What are the ingredients in Advanced Sleep Formula?
Sleep problems are one of the most common reasons for going to the doctor. When they’re not related to disorders such as anxiety or depression, they can be solved by taking a few simple steps, particularly ones using phytotherapy. Plant substances undoubtedly achieve the best results in this area.
This is precisely what Advanced Sleep Formula offers: a combination of the safest and most widely-studied and tested plant-source ingredients.
Hawthorn berry extract (Crataegus oxyacantha)
Very much in vogue, hawthorn is included in many products aimed at improving sleep problems. Its berries contain valuable flavonoids and procyanidins as well as a number of substances that act synergistically.
Passion Flower extract (Passiflora incarnata) 100 mg
Passion flower’s calming effects are widely-documented, though its mechanisms of action have yet to be established. Its efficacy is probably the result of synergy between the plant’s alkaloids, flavonoids, glucosides and a recently-discovered molecule, a benzoflavone moiety (BZF). A 2001 study showed that it may be as effective as a benzodiazepine-type drug widely-prescribed for anxiety (7). It also has the advantage of not causing drowsiness in the morning.
Valerian root extract (Valeriana officinalis) 70 mg
Valerian has been used to treat insomnia for thousands of years and in many parts of the world (8-9). During the First World War, it was popular with European soldiers for calming nervous tension triggered by bombing raids and combat. It’s thought to reduce stress by acting on several of the brain’s chemical messengers. Some studies have also shown that taking valerian supplements improves sleep and reduces fatigue.
Pyridoxal phosphate, a derivative of vitamin B6
This is a bio-active form of vitamin B6 which plays a key role in the transmission of nerve impulses and the production of neurotransmitters such as serotonin, melatonin, dopamine and gamma-aminobutyric acid. It’s an essential vitamin which the body must obtain from the diet (particularly meat and fish).
Melatonin is a hormone produced naturally by the pineal gland. Stimulated by the absence of light, secretion of melatonin makes us feel drowsy and gradually slows down our body functions. Unfortunately, excessive screen-time means our production of this ‘sleep hormone’ has become increasingly disrupted …
It’s recognised as helping to improve sleep problems related to a lack of melatonin, as occurs with an unhealthy lifestyle, night shift work, over-exposure to screens or jet lag.
There are two different forms:
The first helps you get to sleep more quickly, while the second is more suitable for those who experience wakefulness during the night. The scientific literature suggests that it is well-tolerated by both adults and children, and can be helpful for improving sleep (10-11). However, supplementing with low-dose melatonin (as contained in these products) should not be continued indefinitely.
Melatonin is found in poppy seeds, which are included in this formulation, and in flax, coriander and sunflower seeds (12). California poppy (Escholtzia californica) is considered to be an excellent natural aid to sleep, as is hop, a tonic and nervous system relaxant, which also features in this product.
Who is Advanced Sleep Formula for?
This sleep-aid formulation is for anyone who experiences the following symptoms:
- occasional or regular difficulty falling asleep;
- intermittent night wakefulness;
- waking up too early in the morning;
- feeling tired on waking;
- fatigue-related irritability and mood problems;
- anxiety at the prospect of going to bed;
- a reduction in cognitive or physical performance due to the cumulative effects of lack of sleep.
It is aimed more specifically at women, who tend to suffer from insomnia more than men, and at those over 50.
What other measures can be used alongside Advanced Sleep Formula?
To maximise this product’s efficacy, it is advisable to avoid the following aggravating factors:
- too much light exposure in the evening;
- too little physical activity during the day;
- frequent changes to your sleep routine;
- excessive smoking and consumption of alcohol and coffee ;
- stressful or anxiety-inducing situations.
Conversely, the following calming and sleep-inducing practices are recommended:
- listening to relaxing music in the evening;
- light therapy;
- stretching and controlled breathing techniques;
- the Relaxation Response.
Last but not least, it’s a good idea during the evening to eat foods high in tryptophan, an amino acid involved in the synthesis of serotonin and which promotes sleepiness. The best dietary sources of tryptophan are seeds, brown rice, dairy products, eggs, pulses, chocolate and brewer’s yeast. You may want to combine Advanced Sleep Formula with a tryptophan supplement such as L-Tryptophan.
If you think stress is at the root of your sleep problems, it may be better to combine it with PharmaGABA®. If it’s pain that’s keeping you awake, then choose the excellent formulation Natural Pain Relief.
Why should you take Advanced Sleep Formula for your sleep problems?
