Who is Derma Relief for?
Derma Relief is aimed at anyone looking for a natural way to relieve and improve their skin problems and at those for whom standard treatments have not worked.
Stubborn skin problems can include:
- atopic dermatitis;
- eczema ;
- red patches;
- pimples or microcysts;
- hyperseborrhea (oily skin) ;
- scaly patches;
What is Derma Relief?
Derma Relief’s formulation is based on a theory widely-documented in the scientific literature (1): that by taking probiotics, you create a healthy environment for your gut flora and reduce inflammation in the layers of your skin.
DermaRelief contains four strains of probiotic with a dual protective coating enabling them to reach the gut in perfect condition. Designed to colonise the gut, these bacterial strains have been carefully selected for their benefits for the skin, immune system and ability to fight inflammation:
DermaRelief also contains several compounds that support the growth of these probiotics or that act in synergy with them:
- Fructo-oligosaccharides and other oligosaccharides. The role of these carbohydrates, which are naturally present in grains, fruit and the roots of certain vegetables, is to ‘nourish’ the probiotics and help them multiply: they are called prebiotics.
- Vitamin C. Vitamin C optimises immune function and helps maximise collagen formation in the skin.
- Vitamin E (in the form of dl-alpha-tocopheryl acetate). When tocopheryls enter the body they are converted into tocopherols and become active: they play a major role in protecting skin cells from oxidative stress. Vitamin E also has anti-inflammatory and vasodilatory properties unrelated to its antioxidant activity.
- Vitamin B2 (riboflavin). It helps maintain the health of the skin’s mucous membranes (2).
What are the mechanisms of action responsible for DermaRelief’s effects on the skin?
Contrary to what you might think, probiotics are not just for preventing or improving gastrointestinal problems. We now know they confer systemic effects and that these effects can benefit the skin if the probiotic strains are selected carefully.
Fabio Meneghin and his research team analysed 37 clinical trials investigating the dermatological potential of oral probiotics: 13 out of 17 were shown to be effective in terms of prevention, while 15 out of 20 displayed therapeutic efficacy (3).
There are at least three mechanisms responsible for the benefits conferred by the probiotics in DermaRelief.
1) Preservation of the intestinal barrier integrity
Probiotics help strengthen the intestinal barrier’s impermeability, primarily by increasing secretion of immunoglobulin A (IgA) antibodies, the role of which is to neutralise harmful bacteria and toxins in the intestinal lumen. (4).
Strengthening the intestinal barrier prevents various compounds that exacerbate skin inflammation from passing into the bloodstream.
2) Modulation of the skin’s immune system
Probiotics and their derivatives modulate the immune system by activating dendritic cells (5-6), stimulating NK cells (7-8) and inducing T-lymphocyte differentiation.
Dendritic cells and T lymphocytes are indeed instrumental in the improvements observed in the skin following probiotic treatment. Their effects on the immune system produce anti-inflammatory benefits via an increase in production of interleukin 10 (IL10) (9-10), a powerful anti-inflammatory cytokine secreted by the body in response to a number of pathological conditions such as eczema and dermatitis.
3) Modulation of the gut-brain-skin axis
This mechanism relates to the capacity of emotional states (such as depression and anxiety) to alter gut microbiota, increase intestinal permeability and promote systemic inflammation.
Lactic probiotics may be able to moderate the release of a neuropeptide (a polypeptide functioing as a neurotransmitter and neuromodulator) called substance P (11). This neuropeptide is released by the nervous system in response to pain, stress, mood problems and anxiety, but it is found abundantly in the skin in atopic dermatitis, eczema and other skin problems (12). By restricting its release, probiotics thus help reduce skin disorders.
What are the key reasons for taking DermaRelief?
If you’re still wondering whether to try DermaRelief, here are six reasons that should convince you.
- Hyperactivity in the skin’s immune system (keratinocytes, dendritic cells and T lymphocytes) is seen in many dermatological conditions (13-16).
- Intestinal transit problems and diseases such as Crohn’s disease and IBS very often have dermatological manifestations (17-18).
