Rare compound developed by Japanese scientists
This dietary supplement has been formulated to offer the benefits of AHCC (Active Hexose Correlated Compound), a rare compound developed by Japanese scientists. It is obtained by fermenting an extract of a mushroom popular in Asia and Europe called shiitake (Lentinus edodes). Interest in the health benefits of this mushroom is far from recent however – it has been used for many years in traditional Asian medicine. The result of considerable research, AHCC offers the benefits of a combination of different active principles with immune-stimulant and anti-tumour properties.
Potent immune-stimulant in dietary supplement form
Among the active principles in AHCC are the derivatives alpha-glucan and beta-glucan, polysaccharides recognised for their immune-stimulant effects. They boost the immune system by stimulating the activity of various groups of white cells including NK (natural killer) cells, recognised as the body’s first line of defence against attack. The active principles in AHCC also increase concentrations of T and B lymphocytes, white blood cells which act in a specific way against pathogens. These immune-stimulant effects therefore make this fermented shiitake extract a valuable aid in the prevention of various diseases.
AHCC’s anti-cancer potential
The immune-stimulant properties of AHCC, demonstrated in in vitro and clinical studies, have rapidly attracted the interest of the scientific community for their potential to fight certain cancers. There is a particular focus on AHCC’s stimulant effect on NK cells as they are such a vital line of defence against cancer cells. Part of the immediate innate immune response, NK lymphocytes are able to recognise and destroy tumour cells within a few hours. Suffice to say that AHCC’s stimulation of these ‘killer cells’ paves the way for promising new therapeutic perspectives in the fight against cancer!
Since it was developed and its therapeutic virtues revealed, AHCC has been used by many thousands of people, its use supported by studies conducted in over 30 university research institutes and 700 hospitals in Japan and across the world. In order to offer a high-quality immune-stimulant supplement, shiitake extracts standardised to 60% AHCC are obtained in a laboratory in accordance with GMP and ISO 9100 & 22000 standards, and delivered in capsules containing an optimal 500mg, with a suggested dose of one to two capsules a day. This dose can be adapted to individual needs and the advice of your therapist. For optimal efficacy, AHCC’s beneficial effects can be complemented by other natural active principles such as , a powerful antioxidant with immune-stimulant properties. The formulation is also a valuable aid with its exceptional antioxidant content, while the patented product can help prevent mutations to DNA.
Who is Derma Relief for?
Derma Relief is aimed at anyone looking for a natural way to relieve and improve their skin problems and at those for whom standard treatments have not worked.
Stubborn skin problems can include:
- atopic dermatitis;
- eczema ;
- red patches;
- pimples or microcysts;
- hyperseborrhea (oily skin) ;
- scaly patches;
What is Derma Relief?
Derma Relief’s formulation is based on a theory widely-documented in the scientific literature (1): that by taking probiotics, you create a healthy environment for your gut flora and reduce inflammation in the layers of your skin.
DermaRelief contains four strains of probiotic with a dual protective coating enabling them to reach the gut in perfect condition. Designed to colonise the gut, these bacterial strains have been carefully selected for their benefits for the skin, immune system and ability to fight inflammation:
DermaRelief also contains several compounds that support the growth of these probiotics or that act in synergy with them:
- Fructo-oligosaccharides and other oligosaccharides. The role of these carbohydrates, which are naturally present in grains, fruit and the roots of certain vegetables, is to ‘nourish’ the probiotics and help them multiply: they are called prebiotics.
- Vitamin C. Vitamin C optimises immune function and helps maximise collagen formation in the skin.
- Vitamin E (in the form of dl-alpha-tocopheryl acetate). When tocopheryls enter the body they are converted into tocopherols and become active: they play a major role in protecting skin cells from oxidative stress. Vitamin E also has anti-inflammatory and vasodilatory properties unrelated to its antioxidant activity.
- Vitamin B2 (riboflavin). It helps maintain the health of the skin’s mucous membranes (2).
What are the mechanisms of action responsible for DermaRelief’s effects on the skin?
