatory flavanones (naringenin, eriodictyol) (4-5), flavonoids (dihydroquercetin), flavonols (catechin) and polyphenols (caffeic, ferulic, cinnamic, vanillic, hydroxybenzoic and coumaric acids). And it’s the combination of these natural compounds that is responsible both for the anti-inflammatory effects of white willow extract, and its antioxidant, antiseptic, and immune-stimulating effects (6). A number of studies have shown blood levels of salicin to be too low to account exclusively for the analgesic effects of this extract (7-8).

In isolating one of these natural compounds, and offering it in an already-metabolised synthetic form, Bayer undoubtedly produced an effective painkiller, but it is one which is associated with significant side-effects. Its unique mechanism of action requires enormous amounts of salicylic acid which in the long term can damage the body (particularly in terms of gastrointestinal bleeding). In contrast, willow bark’s efficacy comes from a range of anti-inflammatory mechanisms of action and does not directly expose the digestive tract to acetylsalicylic acid. Willow bark extract thus contains a dose of salicylic acid which is potentially 10 times lower than that of standard aspirin tablets, but with physiologically comparable effects.

What are the main benefits of willow bark extract?

Willow Bark Extract offers anti-inflammatory, analgesic and cardioprotective effects. It is particularly good for:

  • Those suffering from acute or chronic pain (headaches, back pain, arthritic pain, menstrual cramps, ‘flu …). Scientific research has clearly demonstrated white willow’s efficacy in relieving chronic and acute pain. A summary published in 2007 concluded that white willow was effective for lumbar pain (13) when taken for around four weeks. Studies similarly show its effectiveness for arthritic pain, particularly in the knee and hip (14-15). The authors point out that its effects take longer to be felt than those of anti-inflammatory drugs, but that they produce far fewer adverse side-effects. In 2009, a research team drawing on three major clinical studies showed white willow extract to be effective against muscle pain (16).
  • Those aged over 50, for reducing the risk of cardiovascular problems, combatting oxidative stress and improving general health. Low-dose aspirin (or ‘baby aspirin’) has for many years been recommended for preventing cardiovascular disease and stroke in those over 50, especially individuals with several risk factors. The action of salicylic acid prevents blood clots from forming and thus reduces the risk of a cardiovascular event. The United States Preventive Services Task Force (USPSTF), an independent group of American researchers, confirmed this anew in 2016: the benefits they measured show that for 10,000 men presenting with a 10% 10-year cardiovascular risk, aspirin prevents 225 heart attacks, 84 strokes and 139 cases of colorectal cancer. That’s a gain of more than 300 years of life. For a few years now, however, some researchers have held the view that the benefits of aspirin may not always outweigh its adverse side effects (particularly the increased risk of bleeding). Gentler and more comprehensive, extract of willow bark thus appears to be the perfect alternative to aspirin for those who want to reduce their likelihood of a cardiovascular event without exposing themselves to other health risks.

How does willow bark extract differ from the drug aspirin (acetylsalicylic acid)?

There are three main differences between the two.

  1. Willow bark acts more slowly than acetylsalicylic acid in relieving pain but its effect is sustained over the long term.
  2. Willow bark extract does not cause the unwelcome side effects (irritation of stomach mucosa and inhibition of coagulation) associated with acetylsalicylic acid. The plant is metabolised very differently from its synthetic counterpart (9). This characteristic lends itself well to multi-target therapy, a new therapeutic approach which focuses on exerting physiological effects by means of a combination of targets rather than the action of a single, high-dose molecule. Scientists have observed that this type of therapy has been able to reduce and even eliminate side-effects because of the lower individual dose of the active compounds (10-12).
  3. Willow bark extract also offers antioxidant, anti-infectious, immune-stimulant and invigorating properties.

What are white willow extract’s mechanisms of action?

Salicin’s mechanism of action remained a mystery for many years. It was only in 1971 that John Vane and his team at the Wellcome Foundation showed that it prevented the action of certain enzymes - COX-1 and COX-2 - involved in metabolising arachidonic acid. These enzymes promote the first stage in the formation of a group of eicosanoids - signalling molecules involved in inflammatory processes.

By blocking the action of these COX enzymes, salicin lowers the production of a number of inflammatory mediators which are responsible for pain, swelling and other symptoms associated with inflammatory processes. Inhibition of COX-1 also reduces levels of thromboxane, a vasoconstrictor which leads to increased blood pressure. It is this mechanism of action which explains the use of low-dose aspirin for lowering the risk of heart attack (17). A number of studies have shown that salicylic acid also interacts with RNA and coenzyme A, opening up a potential application in the area of oncology (18).

All the other compounds in willow extract have complex and complementary cell mechanisms, indirectly inhibiting the pro-inflammatory cytokines TNF-alpha and interleukin-6, inhibiting translocation of the protein NF-kB (19), and inactivating transcription of certain genes associated with inflammation.

CompositionWillow Bark Extract
Daily dose: 2 capsules
Number of doses per pack: 30

Amount per dose

Salicin (from 532 mg of willow bark extract standardised to 15% salicin) 80 mg
Other ingredients: acacia gum.
Directions for useWillow Bark Extract
Adults. Take 2 capsules a day. Each capsule contains 40 mg de salicin.
Caution: Do not take this product if you think you may have an aspirin allergy.

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Willow Bark Extract + Ubiquinol
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