Triple Vino Circulation is a dietary supplement containing 3 vine extracts (Vitis vinifera), standardised in active ingredients.
A source of antioxidants excellent for the circulation, especially heavy legs, this supplement is part of our Heart & Circulation category.
Benefits of our red vine supplement for the circulation and heavy legs
The 3 ingredients in Triple Vino Circulation are both traditionally used and scientifically validated for their antioxidant properties and ability to support cardiovascular health (1-3).
Specifically, the supplement contains:
- an extract of red vine leaf: red vine leaf is a major source of flavonoids and other antioxidant polyphenols, which help protect cells and tissues against oxidative stress. The bioflavonoids in this plant also support the circulation, reducing the permeability and improving the resistance of blood vessels. The European Medicines Agency (EMA) recognises the use and efficacy of red vine for treating heavy legs, varicose veins, episodes of haemorrhoids, calf cramps, oedema (swelling), itching and other problems associated with venous insufficiency (ie, the pooling of blood in the legs due to poor venous return). Finally, red vine helps to maintain healthy blood pressure, a sign of good cardiovascular health, as its polyphenols promote blood vessel dilation (4-8) ;
- an extract of grape seed: grape seeds are also a well-known source of antioxidants, especially proanthocyanidins (including oligo-proanthocyanidins or OPCs), excellent for maintaining cellular health. Grape seeds also promote healthy blood vessels, as their various antioxidants help to protect the endothelium (the inner lining of blood vessels) and their OPCs promote ] nitric oxide production which relaxes blood vessels and improves the circulation (9-10) ;
- an extrait of grape marc: grape marc, or pomace, refers to the solid residues collected after the grapes have been pressed, and consists of the skin, seeds and stalks of the fruit. Rich in OPCs and anthocyanins, grape marc also has antioxidant properties. It’s good for the figure too: it promotes weight loss and helps control cellulite, as a result of its high content of polyphenols which improve energy metabolism and reduce the accumulation of fat (11-14).
3 strengths of the supplement Triple Vino Circulation for tackling venous insufficiency
Our supplement is notable in 3 specific respects:
- parts of the vine naturally rich in polyphenols: each of the 3 extracts come from parts of the vine abundant in polyphenols, some of the most powerful natural antioxidants produced by plants. These polyphenols include bioflavonoids, OPCs, anthocyanins, etc.;
- 3 extracts standardised in active ingredients: the most effective polyphenols in our extracts are present at high, optimal levels. Red vine leaf extract is standardised to 10% polyphenols and 4% bioflavonoids, grape seed extract to 95% polyphenols, 70% proanthocyanidins and 40% OPCs, and grape marc extract to 95% polyphenols, 30% OPCs and 2% anthocyanins, to bring you the very best of the grapevine;
- a dose that’s both safe and effective: a daily dose (2 capsules) of Triple Vino Circulation provides 500mg of red vine leaf extract, 165mg of grape seed extract and 165mg of grape marc extract. This precise dosage has been calculated to ensure the supplement delivers both unparalleled efficacy and maximum safety.
Daily dose: 2 capsules
Number of doses per pack: 30
Vine extracts (Vitis vinifera): |
Amount per dose |
Extract of red vine leaf standardised to 10% polyphenols and 4% bioflavonoids |
500 mg |
Extract of grape seed standardised to 95% polyphenols, 70% proanthocyanidins and 40% OPCs |
165 mg |
Extract of grape marc standardised to 95% polyphenols, 30% OPCs and 2% anthocyanins |
165 mg |
Other ingredients: acacia gum.
|
Recommended dose: take 2 vegetarian capsules a day with meals. Each capsule contains 250mg of red vine leaf extract, 82.5mg of grape seed extract and 82.5mg of grape marc extract.
Duration: 30 days.
Storage: store away from heat, light and humidity.
