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Welcome Shop by health concern Anti-ageing NMN Max
NMN (nicotinamide mononucleotide) dietary supplement
NMN (nicotinamide mononucleotide) dietary supplement
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NMN Max
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152.00 €(165.51 US$) in stock
Description
New design!
One of the most powerfully-dosed NMN supplements on the market
  • Super-potent dose of 1000 mg NMN/day.
  • Nicotinamide mononucleotide (NMN) is an excellent anti-ageing agent which restores cells, and reduces inflammation, fatigue and wrinkles.
  • Most direct precursor of NAD (a coenzyme crucial for the health of cells), production of which declines with age.
  • Perfect for correcting NAD deficiencies, particularly in sports enthusiasts and older people.
  • Dose recommended by Dr David Sinclair, a leading expert in NMN in the US.
  • Supplement comes in vegetarian capsules.
Please note: this label has recently changed its graphic design, but rest assured: the composition of the product has remained strictly the same.
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NMN is an anti-ageing substance that restores cells

NMN supplement 1000mg/day: review, benefits, side effects

NMN Max is a dietary supplement containing nicotinamide mononucleotide (NMN). This is the most direct precursor of nicotinamide adenine dinucleotide (NAD), a coenzyme crucial for the mitochondria, the cells’ powerhouses. Production of NMN and NAD declines with age. Taking NMN helps naturally restore your NMN and NAD levels and thus corrects any deficiency (1).

As its name suggests, NMN Max is powerfully-dosed (1000 mg a day) to guarantee maximum benefits. You’ll find it listed in our ‘Anti-ageing’ category.

What is nicotinamide mononucleotide (NMN)?

Nicotinamide mononucleotide, usually abbreviated to NMN, is a specific form of vitamin B3. It’s produced naturally by the body and is also provided by the diet from foods such as broccoli, cucumber, cabbage, avocados ... NMN crosses the intestinal barrier with ease, entering cells before being converted into NAD. That’s why nicotinamide mononucleotide supplements are considered the best NAD boosters available.

Why should you increase your NAD levels?

According to anti-ageing specialist Dr David Sinclair, NAD is the key to cellular communication. In its NAD+ form, it supports optimal mitochondrial function and production of sirtuins (enzymatic proteins that repair DNA), for example, etc. (2)

As production of NMN and NAD decline with age, the mitochondria lose the ability to communicate both with each other and with the cell nucleus. The latter then atrophies and eventually, the whole cell deteriorates. This is one of the primary causes of ageing. As Dr Andrew Salzman explains: “Despite all the progress made in the health field over the last 100 years, there is still a limiting factor: our NMN and NAD levels fall as we get older. And that decline starts between the ages of 30 and 40.” Indeed 50 year-olds have only half the amount of NMN they had in their twenties (3).

The good news is that this decline in mitochondrial communication appears to be reversible. Dr Sinclair again: “The ageing process can be compared to a married couple - when they're young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solves the problem”.

Dr Sinclair and his team showed that after 2 year-old mice were injected with NMN, the animals’ NAD levels increased and their channels of cellular communication were repaired. According to one of these scientists’ reports, published in the journal Cell, dramatic improvements were seen in the injected mice within less than a week (stronger musculature, improved blood sugar, decreased inflammation …) All these changes made the mice indistinguishable from younger animals. The report also highlighted NMN’s ability to activate the 7 SIRT genes involved in increasing longevity(4).

A different study, published in Cell in 2013, revealed that NMN and another NAD+ precursor, nicotinamide riboside (NR), extended the lifespan of C. elegans, a worm widely used in scientific research, by more than 10% (5).

What are the benefits of NMN?

Many other studies have demonstrated the positive effects of NMN in both animal and human models (6-10).

