- Contains 5mg of nicotinamide adenine dinucleotide (NADH) per vegetarian capsule.
- Helps fight the ageing process.
- Helps increase production of neurotransmitters essential for maintaining neuronal circuits.
- Supports energy metabolism.
NADH 5mg is an anti-ageing supplementcontaining reduced nicotinamide adenine dinucleotide (NADH). This substance is invaluable for helping the body to function normally, but cellular levels decline inexorably with age, contributing to the ageing process.
NADH, or nicotinamide adenine dinucleotide, is an important co-factor which supports the work of enzymes throughout the body. It plays a vital role in the production of energy inside each cell (1) and is involved in the production of L-dopa, which is subsequently converted into an important neurotransmitter.
Studies have investigated the benefits of NADH for treating jetlag, premature ageing, cognitive decline and neurodegeneration, chronic fatigue syndrome, and as a nutritional supplement for sportspeople.
With age, there is a decline in the body’s NAD levels due both to a decrease in its production and an acceleration in its deterioration (2-4). This is a significant since NAD is a major coenzyme in the body, involved in very many cellular processes (5).
One of the only solutions to this irreversible decline in production is supplementation, and there are several different supplements available.
There are three ways of stimulating NAD production in the body and boosting NAD levels in cells.
Rather than supplement with its precursors, why not just supplement directly with NAD(H)? It’s a good question. Unfortunately, studies show that NAD(H) is unable to cross the intestinal barrier. It is broken down in the small intestine by intestinal epithelial cells (6), then converted into NMN by a number of intestinal enzymes, and then into various metabolites such as NR and NAM. It is these metabolites that cross the intestinal barrier and reach all the body’s cells where they are again converted into NAD.
Supplementing with NADH is by no means useless: it does indeed help to produce NAD in cells. But supplementing more directly with NMN, NR or NAM is usually preferable as it avoids several successive stages of breakdown and reconversion. However, NADH supplementation is still an attractive option price-wise as it is much less expensive than supplementing with its precursors.
How can you increase your NAD levels naturally?
The first step is to take a capsule of NADH every morning on an empty stomach, making sure you wait 30 minutes before eating. In addition, there are two different ways of supporting NAD production.
In order to utilise the de novo synthesis pathway, the body needs tryptophan, the best dietary sources of which are wholegrain rice, meat, dairy products, eggs, soy proteins, peanuts, pulses and nuts. You also have the option of nicotinamide riboside (NR), which is found in milk, though the best dietary sources of NAD precursors are raw foods (both plant- and animal-source). The human digestive system, ably aided by its gut flora, breaks down NAD from other organisms into various compounds which can then be used to re-form NAD via the above-mentioned salvage pathway.
In contrast, studies show that over the long term, a diet high in fat (7) accelerates the decline in NADH production. It’s therefore important to ensure you eat a balanced diet.
It is well-known that exercise stimulates growth of new blood vessels and boosts muscle mass. But researchers have discovered that these effects are associated directly with the activation of certain genes (SIRT1) specific to the increase in levels of NAD (8-9).
|Daily serving: 1 capsule
Number of servings per bottle: 60
|Quantity per serving|
|Nicotinamide adenine nucleotide (NADH)||5 mg|
|Other ingredients: Acacia gum, rice bran.|
Take one capsule a day (or as advised by your therapist) with water, in the morning, on an empty stomach. Wait 30 minutes before eating.
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