There are at least five good reasons why you should choose Advanced Sleep Formula to help you tackle your sleep issues:
- the formulation is based on the most widely-studied traditional plant extracts and on low doses of melatonin, a hormone produced by the pineal gland;
- it does not disrupt the various stages of sleep;
- it facilitates drowsiness by promoting a state of relaxation;
- it has no lingering effects in the morning and will not affect daytime alertness;
- it does not lead to dependency;
- the only excipients it contains are completely natural: rice flour and acacia fibre.
How should Advanced Sleep Formula be taken?
It’s best to take one capsule with a little water, half an hour before bed.
This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the directions for use, the recommended daily dose and the ‘use-by’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of reach of young children. Store in a cool, dry place.
(1) EFSA opinion reference 2011;9(6):2241
(2) EFSA opinion reference 2010;8(10):1759
(3) EFSA opinion reference EFSA-Q-2008-2983
(4) EFSA opinion reference EFSA-Q-2008-3369
(5) EFSA opinion reference EFSA-Q-2008-4433
(6) EFSA opinion reference EFSA-Q-2008-4629
(7) Akhondzadeh S, Naghavi HR, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001 Oct;26(5):363-7.
(8) Fernández-San-Martín MI, Masa-Font R, et al. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.. Sleep Med. 2010 Jun;11(6):505-11.
(9) Bent S, Padula A, Moore D, et al. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec;119(12):1005-12.
(10) Buscemi N, Vandermeer B, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8.
(11) Brzezinski A, Vangel MG, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb;9(1):41-50.
(12) Manchester, L.C., Tan, D.X., Reiter et al. High levels of melatonin in the seeds of edible plants: possible function in germ tissue protection. Life Sci. 2000 Nov 10;67(25):3023-9.
CompositionAdvanced Sleep Formula
|Daily dose: 1 capsule
Number of doses per pack: 60
| Pyridoxal-5-phosphate (coenzymated vitamin B6)
| Hawthorn berry extract 10:1 (Crataegus oxyacantha)
| Passion flower extract 4% (Passiflora incarnata)
| Hop extract 10:1 (Humulus lupulus)
| Valerian root extract 10:1 (Valeriana officinalis)
| Lithium orotate
| Other ingredients: Acacia gum, rice flour. |
Directions for useAdvanced Sleep Formula
adults. Take one capsule 30 minutes before going to bed.
- Les femmes enceintes ou allaitantes, les enfants, les personnes souffrant de troubles mentaux graves ou de maladies auto-immunes ne doivent pas prendre de mélatonine. La mélatonine induisant le sommeil et une diminution de la rapidité de réaction, il est déconseillé de conduire ou d'utiliser des outils dangereux après avoir consommé de la mélatonine.
Xanthohumol is a hop flower supplement containing an exceptional antioxidant flavonoid called xanthohumol. It’s a phenolic compound that’s 200 times more powerful than the resveratrol in red wine, and offers truly exceptional, cell-boosting properties. Beer is the only dietary source of xanthohumol though the levels it contains are very low.
Xanthohumol, the antioxidant in beer that has superseded resveratrol in red wine
Wine-lovers appreciate the drink’s subtlety and sophistication but they also know it’s an exceptionally rich source of antioxidants. Indeed one such antioxidant is the most widely-studied anti-ageing substance ever: resveratrol. However, new research shows that beer is more than a match for its great rival. Beer is the only dietary source of xanthohumol, a natural cytoprotective antioxidant that’s 200 times more powerful than the resveratrol in red wine!
It was Hildegarde de Bingen, a 12th century Benedictine nun and pharmacologist, who was responsible for introducing hops into beer. Before that, monks had used mainly coriander, gentian or sage to flavour and preserve their precious nectar, which was given to pilgrims in monasteries and abbeys. It was immediately evident that the hop offered many benefits: with its preservative properties and positive effects, it quickly became an essential ingredient in the recipe. Over the centuries that followed, it would go on to be used by generations of brewers, right up to the present day. Though the monks had no way of knowing it, its meteoric rise was due to the hop’s high content in phenolic compounds – particularly xanthohumol. The problem is that these compounds, which come from the hop flower, are very delicate and tend to make the beer a bit cloudy. The majority of modern, large-scale beer producers therefore use a chemical (pVPP) to eliminate this cloudiness and prevent deposits from forming in the bottle. So in order to obtain the benefits of xanthohumol, you need to drink artisanal beers with a strong hop content if possible (IPA, for example).
But the best way of benefiting from this cytoprotective compound (which we’ll undoubtedly be hearing more about in the future) is to take a hop flower supplement, standardised in xanthohumol, every day. It’s an ultra-modern solution (extracting the xanthohumol from the hop inflorescences is a major technological achievement) which draws on its ancient tradition of use and which avoids the oxidative effects of alcohol.
