You may not be aware of berberine supplements, but this natural active principle has actually been used therapeutically for many years, especially in traditional Asian medicine. Today, scientists are showing particular interest in berberine’s properties in relation to the management of type 2 diabetes...
Berberine is a natural active principle which takes its name from the Berberidaceae plant family from which it was first extracted. One of the best-known of these plants is the shrub barberry, or to give it its scientific name, Berberis vulgaris. Berberine is found in the small berries produced by the barberry plant. Nowadays, this is the main source of berberine but it has also been identified in other plants of the berberidaceae family including the species Berberis aristata and Berberis petiolaris. It is also present in other plant groups, particularly Ranunculaceae (Coptis chinensis, Coptis teeta…), Papaveraceae (Chelidonium malus, Sanguinaria canadensis…), Menispermaceae (Tinospora cordifolia…), Rutaceae, (Phellodendron amurense…), Fumariaceae and Annonaceae.
The berberine-producing berberidaceae family features significantly in traditional Asian pharmacopoeia. Several of its plants are referred to in the texts of Chinese and Ayurvedic medicine. These medicinal plants are traditionally used for their anti-diarrhoea, anti-microbial and anti-protozoal activity. These powerful infection-fighting effects have since been attributed by science to several active principles including berberine. Over the years, research has revealed a number of other benefits for this natural active principle, particularly for the control of type 2 diabetes. You may have heard about the link between berberine and metformin, an oral anti-diabetes drug widely used in the initial management of type 2 diabetes. We explore this further in the next paragraph.
Research conducted on berberine shows it has a similar action to metformin. Considered to be the first treatment for type 2 diabetes, this oral-use drug has the same antihyperglycaemic mode of action as berberine. In other words, both metformin and berberine act by reducing blood sugar levels and preventing the hyperglycaemia that characterises type 2 diabetes. Studies show that these two active principles work via different and complex mechanisms, some of which are described below. Current scientific data suggests that berberine could constitute a useful alternative to metformin. Several studies comparing the efficacy of these two active principles have demonstrated positive results for berberine in reducing blood glucose levels in type 2 diabetics.
As a result of its metformin-like effects, berberine has been the subject of numerous scientific studies in recent years. Though by no means exhaustive, some of the most recent findings are outlined in the following paragraphs.
Antioxidant power. Like many phytonutrients, berberine acts as a natural antioxidant. This means it is able to combat oxidative stress, a process characterised by the production of reactive species in the body, which causes significant damage to cells and thus contributes to cellular ageing.
Anti-ageing effect. Because of these antioxidant properties, berberine helps to protect the body, prevent certain conditions and confer anti-ageing effects. That is why berberine features in the composition of anti-ageing supplements such as the formulation Longevity Nutrients. This combines an extract of Phellodendron amurense standardised in berberine, with an apple extract standardised in polyphenols, and a reishi extract standardised in polysaccharides. This anti-ageing supplement offers even greater efficacy because berberine’s chemical structure means it combines easily with other active principles to increase their effects.
Anti-infection action. Plants from the berberidaceae family are highly-prized in Asia for their infection-fighting properties. Studies show that berberine combats the spread of certain infectious agents. For example, it has anti-bacterial properties that work against staphylococcus, streptococcus and salmonella. It also seems to act against other parasites, exerting anti-amoebic and anti-protozoal effects.
Anti-inflammatory activity. It may also fight inflammatory reactions induced by infectious agents. Several studies have shown that regular administration of berberine helps to reduce inflammatory responses.
Anti-diabetes action. As mentioned, berberine has the same antihyperglycaemic effect as metformin. Studies show that it reduces blood glucose levels in various ways. One such method is its effect on an enzyme involved in glucose metabolism called AMPK. By enabling activation of this enzyme, berberine increases insulin sensitivity and promotes the capture and use of glucose in the body. Studies suggest that it may also regulate neoglucogenesis, a mechanism which leads to synthesis of glucose by the liver. As a result of these different actions, berberine helps reduce blood glucose levels and combats the hyperglycaemia characteristic of type 2 diabetes.
Lipid-lowering potential. Due to its AMPK-activating effect, berberine also appears to improve the lipid profile by reducing blood levels of triglycerides and cholesterol.
Due to its many beneficial properties, berberine is a molecule with significant therapeutic potential. Though not exhaustive, the paragraphs below list its traditional and more recent therapeutic uses.
Infectious diseases. In Asia, berberidaceae plants have been used for years to prevent and treat infectious diseases, particularly for fighting the infectious agents that cause diarrhoea.
Type 2 diabetes. Berberine has been attracting scientific interest for several years for its metformin-like effect against diabetes. It thus constitutes a significant aid to the management of what is an increasingly prevalent condition. In 2014, specialists estimated that type 2 diabetes affected more than 400 million people across the world, and that figure did not include the large number of undiagnosed diabetics.
Metabolic disorders. In addition to its benefits for the management of type 2 diabetes, it may also support the treatment of numerous other metabolic disorders. In particular, it may help prevent complications linked to excess weight and obesity.
