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P.E.A. Supplement
P.E.A. Supplement
0735P.E.A. Supplement Size
Sans nano-particulesSans glutenVegan
Fighting inflammation
4 out of 5
5 stars
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16 reviews
Customer reviews
52.00 €(58.99 US$) in stock
P.E.A. is a natural analgesic formulated from palmitoylethanolamide.
  • Anti-inflammatory and analgesic properties.
  • Natural solution to pain that is inflammatory, neuropathic or a mixture of the two.
  • Reduces the sensation of pain in a number of situations.
48.36 €  
save 3.64 € (7.00%)
save 3.64 € (7.00%)
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52.00 €
60 Veg. Caps.
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Woman with back pain sitting in the office

P.E.A. Supplement – Provides Anti-inflammatory and Analgesic Benefits

P.E.A. dietary supplement is the result of many years' research into palmitoylethanolamide. More commonly known as P.E.A., this compound's considerable therapeutic potential has made it the subject of numerous scientific studies, now available to buy at Supersmart.

What are the benefits associated with P.E.A. supplement?

The anti-inflammatory and analgesic properties of this fatty acid amide have been known for decades but it was in 1990 that its therapeutic benefits were properly recognised by the scientific community as a result of the work of Italian Nobel Laureate Rita Levi-Montalcini. This famous neurologist demonstrated P.E.A.'s efficacy in treating some types of neuropathic pain. Further research then led to the development of P.E.A.-based nutritional supplements. These products have been available since 2010 in the form of powder or capsules and have made quite an impact in the Netherlands where they are offered as a new kind of P.E.A..

According to some scientists, this fatty acid amide works by binding to a specific cell receptor called PPAR-alpha. This receptor activates peroxisomes - cell organelles involved in the regulation of pain and inflammation genes. By binding to the PPAR-alpha receptor, P.E.A. reduces peripheral sensitivity induced by both neural and non-neural cells. In other words, P.E.A.'s action reduces the sensation of pain in a number of situations. In this context, encouraging results have already been obtained in:

  • Diabetic neuropathy.
  • Chemotherapy-induced peripheral neuropathy.
  • Carpal tunnel syndrome.
  • Back pain, sciatica, pelvic pain and multiple sclerosis.

Why opt for P.E.A.?

The effects of this compound are significant, given that pain can be common and varied. It can take the form of acute pain which is temporary in nature, or chronic pain that persists over a long period of time. Scientists also categorise pain by its origin: inflammatory pain which involves the immune system, neuropathic pain which is associated with the nervous system, and a mixture of the two – both inflammatory and neuropathic. A number of treatments have been developed to relieve such pain and it is within this context that P.E.A. has been identified as a natural solution to pain that is inflammatory, neuropathic or a mixture of the two. P.E.A. has the advantage of being a natural molecule, found, for example, in eggs and milk.

P.E.A. has been developed from a high quality, patented P.E.A. formulation called OptiP.E.A.'s. This pain relief supplement is in capsule form with a suggested dose of three capsules a day, although this dosage can be adapted to your needs and the advice of your therapist. It should be noted that taking this supplement may not produce instant pain relief. Several days' supplementation may be necessary to obtain the desired results. You may also be interested in our other formulations aimed at relieving joint pain: OptiMSM® and Joint Support Formula

Buy P.E.A. for pain relief.

Daily dose: 3 capsules
Number of doses per pack: 20

per dose

OptiPEA©(Palmitoylethanolamide) 1 200 mg
Other ingredients :Acacia gum, rice bran.
OptiPEA©, Innexus Nutraceuticals, Holland.
Directions for use
adults. Take 3 capsules a day.
Each capsule contains 400 mg of OptiPEA©.
4 /5 16 reviews
4.1 / 5
4.3 / 5
Value for money
3.9 / 5

Reviews 16
44 %

fidèle à la description
Anne-Mie Rysman
Goed product
Robert Ic.
Semble efficace sur le long terme.
PERILLAT Francoise
Ce produit marche contre les duleurs
Résultat peu visible pour moi - Celadrin beaucoup plus efficace
Produit efficace pour les douleurs lombaire, et me permet de reprendre la marche
BEZU Francoise
j'ai commencé le traitement debut juillet, les douleurs neuropathiques nocturnes sont plus supportables ...sauf au reveil...mais il y a du"mieux"
fibromyalgie, gougreot sjorghen DMLA et pb cardiaque

colette walczak
Excellent pour soulager les douleurs
Très peu efficace pour la douleur
Prodotto buono ed efficace, non rapido come i più noti antinfiammatori ma pericolosi per chi ha patologie vascolari. Con "P E A" mi sento più sicuro, e un grazie a smart per i suoi consigli.
Patrice CREPIN
Calme certaines douleurs neuropathiques.
  1. McKinney MK, Cravatt BF. Annu Rev Biochem. 2005;74:411-32. Structure and function of fatty acid amide hydrolase.
  2. Piomelli D, Sasso O. Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci 2014; 17: 164– 74.
  3. Artamonov M, Zhukov O, Shuba I, Storozhuk L, Khmel T, Klimashevsky V, et al. Incorporation of labelled N‐acylethanolamine (NAE) into rat brain regions in vivo and adaptive properties of saturated NAE under x‐ray irradiation. Ukr Bi
  4. Artukoglu BB et al. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Physician. 2017 Jul;20(5):353-362.

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