These include its ability, once converted into NAD+, to support mitochondrial function, extend the lifespan of cells, regulate glycaemia, promote good quality sleep, reduce fatigue, rejuvenate the skin (anti-wrinkle effect), decrease inflammation of adipose tissue, improve physical performance, support the cardiovascular system, maintain nerve cell function and restore other physiological functions normally compromised by the ageing process (11-17).

It’s therefore often said that NMN can reverse ageing ». NAD+ boosters have become very popular, attracting a wide following.

Why choose the supplement NMN Max?

SuperSmart already offers a best-selling NMN supplement: Nicotinamide Mononucleotide, at a dose of 125mg NMN/day. It’s highly popular with active individuals, especially elite athletes (see interview with Miss Univers Fitness on her supplementation with Nicotinamide Mononucleotide).

NMN Max takes things even further. This supplement offers a powerful dose, one of the highest on the market. Each NMN Max capsule contains 333.33mg of nicotinamide mononucleotide, and we recommend taking 3 capsules a day (ie 1000mg of NMN/day), to maximise your intake of NMN and thus NAD+.

Dr Sinclair himself takes 1000 mg/day, a dose he regularly advocates, and describes taking this supplement as one of his “first priorities” of the day (18-19).

NMN: are there any side-effects or risks?

Studies have shown that nicotinamide mononucleotide is safe and well-tolerated by the body(20-21).

Excessive consumption of NMN (more than 1200 mg/day) may, however, produce side-effects including flushing, nausea, diarrhoea, stomach aches or indigestion. The dose offered by NMN Max, which is very high but deliberately restricted to 1000 mg/day, has been specifically chosen to prevent this kind of adverse effect.

Anti-ageing care: 4 ways to slow down ageing

In addition to supplementing with NMN, adopting these 4 simple measures will support your day to day efforts to slow down the ageing process:

  • exercise: engage in moderately-intense physical activity (running, gym, cycling, walking or even gardening) 4-5 times a week to support your cardiovascular health;
  • stay well-hydrated: drink around a litre and a half of water a day and use a moisturising cream on your face to prevent wrinkles;
  • get enough sleep: lack of sleep can cause the blood vessels to expand, leading to a drop in blood pressure in the brain and a decline in cognitive function. Though sleep requirements vary from one person to another, it’s generally a good idea to aim for 8 hours (or 7 at the very least) ;
  • reduce your oxidative stress: excess free radical production is a contributory factor to inflammation and mutagenesis which promotes ageing and numerous diseases. Try to avoid all pro-oxidant factors: reduce your consumption of grilled/barbecued food, processed meats, fizzy drinks, and alcohol, don’t smoke, and try to manage your psychological stress better …

2 synergistic supplements to take alongside NMN

If you’re keen to maintain your physical and mental health for as long as possible, we’d recommend also taking Longevity Nutrients, a formulation rich in berberine (regulates blood sugar levels, good for the heart…), reishi, known as the ‘mushroom of immortality’ (supports the circulation and immunity), and L-carnosine (levels of which also decline with age), etc. It’s one of the best combinations of nutrients highlighted by anti-ageing research available.

There’s also significant scientific interest in astragaloside IV, an active ingredient in the plant astragalus. Already known for its pro-immunity, cardioprotective and rejuvenating effects, astragaloside IV has also been shown to activate telomerase, an enzyme which prevents the shortening of telomers (the tips of chromosomes) during cell division and thus has a considerable impact on increasing cell longevity. It really makes sense to take Astragaloside IV 98%

Composition
Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
Nicotinamide mononucleotide 1000 mg
Other ingredients: acacia gum.
Directions for use

Adults. Take 3 capsules a day. Each capsule contains 333.33mg of nicotinamide mononucleotide.

