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Ubiquinol: boost your immunity with coenzyme Q10

Coenzyme Q10 is recognised for reducing hypertension and heart problems … but it has other benefits too. Read on to find out how this essential compound can help you stimulate your immune defences.
White blood cells that attack viruses in the body.
Ubiquinone and ubiquinol help strengthen the body’s immune defences.
Rédaction Supersmart.
2020-04-16Comments (0)

Definition of coenzyme Q10, or ubiquinone

What exactly is coenzyme Q10?

Coenzyme Q10, also known as CoQ10 or ubiquinone, is a substance needed for the production of energy in cells. It is present in most living organisms.

Put simply, any human physiological process that involves expending energy requires CoQ10. For this reason, it is found in every region of the body (heart, stomach, kidneys …), hence its common name, ubiquinone, from the Latin word ubique meaning ‘everywhere’.

Sources of ubiquinone

CoQ10 is partly produced by the body and partly absorbed from the diet. Sources include beef, pickled herring, chicken and broccoli, as well as dietary supplementsspecially developed to maximise ubiquinone intake.

Taking these supplements will, of course, mean you benefit more from CoQ10’s many virtues, but in some cases, supplements are taken specifically to compensate for deficiency: for example, statins prescribed for reducing high cholesterol levels can result in inadequate ubiquinone levels.

And what about ubiquinol?

Ubiquinol participates in the Krebs cycle

Ubiquinol is simply the reduced form of coenzyme Q10: when ubiquinone is absorbed by the body, it gets converted into ubiquinol.

It is this compound, with its ability to exchange electrons, that ultimately participates in the Krebs cycle (a metabolic pathway essential to cellular energy production) and in the respiratory chain.

Is it better to supplement with ubiquinone or ubiquinol?

Both substances are effective at increasing blood levels of ubiquinol. However, in the case of ubiquinone, not all of it is absorbed in the gut. The more easily-assimilated ubiquinol therefore offers the advantage of being a directly active compound.

By way of example, a daily dose of 200mg of CoQ10 will increase blood levels of ubiquinol by around 60%, compared with 150% with the same dose of ubiquinol (1). But what exactly does CoQ10 do in the body?

The well-known benefits of coenzyme Q10

CoQ10 combats hypertension and protects the cardiovascular system

Firstly, coenzyme Q10 combats hypertension - the abnormal increase in the pressure of blood pushing against artery walls. Research has shown that ubiquinone is able to reduce both the systolic reading (the highest pressure when blood is pushed round the body) and the diastolic reading (the lowest such pressure) in hypertensive individuals. (2)

Coenzyme Q10 is thus recognised for promoting a healthy heart and cardiovascular system. (3-8) Indeed, in Japan and many European countries, it is used medically to treat problems of this kind.

Effect against corrupted cells, Parkinson’s disease, fatigue ...

It’s important to note that with advancing age, there’s a decline in the body’s production of coenzyme Q10. Lower levels of ubiquinone are generally observed in older patients (or those suffering from hypertension, diabetes, heart problems, cancer …).

Some studies suggest that CoQ10 helps to stem the growth of certain tumours, as well as relieve migraines and reduce the symptoms of Parkinson’s disease. (9-13) Its antioxidant properties may also facilitate post-exercise recovery and reduce feelings of fatigue. (14-16)

How do CoQ10 and ubiquinol boost the immune system?

Stimulation of immune function tissue and cells

In the current context, we naturally want to ensure our immune defences are strong. It just so happens that ubiquinol has significant capacity for boosting immunity.