Contrary to what you might think, probiotics are not just for preventing or improving gastrointestinal problems. We now know they confer systemic effects and that these effects can benefit the skin if the probiotic strains are selected carefully.
Fabio Meneghin and his research team analysed 37 clinical trials investigating the dermatological potential of oral probiotics: 13 out of 17 were shown to be effective in terms of prevention, while 15 out of 20 displayed therapeutic efficacy (3).
There are at least three mechanisms responsible for the benefits conferred by the probiotics in DermaRelief.
1) Preservation of the intestinal barrier integrity
Probiotics help strengthen the intestinal barrier’s impermeability, primarily by increasing secretion of immunoglobulin A (IgA) antibodies, the role of which is to neutralise harmful bacteria and toxins in the intestinal lumen. (4).
Strengthening the intestinal barrier prevents various compounds that exacerbate skin inflammation from passing into the bloodstream.
2) Modulation of the skin’s immune system
Probiotics and their derivatives modulate the immune system by activating dendritic cells (5-6), stimulating NK cells (7-8) and inducing T-lymphocyte differentiation.
Dendritic cells and T lymphocytes are indeed instrumental in the improvements observed in the skin following probiotic treatment. Their effects on the immune system produce anti-inflammatory benefits via an increase in production of interleukin 10 (IL10) (9-10), a powerful anti-inflammatory cytokine secreted by the body in response to a number of pathological conditions such as eczema and dermatitis.
3) Modulation of the gut-brain-skin axis
This mechanism relates to the capacity of emotional states (such as depression and anxiety) to alter gut microbiota, increase intestinal permeability and promote systemic inflammation.
Lactic probiotics may be able to moderate the release of a neuropeptide (a polypeptide functioing as a neurotransmitter and neuromodulator) called substance P (11). This neuropeptide is released by the nervous system in response to pain, stress, mood problems and anxiety, but it is found abundantly in the skin in atopic dermatitis, eczema and other skin problems (12). By restricting its release, probiotics thus help reduce skin disorders.
What are the key reasons for taking DermaRelief?
If you’re still wondering whether to try DermaRelief, here are six reasons that should convince you.
- Hyperactivity in the skin’s immune system (keratinocytes, dendritic cells and T lymphocytes) is seen in many dermatological conditions (13-16).
- Intestinal transit problems and diseases such as Crohn’s disease and IBS very often have dermatological manifestations (17-18).
- In most of the world’s cultures, people have been consuming fermented foods (containing probiotics) for at least 8000 years.
- It has been shown that diet can help protect skin cells from the inside through a targeted intake of tocopherols and vitamin C in particular.
- Animals deprived of gut flora are seen to have fewer B and T lymphocytes, dendritic cells and immunoglobulins, and significantly increased inflammation: all of which are corrected by supplementation with probiotics (19).
- DermaRelief is comprised of four bacterial strains rigorously selected for their probiotic potency, and contains only one natural excipient: corn flour.
Why has our gut flora deteriorated?
Our gut flora enables the production of vitamins which the body is unable to synthesise, as well as the digestion of complex molecules, and even supports the efficacy of the immune system. The symbiotic relationship between the various bacterial strains that make up our gut flora has played a key role in the evolution of the human species.
Nowadays however, a number of factors such as over-consumption of ultra-processed foods and excessive use of anti-microbial agents have unfortunately contributed to a profound change in the diversity and quantity of the beneficial bacteria colonising our intestines, a significant development given that women pass their microbiota onto their babies (20). At the same time, incidence of skin allergies and chronic dermatological conditions is continuing to rise, especially in Western countries.
Probiotic supplementation helps restore the balance of microbiota when it has been disrupted, for example, by antibiotic treatment (21).
What measures can be combined with DermaRelief?
