CBD Oil 6 % 5 mg Supplement | 30 Softgels

What is CBD?

Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp (Cannabis sativa), just like the well-known psychotropic substance, tetrahydrocannabinol (THC). However unlike THC, CBD has no narcotic properties.

THC was the first psychoactive ingredient to be discovered in marijuana (1-3), but it was only in the 1990s that scientists identified the endogenous signalling system now known as the endocannabinoid system. This is a collection of endogenous messengers (endocannabinoids) and specific receptors located on external cell membranes (CB1 and CB2 receptors).

It works on a simple principle: when the body deems it necessary, endocannabinoid messengers are produced which bind to their corresponding receptors, triggering various cellular responses such as stimulation of appetite, limitation of synaptic transmission, anti-nociceptive effects (pain relief), hypothermia or reduction of spontaneous locomotion (4).

We know, for example, that endocannabinoids are effective at inhibiting the transmission of small diameter nociceptive fibres (which are involved in the pain process) and at reducing the release of neurotransmitters such as substance P, which are responsible for the transmission of pain. What’s less straightforward is how this system influences several complex mechanisms such as neuroplasticity, apoptosis, neuro-inflammation and traumatic memory.

It so happens that plants produce molecules that have a strong resemblance to endocannabinoids, so much so that they are able to bind to the same receptors (with varying degrees of affinity). Some of them, including THC, produce cellular responses which are very similar to – or even greater than - those triggered by endocannabinoids.

Cannabis contains more than 200 types of molecule that mimic endocannabinoids, including cannabidiol (CBD) which may account for up to 40% of the plant’s dry extract.

How does CBD work? What are its benefits?

The CB1 and CB2 receptors to which endocannabinoids and phytocannabinoids bind are not randomly located in the body. They’re primarily found on the surface of cells of the human brain, central nervous system and immune system tissues. The hippocampus (particularly the dentate gyrus) as well as the Globus pallidus which controls movements (5) have a very high concentration of CB1 receptors, whereas immune tissue has a higher density of CB2 receptors (6). Their specific siting suggests that cannabinoids are involved in modulating memory, emotion, pain (chronic, inflammatory and neuropathic) (7-8) and movements (9-10).

CBD binds more to CB2 receptors, and THC to CB1 receptors. When CBD binds to its receptors, it triggers a chain reaction which results in a decrease in the release of neurotransmitters.

The binding of CBD to CB2 receptors appears primarily to reduce the inflammatory response. This involves multiple cellular targets and leads to a rise in BDNF (a protein that encourages the growth and differentiation of new neurons), a reduction in microglial cells and a fall in pro-inflammatory mediators (11-13). It is this anti-inflammatory effect which makes CBD so useful for pain relief.

CBD thus helps lower the production of inflammatory cytokines, maintain cerebral circulation during ischaemic events and reduce neuro-inflammation (14). It also helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation (15). In addition, it helps to activate PPARs (16), proteins that act as transcription factors of certain genes involved in inflammation and pain transmission.

Several studies have shown it to have additional benefits: it promotes vasodilation (17-18) and helps reduce reactive oxygen species (ROS) as well as lipid peroxidation (19-21). CBD is also involved in modulating receptors outside of the endocannabinoid system. For example, serotonin receptors also appear to play a part in CBD’s benefits and therapeutic properties.

CBD can reduce the intensity and impact of symptoms associated with chronic anxiety and stress (22-23). Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several psychiatric disorders. According to one study, a single dose of CBD administered orally to healthy volunteers altered resting activity in limbic and paralimbic regions of the brain (24-25).

Research has also shown a potential reduction in memory associated with traumatic experience.

The use of CBD oil for pain or anxiety is currently enjoying sustained popularity. Though media attention has played a substantial part in this, it is CBD’s properties and benefits, which are now well-documented, which are largely responsible for its success. Following is a summary of the properties variously demonstrated by in vitro, animal and clinical studies (26):

• pain relief;
• an effect on receptors in the brain, particularly serotonin, a neurotransmitter that regulates mood and social behaviour;
• anti-inflammatory potential against cytokines;
• neuroprotective benefits;
• anxiolytic and stress-fighting properties;
• anti-addiction benefits;
• an effect on certain stress responses.

How is CBD Oil 6% produced?

Following extraction, CBD is diluted in hemp seed oil.

Ordinarily, hemp seed oil contains very little CBD (0.0025%). CBD is mostly found in the flowers of Cannabis sativa and, to a lesser degree, the leaves, but not in the seeds. CBD Oil 6% therefore contains hemp seed oil to which CBD extracted from hemp flowers has been added.

When cannabis grows, it produces THC-A and CBD-A, not THC or CBD. It is only when the two molecules are heated that they are decarboxylated into their active forms (27). The conversion of CBD-A into CBD can also be achieved more slowly by exposing the molecule to light, to heat (the temperature of gastric fluids is 37°C) or over time (28). CBD Oil 6% contains CBD and not CBD-A, as well as small amounts of a number of other phytocannabinoids. There is currently no product on the market offering greater CBD oil benefits.