Precautions: for adults. Do not exceed the recommended daily dose. This product is a nutritional supplement which should not be used as a substitute for a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat and humidity. As with all nutritional supplements, consult a healthcare professional before taking if you are pregnant, breastfeeding or have a health condition
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- Jung HJ, Choo KS. Pilot study on the effect of grape seed proanthocyanidin extract on inferior vene cava blood flow in patients with chronic venous insufficiency using 4D flow MRI. Medicine (Baltimore). 2022 Nov 18;101(46):e31792. doi: 10.1097/MD.0000000000031792. PMID: 36401399; PMCID: PMC9678586.
- Bocsan IC, Măgureanu DC, Pop RM, Levai AM, Macovei ȘO, Pătrașca IM, Chedea VS, Buzoianu AD. Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases. Biomedicines. 2022 Sep 20;10(10):2337. doi: 10.3390/biomedicines10102337. PMID: 36289599; PMCID: PMC9598344.
- https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-vitis-vinifera-l-folium-revision-1_en.pdf
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- Kiesewetter H, Koscielny J, Kalus U, Vix JM, Peil H, Petrini O, van Toor BS, de Mey C. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000 Feb;50(2):109-17. doi: 10.1055/s-0031-1300174. PMID: 10719612.
- Stücker M, Rabe E, Meyer K, Ottillinger B, Schütt T. Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). Pharmazie. 2019 Apr 1;74(4):193-200. doi: 10.1691/ph.2019.9326. PMID: 30940301.
- https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-vitis-vinifera-l-folium-revision-1_en.pdf
- Gupta M, Dey S, Marbaniang D, Pal P, Ray S, Mazumder B. Grape seed extract: having a potential health benefits. J Food Sci Technol. 2020 Apr;57(4):1205-1215. doi: 10.1007/s13197-019-04113-w. Epub 2019 Sep 30. PMID: 32180617; PMCID: PMC7054588.
- Jung HJ, Choo KS. Pilot study on the effect of grape seed proanthocyanidin extract on inferior vene cava blood flow in patients with chronic venous insufficiency using 4D flow MRI. Medicine (Baltimore). 2022 Nov 18;101(46):e31792. doi: 10.1097/MD.0000000000031792. PMID: 36401399; PMCID: PMC9678586.
- Sri Harsha PSC, Lavelli V. Use of Grape Pomace Phenolics to Counteract Endogenous and Exogenous Formation of Advanced Glycation End-Products. Nutrients. 2019 Aug 15;11(8):1917. doi: 10.3390/nu11081917. PMID: 31443235; PMCID: PMC6723612.
- Taladrid D, Rebollo-Hernanz M, Martin-Cabrejas MA, Moreno-Arribas MV, Bartolomé B. Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment. Antioxidants (Basel). 2023 Apr 21;12(4):979. doi: 10.3390/antiox12040979. PMID: 37107354; PMCID: PMC10135959.
- Bocsan IC, Măgureanu DC, Pop RM, Levai AM, Macovei ȘO, Pătrașca IM, Chedea VS, Buzoianu AD. Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases. Biomedicines. 2022 Sep 20;10(10):2337. doi: 10.3390/biomedicines10102337. PMID: 36289599; PMCID: PMC9598344.
- Chedea VS, Macovei ȘO, Bocșan IC, Măgureanu DC, Levai AM, Buzoianu AD, Pop RM. Grape Pomace Polyphenols as a Source of Compounds for Management of Oxidative Stress and Inflammation-A Possible Alternative for Non-Steroidal Anti-Inflammatory Drugs? Molecules. 2022 Oct 12;27(20):6826. doi: 10.3390/molecules27206826. PMID: 36296420; PMCID: PMC9612310.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=La%20dur%C3%A9e%20de%20traitement%20recommand%C3%A9e,pour%20ressentir%20ses%20effets%20b%C3%A9n%C3%A9fiques.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=Les%20seuls%20effets%20ind%C3%A9sirables%20signal%C3%A9s,une%20allergie%20de%20la%20peau.
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=Les%20seuls%20effets%20ind%C3%A9sirables%20signal%C3%A9s,une%20allergie%20de%20la%20peau.