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Welcome Shop by health concern Fighting inflammation CDB 25mg + Natural Pain Relief
CDB 25mg + Natural Pain Relief
Fighting inflammation Customer reviews
87.00 €(96.36 US$) is available
Description
P.E.A., an all-round, natural analgesic
  • formulated from palmitoylethanolamide (PEA);
  • anti-inflammatory and analgesic properties;
  • used for relieving neuropathic and inflammatory pain.
Natural, powerful analgesic for long-lasting pain relief
  • Relieves pain (chronic, muscular, joint …).
  • Helps reduce inflammation.
  • Soothing and calming effects.
  • High concentration (25mg of CBD per capsule) and broad-spectrum (other phytocannabinoids).
  • Contains no psychotropic substances (THC).
  • 100% natural.
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CDB 25mg + Natural Pain Relief
CDB 25mg + Natural Pain Relief CDB 25mg + Natural Pain Relief CDB 25mg + Natural Pain Relief
CBD 25 mg

A powerful and original nutrient, CBD 25mg is emerging as an important natural painkiller: it is aimed at anyone who is exhausted by pain and the impact it has on their everyday life. It is similar to CBD Oil 6% but has a much higher concentration of active principles (25mg vs 5mg for CBD Oil).

Its main applications are for:

  • severe or intractable pain;
  • acute and chronic pain;
  • muscle and joint pain;
  • headache and migraine, particularly those caused by stress and sleep problems;
  • neuropathic and fibromyalgia pain;
  • sleep problems caused by pain of various sorts.

What is CBD?

Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp ((Cannabis sativa) alongside the well-known psychotropic substance tetrahydrocannabinol (THC). However, unlike THC, CBD does not have any narcotic properties.

It is a natural compound which mimics the action of endocannabinoid messengers produced by the body. Like them, it is able to bind to specific receptors (CB1 and CB2) located on external cell membranes, and trigger various cellular responses such as restricting synaptic transmission, relieving pain and reducing spontaneous locomotion (1). Just like endogenous cannabinoids, CBD thus inhibits the transmission of small diameter nociceptive fibres (which are involved in the pain process) and reduces the release of neurotransmitters like substance P, responsible for transmitting pain .

Unlike THC, which has a strong affinity for CB1 receptors, CBD binds more to CB2 receptors. These are found on the surface of cells of the central nervous system and in particular in immune system tissues where they are involved in modulating memory, emotions and pain (chronic, inflammatory or neuropathic) (2-3).

What are the effects of CBD 25mg ?

What are the effects of CBD 25mg on pain?

The binding of CBD to CB2 receptors, and the modulation of serotonin receptors triggers a cascade of molecular reactions, the main effects of which are:

  • A reduction in the inflammatory response . The modulation of receptors leads to both a rise in BDNF (a protein that promotes growth and differentiation of new nerve cells), and a reduction in microglial cells and pro-inflammatory mediators (4-5).
  • Stimulation of vasodilation. (6-7).
  • A decrease in sensitivity to pain. CBD promotes activation of PPARs, proteins that act as a transcription factor for certain genes involved in pain transmission.
  • A neuro-protective effect . CBD helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation. (8).
  • An analgesic effect (by reducing the transmission of nociceptive fibres).
  • An anxiolytic effect. . Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several disorders such as stress and anxiety.
  • An improvement in sleep (9).

What’s the right CBD dose for optimal efficacy?

This depends on several factors:

  • the concentration of the CBD;
  • a person’s weight;
  • individual biological factors;
  • the severity of the initial problem or symptoms.

For someone with a bodyweight of 70kg, and where the product is standardised to 17% CBD, the optimal dose would be 25mg, although this can be gradually increased to 50mg depending on the results obtained (though this higher dose should not be exceeded). CBD can also be vaporised but the most stable and consistent mode of administration is expertly-dosed, oral capsules.

Over a lifetime, our body’s physiology changes, as does the number and distribution of receptors in the endocannabinoid system which are directly responsible for interactions with CBD. The optimal dose will therefore change depending on the individual and ageNick Jikomes, PhD, neuro-physician.

How is CBD 25mg produced?

CBD 25mg is obtained by plant extraction using supercritical carbon dioxide (sCO₂). This is an alternative mode of extraction to the organochlorine solvents normally used in such processes but which are potentially harmful to the environment. Very eco-friendly, sCO₂ both ensures the final product is free from solvent residues and helps maintain the chemical integrity of the heat-sensitive molecules. It is odourless, colourless, non-toxic and non-inflammable and is completely safe for our health and our environment.

Does CBD 25mg produce any side-effects?

Unlike the drug cannabis which usually contains around 15% THC, the form used in this product has none. It therefore has no psychotropic effects and has an excellent safety profile in humans.

Once ingested, CBD is rapidly distributed around the body. It is lipophilic and thus quickly crosses the blood-brain barrier to reach brain tissues. It has no effect on heart rate, blood pressure or body temperature. CBD’s half-life is around 9 hours after which it is excreted in a metabolised form in urine.

To date, no public health problem has been associated with the nutritional use of CBD.

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place

Written : November 2018.

