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Vitamin D3 5000 IU
Vitamin D3 5000 IU Vitamin D3 5000 IU
Vitamin D3 5000 IU
Algehele versterking van het lichaam Klantenbeoordelingen
18.00 €(20.03 US$) op voorraad
Bioavailable form of vitamin D for optimal absorption
  • Corrects widespread deficiency in vitamin D.
  • Promotes good cardiovascular health.
  • Strengthens bones and improves calcium uptake.
  • Helps reduce the risk of falls associated with muscle weakness and osteoporosis.
  • Helps prevent loss of bone minerals in menopausal women.
  • 5000 IU dose.
60 softgels
In winkelmand Analysecertificaat
Vitamin D3 5000 IU

Vitamin D3 5000 IU

Vitamin D3 5000 IU is an exceptional supplement containing 5000IU of vitamin D3 (the most bioavailable form) per softgel. It is enriched with sunflower oil to maximise its absorption.

Daily or twice-weekly supplementation with Vitamin D3 5000 IU produces a rapid increase in circulating levels of the vitamin, as confirmed by blood tests, and has a positive effect on cardiovascular, endocrine, nervous system, immune and cognitive function.

Who is Vitamin D3 5000 IU aimed at?

The latest studies show that between the months of October and April, almost everyone (1-4) living at a high latitude has an inadequate level of vitamin D (5-6). March sees levels reach their lowest point (7-8).

Vitamin D3 5000 IU is thus aimed at anyone living in France, Italy, Germany, Spain, the Netherlands, Portugal, Poland, the UK, Canada and the United States throughout autumn and winter.

Vitamin D is produced by the body on exposure of the skin to the sun’s ultra-violet rays (UVB). However, in temperate regions of the Northern Hemisphere, the conditions are not conducive to this process, both because of the sun’s angle of elevation and the weather during these seasons, as well as urban lifestyles: at this time of year, we tend to stay indoors and cover ourselves up too much to maintain adequate vitamin D production. Peak production rapidly plummets from November onwards and reserves are quickly exhausted.

Vitamin D3 5000 IU can also be used in the spring and summer by many groups of people (40% of individuals have inadequate levels even during these periods):

  • Those with dark skin who live at high or middle latitudes, because they need more sun than a fair-skinned person to produce the same amount of vitamin D.
  • Those who are less mobile or who do not get much exposure to the sun.
  • Those who are overweight, because vitamin D produced from the sun’s rays is sequestered by the fatty layers under the skin.
  • Those over 50 (9), both due to less exposure to the sun (delicate skin) and less efficient conversion of vitamin D precursors into vitamin D in the superficial epithelial layers of the skin.
  • Those suffering from bone disease.
  • Those with malabsorption problems and inflammatory bowel disease because this makes absorbing fats more difficult.
  • Those following specific diets (excluding meat, fish, eggs or products fortified with vitamin D).
  • Those living in areas of high pollution, as CO2 absorbs UV rays.
  • Those who regularly use UVB-blocking sunscreens (with a SPF above 15) as these can prevent up to 99% of UVB from penetrating the skin.

For all these groups of people, Vitamin D3 5000IU is often the safest way of quickly increasing their levels of vitamin D and of maintaining them throughout the year.

What are the effects of too little vitamin D?

Vitamin D is not really a vitamin: it should actually be thought of as a hormone. It performs many functions in the body, the best-known of which are its key roles in the intestinal absorption and binding to bones of dietary calcium, in muscle function, in maintaining cognitive function, in supporting the immune system and in tissue cell renewal.

The effects of a lack of vitamin D may go unnoticed for years but in the long term, they can be serious: softening of bones (osteomalacia), osteoporosis, bone pain, muscle weakness, joint pain (particularly in the wrists, ankles and shoulders), migraines, increased risk of depression, insomnia, hair loss (10) …

Conversely, optimal vitamin D levels bring numerous benefits for our health:

  • optimisation of bone health (11-13) ;
  • reduced risk of cardiovascular disease and stroke (at doses of at least 600IU a day(14)) ;
  • a decrease in blood pressure (at doses of at least 2000IU a day (15)) ;
  • improved blood cholesterol levels (at doses of at least 2000IU a day (16)) ;
  • increased strength and muscular balance (at doses of at least 800- 1000 IU a day (17)) ;
  • reduced risk of neurocognitive problems and auto-immune diseases;
  • potential reduction in fibromyalgia pain (at doses of at least 2400 IU a day) (18).

What is the optimal intake for vitamin D?

