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Sarcosine 500 mg
Sarcosine 500 mg
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Sarcosine 500 mg
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27.00 €(32.74 US$) na stanie
Opis
Sarcosine (N-methylglycine) supplement
  • Naturally present for brief periods in muscles and various tissues.
  • Used for improving speech and behaviour in those with autism, and for increasing attention and neurological function.
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100 Veg. Caps.
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Lista życzeń
Sarcosine 500 mg

Sarcosine 500 mg

Sarcosine (N-methylglycine) is a methyl derivate of the amino acid glycine. It is found in egg yolk, turkey, ham, vegetables and legumes. It was first isolated and named by the German chemist Justus von Liebig in the mid-19th century.

Sarcosine is naturally present in the body in muscles and various tissues via the enzyme glycine dehydrogenase. It is formed from choline intake and from the metabolism of methionine, and is then broken down into glycine, an important constituent of protein.

Sarcosine is essential for muscle synthesis and composition but it is also the principal metabolic source of glutathione, creatine and serine.

Apart from its critical role in certain metabolic processes, it has three main properties:
    • It naturally increases levels of testosterone when combined with D-aspartic acid. By encouraging production of GnRH (gonadotropin-releasing hormone) by the hypothalamus, it boosts the release of FSH and LH which in turn stimulate the testes to produce more testosterone.
    • It also inhibits the transport of type 1 glycine (GlyT-1). Sarcosine supplementation therefore increases glycine concentrations in the brain, so activating N-methyl-D-aspartate (NMDA) receptors. According to clinical trials, it therefore has nootropic effects and improves symptoms of depression. In addition, an ongoing avenue of investigation shows that sarcosine supplementation, at a dose of 2g a day, may even reduce symptoms of schizophrenia when used alongside existing treatments. Promising results show reductions in cognitive symptoms and depression.
It may improve cognition and mental processes, increase memory and rate of recall and develop capacity for learning. These effects may be linked to its effects on glycine receptors in the brain.

Sarcosine thus constitutes a new nootropic, along with noopept, or AFA extract. Supplementation benefits healthy adults just as it does those with Alzheimer’s disease undergoing what can be aggressive treatment to alleviate degenerative cognition problems.

As with any nootropic, it supports the body in adapting better to life’s challenges, facilitates motivation and decision-making and improves cognitive and neurosensorial processes as a whole.

The recommended dose is between 1.5g and 3g a day, preferably split into two doses.
Sarcosine is free from toxicity and few side-effects have been reported, apart from a few headaches or gastric problems when starting supplementation, as is the case with any brain tropism nutritional supplement, but this does not, however, constitute a contraindication.
Informacje żywieniowe
Daily dose: 6 capsules
Number of doses per pack: 16
Amount per dose
Sarcosine 3 000 mg
Other ingredients: Guma akacjowa, maka ryzowa.
Sposób stosowania
adults. Take 3 to 6 capules a day.
Each capsule contains 500 mg of sarcosine.
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Oceny 1
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Sam
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Op 2 gram sarcosine per dag: goede stemming. Vaker blije gevoelens. Soms brede glimlach.
Bibliografia
  1. Allen RH, Stabler SP, Lindenbaum J (November 1993). "Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism". Metabolism. 42 (11): 1448–60. doi:10.1016/0026-0495(93)90198-W. PMID 7694037.
  2. Guastella J, Brecha N, Weigmann C, Lester HA, Davidson N. Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc Natl Acad Sci U S A. 1992;89(15):7189–93.
  3. Zhang HX, Lyons-Warren A, Thio LL. The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist. Neuropharmacology. 2009;57(5–6):551–5.
  4. Zhang HX, Hyrc K, Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009;587(Pt 13):3207–20.
  5. Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P, Tun R, Huang KH, Chang YC, Lane HY, Tsai GE. Inhibition of glycine transporter-I as a novel mechanism for the treatment of depression. Biol Psychiatry. 2013;74(10):734–41.
  6. Lane HY, Liu YC, Huang CL, Chang YC, Liau CH, Perng CH, Tsai GE. Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study. Biol Psychiatry. 2008;63(1):9–12.
  7. Singh SP, Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 2011;25(10):859–85.
  8. Strzelecki D, Szyburska J, Rabe-Jablonska J. Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction. Neuropsychiatr Dis Treat. 2014;10:263–6.
  9. Lee, MY., Lin, YR., Tu, YS. et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci 24, 18 (2017). https://doi.org/10.1186/s12929-016-0314-8
  10. Curtis, D. (2019). A possible role for sarcosine in the management of schizophrenia. British Journal of Psychiatry, 215(6), 697-698. doi:10.1192/bjp.2019.194

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