The recommended daily dose for PharmaGABA is 100mg-200mg, which corresponds to one or two capsules a day.

No particular adverse side-effects have been demonstrated in oral supplementation toxicology studies using a wide range of doses (from 1 to 300mg) over moderate treatment periods (5).

CBD is very different from THC, the psychoactive substance found in the same plant. It has an excellent safety profile in humans and is in no way associated with the public health problems posed by cannabis. Its half-life is around nine hours, after which it is excreted in urine in a metabolised form.

PharmaGABA is a very safe supplement and has recently been assessed as such by an expert panel of the US Food and Drug Administration (FDA).

Stress is a normal manifestation which occurs in response to either a dangerous or worrying situation in the future, in the short or medium term.

• The person is particularly sensitive to stressors.
• The stressor persists over time and the person is unable to change or prevent it. It may be money problems, coping with a troubled family member, a challenging work relationship …
• The person is subjected to several stressors at the same time.

Chronic stress is toxic: it sucks the pleasure out of life and is a contributory factor in numerous illnesses. It leads to acute and intermittent stress attacks which sometimes mask the chronic nature of the problem.

To maximise the effects of supplementing with this formulation, you can also follow the steps below:

1. Try to maintain a healthy lifestyle, particularly by avoiding frequent changes to your sleep habits, smoking, excess alcohol consumption, and using electronic devices in bed (mobile phones, tablets, computers …) Instead, establish a calm routine before you go to sleep - listen to soothing music, read, practise yoga or do breathing exercises, for example.
2. Restrict intense visual, physical auditory or mental stimulation in the two hours before bed.
3. Eat dinner at least two hours before you go to bed, and prioritise foods high in tryptophan, an amino acid involved in the production of melatonin and which encourages drowsiness. Good sources are seeds, wholegrain rice, dairy products, eggs, pulses, chocolate and brewer’s yeast.

In addition, light therapy can be valuable, potentially boosting the effects of melatonin, especially in people who spend a lot of time indoors.

One capsule taken 30 minutes before bed is generally enough to obtain this supplement’s benefits. It’s worth noting that melatonin receptors are usually more sensitive between the hours of 7pm and 8pm (21).

This expertly-dosed formulation is not designed to replace the many plant-based combinations already available (such as the highly-effective Advanced Sleep Formula); it does, however, offer a more powerful alternative if you take into account the impact stress and pain can have on sleep problems.

Precautions: Do not exceed the recommended dose. This product should not be used as a substitute for a varied, balanced diet. Keep out of children’s reach. Protect from light, heat and humidity. Not recommended for women who are pregnant or breastfeeding, or for those suffering from mental disorders or auto-immune diseases. Consult a health professional before taking this product if you have any health problems. Do not take melatonin before driving or using machinery.

There are three types of symptom related to chronic stress: physical, mental and behavioural:

A number of physiological mechanisms are involved in chronic stress and they play a role in countless disorders. The main ones include:

• Accelerated ageing caused by increased free radical damage.
• Nutritional deficiencies as a result of a decrease in nutrient absorption and an increase in the rate of their metabolism.
• Reduced immunity caused by high cortisol production.
• Disturbed mental state due to profound structural changes in the brain.

There are several natural ways of combatting stress and breaking its vicious circle:

• Keep in touch with your loved ones, friends and family members.
• Eat a good quality diet with plenty of antioxidants (fresh fruits and vegetables), essential fatty acids (preferably omega-3), and minerals, and avoid ready-meals and processed foods which usually contain ingredients likely to aggravate stress. Poor diet is a factor in reducing your body’s ability to adapt well to stressors.
• Take advantage of traditional ‘adaptogen’ plants, which enable the body to manage stress better. These include Eleutherococcus (Eleutherococcus senticosus) which helps protect the body against external stressors (2) and Reishi (Ganoderma lucidum) (3).
• Learn how to trigger the relaxation response (which engages the parasympathetic nervous system) using techniques such as abdominal (or diaphragmatic) breathing, exercise, massage, meditation, creative pursuits (such as dancing, painting, drawing, DIY, gardening …).

This product’s capsules are made of pullulan, a natural polysaccharide obtained by fermenting tapioca or corn. Pullulan contains no animal ingredients and provides an excellent barrier to oxygen, helping to preserve the integrity of the capsule’s ingredients. It is also an eco-friendly alternative to synthetic materials.

This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.