- In most of the world’s cultures, people have been consuming fermented foods (containing probiotics) for at least 8000 years.
- It has been shown that diet can help protect skin cells from the inside through a targeted intake of tocopherols and vitamin C in particular.
- Animals deprived of gut flora are seen to have fewer B and T lymphocytes, dendritic cells and immunoglobulins, and significantly increased inflammation: all of which are corrected by supplementation with probiotics (19).
- DermaRelief is comprised of four bacterial strains rigorously selected for their probiotic potency, and contains only one natural excipient: corn flour.
Why has our gut flora deteriorated?
Our gut flora enables the production of vitamins which the body is unable to synthesise, as well as the digestion of complex molecules, and even supports the efficacy of the immune system. The symbiotic relationship between the various bacterial strains that make up our gut flora has played a key role in the evolution of the human species.
Nowadays however, a number of factors such as over-consumption of ultra-processed foods and excessive use of anti-microbial agents have unfortunately contributed to a profound change in the diversity and quantity of the beneficial bacteria colonising our intestines, a significant development given that women pass their microbiota onto their babies (20). At the same time, incidence of skin allergies and chronic dermatological conditions is continuing to rise, especially in Western countries.
Probiotic supplementation helps restore the balance of microbiota when it has been disrupted, for example, by antibiotic treatment (21).
What measures can be combined with DermaRelief?
There are a number of additional steps you can take to enhance the effects of DermaRelief:
- try to eat a diet with an omega 6:omega 3 ratio as close as possible to 1:1
: this should reduce pro-inflammatory eicosanoids and hyperkeratinisation of the pilosebaceous follicle (22), two mechanisms seen in acne;
- avoid irritants to the skin such as wool, chemicals and harsh detergents;
- try not to scratch affected areas: this aggravates inflammation and irritation. Instead, apply damp dressings to angry skin;
- don’t wear too many clothes and avoid exposure to temperatures likely to make you sweat profusely;
- take steps to reduce your stress levels: it stimulates allergic responses and exacerbates eczema flare-ups (23).
Can I take other supplements at the same time as DermaRelief?
DermaRelief can be happily combined with other supplements formulated to boost the immune system such as AHCC or those designed to maintain the structure of skin tissue such as Polypodium leucotomos, an extract of fern popular in South American traditional medicine. In order to achieve the 1:1 ratio of omega 6:omega 3, it may also be helpful to take omega-3 supplements.
How should DermaRelief be taken?
The product comes in 2g sachet ‘sticks’ which contain 3 billion lactic bacteria, which should be kept refrigerated. One stick a day is a sufficient dose.
You can either dilute the contents of the stick in a glass of water and drink, or swallow it straight from the sachet.
- Adrián D. Friedrich, Mariela L. Paz et al. Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics, Int J Mol Sci. 2017 Jun; 18(6): 1067.
- Meneghin F., Fabiano V., Mameli C., Zuccotti G.V. Probiotics and atopic dermatitis in children. Pharmaceuticals. 2012;5:727–744. doi: 10.3390/ph5070727
- Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric Research. 1992;32(2):141–144
- Sivan A., Corrales L., Hubert N., Williams J.B., Aquino-Michaels K., Earley Z.M., Benyamin F.W., Lei Y.M., Jabri B., Alegre M.L., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015;350:1084–1089. doi: 10.1126/science.aac4255.
- Peguet-Navarro J., Dezutter-Dambuyant C., Buetler T., Leclaire J., Smola H., Blum S., Bastien P., Breton L., Gueniche A. Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. Eur. J. Dermatol. 2008;18:504–511.
- Bouilly-Gauthier D., Jeannes C., Maubert Y., Duteil L., Queille-Roussel C., Piccardi N., Montastier C., Manissier P., Piérard G., Ortonne J.P. Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage. Br. J. Dermatol. 2010;163:536–543. doi: 10.1111/j.1365-2133.2010.09888.x.
