The ground-breaking synergy of H. Pylori Fight Advanced Formula reflects the latest scientific advances in the fight against the pathogenic bacteria Helicobacter pylori (or H. pylori). This ‘premium natural treatment’ is part of our Digestion and Oro-gastrointestinal health.
The premium formulation H. Pylori Fight Advanced Formula combines the excellent postbiotic Pylopass™ with 3 carefully-selected probiotics, as well as inulin and mastic gum, for unprecedented efficacy.
A ’premium, natural treatment’ with no antibiotics, targeted at Helicobacter pylori
An improved version of our famous H. Pylori Fight, the synergistic formulation H. Pylori Fight Advanced Formula combines all the most promising compounds for fightingHelicobacter pylori :
- Pylopass™ DSM17648: supported by more than 10 clinical studies, this patented postbiotic obtained from an inactivated probiotic strain of Lactobacillus reuteri, already a central component of H. Pylori Fight, is able to bind specifically to Helicobacter pylori bacteria. This co-aggregation significantly impedes its mobility and prevents it from adhering to the gastric mucosa. A study of 11 adults testing positive for H. pylori showed a reduction in bacterial load in 62.5% of participants after 28 days’ supplementation (1).
- Lactobacillus acidophilus: this lactic acid bacteria present in fermented dairy products helps promote a balanced gut microbiota. Studies also show it adheres to the gastric mucosa, preventing H. pylori from doing so itself. Other studies suggest that Lactobacillus acidophilus may also modulate the immune response and produce organic acids and other compounds able to inhibit the growth of H. pylori (2-3).
- Bifidobacterium bifidum: this probiotic strain, often used for treating gastritis associated with Helicobacter pylori, acts in a similar way to Lactobacillus acidophilus. By attaching to the lining of the stomach, it competes with Helicobacter pylori, thus reducing the number of potential attachment sites for this pathogenic bacteria. Bifidobacterium bifidum may also support immunity (4-5).
- Streptococcus thermophilus: this probiotic’s exopolysaccharides have also been shown to attach to the gastric epithelium (the first layer of the gastric mucosa which comes into contact with the contents of the stomach), and so these too reduce adhesion of Helicobacter pylori (6).
- Inulin: this fibre, typically described as a natural prebiotic, is found in various vegetables (chicory, artichoke, garlic, etc …). It supports the benefits of this microbiotic combo by ‘feeding’ the good bacteria and promoting their growth (7).
- Mastic gum: obtained from the mastic tree, this resin may, according to the scientific literature, have a bactericidal effect beneficial in reducing colonisation by Helicobacter pylori. Its effects are thought to be due to its acid fraction composed of terpene acids (8). It may also help to restore the gastric epithelium.
Reminder: what exactly is H. pylori bacteria?
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium which colonises the inner lining of the stomach (9). Equipped with formidable adaptive mechanisms, it is one of the few pathogens able to survive in such an acidic environment. In particular, it produces an enzyme called urease which converts urea into ammonia, thus reducing stomach acidity and helping it proliferate in mucus (10). Once established, it will not go away by itself, persisting throughout life if not properly eradicated.
H. pylori contamination is extremely common, affecting around 50% of the world’s population (11). It usually occurs in childhood, primarily through direct contact with gastric secretions (regurgitation, vomiting …), or more rarely through stools, especially in developing countries with poor hygiene conditions. It can remain symptomless for long periods, but as we’ll see below, it can sometimes lead to serious complications.
Supplements to take alongside H. Pylori Fight Advanced Formula
To help restore the gastric mucosa, we’d suggest also taking DGL 500, a deglycyrrhizinated liquorice root supplement which supports gastrointestinal health by promoting mucus secretion, as well as Zinc L-Carnosine, as zinc helps protect cells against oxidative stress (21-22).
To relieve the gastric inflammation caused by H. pylori, you could also take turmeric (such as the product Super Curcuma which offers unrivalled absorption). Turmeric root has anti-inflammatory and antioxidant properties and has been used for thousands of years in Ayurvedic medicine to support digestive processes (23).
