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Welcome Shop by health concern Fighting inflammation CBD 25 mg
CBD 25 mg
CBD 25 mg CBD 25 mg
CBD 25 mg
Fighting inflammation
4.5
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23 reviews
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63.00 €(70.16 US$) is available
Description
Natural, powerful analgesic for long-lasting pain relief
  • Relieves pain (chronic, muscular, joint …).
  • Helps reduce inflammation.
  • Soothing and calming effects.
  • High concentration (25mg of CBD per capsule) and broad-spectrum (other phytocannabinoids).
  • Contains no psychotropic substances (THC).
  • 100% natural.
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30 Veg. Caps
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A inflamed back and hemp leafs

CBD Natural Supplement

A powerful and original nutrient, CBD 25mg is emerging as an important natural painkiller: it is aimed at anyone who is exhausted by pain and the impact it has on their everyday life. It is similar to CBD Oil 6% but has a much higher concentration of active principles (25mg vs 5mg for CBD Oil).

Its main applications are for:

  • severe or intractable pain;
  • acute and chronic pain;
  • muscle and joint pain;
  • headache and migraine, particularly those caused by stress and sleep problems;
  • neuropathic and fibromyalgia pain;
  • sleep problems caused by pain of various sorts.

What is CBD?

Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp ((Cannabis sativa) alongside the well-known psychotropic substance tetrahydrocannabinol (THC). However, unlike THC, CBD does not have any narcotic properties.

It is a natural compound which mimics the action of endocannabinoid messengers produced by the body. Like them, it is able to bind to specific receptors (CB1 and CB2) located on external cell membranes, and trigger various cellular responses such as restricting synaptic transmission, relieving pain and reducing spontaneous locomotion (1). Just like endogenous cannabinoids, CBD thus inhibits the transmission of small diameter nociceptive fibres (which are involved in the pain process) and reduces the release of neurotransmitters like substance P, responsible for transmitting pain .

Unlike THC, which has a strong affinity for CB1 receptors, CBD binds more to CB2 receptors. These are found on the surface of cells of the central nervous system and in particular in immune system tissues where they are involved in modulating memory, emotions and pain (chronic, inflammatory or neuropathic) (2-3).

What are the effects of CBD 25mg ?

What are the effects of CBD 25mg on pain?

The binding of CBD to CB2 receptors, and the modulation of serotonin receptors triggers a cascade of molecular reactions, the main effects of which are:

  • A reduction in the inflammatory response . The modulation of receptors leads to both a rise in BDNF (a protein that promotes growth and differentiation of new nerve cells), and a reduction in microglial cells and pro-inflammatory mediators (4-5).
  • Stimulation of vasodilation. (6-7).
  • A decrease in sensitivity to pain. CBD promotes activation of PPARs, proteins that act as a transcription factor for certain genes involved in pain transmission.
  • A neuro-protective effect . CBD helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation. (8).
  • An analgesic effect (by reducing the transmission of nociceptive fibres).
  • An anxiolytic effect. . Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several disorders such as stress and anxiety.
  • An improvement in sleep (9).

What’s the right CBD dose for optimal efficacy?

This depends on several factors:

  • the concentration of the CBD;
  • a person’s weight;
  • individual biological factors;
  • the severity of the initial problem or symptoms.

For someone with a bodyweight of 70kg, and where the product is standardised to 17% CBD, the optimal dose would be 25mg, although this can be gradually increased to 50mg depending on the results obtained (though this higher dose should not be exceeded). CBD can also be vaporised but the most stable and consistent mode of administration is expertly-dosed, oral capsules.

Over a lifetime, our body’s physiology changes, as does the number and distribution of receptors in the endocannabinoid system which are directly responsible for interactions with CBD. The optimal dose will therefore change depending on the individual and ageNick Jikomes, PhD, neuro-physician.

How is CBD 25mg produced?

CBD 25mg is obtained by plant extraction using supercritical carbon dioxide (sCO₂). This is an alternative mode of extraction to the organochlorine solvents normally used in such processes but which are potentially harmful to the environment. Very eco-friendly, sCO₂ both ensures the final product is free from solvent residues and helps maintain the chemical integrity of the heat-sensitive molecules. It is odourless, colourless, non-toxic and non-inflammable and is completely safe for our health and our environment.

Does CBD 25mg produce any side-effects?

Unlike the drug cannabis which usually contains around 15% THC, the form used in this product has none. It therefore has no psychotropic effects and has an excellent safety profile in humans.

Once ingested, CBD is rapidly distributed around the body. It is lipophilic and thus quickly crosses the blood-brain barrier to reach brain tissues. It has no effect on heart rate, blood pressure or body temperature. CBD’s half-life is around 9 hours after which it is excreted in a metabolised form in urine.

To date, no public health problem has been associated with the nutritional use of CBD.

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place

Written : November 2018.