CompositionCBD 25 mg
Daily dose: 1 capsule
Number of doses per pack: 30
Amount per dose
Cannabidiol (CBD) extracted from non-psychotropic hemp leaf standardised to 17% CBD 25 mg
Other ingredients:  Acacia gum, rice flour.
Directions for useCBD 25 mg
adults. Take 1 capsule a day.
This supplement contains no psychotropic substances.
PEA

Powerful and natural active principle

Our dietary supplement Natural Pain Relief is the result of many years’ research into pal

Powerful and natural active principle

Our dietary supplement P.E.A. is the result of many years’ research into palmitoylethanolamide. More commonly-known as PEA, this compound’s considerable therapeutic potential has made it the subject of numerous scientific studies. The anti-inflammatory and analgesic properties of this fatty acid amide have been known for decades but it was in 1990 that its therapeutic benefits were properly recognised by the scientific community as a result of the work of Italian Nobel Laureate Rita Levi-Montalcini. This famous neurologist demonstrated PEA’s efficacy in treating some types of neuropathic pain. Further research then led to the development of PEA-based nutritional supplements. These products have been available since 2010 in the form of powder or capsules and have made quite an impact in the Netherlands where they are offered as a new kind of P.E.A..

P.E.A., a natural analgesic

Our new product, P.E.A., offers all the anti-inflammatory and analgesic properties of palmitoylethanolamide (PEA). The effects of this compound are significant given that pain can be common and varied. It can take the form of acute pain which is temporary in nature, or chronic pain that persists over a long period of time. Scientists also categorise pain by its origin: inflammatory pain which involves the immune system, neuropathic pain which is associated with the nervous system, and a mixture of the two – both inflammatory and neuropathic. A number of treatments have been developed to relieve such pain and it is within this context that PEA has been identified as natural solution to pain that is inflammatory, neuropathic or a mixture of the two. PEA has the advantage of being a natural molecule, found, for example, in eggs and milk.

Anti-inflammatory and analgesic properties of PEA

It is PEA’s particular mechanism of action which is responsible for its exceptional properties. According to some scientists, this fatty acid amide works by binding to a specific cell receptor called PPAR-alpha. This receptor activates peroxisomes - cell organelles involved in the regulation of pain and inflammation genes. By binding to the PPAR-alpha receptor, PEA reduces peripheral sensitivity induced by both neural and non-neural cells. In other words, PEA’s action reduces the sensation of pain in a number of situations. In this context, encouraging results have already been obtained in the management of diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, back pain, sciatica, pelvic pain and multiple sclerosis.

P.E.A., an optimal PEA formulation

P.E.A. has been developed from a high quality, patented PEA formulation called OptiPEA©. This pain relief supplement is in capsule form with a suggested dose of three capsules a day, although this dosage can be adapted to your needs and the advice of your therapist. It should be noted that taking this supplement may not produce instant pain relief. Several days’ supplementation may be necessary to obtain the desired results. You may also be interested in our other formulations aimed at relieving joint pain: OptiMSM® and Joint Support Formula.mitoylethanolamide. More commonly-known as PEA, this compound’s considerable therapeutic potential has made it the subject of numerous scientific studies. The anti-inflammatory and analgesic properties of this fatty acid amide have been known for decades but it was in 1990 that its therapeutic benefits were properly recognised by the scientific community as a result of the work of Italian Nobel Laureate Rita Levi-Montalcini. This famous neurologist demonstrated PEA’s efficacy in treating some types of neuropathic pain. Further research then led to the development of PEA-based nutritional supplements. These products have been available since 2010 in the form of powder or capsules and have made quite an impact in the Netherlands where they are offered as a new kind of natural pain relief.

Natural Pain Relief, a natural analgesic

Our new product, Natural Pain Relief, offers all the anti-inflammatory and analgesic properties of palmitoylethanolamide (PEA). The effects of this compound are significant given that pain can be common and varied. It can take the form of acute pain which is temporary in nature, or chronic pain that persists over a long period of time. Scientists also categorise pain by its origin: inflammatory pain which involves the immune system, neuropathic pain which is associated with the nervous system, and a mixture of the two – both inflammatory and neuropathic. A number of treatments have been developed to relieve such pain and it is within this context that PEA has been identified as natural solution to pain that is inflammatory, neuropathic or a mixture of the two. PEA has the advantage of being a natural molecule, found, for example, in eggs and milk.

Anti-inflammatory and analgesic properties of PEA

It is PEA’s particular mechanism of action which is responsible for its exceptional properties. According to some scientists, this fatty acid amide works by binding to a specific cell receptor called PPAR-alpha. This receptor activates peroxisomes - cell organelles involved in the regulation of pain and inflammation genes. By binding to the PPAR-alpha receptor, PEA reduces peripheral sensitivity induced by both neural and non-neural cells. In other words, PEA’s action reduces the sensation of pain in a number of situations. In this context, encouraging results have already been obtained in the management of diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, back pain, sciatica, pelvic pain and multiple sclerosis.

Natural Pain Relief, an optimal PEA formulation

Natural Pain Relief has been developed from a high quality, patented PEA formulation called OptiPEA©. This pain relief supplement is in capsule form with a suggested dose of three capsules a day, although this dosage can be adapted to your needs and the advice of your therapist. It should be noted that taking this supplement may not produce instant pain relief. Several days’ supplementation may be necessary to obtain the desired results. You may also be interested in our other formulations aimed at relieving joint pain: OptiMSM® and Joint Support Formula.
CompositionPEA
Daily dose: 3 capsules
Number of doses per pack: 20

Amount
per dose

OptiPEA©(Palmitoylethanolamide) 1 200 mg
Other ingredients :Acacia gum, rice bran.
OptiPEA©, Innexus Nutraceuticals, Holland.
Directions for usePEA
adults. Take 3 capsules a day.
Each capsule contains 400 mg of OptiPEA©.
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CDB 25mg + Natural Pain Relief
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87.00 €
(96.36 US$)
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