The reason for this is that the tissues and cells involved in immune function have considerable energy needs and therefore require a substantial supply of CoQ10. One study maintained that “CoQ10 plays an important role in stimulating the immune system and physical performance”. (17)

Viruses and CoQ10 levels in the body

It’s also interesting to look at the findings of a study published in January 2019. The objective of this clinical trial, randomised over three influenza seasons, was to determine if acute influenza infection is associated with depletion of CoQ10. The researchers involved found that CoQ10 levels were significantly lower in patients with acute influenza infection than in healthy controls. (18)

In 2012, researchers had examined the link between CoQ10 levels and clinical outcome in children hospitalised with pandemic influenza H1N1. This study similarly suggested that CoQ10 levels in children with influenza were significantly decreased compared with healthy controls. (19)

Increase in ratio of T4/T8 lymphocytes

All the evidence suggests that ubiquinone also promotes high blood levels of cytotoxic T lymphocytes which destroy infected cells.

One study from 1993, which evaluated the effect of coenzyme Q10 on immune response, concluded that the T4/T8 ratio of lymphocytes increased following administration of coenzyme Q10. (20)

Discover SuperSmart’s ubiquinone and ubiquinol supplements

Co-Enzyme Q10

This first supplement, rich in coenzyme Q10, was developed to improve cardiovascular health and promote energy production. As we’ve seen, in addition to helping the heart pump blood, Co-Enzyme Q10 constitutes a valuable aid to boosting your immunity.

PQQ & Q10

The supplement PQQ & Q10, is an antioxidant formulation designed to fight cognitive impairment and optimise cardiovascular function. Its high ubiquinone content will also help improve your body’s defences.

Ubiquinol

This final supplement contains the reduced form of CoQ10, ubiquinol, known for its exceptional bioavailability. Choose Ubiquinol™ to help maintain your cardiovascular system, protect your brain from oxidative stress, increase your energy supply and boost your immune system.


Note 1:if you think you’re suffering from hypertension and cardiovascular problems, be sure to seek advice from a health professional.

Note 2: remember that it’s best to take CoQ10 supplements with food. This substance is more easily absorbed when taken with some fat.

References

  1. Zhang Y, Liu J , Chen XQ , Oliver Chen CY ., Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659.
  2. Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens.2007;21(4):297–306.
  3. Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466–467.
  4. Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. 2018;9:44. Published 2018 Feb 5.
  5. Ayers J, Cook J, Koenig RA, Sisson EM, Dixon DL. Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review. Curr Atheroscler Rep. 2018;20(6):29. Published 2018 May 16.
  6. Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med. 1997;18 Suppl:S145–S151.
  7. Kuklinski B, Weissenbacher E, Fähnrich A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol Aspects Med. 1994;15 Suppl:s143–s147.
  8. Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. 2018;9:44. Published 2018 Feb 5.
  9. Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Biol Pharm Bull. 2007;30(2):367–370.
  10. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, et al. Coenzyme q10 therapy. Mol Syndromol. 2014;5(3-4):187–197.
  11. Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466–467.
  12. Zeng Z, Li Y, Lu S, Huang W, Di W. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019;139(3):284–293.
  13. Müller T, Büttner T, Gholipour AF, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neurosci Lett. 2003;341(3):201–204.
  14. Sharma A, Fonarow GC, Butler J, Ezekowitz JA, Felker GM. Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. Circ Heart Fail. 2016;9(4):e002639.
  15. Kon M, Tanabe K, Akimoto T, et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr. 2008;100(4):903–909.
  16. Mizuno K, Tanaka M, Nozaki S, et al. Antifatigue effects of coenzyme Q10 during physical fatigue [published correction appears in Nutrition. 2008 Jun;24(6):616]. Nutrition. 2008;24(4):293–299.
  17. Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466–467.
  18. Chase M, Cocchi MN, Liu X, Andersen LW, Holmberg MJ, Donnino MW. Coenzyme Q10 in acute influenza. Influenza Other Respir Viruses. 2019;13(1):64–70.
  19. Kelekçi S, Evliyaoğlu O, Sen V, et al. The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ 10) in children with pandemic influenza (H 1 N1) and seasonal flu. Eur Rev Med Pharmacol Sci. 2012;16(8):1033–1038.
  20. Folkers K, Morita M, McRee J Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993;193(1):88–92.
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