NAD+ Cellular Activator is an anti-ageing face cream with a revolutionary composition that is extremely effective at reducing wrinkles, firming the skin and giving you a radiant complexion.
Its innovative formula, the direct result of the latest research into NAD+, combines the most powerful active ingredients in the field of skin rejuvenation.
This premium facial treatment is therefore included in our category of products dedicated to the skin.
Composition and proven benefits of our anti-ageing face cream
What does this moisturising and firming facial care product contain?
NAD+ Cellular Activator combines 6 key active ingredients:
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RejuveNAD™: this young sunflower shoot extract stimulates the skin's natural vitality mechanisms by increasing levels of NAD+, a cofactor essential for energy production in cells, and therefore for their performance, regeneration and longevity. RejuveNAD™ exerts this action by improving the expression of the NAMPT enzyme (+111%) (1). A randomised, placebo-controlled clinical study on 22 women aged 52 to 65 found an improvement in skin smoothness, a lifting effect and a visible reduction in signs of ageing, including wrinkles and crow's feet, after 42 days' application of a cream containing 2% RejuveNAD™, the same concentration used in our product (2);
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niacinamide: this active form of vitamin B3 is a precursor of NAD+, the well-known molecule just mentioned, which is essential for the production of cellular energy and therefore for skin youthfulness. In this cream, niacinamide helps to improve the skin's elasticity and radiance, reduce visible pores and discolouration and strengthen the skin's resilience in the face of daily stress (3);
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Alpine Rose Active: the Alpine rose is a plant that grows at high altitude in acidic, nutrient-poor soil, and has developed impressive strategies to protect itself from free radical attack. Its leaf extract has been studied for its ability to eliminate senescent fibroblasts (the main cells in connective tissue) without affecting healthy cells, by inhibiting the carbonylation of skin proteins induced by reactive oxygen species (4-5). A placebo-controlled study of 44 women aged between 40 and 65 who applied a cream based on 2% of the ingredient (the same concentration used in our product) for 14 days showed its ability to make skin more elastic and reduce skin redness (6);
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Ameliox™: this liposomal preparation combines carnosine, an antioxidant peptide, with two powerful fat-soluble antioxidants, silymarin and tocopherol. Ameliox™ helps maintain skin elasticity and firmness by preventing glycation, a slow natural process that affects the structure and activity of dermal proteins (collagen and elastin), leading to premature ageing. An in vivo study of 20 women aged between 38 and 65 showed an improvement in skin softness, firmness and hydration, as well as a reduction in the depth of wrinkles on the forehead and crow's feet, after 28 days of topical application of a cream containing 2% of the ingredient, the same concentration as that used in our product (7);
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resveratrol: this polyphenol is recognised for its powerful antioxidant properties and its ability to activate sirtuins and support mitochondria, the cell's energy centres. In this anti-wrinkle cream, it helps to support the skin's youthfulness and firmness, giving it a more even, luminous complexion (8);
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low molecular weight hyaluronic acid: hyaluronic acid is an essential component of connective tissue, responsible for retaining water to ensure the skin's hydration, suppleness and volume. Thanks to its smaller molecular size, the hyaluronic acid in this product penetrates deeper into the epidermis to provide long-lasting hydration, plump your skin and reduce the appearance of fine lines and wrinkles (9).
The formula is completed by functional agents which guarantee its stability, texture and good tolerance, while optimizing hydration and skin comfort.
We have chosen not to include fragrance in the cream, which is the main source of allergens in cosmetic products on the market.
Anti-wrinkle cream results and clinical evidence
A number of studies carried out on our facial care product have quantified its invaluable benefits:
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record satisfaction and efficacy: in a dermatologically controlled use test with clinical scoring (carried out on 21 people with wrinkles, aged between 48 and 68, who applied NAD+ Cellular Activator to their face twice a day for 28 days), 95% of the panel said they liked the product. 95% of those tested also felt that it softened and moisturised their skin well. For 90%, it made their skin firmer, and for 81%, it helped to reduce facial sagging and had a noticeable rejuvenating effect. What's more, 100% of the subjects surveyed agreed that the cream did not leave their skin greasy, was easy to spread and absorbed quickly;
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a visible reduction in wrinkles: at the end of the same test, clinical evaluations carried out by a dermatologist showed a statistically significant reduction in forehead wrinkles (-15%) and crow's feet (-13%);
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proven moisturising power: the formula provides a long-lasting moisturising effect that is maintained at +56% for up to 8 hours, according to a test carried out on 10 women with dry to very dry skin, aged between 51 and 70, using corneometer measurements. More than 6 out of 10 subjects even considered this cream to be the most effective they had ever tested;
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exemplary skin tolerance: a compatibility test confirmed the ‘very good skin tolerance’ of this facial care product.
