Magnesium bisglycinate dietary supplement: stress, sleep...

Magnesium Bisglycinate is a dietary supplement containing magnesium bisglycinate in 120 capsules, an excellent aid for stress reduction, muscle relaxation and improved sleep quality.

This supplement stands out for its unbuffered form (100% chelated), its exceptional bioavailability, its excellent tolerability and its high dosage of 3,000 mg/day, the effectiveness of which has been established by clinical studies.

Definition of magnesium bisglycinate and reasons for its unrivalled bioavailability

What is magnesium bisglycinate (or magnesium glycinate)?

Magnesium bisglycinate (often simplified to magnesium glycinate, although this term is less precise) is a form of magnesium bound to two molecules of glycine, an amino acid that plays a natural role in regulating the nervous system (1).

It is a chelated form, meaning that the magnesium is ‘bound’ and surrounded by glycine, forming an organised structure rather than being present in free form.

Why is this form of magnesium the most bioavailable and best tolerated of all?

Unlike inorganic forms (such as magnesium oxide, chloride or sulphate), where magnesium is rapidly dissociated, here it is maintained within a complex that limits its reactivity in the digestive environment and reduces interactions with compounds such as phytates, fibre or certain minerals.

Because magnesium is bound to an amino acid, the complex is also partly recognised by the body as a dipeptide or a related compound and can utilise certain amino acid or peptide transporters in the intestine, in addition to the conventional magnesium pathways.

All these mechanisms facilitate its passage through the intestinal wall and ensure superior bioavailability of the mineral.

Better absorption also means that a smaller amount of magnesium remains in the intestine, which limits osmotic effects (water attraction) that are often the cause of intestinal discomfort.

Unlike forms such as oxide or carbonate, which are associated with laxative effects, bisglycinate is therefore very well tolerated by the digestive system, making it particularly suitable for long-term use, even at high doses.

Benefits of magnesium bisglycinate capsules

What are the effects of magnesium and glycine on stress, sleep, etc.?

Magnesium absorbed in this way contributes to:

• the normal functioning of the nervous system and normal psychological functions, by contributing to the transmission of nerve impulses via calcium fluxes in neurons and by participating in the regulation of excitatory (glutamate, NMDA receptors) and inhibitory (notably GABA) systems, which are involved in the stress response, mood regulation and emotional balance;
• to normal energy metabolism and the reduction of fatigue, by acting as a cofactor for numerous enzymes involved in the production and utilisation of energy (ATP);
• to normal muscle function, by modulating muscle contraction and relaxation via the balance between magnesium and calcium in muscle fibres;
• normal protein synthesis, by participating in RNA translation and protein formation at the cellular level;
• electrolyte balance, by helping to regulate the exchange of ions (sodium, potassium, calcium) essential for proper cellular function;
• the maintenance of normal bones, by playing a role in bone structure and calcium metabolism;
• the maintenance of normal teeth, by contributing to the mineralisation of dental tissue;
• and it plays a role in the process of cell division, by being involved in DNA replication and the cell cycle (2).

The presence of glycine offers an additional benefit: it acts as an inhibitory neurotransmitter involved in relaxation and neuromuscular balance, making magnesium bisglycinate particularly valued for combating stress and fatigue, supporting sleep and promoting nervous system health.

Clinical data on magnesium and stress that informed the formulation of TRAACS®

Several clinical studies have assessed the effects of magnesium in individuals with high stress levels or insufficient magnesium status.

In a randomised controlled trial involving 264 adults, daily supplementation with 300 mg of magnesium for 8 weeks was associated with a significant reduction in stress and anxiety scores, which fell from severe levels at baseline to near-normal levels by week 8, with the majority of improvements occurring within the first 4 weeks (3).

The study also compared magnesium alone with a magnesium + vitamin B6 combination, with no significant difference between the groups in anxiety and depression scores.

A recent systematic review also indicates that the majority of available clinical trials report a reduction in anxiety symptoms with magnesium supplementation, particularly at doses of 300 mg per day (4).

With 300 mg of elemental magnesium provided daily in the form of TRAACS® magnesium bisglycinate, Magnesium Bisglycinate offers a dosage directly based on the amounts most extensively studied in clinical trials.