- Patra V., Byrne S.N., Wolf P. The skin microbiome: Is it affected by UV-induced immune suppression? Front. Microbiol. 2016;7:1235. doi: 10.3389/fmicb.2016.01235
- Christensen HR, Frøkiær H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. Journal of Immunology. 2002;168(1):171–178.
- Salminen SJ, Gueimonde M, Isolauri E. Probiotics that modify disease risk. Journal of Nutrition. 2005;135(5):1294–1298.
- Verdú E.F., Bercik P., Verma-Gandhu M., Huang X.X., Blennerhassett P., Jackson W., Mao Y., Wang L., Rochat F., Collins S.M. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut. 2006;55:182–190. doi: 10.1136/gut.2005.066100
- Pavlovic S., Daniltchenko M., Tobin D.J., Hagen E., Hunt S.P., Klapp B.F., Arck P.C., Peters E.M.J. Further exploring the brain-skin connection: Stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J. Investig. Dermatol. 2008;128:434–446. doi: 10.1038/sj.jid.5701079.
- Greb J.E., Goldminz A.M., Elder J.T., Lebwohl M.G., Gladman D.D., Wu J.J., Mehta N.N., Finlay A.Y., Gottlieb A.B. Psoriasis. Nat. Rev. Dis. Prim. 2016;2:16082. doi: 10.1038/nrdp.2016.82
- Brown S.J. Molecular mechanisms in atopic eczema: Insights gained from genetic studies. J. Pathol. 2017;241:140–145. doi: 10.1002/path.4810.
- Martin S.F., Jakob T. From innate to adaptive immune responses in contact hypersensitivity. Curr. Opin. Allergy Clin. Immunol. 2008;8:289–293. doi: 10.1097/ACI.0b013e3283088cf9
- Gober M.D., Gaspari A.A. Dermatologic Immunity. Volume 10. KARGER; Basel, Switzerland: 2008. Allergic contact dermatitis; pp. 1–26
- Huang B.L., Chandra S., Shih D.Q. Skin manifestations of inflammatory bowel disease. Front. Physiol. 2012;3:13. doi: 10.3389/fphys.2012.00013.
- Skin manifestations of inflammatory bowel disease. Front Physiol. 2012 Feb 6;3:13. doi: 10.3389/fphys.2012.00013. eCollection 2012
- Hormannsperger G, Clavel T, Haller D. Gut matters: microbe-host interactions in allergic diseases. J Allergy Clin Immunol. 2012;129(6):1452-9.
- Cebra J.J. Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 1999;69:1046S–1051S.
- Engelbrektson A., Korzenik J.R., Pittler A., Sanders M.E., Klaenhammer T.R., Leyer G., Kitts C.L. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J. Med. Microbiol. 2009;58:663–670. doi: 10.1099/jmm.0.47615-0.
- Logan AC. Omega-3 fatty acids and acne. Arch Dermatol 2003 ; 139 : 941-2.
- Kimata H. Enhancement of allergic skin wheal responses in patients with atopic eczema/dermatitis syndrome by playing video games or by a frequently ringing mobile phone. Eur J Clin Invest. 2003 Jun;33(6):513-7.
Super Omega 3 has been formulated to offer an optimal intake of marine-source omega-3 fatty acids. These natural lipids have scientifically-proven effects on the composition of cell membranes as well as on numerous biochemical and physiological processes: regulation of blood pressure, anti-inflammatory responses, platelet aggregation, secretion of mood-influencing neurotransmitters, neuron activity …
Who is Super Omega 3 aimed at?
Super Omega 3 is for all sections of the population.
The World Health Organization, along with all Western countries, recommends a minimum intake of 500mg a day of EPA+DHA in order to maintain health (1), and in particular, to support brain development and function.
Yet numerous studies have shown that this level of intake is a long way from that currently achieved by American and European populations (2-8 times lower than daily recommended amounts).
And while these recommendations apply to healthy individuals, all the indications are that certain categories of people need more of these fatty acids (up to 1000mg/day (2)):
- those over 50 (to protect against cognitive decline);
- those suffering from chronic inflammation;
- those with a large waistline (excess adipose fat) ;
- those with hypertension, hypertriglyceridaemia, hypercholesterolaemia or hyperglycaemia;
- those suffering from fatigue or low mood;
- those at risk of cardiovascular problems.