What benefits are offered by the supplement Xanthohumol?
Hop flower extract standardised in xanthohumol offers four main benefits, all of which are backed up by the scientific literature:
- It supports optimal cellular health and combats oxidative stress. Xanthohumol and the phenolic compounds present in hop cones are the most effective natural antioxidants in the plant kingdom. In 2014, Professor Wang and his team showed that at the same concentration, they had greater antioxidant activity than the antioxidants in green tea. A number of studies have also demonstrated the broad-spectrum chemopreventive properties of xanthohumol on cells (1-3): induction of detoxification enzymes, inhibition of angiogenesis and inflammatory signals, cytoprotective effects, induction of apoptosis, inhibition of free radicals and procarcinogens … (4).
- It helps lower blood cholesterol levels. In 2017, scientists discovered that xanthohumol promotes HDL cholesterol in the blood, helping to clear arteries and tissues of oxidised cholesterol and direct it towards the liver where it is broken down (5). In addition, the other natural compounds that give hop its characteristics disrupt the molecular mechanisms responsible for the initiation, progression and rupture of the atherosclerotic plaques that cause stroke.
- It’s a valuable aid against sleep problems and nervous agitation.. Did you know that in Belgium, where hops are widely grown, people are advised to put dried hop cones in their ears to improve their sleep? Research has indeed demonstrated that the compounds in hop produce similar effects to those of melatonin and can normalise circadian rhythms (6). Several studies have even shown a valerian and hop flower combination to be as effective for improving sleep as synthetic sleeping tablets (the famous benzodiazepines) but without causing the side-effects associated with these drugs (7).
- It reduces problems related to the menopause and pre-menopause. Hop flowers contain the most powerful phytooestrogen isolated to date: 8-Prenylnaringenin (8-11). It acts as a selective modulator of oestrogen receptors, helping to reduce discomfort associated with the menopause (12-13), such as hot flushes. In addition, xanthohumol is a powerful inhibitor of the bone resorption responsible for osteoporosis.
Other studies have demonstrated its ability to regulate fat metabolism (by improving lipid parameters) and to boost the body’s defences and vitality. By no means exhaustive, this list identifies xanthohumol as a substance of major interest in terms of protection and actively contributing to factors affecting recovery.
Where does xanthohumol come from?
Xanthohumol is extracted from the female cones of the hop plant, a climbing perennial which is added to beer to improve its taste, aroma, bitterness, frothy texture and preservation (14). It’s a chalcone-type antioxidant flavonoid, the only one of its kind, which is found solely in hop flowers. It’s therefore present in beer but in tiny amounts: due to the high temperatures used in the brewing process, it gets converted into another less powerful compound called isoxanthohumol. Some very hoppy beers (such as IPA) (15) contain more, as hops are added after brewing.
The hop has been regarded as a medicinal plant for centuries (16-17). Its use dates back to the monasteries of 8th century Europe(18), when it was used for its pharmacological properties, in particular for treating anxiety and sleep problems, for its benefits for the endocrine system and for its anti-tumour effects.
What are Xanthohumol’s mechanisms of action?
Xanthohumol’s mechanisms of action come from its extraordinarily high content of phenolic compounds. Recent studies show that regular consumption of these compounds can, in the long term, reduce the risk of many chronic health disorders such as cardiovascular disease (19). Phenols, and in particular, xanthohumol, exert modulatory effects in cells by interacting with a wide range of molecular targets of signalling pathways (mitogen-activated protein kinase, protein kinase C, detoxifying antioxidant enzymes …) (20). These effects translate into increased expression of certain cytoprotective genes,regulation of the normal cell cycle, inhibition of growth, an increase in apoptosis, inhibition of angiogenesis, as well as suppression of oxidative stress, a state of imbalance which impairs the structural and functional integrity of cell membranes (21). The role played by oxidative stress in the development of chronic diseases is now widely-documented in the scientific literature (22). Phenolic compounds can also influence the composition of gut microbiota and re-establish intestinal barrier function, thus modulating the chronic inflammation associated with metabolic diseases (23).
Following ingestion, phenolic compounds such as xanthohumol are absorbed, distributed to various tissues and then metabolised by the liver. A proportion undergo partial conversion by gut flora. (24).
How should Xanthohumol be taken?
The recommended dose is two capsules a day, to be taken with meals.
If you want to boost its effects on sleep, it’s worth knowing that hops acts synergistically with valerian (found in the natural formulation Advanced Sleep Formula). For improving hormone balance, it’s better to combine it with an extract of pumpkin seeds.
