GlucoFit™ - banaba-based anti-diabetes supplement

Controlling blood sugar is essential. Glucose that is not transported into cells stagnates in the blood and is often converted into fat. Elevated blood sugar levels not only lead to weight gain but also to glycation, a specific type of damage caused by a reaction between glucose and protein, as well as to other common diseases such as atherosclerosis.
Glucofit™ is an oily extract form of corosolic acid derived from the leaves of the plant lagestroemia speciosa L. grown in Asia. Corosolic acid is a powerful transporter of glucose across cell membranes. The concentration of corosolic acid in Glucofit™ is far more superior from its predecessor, Glucotrim®

In human studies, Glucofit™ reduced blood sugar levels in non-insulin dependent (Type II) diabetics. In animal studies, it lowered blood glucose in both diabetic and healthy animals. In fact, studies show that Glucofit™ is the most effective nutritional supplement for controlling blood sugar.

Recently-published preliminary results of a comparative clinical study show that patients supplemented with the new Glucofit™ for 60 days lost over 4.5 kg, including 70% body fat mass, while those supplemented with the original Glucosol™ lost ‘only' 3 kg. These results would seem to confirm the dose-dependent efficacy of corosolic acid in weight control.

Adults. Take one softgel every 12 to 24 hours or according to the advice of your therapist.
Glucofit™ is remarkably free from contra-indications and side-effects. It should only be avoided by those predisposed to hypoglycaemia, to prevent an excessive drop in their blood sugar.
Each softgel contains 2.65 mg of Glucofit™.

A natural formula produced from olive leaves, Olive Leaf Extract is designed to control lipidemia. It is supported by three clinical studies which have confirmed its ability to lower LDL-cholesterol and triglyceride levels, increase HDL-cholesterol and fight lipid peroxidation.

What exactly is Olive Leaf Extract?

Olive Leaf Extract a natural-source dietary supplement produced from olive leaves. It contains a very high level of oleuropein, a bioactive phytonutrient specific to the olive tree, which helps control blood lipids and prevent carbohydrate absorption.

It is aimed at anyone who wants to improve their cardiovascular health and maintain the integrity of their blood vessels. Individuals with the following risk factors are likely to be particularly interested in this product:

• those who are overweight;
• those with type 2 diabetes;
• those prone to circulation problems;
• those with high blood pressure;
• those who are stressed;
• those who have hypercholesterolemia

What compounds are in Olive Leaf Extract?

The beneficial effects of the olive tree are attributed to its exceptionally high content in phenolic compounds, molecules known for their antioxidant potency. In the olive tree, these compounds play a part in defending the tree from insects, infection, multiple microbial attacks and UV radiation (1-2), but they are also biologically active when ingested by humans. They are known to reduce the risk of a number of diseases by combatting free radicals and improving enzymatic balance.

Oleuropein is the most abundant phenolic compound in the olive tree (3) (accounting for around 25% of the extract). It is oleuropein that gives extra virgin olive oil its characteristic bitterness, but there are many other such compounds found in Olive Leaf Extract: apigenin, caffeic acid, catechins, coumaric acid, diosmetin, ferulic acid, gallic acid, hesperidin, hydroxytyrosol, luteolin, oleoside, quercetin, rutin, tyrosol, vanillin, verbascoside…

As the oleuropein in olive leaves has been scientifically shown to be responsible for the plant’s benefits, Olive Leaf Extract is formulated to contain an optimum amount of this compound.

What are the mechanisms of action of Olive Leaf Extract?

Olive leaves have been used in phytotherapy since antiquity apparently for their antilipidemic, antiseptic and antiviral properties.

Scientific research has since confirmed these applications and identified new properties: antimicrobial (4-5), antiviral (6), antifungal (7), gastro-protective (8), blood glucose-lowering (9), blood pressure-lowering (10), antioxidant (11-12), antiatherogenic (13), hypolipidemic (14), anti-inflammatory (15), neuro-protective (16), vasodilatory (17) and anti-ageing (18).

There are three precise mechanisms of action which are responsible for the majority of Olive Leaf Extract’s effects on the cardiovascular system:

1) cholesterol-lowering action

The olive tree’s polyphenols, particularly oleuropein, act on cholesterol excretion (19). They promote the elimination of excess cholesterol via the bile ducts, duodenum and finally faeces.

2) antioxidant action

The antioxidant potential of oleuropein is exceptional. When elderly institutionalised individuals followed a diet enriched with an extract of oleuropein and its derivatives for six weeks, their antioxidant capacity was shown to improve (20). It is a natural solution to combatting oxidative stress and inhibiting LDL oxidation (21).

3) action on sugar absorption

By binding to sucrase and maltase, two digestive enzymes, oleuropein limits sugar absorption and thus reduces spikes in blood glucose. It also does this by slowing down activity of the sugar transporter, GLUT2.