Why take marine-source Omega-3?
In theory, the body is able to produce EPA and DHA from plant-source omega-3 fatty acids, but intake of these has declined significantly over the years as a result of modern farming methods and changes in our diet (3).
What’s more, the rate at which they’re converted is now very low as a result of our inappropriately-high consumption of omega-6 (4). Of far less benefit to the body, these fatty acids are nonetheless ubiquitous in modern processed foods and they mobilise all the enzymes (elongases and desaturases) needed for the conversion of plant-source omega-3s into DHA and EPA.
So if you decided to increase your intake of plant-source omega-3 fatty acids, you would not see any benefits unless you simultaneously made significant cuts to your omega-6 intake. The fact is, we actually need to consume the same amount of plant omega-3 as we do omega-6, but our actual consumption of omega-6 is 15-50 times greater than that of our plant-source omega-3.
In excess, omega-6 displace omega-3 and invade cell membranes in their place, resulting in the formation of billions of pro-inflammatory molecules (5-6) which are thought to play a key role in the development and exacerbation of chronic diseases.
This adverse imbalance could be rectified through daily consumption of oily fish rich in EPA and DHA. Unfortunately, however, the level of contamination of these fish and the fact that they’re relatively inaccessible makes this an untenable option … Our actual intake of marine-source omega-3, EPA and DHA, is very far from the minimum amounts recommended, and further still from optimal levels.
Supplementing with EPA and DHA is thus the simplest and most effective way of rapidly restoring healthy membranes.
What are the
recognised benefits of EPA and DHA?
EPA and DHA are molecules that penetrate cell membranes – the layers of fat that demarcate our body’s cells. From this strategic space, they influence a wide variety of the body’s functions.
chronic inflammation and metabolic problems.
When cell membranes take up EPA and DHA, they become more fluid and permeable. This is a really important point as when they’re more rigid, membrane exchange is restricted, promoting chronic inflammation.
In addition, in cases of systemic inflammation, the body can ‘dip into’ this store of omega-3 fatty acids and convert them into anti-inflammatory molecules. With omega-6, the complete reverse happens – they are converted into pro-inflammatory compounds which encourages the development of metabolic dysfunctions such as insulin-resistance and metabolic syndrome.
They reduce the risk of cardiovascular problems
In recent years, 12 studies have demonstrated the benefits of supplementing with omega-3 for
preventing acute coronary syndrome and other cardiovascular problems (7).
Several mechanisms are responsible for these effects. First and foremost, supplementing with omega-3 helps lower omega-6 concentrations in membranes, and as a result, reduces their conversion into pro-inflammatory derivatives (8). It also acts on the atheromatous plaque that causes cardiovascular problems: omega-3 help lower blood pressure and reduce triglycideraemia (9) - high levels of triglycerides being a recognised risk factor for heart problems - by lowering the liver’s production of these fats and by increasing their elimination via LDL-transporters.
They also stabilise atheromatous plaque by reducing production of inflammatory cytokines and by preventing monocytes from adhering to the vascular wall (10-11). Last but not least, omega-3 regulate a large number of genes, particularly those involved in fat metabolism.
They optimise cognitive function
Several studies, including a prominent one published in 2002, show that supplementing with EPA for several weeks produces a
significant decrease in depressive disorders
in a high proportion of people suffering from major depression (12-13).
In the same vein,
post-partum depression may actually be linked to a reduction in cellular levels of EPA and DHA in pregnant women, resulting in significantly-reduced reserves by the end of their pregnancy (14). Scientists have discovered that it takes around a year for initial reserves to be restored to the levels required for healthy functioning of the serotonergic and cholinergic systems (DHA normally represents 10-20% of the fatty acid composition of the brain (15)). Low DHA levels in brain cell membranes do not only result in depression. They also lead to a lack of dopamine in the brain’s cortical regions, which may play a role in cognitive decline and impair the growth and development of the nervous system.
