Senolytic Complex is a completely new ‘senolytic’ formulation for fighting the ageing process, based on the very latest discoveries in anti-ageing medicine, now available to buy at Supersmart. The term ‘senolytic’, recently coined by the scientific community, describes the ability to eliminate senescent cells (ie, aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of ageing. Since there was previously no way of preventing or slowing down this process, Senolytic Complex constitutes a truly revolutionary treatment.
The formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin (in a form 20 times more bioavailable than standard quercetin), theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s really setting the scientific community alight.
Senolytic Complex is for anyone over 40, whether as a course of treatment, or as long-term supplementation, to eliminate senescent cells and prevent their reappearance.
It is particularly recommended for the following groups of people:
In 2014, researchers achieved a major advance in the fight against ageing. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed ‘senescent’, these zombie-like cells (1) are deformed and unable to divide, and are distributed throughout the body’s tissues. Though no longer functioning normally, they are not eliminated and thus accumulate pathologically.
These cells are rare in young people but increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin (2-3).
Unfortunately, senescent cells do not just take over, they also impede the activity of neighbouring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment (4-7). These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighbouring healthy cells (8)!
Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of ageing (9) and the development of age-related health problems. Even a small amount of these cells is enough to wreak havoc in tissues(10) and induce the onset of many age-related problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases (11), sarcopenia, cataracts, insulin resistance, vascular hypo-reactivity (12) (13) ...
These cells normally destroy themselves in a process called apoptosis, in order to avoid damaging the body. However, this mechanism does not always work in which case the senescent cells continue to parasitize the body and cause chaos all around them (14).
Fortunately, researchers have identified several compounds that are specifically capable of repairing this defective mechanism and bringing about the self-destruction of these senescent cells. These extraordinary compounds are called ‘senolytics’.
The first study to identify senolytics was published in 2015 in the well-known scientific journal Aging Cell (15). Quercetin, a natural flavonol compound, combined with an anti-cancer drug, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. In just five weeks, this combination resulted in a significant reduction in mortality and physical deterioration.
Dozens of studies have since identified natural compounds with the same properties (16-17). This has led to the development of a revolutionary new therapy, senolytic treatment, which is able to selectively destroy senescent cells and thus reduce the severity of age-related diseases, increase resilience and longevity, and delay the effects of ageing.
The treatment is essentially a massive ‘spring clean’, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against ageing.
Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-ageing compounds of interest (vitamin C, nicotinamide mononucleotide and bromelain).
How does Senolytic Complex work?
Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants (18) found in small amounts in strawberries, mangos and certain plants. Of all the flavonoids tested, it was shown to be the most effective at reducing senescent cells (19).
It helps extend longevity (20-21) and reduce markers of senescence in humans. Its hydrophobic nature means it penetrates cells easily via cell membranes (22) and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its specific abilities is to reduce the fraction of senescent cells in the immune system (T lymphocytes and NK cells), thus increasing its beneficial effect, since immune cells are important for clearing out senescent cells (23). In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and also offers anti-hyperlipidaemia effects (24).
It is supplied at a dose of 100mg a day (an average 0.4mg a day is consumed from the diet (25)).
For more information on fisetin and its senolytic properties, see: Fisetin is a senotherapeutic that extends health and lifespan.
Since senescent cells use different mechanisms to resist programmed cell death (26-27), it’s important that other senolytic compounds are included in the formulation. Quercetin and theaflavin have been selected as two natural senolytics highlighted in the research.
Like fisetin, quercetin is also a member of the flavonoid family. It is extracted from Styphnolobium japonicum, the ‘Japanese pagoda tree’ or ‘honey tree’, and is delivered in a phytosome form which maximises its absorption into the bloodstream. It is recognised as being a benchmark senolytic, in combination with theaflavin, a polyphenol from black tea.
Senolytic Complex is enhanced by the addition of anti-ageing substances that work in symbiosis, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.
Senolytic Complex can either be used as an annual or quarterly treatment (28), or taken continuously, according to your needs. The capsules should be taken at mealtimes.
Senolytic treatment (senotherapy) can be undertaken as a three-step programme:
Attention: fisetin should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants (30).
The very latest research shows that a formulation such as this can produce powerful rejuvenating effects, improve the condition of those affected by age-related health problems, slow down the ageing process and extend lifespan. Exceptional benefits which place this dietary supplement right at the top of anti-ageing nutrition and which should come as welcome news for many people…
Written: April 2019
Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.
Buy Senolytic Complex to fight the ageing process.
| Daily dose: 3 capsules Number of doses per pack: 30 |
Amount per dose |
| Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardised to 40% lecithin and 40% quercetin) | 400 mg |
| Bromelain 2000 GDU/g | 200 mg |
| Vitamin C (Ester C®) | 100 mg* |
| Fisetin from Rhus succedanea stem | 100 mg |
| Extract of decaffeinated black tea leaves | 300 mg |
| Nicotinamide mononucleotide | 10 mg |
| Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C Quercefit®, Indena, Italy. Ester C®, Ester C Company. |
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A senescent cell is one whose life cycle has come to a permanent end. In the normal scheme of things, such cells are eliminated from the body by the immune system. But in some cases, this fails to happen and they accumulate in tissues, with potentially serious consequences for health.
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