There is still debate about which vitamin D blood levels produce benefits. The very latest evidence suggests that circulating levels in excess of 50 nmol/L, or even 75 nmol/L, may be optimal for overall health. Those below 30 nmol/L, on the other hand, are associated with adverse effects on health.

Achieving a blood concentration of 75 nmol/L often requires supplementation with at least 2000IU a day. In the same vein, taking 3000IU a day for eight weeks has been shown to result in a concentration of more than 75 nmol/L of 25(OH)D (19-20).

In 2010, more than 40 international scientists called for greater awareness among doctors of the importance of vitamin D in preventing osteoporosis and cardiovascular disease. They recommended that the entire Western population (living at middle latitudes) should supplement with 1000-2000IU, especially from October to March.

What about dietary intake?

There are very few sources of vitamin D in the diet. They are mainly restricted to animal-source fats, particularly those from oily fish, and fortified foods such as dairy products, and some vegetable oils and plant-based drinks.

According to the French SUVIMAX study, the diet may only provide an average of 136IU of vitamin D a day. It is thus the body’s endogenous production from UV-B which is primarily responsible for circulating levels.

How does Vitamin D3 5000 UI differ from other such supplements?

Vitamin D3 5000 UI is an exceptional supplement which offers three main advantages:

  1. It contains vitamin D3, which is more effective than the vitamin D2 form found in plant-source products (23). The two forms were long thought to be equivalent but recent trials have shown this is not the case.
  2. It offers a powerful dose of 5000IU per supplement. It is designed to be taken every day (in which case it’s best to check your 25-hydroxyvitamin D status), twice-weekly, or weekly. Several studies have confirmed supplementation with 1000-10,000IU a day to be effective (24-27).
  3. It comes in the form of softgels and contains sunflower oil to maximise the absorption of the vitamin D. Comparative studies have shown that this form is better absorbed than the dry form and that it produced a more significant increase in 25(OH)D levels.

Frequently-asked questions from internet-users

How often should you take Vitamin D3 5000 IU?

As vitamin D is fat-soluble, the body is able to store it in fats when intake exceeds requirements.

In theory, therefore, you could take mega-doses of vitamin D (100,000-500,000IU) each month or even each year. However, it has been demonstrated that daily ingestion is closer to what our bodies naturally prefer. High doses of vitamin D are also linked with several adverse effects, such as an increased risk of falls and fractures, respiratory infections (28), and hypercalcaemia (too much calcium in the blood, producing symptoms such as constipation) as well as a fall in natural production of melatonin (a mediator of sleep).

It’s therefore better to opt for a supplement like VitaminD3 5000IU which can be taken every day (5000IU a day), every other day (2500IU a day), twice-weekly (around 1400IU a day) or weekly (around 700IU a day).

I’ve spent a lot of time in the sun this summer. Could my vitamin D levels be high already?

No. Spending long periods in the sun will not increase your vitamin D levels beyond a certain limit. Excessive exposure to the sun degrades pre-vitamin D3 (which is converted into D3 in the skin) and vitamin D3 itself. Lengthy sun exposure over the summer will therefore not be enough to maintain adequate levels over the winter months .

Does ageing reduce the ability to produce vitamin D ?

Those over 50 are still able to produce vitamin D from the sun’s rays but for several reasons, production is less effective and levels of circulating vitamin D tend to be lower.

What effects does vitamin D have on cognitive problems?

Research has demonstrated the presence of vitamin D hormone receptors (VDRs) in neurons and glial cells in the hippocampus, hypothalamus, cortex and subcortex, all areas of the brain involved in cognitive function (29).
In binding to these receptors, vitamin D triggers mechanisms which protect against the processes involved in neurocognitive problems (30). Vitamin D also exerts an antiatrophic effect by controlling the production of neurotrophic agents such as Nerve Growth Factor (NGF) and Glial cell line-Derived Neurotrophic Factor (GDNF) (31).

These properties may explain why low vitamin D levels in older people have been associated with cognitive problems (32-33) and Alzheimer’s disease (34).

The cohort analysis InCHIANTI established a link between hypovitaminosis D and cognitive problems, and showed that elderly people lacking in vitamin D (< 25 nmol/L) had a significantly-increased risk of overall cognitive decline compared to those with higher levels (> 75 nmol/L) (35). This finding has been confirmed by other prospective studies, particularly analysis of the MrOS (36) and SOF (37) cohorts. One study even showed that taking in excess of 800IU of vitamin D a day reduced the risk of Alzheimer’s disease by a factor of 5 after 7 years (38).

Most elderly people are deficient in vitamin D but not all will develop Alzheimer’s disease. It is therefore unlikely that a lack of vitamin D is the only factor responsible for the onset of the disease and that supplementing with vitamin D alone will be enough to prevent it (42).