- Cell strengthening
- Technique that increases our cells’ natural defences against aggressive agents.
- Process whereby new blood vessels grow from existing ones.
- Physiological process of programmed cell death.
- Free radicals
- Unstable molecules that seek to bind to other atoms and cause chain reactions.
- A carcinogen precursor that can provoke, aggravate or sensitise cancer or its onset.
- Ceh, B., Kac, M., Kosir, I.J., Abram, V., 2007. Relationships between xanthohumol and polyphenol content in hop leaves and hop cones with regard to water supply and cultivar. International Journal of Molecular Sciences 8, 989-1000.
- Magalhaes, P.J., Guido, L.F., Cruz, J.M., Barros, A.A., 2007. Analysis of xanthohumol and isoxanthohumol in different hop products by liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. Journal of Chromatography A 1150, 295-301.
- Miranda, C.L., Stevens, J.F., Helmrich, A., Henderson, M.C., Rodriguez, R.J., Yang, Y.H., Deinzer, M.L., Barnes, D.W., Buhler, D.R., 1999. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food and Chemical Toxicology 37, 271-285.
- Stevens, J.F., Page, J.E., 2004. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 65, 1317-1330.
- J Nutr Biochem. 2017 Sep;47:29-34. doi: 10.1016/j.jnutbio.2017.04.011. Epub 2017 Apr 22. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K.
- Koetter, U., Schrader, E., Kaufeler, R., Brattstrom, A., 2007. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytotherapy Research 21, 847-851.
- Morin CM, Koetter U, et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005 Nov 1;28(11):1465-71.
- Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids.J Clin Endocrinol Metab 2000 Dec;85(12):4912-5.
- Milligan SR, Kalita JC, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer.J Clin Endocrinol Metab 1999 Jun;84(6):2249-52.
- Bowe J, Li XF, et al. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J Endocrinol. 2006 Nov;191(2):399-405.
- Nikolic D, Li Y, et al. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab Dispos. 2004 Feb;32(2):272-9. Texte intégral : http://dmd.aspetjournals.org
- Heyerick A, Vervarcke S, et al. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006 May 20;54(2):164-75.
- A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Erkkola R, Vervarcke S, et al. Phytomedicine. 2010 May;17(6):389-96.
- Haseleu, G., Intelmann, D., Hofmann, T., 2009. Structure determination and sensory evaluation of novel bitter compounds formed from beta-acids of hop (Humulus lupulus L.) upon wort boiling. Food Chemistry 116, 71-81.
- Gerhauser, C., 2005a. Beer constituents as potential cancer chemopreventive agents. European Journal of Cancer 41, 1941-1954.
- Callemien, D., Jerkovic, V., Rozenberg, R., Collin, S., 2005. Hop as an interesting source of resveratrol for brewers: Optimization of the extraction and quantitative study by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry 53, 424-429.
- Nagasako-Akazome, Y., Honma, D., Tagashira, M., Kanda, T., Yasue, M., Ohtake, Y., 2007. Safety evaluation of polyphenols extracted from hop bracts. Food and Chemical Toxicology 45, 1383-1392.
- Larson, A.E., Yu, R.R.Y., Lee, O.A., Price, S., Haas, G.J., Johnson, E.A., 1996. Antimicrobial activity of hop extracts against Listeria monocytogenes in media and in food. International Journal of Food Microbiology 33, 195-207
- Crozier, A., Jaganath, I.B., Clifford, M.N., 2009. Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports 26, 1001-1043.
- Hou, Z., Lambert, J.D., Chin, K.V., Yang, C.S., 2004. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutation ResearchFundamental and Molecular Mechanisms of Mutagenesis 555, 3-19.
- Makena, P.S., Chung, K.T., 2007. Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food and Chemical Toxicology 45, 1899- 1909.
- Soobrattee, M.A., Neergheen, V.S., Luximon-Ramma, A., Aruoma, O.I., Bahorun, T., 2005. Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 579, 200-213.
- Anhe, F.F., Roy, D., Pilon, G., Dudonne, S., Matamoros, S., Varin, T.V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., Marette, A., 2015. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64, 872-883.
- Khanal, R., Howard, L.R., Prior, R.L., 2014. Urinary excretion of phenolic acids in rats fed cranberry, blueberry, or black raspberry powder. Journal of Agricultural and Food Chemistry 62, 3987-3996
|Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
|Extract of hop flower standardised to 10% xanthohumol
||150 mg |
|Other ingredients: acacia gum, white rice flour.
Directions for useXanthohumol
Adults. Take 3 capsules a day.
Each capsule contains 50mg of hop flower extract standardised to 10% xanthohumol.