Composition
Daily dose: 1 capsule
Number of doses per pack: 30
Amount per dose
Cannabidiol (CBD) extracted from non-psychotropic hemp leaf standardised to 17% CBD 25 mg
Other ingredients:  Acacia gum, rice flour.
Directions for use
adults. Take 1 capsule a day.
This supplement contains no psychotropic substances.
4.5
4.4 /5 23 reviews
Description
5
4.5 / 5
Quality
5
4.5 / 5
Value for money
4
4.0 / 5

Reviews 23
Excellent
57 %
Great
30%
Average
9%
Poor
4%
Bad
0%

Raffaella Frasca Comati
5
Avevo un dolore alla spalla che mi creava parecchi problemi. Ci sono stati momenti in cui non sapevo nemmeno come mettere il braccio perchè era davvero insopportabile. Ho provato con antidolorifici, fisioterapia antalgica, apparecchiature di varia natura, ma il dolore si era attenuato di poco e la mia mobilità era comunque limitata. Alla fine ho tentato con il CBD 25 e dopo un paio di settimane ho iniziato ad accorgermi che il dolore si stava attenuando. Dopo una scatola di trattamento ero in grado di muovere il braccio in modo quasi normale. Felicità assoluta. Dopo questo piccolo miracolo, l'ho consigliato a mio figlio che aveva una pubalgia in corso e anche in quel caso si è dimostrato efficacissimo. Lo adoro.
ROSA MONTAGUT Juan Carlos
3
Disminuye el dolor, pero no lo suficiente para casos de dolor extremo. He de suponer que la calidad es buena, aunque no soy experto en ello.
EYNARD EMMA
4
Difficile de dire son efficacité quand on souffre beaucoup. L attente est trop grande ! A refaire l essai
Mme Nicole SCHALK
5
Bons résultats anti douleur
BOAVENTURA David
5
un super produit
elisabeth
5
Souffrant de douleurs musculaires du a ma maladie je ressent moins de douleurs lorsque je l utilise.
Yves Boden
5
Permet avec Alpha Lipoic Acid une gestion efficace de ma polyneuropathie!
Stéphane VANNIER
3
très cher pour une efficacité douteuse
LYONNET Sophie
4
C est une aide précieuse, pour les douleurs et également pour donner un coups de pousse au sommeil. Rien dé miraculeux, mais une aide non négligeable.
BERTIN Cathy
5
Excellents
francoise
4
Aide à dormir en calmant la douleur de l'arthrose.
Sra. Montealegre Moure
5
Ik gebruik CBD 25 mg dagelijks, samen met Super Curcuma en Willow bark ben ik vrij van pijn en kan mijn werkzaamheden verrichten.
Roberto
5
Ottimo prodotto, consegna veloce, ha funzionato su dolori cronici, ormai refrattari agli antidolorifici (fans). È una buona alternativa agli oppiodi di sintesi.
Corinne jeunesse
4
bon produit bonne aide pour les douleurs chroniques
Patrice CREPIN
4
Efficace contre les douleurs chroniques. Sans effets secondaires.
Armelle JOURDREN-BIDON
4
Produit à la hauteur de mes attentes. Je le donne à ma mère de 85 ans atteintes de douleurs chroniques dues à l'arthrose, elle a diminué ses antidouleurs habituels.
JOUAULT Janine
4
Bon rapport qualité/prix. Produit sans aucun effet secondaire. Seul produit qui a réussi à apporter une amélioration non négligeable au niveau de mes douleurs neuropathiques. (2 gélules/jour) Remarque: Lors de la 1ère prise, il y a eu une exacerbation des douleurs pendant 2 à 3 jours avant d avoir une amélioration assez rapidement.
Anabelle
2
the dosage is not enough for neuropathy.the price is very expansive foe this very low load
Jose Camacho Garcia
5
muy buen resultado.
FAYOLLE Yvette
5
Grâce à ce produit, j’ai une partie de la journée sans douleurs et c’est très appréciable.
Herrault daniel
5
Ce produit est excellent mais cher, il y a des mois où je n'ai pas les moyens de me le payer et je subi les douleurs plein pot. Les autres produits ne me font rien, à part me déglinguer l'estomac.
Sra. Montealegre Moure
5
Eil deze producten alleen bij SuperSmart kopen. Ik weet dat ik ze ook bij andre leverantiers kan krijgen, maar ik vertrouw alleen SuperSmart
HELENE
5
très efficace contre l'inflammation et les douleurs
References
  1. Venance L, Maldonado R, Manzoni O. Le système endocannabinoïde central. Med Sci (Paris) 2004 ; 20 : 45-53.
  2. Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: A clinical review. JAMA. 2015;313:2474–83
  3. Rog DJ, Nurmikko TJ, Friede T, Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology. 2005;65:812–9
  4. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34:13–25
  5. Wang Q, Shao F, Wang W. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Front Mol Neurosci. 2015;8:49
  6. Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther. 2000;294:27–32.
  7. Schultes RE. Hallucinogens of Plant Origin.Science. 1969;163:245–54.
  8. Castillo A, Tolóna MR, Fernández-Ruizb, J, Romeroa J, Martinez-Orgadoa J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis. 2010;37:434–40.
  9. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. Br J Clin Pharmacol. 2011; 72(5):735-44

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