Once integrated into the membrane,
DHA makes it more flexible, improving the speed of transduction and neurotransmission. It also affects neural extension development, synapsis establishment, neural plasticity, maturation of neurons and their migration towards appropriate sites, and thus plays a significant role in motor, sensory and cognitive abilities (16). Carlson and his team thus demonstrated the benefits on learning capacity of a diet rich in omega-3.
They protect visual function
DHA represents more
than 30% of all the fatty acids present in the retina (17). It is one of the most important compounds constituting the membranes of the outer segments of photoreceptors (18). The constant renewal of these cell components requires a regular and high intake of DHA or its precursors. DHA also supports a fundamental step in the phototransduction mechanism (19) which allows the conversion of light energy into a nerve signal (20). It is thus no surprise that deficiencies in DHA are associated with a number of visual dysfunctions such as AMD (21-23).
Super Omega 3 so exceptional?
1) It’s a 100% natural supplement
with optimal bioavailability
Like all our omega-3 supplements (Super EPA and Super DHA), Super Omega 3 contains
EPA and DHA fatty acids
in their natural form (triglycerides). These are more expensive than the synthetic form (ethyl esters), but studies show they may be more easy to digest (no ethanol is released) and twice as bioavailable.
unlike many other laboratories, we have chosen to develop our product from wild fish oil. A number of studies have shown that
farmed fish contain less omega-3 and more omega-6 (24). This is because such fish are fed inferior food: whereas wild fish feed on tiny fish, crustaceans and microalgae which are very rich in omega-3, farmed fish are often fed cereals and vegetable oils high in omega-6. What’s more, they are often farmed in inhumane and unsanitary conditions, and are routinely given antibiotics and anti-fungals.
2) The production methods used
respect the environment
it offers optimal quality, Super Omega 3 is produced from a top quality fish oil, obtained from fishing zones off the coasts of Peru and Chile free from any industrial contamination. Fish are selected for their naturally high content in omega-3 fatty acids (sardines, mackerel and anchovies). These fish oils are thus certified Friend of the Sea® which means they come from sustainable fisheries that meet strict criteria, with guaranteed management of fishing quotas. Smaller fish are prioritised as larger ones have lived longer and have accumulated waste products: mercury, dioxins and even pesticides.
3) It has
an optimal safety profile
In order to guarantee it is completely free
from contaminants (PCB, heavy metals, dioxins), SuperSmart uses
patented purification technology. This is a natural process
called enzymatic hydrolysis which produces the highest
concentration of EPA and DHA in
a 100 % pure oil.
In addition, as omega-3 fatty acids are highly-vulnerable to oxidation, we add natural ingredients to protect them and maximise their shelf life. Indeed, when omega-3 are oxidised, they are converted into
trans fatty acids devoid of any health benefits. It’s therefore essential to protect them with antioxidants so that they retain their beneficial effects over time. That’s why SuperSmart has chosen to add tocopherols (vitamin E) to this exceptional formulation.
It’s also why it’s best to store them in a cool, dry place, away from sunlight.
What happens to the omega-3 once they’ve been ingested?
Following ingestion and absorption, EPA and DHA are incorporated into cell membranes with phospholipids. This is a slow process: Super Omega 3 therefore needs to be taken every day for several weeks or even months in order to fully obtain its benefits.
At the end of the supplementation period, the increased intake in omega-3 will be reflected in the composition of the phospholipid membranes. The NAT-2 study showed that supplementation with omega-3 produced a significant increase (up to 70%) in levels of these fatty acids in membranes. To achieve this, it is advisable to reduce your intake of omega-6 throughout the supplementation period.
Do we know for sure that EPA and DHA reach the brain?
Yes. These two compounds definitely cross the blood-brain barrier, by means of transport proteins specific to long-chain polyunsaturated fatty acids. Several clinical trials have proved that oral administration of omega-3 results in accumulation of these fatty acids in tissues of the central nervous system (25-26).
Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.