How should Vitamin D3 5000 IU be taken?

Vitamin D3 5000IU should be taken alongside the meal of the day with the highest fat content. Doing so will increase the supplementation’s efficacy by 30%-60%. Fats encourage bile secretion which increases the absorption of vitamin D.

You can check how effective Vitamin D 5000IU is by asking your doctor for a 25-hydroxyvitamin D test (40) before and after supplementation. It’s the best biomarker of vitamin D (41).

Updated: January 2019

Dose journalière : 1 Softgel
Aantal doses per potje: 60
Hoeveelheid per dosis
Vitamine D3 5000 IE
Overige ingrediënten: zonnebloemolie
aanbevelingen voor gebruik
volwassenen. Neem dagelijks 1 softgel, of volg het advies van uw arts.
Let op: Bij een hoeveelheid van meer dan 2 000 IE per dag, verdient het de voorkeur een 25-hydroxy vitamine D- analyse te doen. Bij nieraandoeningen geen vitamine D3 innemen zonder toestemming van uw arts. De totale dosering van 10 000 IE per dag, met inbegrip van alle andere vitamine D-bronnen, niet overschrijden zonder dat uw arts u dit heeft aangeraden.
  1. Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr 2012;142(3):498–507. doi: 10.3945/jn.111.151977
  2. Greene-Finestone LS, Berger C, de Groh M, Hanley DA, Hidiroglou N, Sarafin K et al. 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates. Osteoporos Int2011;22(5):1389–1399. doi: 10.1007/s00198-010-1362-7
  3. Płudowski P. Konstantynowicz J, Jaworski K. Assessment of vitamin D status in Polish adult population. Standardy Medyczne/Pediatria 2014;(11):609–617.
  4. Vierucci F, Del Pistoia M, Fanos M, Erba P, Saggese G. Prevalence of hypovitaminosis D and predictors of vitamin D status in Italian healthy adolescents. It J Pediatr 2014;40:54 doi: 10.1186/1824-7288-40-54
  5. Hyppo¨nen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J
  6. Darling AL, Hart KH, Macdonald HM, Horton K, Kang’ombe AR, Berry JL, Lanham-New SA. Vitamin D deficiency in UK South Asian women of childbearing age: a comparative longitudinal investigation with UK European women. Osteoporos Int 2013;24:477–88
  7. Kroll MH, Bi C, Garber CC, Kaufman HW, Liu D, Caston-Balderrama A et al. Temporal Relationship between Vitamin D Status and Parathyroid Hormone in the United States. PLoS ONE 2015;10(3): e0118108 doi: 10.1371/journal.pone.0118108
  8. Brot C, Vestergaard P, Kolthoff N, Gram J, Hermann AP, Sùrensen OH. Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr. 2001;86 Suppl 1:S97–103. doi: 10.1079/BJN2001345
  9. http://ajcn.nutrition.org/content/36/6/1225.full.pdf
  10. Khan, Q. J., & Fabian, C. J. (2010). How I Treat Vitamin D Deficiency. Journal of Oncology Practice, 6(2), 97–101. doi:10.1200/jop.091087
  11. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews 2016; 96 (1): 365–408. doi: 10.1152/physrev.00014.2015 [PMC free article] [PubMed]
  12. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab2012;97:1153–1158. doi: 10.1210/jc.2011-2601
  13. Romagnoli E, Pepe J, Piemonte S, Cipriani C, Minisola S. Management of endocrine disease: value and limitations of assessing vitamin D nutritional status and advised levels of vitamin D supplementation. Eur J Endocrinol 2013;169(4):59–69.
  14. Sun et al, Vitamin D intake and risk of cardiovascular disease in US men and women, Am J Clin Nutr. 2011 June 8
  15. Qin, X. F., Zhao, L. S., Chen, W. R., Yin, D. W., & Wang, H. (2015). Effects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial. Clinical Nutrition, 34(2), 201–206. doi:10.1016/j.clnu.2014.04.017
  16. Qin, X. F., Zhao, L. S., Chen, W. R., Yin, D. W., & Wang, H. (2015). Effects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial. Clinical Nutrition, 34(2), 201–206. doi:10.1016/j.clnu.2014.04.017
  17. Cangussu, L. M., Nahas-Neto, J., Orsatti, C. L., Bueloni-Dias, F. N., & Nahas, E. A. P. (2015). Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial. Osteoporosis International, 26(10), 2413–2421. doi:10.1007/s00198-015-3151-9
  18. Wepner, F., Scheuer, R., Schuetz-Wieser, B., Machacek, P., Pieler-Bruha, E., Cross, H. S., … Friedrich, M. (2014). Effects of vitamin D on patients with fibromyalgia syndrome: A randomized placebo-controlled trial. Pain, 155(2), 261–268. doi:10.1016/j.pain.2013.10.002