4 key benefits and reasons to buy the best magnesium bisglycinate on the market

Magnesium Bisglycinate stands out for 4 key benefits:

1. a patented TRAACS® form, fully chelated and unbuffered: unlike many ‘bisglycinates’ on the market that are partially mixed with magnesium oxide, our dietary supplement uses exclusively patented TRAACS® magnesium bisglycinate (Albion® Minerals), a 100% chelated and unbuffered form (5). The magnesium is therefore fully bound to two glycine molecules, without dilution by less bioavailable inorganic forms used to artificially increase the elemental magnesium content. TRAACS® technology (short for The Real Amino Acid Chelate System) is now the gold standard in the field of chelated minerals. It is based on fully chelated and structurally verified mineral-amino acid complexes;
2. superior bioavailability and digestive tolerance: thanks to its stable, unbuffered chelated structure, our magnesium bisglycinate significantly limits interactions with certain compounds that may reduce magnesium absorption. As it is bound to glycine, it can also utilise amino acid or peptide transporters in the intestine, for improved bioavailability. Unlike certain ‘bisglycinates’ that are partially mixed with magnesium oxide, our form is particularly well tolerated by the digestive system, without the laxative effects of inorganic forms;
3. a high and appropriate dosage: each daily dose provides 3,000 mg of magnesium bisglycinate, equivalent to 300 mg of elemental magnesium, a high dosage but perfectly suited to daily supplementation, consistent with the amounts shown to be beneficial in several clinical studies on magnesium;
4. a vegan and refined formula: our supplement uses only vegetable-based hypromellose capsules (derived from cellulose, a natural fibre), with no controversial excipients or unnecessary bulking agents, to offer you a vegan formulation that is as pure as possible.

Who is this supplement for?

Magnesium bisglycinate is particularly suitable for:

• people exposed to high levels of stress or a demanding lifestyle;
• those wishing to support the normal functioning of their nervous system and psychological function;
• people experiencing fatigue or looking to support their energy-yielding metabolism;
• athletes and physically active people wishing to help maintain normal muscle function;
• individuals with a sensitive digestive system looking for a well-tolerated form of magnesium;
• people wishing to choose a highly bioavailable form to optimise their magnesium intake.

Thanks to its 100% chelated, non-buffered form, Magnesium Bisglycinate is also suitable for people who have not been satisfied with certain forms of magnesium that are less well absorbed or associated with digestive discomfort.

Which synergistic dietary supplements should you take with our magnesium glycinate capsules?

Magnesium and omega 3

Are you looking to support your nervous and brain health?

Alongside your magnesium bisglycinate, you can take an omega-3 dietary supplement.

Omega-3 DHA, in particular, is recognised for contributing to normal brain function by supporting the structure and fluidity of neuronal membranes, which are essential for communication between neurons (ideally, purchase the pure and stable Super Omega 3 fish oil, rich in DHA and EPA).

Magnesium and GABA

Another interesting combination, particularly for immediate nervous relaxation, stress relief and sleep, is to combine magnesium bisglycinate with GABA, the main inhibitory neurotransmitter in the central nervous system.

GABA limits neuronal excitability and promotes a state of calm.

It is available as a dietary supplement (for example, you can buy PharmaGABA®, a high-quality natural form of GABA produced by fermentation from Lactobacillus hilgardii).

Magnesium deficiency: possible causes and consequences

Why can magnesium levels decrease?

Magnesium is an essential mineral involved in hundreds of biological reactions.

However, dietary intake is often below recommended levels, particularly due to the insufficient consumption of foods naturally rich in magnesium.

Other factors may also contribute to lower magnesium levels or increase the body's requirements, including:

• chronic stress;
• intense physical activity;
• ageing;
• or certain specific physiological conditions.

What are the possible consequences of magnesium deficiency?

Over time, an insufficient magnesium intake may affect numerous bodily functions.

Insufficient magnesium intake may result in:

• increased fatigue;
• reduced resistance to stress;
• greater irritability;
• difficulty concentrating;
• muscle tension and discomfort;
• as magnesium also contributes to the normal functioning of the nervous system and energy-yielding metabolism, maintaining an optimal intake is important for preserving the body's overall balance.

An appropriate supplement may therefore be a relevant way to complement dietary intake when it is insufficient.

Quality, purity and traceability

Magnesium Bisglycinate uses exclusively TRAACS® magnesium bisglycinate supplied by Albion® Minerals, one of the leading names in the field of chelated minerals.

Each batch undergoes rigorous quality control to verify its compliance with established specifications.

Certificates of Analysis (COAs) are available on request.

This strict approach to raw material selection and traceability reflects SuperSmart's commitment to quality.