Are there any CBD oil side-effects?

The hemp used in this product contains no THC. It therefore has no narcotic effect and has an excellent safety profile in humans.

Once ingested, CBD is quickly distributed around the body. Its lipophilic nature means it rapidly crosses the blood-brain barrier to reach tissues in the brain. It does not alter the heart rate and affects neither blood pressure nor body temperature. The half-life of CBD is 9 hours, after which it is eliminated vie urine in a metabolised form.

Its softgel format and the fact that SuperSmart guarantees the purity of its ingredients means there are no particular contraindications associated with its use. To date, there have been no public health problems reported with the use of a THC-free hemp oil standardised in CBD.

What other steps can be combined with taking CBD Oil 6%?

CBD Oil 6% can be combined with InflaRelief Formula, an enhanced formulation for relief of inflammation problems, with Natural Pain Relief, a natural, universal painkiller, and with Posinol 50 mg, an extract of Apocynum venetum which promotes mental relaxation.

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

1. Gaoni Y, Mechoulam R. Isolation structure and partial synthesis of an active constituent of hashish. J Am Chem Soc. 1964;86:1646–7.
2. Mechoulam R, Braun P, Gaoni YA. Stereospecific synthesis of (-)-delta 1- and (-)-delta 1(6)-tetrahydrocannabinols. J Am Chem Soc. 1967;89:4552–4.
3. Mechoulam R, Shvo Y, Hashish I. The structure of cannabidiol. Tetrahedron. 1963;19:2073–8.
4. Venance L, Maldonado R, Manzoni O. Le système endocannabinoïde central. Med Sci (Paris) 2004 ; 20 : 45-53.
5. Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153:199–215.
6. Pettit DAD, Harrison MP, Olson JM, Spencer RF, Cabral GA. Immunohistochemical localization of the neural cannabinoid receptor in rat brain. J. Neurosci Res. 1998;51:391–402
7. Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: A clinical review. JAMA. 2015;313:2474–83
8. Rog DJ, Nurmikko TJ, Friede T, Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology. 2005;65:812–9
9. Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, Bifulco M. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis. FASEB J. 2003;17:1771–3
10. Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol Rev. 2003;83:1017–66.
11. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34:13–25
12. Wang Q, Shao F, Wang W. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Front Mol Neurosci. 2015;8:49
13. Wee N, Kandiah N, Acharyya S, Chander RJ, Ng A, Au WL, et al. Depression and anxiety are co-morbid but dissociable in mild Parkinson's disease: A prospective longitudinal study of patterns and predictors. Parkinsonism Relat Disord. 2016;23:50–6
14. Camposa AC, Fogac MV, Sonegoa AB, Guimarãesa FS. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res. 2016;112:119–27
15. Castillo A, Tolóna MR, Fernández-Ruizb, J, Romeroa J, Martinez-Orgadoa J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis. 2010;37:434–40.
16. Esposito G, Scuderi C, Valenza M, Togna GI, Latina V, et al. Cannabidiol reduces ab-induced neuroinflammation and promotes hippocampal neurogenesis through PPARc involvement. PLoS One. 2011;6:e28668.
17. Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther. 2000;294:27–32.
18. Schultes RE. Hallucinogens of Plant Origin.Science. 1969;163:245–54.
19. Esposito G, Scuderi C, Savani C, Steardo L, Jr, De Filippis D, Cottone P, et al. Cannabidiol in vivoblunts beta-amyloid induced neuroinflammation by suppressing IL-1ß and iNOS expression. Br J Pharmacol. 2007;151:1272–9.
20. Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-)Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA. 1998;95:8268–73.
21. Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA. Neuroprotective effect of cannabidiol, a non-psychoactive componentpCannabis sativa, on ß-amyloid-induced toxicity in PC12 cells. J Neurochem. 2004;89:134–41.
22. Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 2012;367:3364–78.
23. Bergamaschi MM, Queiroz RHC, Chagas MHN, de Oliveira DCG, De Martinis BS, Kapczinski F, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Neuropsychopharmacology. 2011;36:1219–26.
24. Crippa JA, Zuardi AW, Garrido GE, Wichert-Ana L, Guarnieri R, Ferrari L, et al. Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology. 2004;29:417–26
25. Fusar-Poli P, Crippa JA, Bhattacharyya S, Borgwardt SJ, Allen P, Martin-Santos R, et al. Distinct effects of Δ9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry. 2009;66:95–105.
26. Pisanti, S., et al., Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther, 2017. 175: p. 133-150
27. Gowran A, Noonan J, Campbell VA. The multiplicity of action of cannabinoids: Implications for treating neurodegeneration. CNS Neurosci Ther. 2011;17:637–44.
28. Russo, E.B., Cannabidiol Claims and Misconceptions.Trends in pharmacological sciences, 2017. 38(3): p. 198-201.