Is it supported by scientific studies?

The effect of Olive Leaf Extract has been directly measured in three clinical trials (22).

1) One year’s supplementation with 250mg a day

Following 12 months’ daily supplementation by subjects with elevated cholesterol levels, researchers recorded:

• a 20% reduction in ‘bad’ LDL-cholesterol;
• a 13% increase in ‘good’ HDL-cholesterol;
• a 10% decrease in total cholesterol and a 5% decrease in triglycerides.

2) Four weeks’ supplementation with 250mg a day

In overweight subjects, there was a significant improvement over four weeks in the expected ratio of coronary risk as compared with placebo. A clear decrease in triglycerides was observed.

3) Eight weeks’ supplementation with 250mg a day

The third study examined the ability of Olive Leaf Extract to reduce oxidative stress. Results showed that daily supplementation with 250mg reduced levels of MDA (malondialdehyde) by almost a third, a urinary marker of oxidative stress.

Why use extracts of olive leaf rather than olives?

Studies suggest that the leaves and fruit are equally rich in oleuropein (23), but olive leaf is considered a more renewable natural source for extraction (24). Hence its use in Olive Leaf Extract, and its ingredient Olécol®.

Five good reasons to choose Olive Leaf Extract to maintain healthy blood vessels

1) The antioxidant content of olives depends to a large extent on variety, maturity and preservation. Therefore, if you live a long way away from the Mediterranean region where they’re grown, you can’t really rely on eating olives all year round to boost your cardiovascular health. With its exceptional and stable content in olive tree polyphenols, Olive Leaf Extract provides a solution to this problem, offering populations the world over the opportunity to fully benefit from the advantages of a Mediterranean diet.

2) Eating a Mediterranean diet is associated with a lower risk of all-cause mortality (25). Scientific studies have in large part attributed these protective effects to the role played by the olive tree (26).

3) The bioavailability of oleuropein in humans is very high – between 55% and 60% (27). Maximal plasma concentration occurs two hours after oral administration. Studies have also shown that oleuropein crosses the blood-brain barrier easily.

4) The Mediterranean diet was recognized by UNESCO in 2010 as an Intangible Cultural Heritage of Humanity.

5) Cardiovascular disease is the leading cause of mortality across the world, claiming more than 17 million lives each year.

Additional steps to maximise the benefits of Olive Leaf Extract

To further enhance the efficacy of Olive Leaf Extract, you can adopt these additional measures throughout the supplementation period:

1. Significantly increase your intake of fruit, vegetables, nuts and wholegrains.
2. Make liberal use of herbs, spices, garlic and onion.
3. Only use olive oil for dressings and rapeseed oil for cooking.
4. Eat at least one yogurt a day (preferably sheep’s milk).
5. Limit your intake of poultry and red meat, and instead choose fish and seafood whenever possible.
6. Be physically active every day (go for a walk after a meal, take part in sports, do some exercises …).
7. Take a daily multivitamin supplement.

These measures are part of the Mediterranean diet which is based on the long-term food habits of Mediterranean populations. They are a good accompaniment to supplementing with Olive Leaf Extract though not essential for obtaining the benefits of this product.

Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

References

1. Lo Scalzo, R., Scarpati, M.L., Verzebgnassi, B., Vita, G., (1994). Olea europaea chemical repellent to Dacis oleae females. J. Chem. Ecol., 20, 1813-1923.
2. Uccella, N., (2001). Olive biophenols : biomolecular characterization, distribution and phytolexin histochemical localization in the drupes. Trends Food Science and Technology. 11, 315-327.
3. Benavente-Garcia, O., Castillo, J., Lorente, J., Ortuno, A., Del Rio, J. A., (2000). Antioxidant activity of phenolics extracted from Olea europaea L-leaves. Food Chemistry, 68(4), 457-462.
4. Sudjana, A.N., D’Orazio, C., Ryan, V., Rasool, N., Ng, J., Islam, N., Rileya, T.V. Hammera, K.A., (2009). Antimicrobial activity of commercial Olea europaea (olive) leaf extract. International Journal of Antimicrobial Agents, 33, 461-463.
5. Pereira, A. P., Ferreira, I.C.F.R., Marcelino, F., Valentão, P., Andrade, P.B., Seabra, R., Estevinho, L., Bento, A., Pereira, J.A., (2007). Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves. Molecules, 12, 1153-1162.
6. Micol, V., Caturla, N., Pérez-Fons, L., Más, V., Pérez, L., Estepa, A., (2005). The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res., 66(2-3):129-36.
7. Korukluoglu, M., Sahan, Y., Yigit, A., (2008), Antifungal properties of olive leaf extracts and their phenolic compounds. Journal of Food Safety, 28 (1), 76-87.
8. Dekanski, D., Janicijevic-Hudomal, S., Tadic, V., Markovic, G., Arsic, I., Mitrovic, D. M., (2009). Phytochemical analysis and gastroprotective activity of an olive leaf extract. Journal of the Serbian chemical society, 74 (4), 367-377.
9. Takeshi, Y., Hiroshi, S., Gustavo, S., Naohide, K., Shuichi, M., (2007). Food containing olive leaf extract and -lipoic acid and prevention of diseases due to accumulation of advanced glycation end products with the food. Patent written in Japanese. JP 2006-167353 20060616. 7 pp.
10. Susalit, E., Agus, N., Effendi, I., Tjandrawinata, R.R., Nofiarny, D., Perrinjaquet-Moccetti, T., Verbruggen, M., (2011). Olive (Olea europaea) leaf extract effective inpatients with stage-1 hypertension: Comparison with Captopril. Phytomedicine, 18(4), 251-258.
11. Altiok, E., Baycin, D., Bayraktar, O., Ulku, S., (2008). Isolation of polyphenols from the extracts of olive leaves (Olea europaea L.) by adsorption on silk fibroin. Sep. Purif. Technol., 62(2), 342-348.
12. Lee, O.H., Lee, B.Y., (2010). Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresource Technology, 101(10), 3751-3754.
13. Somova, L.I., Shode, F.O., Ramnanan, P., Nadar, A., (2003). Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. Journal of Ethnopharmacology, 84(2-3), 299-305.
14. Jemai, H., Bouaziza, M., Fki, I., El Feki, A., Sayadi, S., (2008). Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chemico-Biological Interactions 176, 88–98
15. Miljkovic, D., Dekanski, D., Miljkovic, E., Momcilovic, M., Mostarica-Stojkovic, M., (2009). Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis. Clinical Nutrition, 28, 346-350.
16. Mohagheghi, F., Bigdeli, M. R., Rasoulian, B., Hashemi, P., Rashidi, M.P., (2011). The neuroprotective effect of olive leaf extract is related to improved blood–brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia Phytomedicine, 18 (2-3), 170-175.
17. Zarzuelo, A., Duarte, J., Jiménez, J., Gonzalez, M., Utrilla, M.P., (1991). Vasodilator effect of olive leaf. Planta Medica, 57(5), 417-419.
18. Julián Castillo, J., Alcaraz, M., Benavente-García, O., (2010). Antioxidant and Radioprotective Effects of Olive Leaf Extract. Olives and Olive Oil in Health and Disease Prevention, 951-958.
19. Coni E, Di Benedetto R, Di Pasquale M, et al. 2000. Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits. Lipids 35 : 45–54.
20. Oliveras-López MJ, Molina JJ, Mir MV, Rey EF, Martín F, de la Serrana HL. 2013. Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans. Arch. Gerontol. Geriatr. 57 : 234–242.
21. Visioli F, Caruso D, Galli C, Sala A. 2000. Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans. Biochem Biophys. Res. Commun. 278 : 797–799.
22. The Effect of Olive Leaf Extract Administration on Cardiovascular Health, Avril 2017, https://ichgcp.net/clinical-trials-registry/NCT02990637] Consulté le 15 octobre 2018.
23. Briante, R., La Cara, F., Febbraio, F., Patumi, M., Nucci, R., (2002). Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts. Journal of Biotechnology, 93, 109– 119.
24. Bouaziz, M., Sayadi, S., (2005). Isolation and evaluation of antioxidants from leaves of a Tunisian cultivar olive tree. Eur. J. Lipid Sci. Technol., 107, 497-504.
25. Perez-Lopez FR, Chedraui P, Haya J, Cuadros. JL. 2009. Effects of the Mediterranean diet on longevity and age-related morbid conditions. Maturitas 64 : 67–79.
26. Keys A. 1995. Mediterranean diet and public health : personal reflexions. Am. J. Clin. Nutr. 61 : 1321S–1323S.
27. Vissers MN, Zock PL, Roodenburg AJ, Leemen R, Katan MB. 2002. Apparent absorption of olive oil phenols in humans. J. Nutr. 132 : 409–417.
28. Serra A, Rubió L, Borràs X, Macià A, Romero MP, Motilva MJ. Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake, Mol Nutr Food Res. 2012 Mar;56(3):486-96. doi: 10.1002/mnfr.201100436. Epub 2011 Dec 20.

Dose: 2 capsules Number of doses per pack: 30	Amount per dose
Olecol®, extract of Olea Europaea leaf standardised to 32% oleuropein	250 mg
Other ingredients: acacia gum, rice bran. Olecol®, Bioactor, Netherlands.

Adults. Take 2 capsules a day. Each capsule contains 125mg of Olecol®.