  19. Gröber U, Spitz J, Reichrath J, Kisters K, Holick MF. Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare. Dermatoendocrinol 2013;5(3):331–347. doi: 10.4161/derm.26738
  20. Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinol2013;5(1):51–108. doi: 10.4161/derm.24494
  21. Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinol2013;5(1):51–108. doi: 10.4161/derm.24494
  22. Engelsen O. The relationship between ultraviolet radiation exposure and vitamin D status. Nutrients. 2010. May;2(5):482–95. doi: 10.3390/nu2050482
  23. Tripkovic, L., Wilson, L. R., Hart, K., Johnsen, S., de Lusignan, S., Smith, C. P., … Lanham-New, S. A. (2017). Daily supplementation with 15 μg vitamin D 2 compared with vitamin D 3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial . The American Journal of Clinical Nutrition, 106(2), 481–490. doi:10.3945/ajcn.116.138693.
  24. Al-Shaar L, Mneimneh R, Nabulsi, Maalouf J, Fuleihan Gel-H. Vitamin D3 dose requirement to raise 25-hydroxyvitamin D to desirable levels in adolescents: Results from a randomized controlled trial. J Bone Miner Res 2014;29(4):944–51. doi: 10.1002/jbmr.2111
  25. Biancuzzo RM, Clarke N, Reitz RE, Travison TG, Holick MF. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. J Clin Endocrinol Metab 2013;98:973–979. doi: 10.1210/jc.2012-2114
  26. Heaney RP, Davies K, Chen T, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77:204–210.
  27. Ng K, Scott JB, Drake BF, Chan AT, Hollis BW, Chandler PD et al. Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. Am J ClinNutr 2014;99(3):587–98. doi: 10.3945/ajcn.113.067777
  28. Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, Sheikh A, Griffiths CJ, Stefanidis C. Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews 2016, Issue 9. Art. No.: CD011511. DOI: 10.1002/14651858.CD011511.pub2.
  29. Annweiler C, Brugg B, Peyrin JM, Bartha R, Beauchet O. 2014. Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate. Neurobiol. Aging 35: 331–335.
  30. Annweiler C, Beauchet O. 2011. Vitamin D-mentia: randomized clinical trials should be the next step. Neuroepidemiology 37: 249– 258.
  31. Brown J, Bianco JI, McGrath JJ, Eyles DW. 2003. 1,25-Dihydroxyvitamin D-3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci. Lett. 343: 139–143.
  32. Buell JS, Dawson-Hughes B, Scott TM, et al. 2010. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 74: 18–26.
  33. Etgen T, Sander D, Bickel H, Sander K, Förstl H. 2012. Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement. Geriatr. Cogn. Disord. 33: 297–305
  34. Annweiler C, Llewellyn DJ, Beauchet O. 2013. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J. Alzheimers Dis. 33: 659–674.
  35. Llewellyn DJ, Lang IA, Langa KM, et al. 2010. Vitamin D and risk of cognitive decline in elderly persons. Arch. Intern. Med. 170: 1135–1141.
  36. Slinin Y, Paudel ML, Taylor BC, et al. 2010. Osteoporotic Fractures in Men (MrOS) Study Research Group. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 74: 33–41.
  37. Slinin Y, Paudel M, Taylor BC, et al. 2012. Study of Osteoporotic Fractures Research Group. Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. J. Gerontol. A Biol. Sci. Med. Sci. 67: 1092–1098.
  38. Annweiler C, Beauchet O. 2012. Possibility of a new anti-alzheimer’s disease pharmaceutical composition combining memantine and vitamin D. Drugs Aging 29: 81–91.
  39. Dawson-Hughes, B., Harris, S. S., Lichtenstein, A. H., Dolnikowski, G., Palermo, N. J., & Rasmussen, H. (2015). Dietary Fat Increases Vitamin D-3 Absorption. Journal of the Academy of Nutrition and Dietetics, 115(2), 225–230. doi:10.1016/j.jand.2014.09.014
  40. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317–322.
  41. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135:317–322.
  42. Cédric Annweiler. Les effets neurocognitifs de la vitamine D chez la personne âgée. OCL 2014, 21(3) D307. Clin Nutr 2007;85:860–8.

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Vitamin D3 5000 IU
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