Daily dose: 2 capsules Number of doses per pack: 30 |
Amount per dose |
Inulin |
1000 mg |
Mastic gum |
175 mg |
Pylopass™ (Lactobacillus reuteri) DSM17648 |
100 mg (10*109 CFU) |
Lactobacillus acidophilus |
3.33 mg (1*109 CFU) |
Bifidobacterium bifidum |
2 mg (1*109 CFU) |
Streptococcus thermophilus |
3.33 mg (1*109 CFU) |
Other ingredients: white rice flour. Pylopass™, Organobalance, Germany. |
Adults. Take 2 vegetarian capsules a day.
Attention: keeps best in a cool place.
- Buckley M, Lacey S, Doolan A, Goodbody E, Seamans K. The effect of Lactobacillus reuteri supplementation in Helicobacter pylori infection: a placebo-controlled, single-blind study. BMC Nutr. 2018 Dec 7;4:48. doi: 10.1186/s40795-018-0257-4. PMID: 32153909; PMCID: PMC7050722.
- Yang YJ, Chuang CC, Yang HB, Lu CC, Sheu BS. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways. BMC Microbiol. 2012 Mar 19;12:38. doi: 10.1186/1471-2180-12-38. PMID: 22429929; PMCID: PMC3340303.
- Asgari B, Kermanian F, Hedayat Yaghoobi M, Vaezi A, Soleimanifar F, Yaslianifard S. The Anti-Helicobacter pylori Effects of Lactobacillus acidophilus, L. plantarum, and L. rhamnosus in Stomach Tissue of C57BL/6 Mice. Visc Med. 2020 Apr;36(2):137-143. doi: 10.1159/000500616. Epub 2019 May 14. PMID: 32356850; PMCID: PMC7184849.
- Shirasawa Y, Shibahara-Sone H, Iino T, Ishikawa F. Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells. J Dairy Sci. 2010 Oct;93(10):4526-34. doi: 10.3168/jds.2010-3274. PMID: 20854986.
- Shibahara-Sone H, Gomi A, Iino T, Kano M, Nonaka C, Watanabe O, Miyazaki K, Ohkusa T. Living cells of probiotic Bifidobacterium bifidum YIT 10347 detected on gastric mucosa in humans. Benef Microbes. 2016 Jun;7(3):319-26. doi: 10.3920/BM2015.0138. Epub 2016 Mar 1. PMID: 26925600.
- Marcial G, Villena J, Faller G, Hensel A, de Valdéz GF. Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori. Benef Microbes. 2017 May 30;8(3):451-461. doi: 10.3920/BM2016.0186. Epub 2017 May 15. PMID: 28504579.
- Hughes RL, Alvarado DA, Swanson KS, Holscher HD. The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review. Adv Nutr. 2022 Mar;13(2):492-529. doi: 10.1093/advances/nmab119. Epub 2023 Feb 10. PMID: 34555168; PMCID: PMC8970830.
- Paraschos S, Magiatis P, Mitakou S, Petraki K, Kalliaropoulos A, Maragkoudakis P, Mentis A, Sgouras D, Skaltsounis AL. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob Agents Chemother. 2007 Feb;51(2):551-9. doi: 10.1128/AAC.00642-06. Epub 2006 Nov 20. PMID: 17116667; PMCID: PMC1797732.
- de Brito BB, da Silva FAF, Soares AS, Pereira VA, Santos MLC, Sampaio MM, Neves PHM, de Melo FF. Pathogenesis and clinical management of Helicobacter pylori gastric infection. World J Gastroenterol. 2019 Oct 7;25(37):5578-5589. doi: 10.3748/wjg.v25.i37.5578. PMID: 31602159; PMCID: PMC6785516.
- Mobley HL, Hu LT, Foxal PA. Helicobacter pylori urease: properties and role in pathogenesis. Scand J Gastroenterol Suppl. 1991;187:39-46. PMID: 1775923.
- Parikh NS, Ahlawat R. Helicobacter Pylori. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534233/
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- Narayanan M, Reddy KM, Marsicano E. Peptic Ulcer Disease and Helicobacter pylori infection. Mo Med. 2018 May-Jun;115(3):219-224. PMID: 30228726; PMCID: PMC6140150.
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