4 key benefits of our anti-wrinkle facial treatment
NAD+ Cellular Activator has 4 strong points:
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an innovative formula based on science and SuperSmart's expertise in longevity: this anti-ageing treatment is based on the latest advances concerning NAD+, SuperSmart's unique expertise and ingredients renowned for their effects on firmness, hydration and radiance;
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renowned, effective and synergistic active ingredients: the formula combines rare and powerful ingredients, such as RejuveNAD™, Alpine Rose Active and Ameliox™, with complementary properties;
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clinically proven results: dermatological tests reveal remarkable effectiveness in reducing wrinkles and improving skin comfort and appearance;
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a healthy, velvety composition: vegan, fragrance-free and 98% natural origin, this anti-wrinkle product offers a light, silky texture that is quickly absorbed, without leaving a sticky residue.
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Formulated with the best anti-ageing ingredients:
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RejuveNAD™, young sunflower shoot extract
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Ameliox™, liposomal carnosine and silymarin
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Alpine Rose Active
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Resveratrol
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Hyaluronic acid
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Niacinamide
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| Ingredients: |
| Aqua (Water), Isoamyl Laurate, Dicaprylyl Ether, C10-18 Triglycerides, Glycerin, Glyceryl Stearate Citrate, Glyceryl Dibehenate, Cetearyl Alcohol, Pentylene Glycol, Maltodextrin, Tribehenin, Butylene Glycol, Niacinamide, Hydrolyzed Hyaluronic Acid, Resveratrol, Carnosine, Tocopherol, Rhododendron Ferrugineum Extract, Helianthus Annuus (Sunflower) Sprout Extract, Silybum Marianum Fruit Extract, Glycine Soja (Soybean) Oil, Lecithin, Cellulose Gum, Microcrystalline Cellulose, Sodium Stearoyl Glutamate, Xanthan Gum, Glyceryl Behenate, Alcohol, Lactic Acid, Dehydroacetic Acid, Benzyl Alcohol.
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98% natural origin. Fragrance-free. Vegan.
Tolerance tested under dermatological control.
RejuveNAD™ and Ameliox™ are registered trademarks of Mibelle.
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apply to clean, dry skin on the face morning and evening.
- Mibelle Biochemistry. “Boosting NAD⁺ Levels for Skin Longevity – RejuveNAD™.” Technical Brochure, 2023. Data on file.
- In vivo Rejuvenation Study. Mibelle Biochemistry, internal clinical study, 2023. Data on file.
- Marques C, Hadjab F, Porcello A, Lourenço K, Scaletta C, Abdel-Sayed P, Hirt-Burri N, Applegate LA, Laurent A. Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products. Antioxidants (Basel). 2024 Mar 30;13(4):425. doi: 10.3390/antiox13040425. PMID: 38671873; PMCID: PMC11047333.
- In vitro study on dermal human fibroblasts with stress-induced senescence treated with Alpine Rose Active™. Mibelle Biochemistry, internal study, 2022. Data on file.
- In vivo study on 12 volunteers aged 40–52 years for 14 days (UVA-induced stress). Alpine Rose Active™. Mibelle Biochemistry, internal study, 2022. Data on file.
- Mibelle Biochemistry. “Alpine Rose Active – Protecting Skin Proteins against Aging.” Technical Brochure, 2022. Data on file.
- In vivo study on 20 women aged 38–65 years for 28 days. Ameliox™. Mibelle Biochemistry, internal clinical study, 2006. Data on file.
- Leis K, Pisanko K, Jundziłł A, Mazur E, Mêcińska-Jundziłł K, Witmanowski H. Resveratrol as a factor preventing skin aging and affecting its regeneration. Postepy Dermatol Alergol. 2022 Jun;39(3):439-445. doi: 10.5114/ada.2022.117547. Epub 2022 Jul 15. PMID: 35950117; PMCID: PMC9326919.
- Bravo B, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol Ther. 2022 Dec;35(12):e15903. doi: 10.1111/dth.15903. Epub 2022 Oct 21. PMID: 36200921; PMCID: PMC10078143.