There are a number of additional steps you can take to enhance the effects of DermaRelief:
- try to eat a diet with an omega 6:omega 3 ratio as close as possible to 1:1
: this should reduce pro-inflammatory eicosanoids and hyperkeratinisation of the pilosebaceous follicle (22), two mechanisms seen in acne;
- avoid irritants to the skin such as wool, chemicals and harsh detergents;
- try not to scratch affected areas: this aggravates inflammation and irritation. Instead, apply damp dressings to angry skin;
- don’t wear too many clothes and avoid exposure to temperatures likely to make you sweat profusely;
- take steps to reduce your stress levels: it stimulates allergic responses and exacerbates eczema flare-ups (23).
Can I take other supplements at the same time as DermaRelief?
DermaRelief can be happily combined with other supplements formulated to boost the immune system such as AHCC or those designed to maintain the structure of skin tissue such as Polypodium leucotomos, an extract of fern popular in South American traditional medicine. In order to achieve the 1:1 ratio of omega 6:omega 3, it may also be helpful to take omega-3 supplements.
How should DermaRelief be taken?
The product comes in 2g sachet ‘sticks’ which contain 3 billion lactic bacteria, which should be kept refrigerated. One stick a day is a sufficient dose.
You can either dilute the contents of the stick in a glass of water and drink, or swallow it straight from the sachet.
- Adrián D. Friedrich, Mariela L. Paz et al. Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics, Int J Mol Sci. 2017 Jun; 18(6): 1067.
- Meneghin F., Fabiano V., Mameli C., Zuccotti G.V. Probiotics and atopic dermatitis in children. Pharmaceuticals. 2012;5:727–744. doi: 10.3390/ph5070727
- Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric Research. 1992;32(2):141–144
- Sivan A., Corrales L., Hubert N., Williams J.B., Aquino-Michaels K., Earley Z.M., Benyamin F.W., Lei Y.M., Jabri B., Alegre M.L., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015;350:1084–1089. doi: 10.1126/science.aac4255.
- Peguet-Navarro J., Dezutter-Dambuyant C., Buetler T., Leclaire J., Smola H., Blum S., Bastien P., Breton L., Gueniche A. Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. Eur. J. Dermatol. 2008;18:504–511.
- Bouilly-Gauthier D., Jeannes C., Maubert Y., Duteil L., Queille-Roussel C., Piccardi N., Montastier C., Manissier P., Piérard G., Ortonne J.P. Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage. Br. J. Dermatol. 2010;163:536–543. doi: 10.1111/j.1365-2133.2010.09888.x.
- Patra V., Byrne S.N., Wolf P. The skin microbiome: Is it affected by UV-induced immune suppression? Front. Microbiol. 2016;7:1235. doi: 10.3389/fmicb.2016.01235
- Christensen HR, Frøkiær H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. Journal of Immunology. 2002;168(1):171–178.
- Salminen SJ, Gueimonde M, Isolauri E. Probiotics that modify disease risk. Journal of Nutrition. 2005;135(5):1294–1298.
- Verdú E.F., Bercik P., Verma-Gandhu M., Huang X.X., Blennerhassett P., Jackson W., Mao Y., Wang L., Rochat F., Collins S.M. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut. 2006;55:182–190. doi: 10.1136/gut.2005.066100
- Pavlovic S., Daniltchenko M., Tobin D.J., Hagen E., Hunt S.P., Klapp B.F., Arck P.C., Peters E.M.J. Further exploring the brain-skin connection: Stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J. Investig. Dermatol. 2008;128:434–446. doi: 10.1038/sj.jid.5701079.
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- Brown S.J. Molecular mechanisms in atopic eczema: Insights gained from genetic studies. J. Pathol. 2017;241:140–145. doi: 10.1002/path.4810.
- Martin S.F., Jakob T. From innate to adaptive immune responses in contact hypersensitivity. Curr. Opin. Allergy Clin. Immunol. 2008;8:289–293. doi: 10.1097/ACI.0b013e3283088cf9
- Gober M.D., Gaspari A.A. Dermatologic Immunity. Volume 10. KARGER; Basel, Switzerland: 2008. Allergic contact dermatitis; pp. 1–26
- Huang B.L., Chandra S., Shih D.Q. Skin manifestations of inflammatory bowel disease. Front. Physiol. 2012;3:13. doi: 10.3389/fphys.2012.00013.
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