Non-alcoholic steatohepatitis (fatty liver disease). Recent research has also identified benefits for the prevention and treatment of non-alcoholic steatohepatitis, more commonly-referred to as NASH. This is essentially inflammation of the liver caused by abnormal levels of fat storage in liver cells. In just a few years, NASH has become a major public health issue, as can be seen by the publication of several articles on the subject. Their titles - ‘Fizzy drink disease’, ‘Junk food disease’, or ‘Disease of the century’ - refer to its primary causes, namely our changing lifestyles and the trend towards consumption of fast-food and high-calorie products. With its antihyperglycaemic and lipid-lowering benefits, berberine is considered a promising therapeutic approach to preventing the complications associated with NASH.
Berberine is extracted from various plants and comes in the form of a yellow powder which is used to formulate a number of dietary supplements. For example, the berberine supplement offered in the SuperSmart catalogue is formulated from an extract of barberry (Berberis vulgaris) standardised to 97% berberine, one of the best doses available!
It can also be found in supplements combined with other active principles. An innovative formulation has been developed which contains extracts of Berberis vulgaris standardised to 97% berberine, Gynostemma pentaphyllum standardised to 98% gypenosides, and Buxus sinica standardised to 98% fisetin. Combined in the supplement AMPK Booster, these three extracts naturally boost AMPK, a key metabolic enzyme, the activation of which helps fight a large number of metabolic disorders: hyperlipidaemia, hypercholesterolaemia, and the hyperglycaemia characteristic of type 2 diabetes … Studies conducted on animal models show that AMPK activation may help increase longevity.
As yet, there is no officially recommended dose for berberine. Current scientific data suggests that the dose may vary between 500mg and 1500mg a day, depending on individual needs, with some studies suggesting that in certain cases, this could even be increased to 2000mg/day for short periods and under medical supervision. In all cases, it’s advisable to seek guidance from a health professional in choosing the right supplement for your particular needs.
No major side-effects have so far been reported as a result of taking berberine supplements. However, as with any active principle, there may be certain contraindications. In particular, medical advice should be sought by those on any medication as berberine may interact with the active principles in certain drugs. And as a precautionary measure, berberine supplements are not recommended for children or for women who are pregnant or breastfeeding.
Keywords
52 Days
Reliable delivery. Good product.
Viva
66 Days
Great service
cl
68 Days
Received product promptly and its early days but seems to have improved my daughters alertness.
Anandi
78 Days
Amazing, great product!
ALEX Sinclair
81 Days
Good products and Swift handling
Trusted
86 Days
I trust the company's products, the quality is trustworthy and the speed of delivery is also appreciated.
NAJIB Malaah
86 Days
This company is serious when it comes to serving it's customers. They are fast to send out the orders. Their site is great and easy. Also, they treat their return customers with great deals and discounts. Keep up the good work.
ABDULQADER Jehad
88 Days
I know frech ( level 3 of 6) and can read your messages, but since order are official documents I'd like to have this in english. Merci Ursula Mathes
Ursula Mathes
91 Days
Box was intact, content correct but delivery time was 12 days. I started to worry!
VIITANEN Esa
94 Days
The company has provided the required product efficiently with no complications.
OldBear
95 Days
Supersmart sell a lot of interesting stuff. More than jut the usual vitamins though they do all those as well. Ordering pretty straightforward - you may need to try a couple of times to get the offers to apply but they do work. I queried something and had a fairly quick sensible reply. Postage takes a couple if days but you do get good progress information. Very well packed. Bought from Supersmart a few times and will do so again.
AT Griffin
14 Days
Livraison Express Service client réactif Produits de qualité Je vous recommande Supersmart !
CIAMPI Brenda
20 Days
Cela fait des années que je me fournis chez Supersmart. Ces derniers temps j'ai constaté une baisse significative de la qualité de travail et d'exécution conforme des commandes permanentes. Une erreur de paramétrage du programme robotisé de livraison m'a valu 2 réceptions d'un article non commandé en lieu et place de celui qui figure sur mon espace personnel ET sur la facture émise par Supersmart. Ensuite, la succession de tickets numérotés différents pour les demandes de rectification portant sur le même sujet s'avère être une nouvelle source d'erreur et de précisions de traitement. Cela va de mal en pis, entre délai de réponse et pertinence de celles-là ... Je suis profondément déçu et inquiet : Supersmart est basé en Espagne et son centre logistique au Luxembourg, ce qui obligerait ma PJ à saisir les 2 autorités judiciaires. SUITE À LA RÉPONSE APPORTÉE PAR ANNA : Je pense que je pourrai réintroduire la commande permanente de mes articles augmentée d'un moyen curatif pour mon épouse. La morale de cela est que rien ne vaut l'humain dans l'exécution des conditionnements pour envois... et qu'il est inapproprié de s'asseoir sur des systèmes automatisés sans contrôles.
Thierry Gérard Droz
22 Days
Transgenre (52 ans) et potentiellement intersexe au sens partiel (mosaïcisme) j'ai pris pendant 4/5 ans de la Pueraria Mirifica sans avis d'un médecin... Je suis arrivé/e à ce que je voulais ; rendre plus féminin mon aspect, arrêt des érections et des éjaculations (qui étaient déjà difficiles). Tout dépend des récepteurs hormonaux (oestrogènes) dans chaque cellules de notre corps, XX et XY et phénotypes ne veulent rien dire. J'ai une poitrine, petite, pousse système pileux ralenti. Trop tard pour ma calvitie. Reprise après une pause (20/07/2025) en me fixant 2 pills par jour pendant 6 mois.
GAYET Alexia
28 Days
Ottimi prodotti. Spedizioni rapide.
Enzo