5
4.8 /5 5 reviews
Description
5
5.0 / 5
Quality
5
5.0 / 5
Value for money
4
4.0 / 5

Reviews 5
Excellent
80 %
Great
20%
Average
0%
Poor
0%
Bad
0%

Maria Teresa Novella
5
Están reconocidos por numerosos doctores, publicados en revistas científicas y le han comportado el Nobel en medicina a su descubridor a.
Evidencias de rejuvenecimiento e, incluso, de redimir algún cáncer de pulmón.
Llevo 3 botes tomados y, aunque el precio es muy elevado, los beneficios son grandes.

klant
5
J’ai mis des notes favorables à ce produit, mais je n’ai pas encore assez de recul pourtant je pense qu’il commence à agir sur mon organisme.
Martin
4
Mon expérience ne date que de trois semaines, il est donc difficile de donner un avis définitif. Ce qui est sûr, c'est que je me sens mieux en général, si c'est le résultat du NMN Max, je dis cool... juste dommage qu'il soit si cher.
Sol
5
Funciona muy bien
Klant
5
het werkt meer energie meer welvoelen meer kracht duidelijk speciaal
References
  1. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotina-mide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.
  2. https://www.insb.cnrs.fr/fr/cnrsinfo/lenergie-cellulaire-controle-la-synthese-dune-molecule-clef-du-vieillisse-ment#:~:text=Le%20nicotinamide%20ad%C3%A9nine%20di%2Dnucl%C3%A9otide%20(NAD%2B%2FNADH),dans%20les%20processus%20de%20vieillissement.
  3. https://longevity.technology/lifestyle/nmn-supplements-what-are-the-benefits-side-effects-and-dosages/
  4. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signal-ing Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945. PMID: 29570999; PMCID: PMC5884172.
  5. Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswa-nathan M, Schoonjans K, Guarente L, Auwerx J. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016. PMID: 23870130; PMCID: PMC3753670.
  6. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.
  7. de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016 Jun;15(3):522-30. doi: 10.1111/acel.12461. Epub 2016 Mar 11. PMID: 26970090; PMCID: PMC4854911.
  8. Stefano Tarantini, Marta Noa Valcarcel-Ares, Peter Toth, Andriy Yabluchanskiy, Zsuzsanna Tucsek, Tamas Kiss, Peter Hertelendy, Michael Kinter, Praveen Ballabh, Zoltán Süle, Eszter Farkas, Joseph A. Baur, David A. Sinclair, Anna Csiszar, Zoltan Ungvari, Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice, Redox Biology, Volume 24, 2019, 101192, ISSN 2213-2317, https://doi.org/10.1016/j.redox.2019.101192.
  9. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Erratum in: Cell. 2019 Feb 7;176(4):944-945. PMID: 29570999; PMCID: PMC5884172.
  10. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotina-mide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.
  11. Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020 Feb;19(1):12-14. PMID: 32549859; PMCID: PMC7238909.
  12. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotina-mide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.
  13. Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2022 Dec 8:1–15. doi: 10.1007/s11357-022-00705-1. Epub ahead of print. PMID: 36482258; PMCID: PMC9735188.
  14. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442-4
  15. Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-528. doi:10.1016/j.cmet.2017.11.002
  16. Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020;19(1):12-14.
  17. Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. Geroscience. 2019 Aug;41(4):419-439. doi: 10.1007/s11357-019-00095-x. Epub 2019 Aug 28. PMID: 31463647; PMCID: PMC6815288.
  18. https://healthnews.com/longevity/longevity-supplements/nmn-dosage-is-it-the-same-for-all-age-groups/#:~:text=The%20site%20recommends%20500%20mg,elderly%20age%20groups%20as%20well.
  19. https://novoslabs.com/best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes/
  20. Nadeeshani H, Li J, Ying T, Zhang B, Lu J. Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns. J Adv Res. 2021 Aug 11;37:267-278. doi: 10.1016/j.jare.2021.08.003. PMID: 35499054; PMCID: PMC9039735.
  21. Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2020 Feb 28;67(2):153-160. doi: 10.1507/endocrj.EJ19-0313. Epub 2019 Nov 2. PMID: 31685720.

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