Many scientists are looking to halt age-related cognitive decline. The COSMOS study looked at the impact of multivitamin and mineral supplementation on cognition. Find out more about the results of this large-scale study.
The COSMOS (COcoa Supplement and Multivitamin Outcomes Study) is a randomised, double-blind, placebo-controlled clinical trial involving 21,442 adults, published in March 2024 in The American Journal of Clinical Nutrition.
This large-scale study examines the effect of cocoa flavanol supplements and multivitamin supplements on several aspects of the health of older adults, including cardiovascular disease, cancer and cognitive function (1).
Within this vast COSMOS study, a meta-analysis combined the results of three sub-studies called COSMOS-Clinic, COSMOS-Mind and COSMOS-Web, which evaluated the effects of multivitamins on cognition.
The COSMOS-Clinic sub-study was conducted on 573 people aged over 60.
It observed certain benefits in people taking a multivitamin supplement compared with those taking a placebo, in terms of overall cognition.
According to this sub-study, the difference proved to be particularly significant in terms of episodic memory, which refers to the ability to remember past events by linking them to their context.
The meta-analysis of the various sub-studies also showed clear evidence of these same benefits in the context of daily multivitamin and mineral supplementation over 2 years.
The tests carried out determined that the difference observed in overall cognition would be equivalent to a reduction in cognitive ageing of around 2 years.
The results of the COSMOS study therefore confirm the benefits of this type of supplementation in preventing cognitive decline in the elderly.
Vitamins and minerals are known to play an essential role in maintaining numerous physiological functions, including cognitive health (2).
More specifically, the nutrients that play a decisive role in cognitive function are:
Age-related cognitive decline is the result of a number of factors, including oxidative stress, inflammation, reduced neurotransmitters, reduced cerebral blood flow, loss of synaptic plasticity, accumulation of toxic proteins, and so on.
Vitamins and minerals in the diet help to combat this phenomenon.
However, ageing is generally accompanied by a reduction in the intestinal absorption of nutrients, or even less effective cellular utilisation, which may require higher intakes of vitamins and minerals, particularly through supplementation.
The high vitamin and mineral intake provided by a quality food supplement (such as Daily 3®) helps to compensate for the deficiencies caused by ageing.
This helps to reduce oxidative stress, modulate inflammation, support cellular energy and protect neurons, thereby helping to preserve cognitive functions such as memory.
Some multivitamins may contain other nutrients of interest for brain health, in particular antioxidant compounds - in addition to vitamin B2, vitamin C, zinc and selenium, which are themselves antioxidants.
Examples of antioxidants include anthocyanidins in bilberry extract, proanthocyanidins in pine bark extract, polyphenols in green tea or grape seed extracts, oleuropein in olive extract, etc. (all these phytonutrients are found in Daily 3® multivitamin, in addition to the vitamins and minerals mentioned above) (3).
Some multivitamins even supplement this arsenal with valuable compounds such as:
So, for more complete coverage of your needs, you should ideally turn to multivitamin formulas that include not only the targeted vitamins and minerals, but also antioxidant compounds and/or compounds of interest for cognition and general health (this is true of our flagship multivitamin Daily 3®, the most complete and highest dose on the market).
References
Keywords
71 Days
Como siempre estáis siempre ofreciendo alternativas naturales a los diversos problemas de Salud con un buen despliegue de información y una variada gama de productos. Y os felicito por el servicio de entrega que hacéis ahora que supera con creces el de antes.
Mariano Navarro Sanchez
71 Days
produits innovants, avec une composition claire
véronique de sainte marie
71 Days
Ravie et Très Satisfaite de Ma Commande et de Mes Commandes Très Bons Produits
Brigitte D.
71 Days
Produits fiables
jacqueline
71 Days
Tout est OK 👌
RICHARD Bertrand
71 Days
Bestelle das Produkt seit Jahren immer wieder ist echt super, Preis Leistung ist ok könnte noch ein bisschen billiger sein aber sonst ok
SONJA Hofbauer
71 Days
Excellent services
DIDDY Mohamed
72 Days
Livraison rapide
devouass
72 Days
Schnelle Lieferung. Gute Begleitung der Lieferung
SCHARWAECHTER Hans Juergen
72 Days
J’ai commencé à prendre les facteurs de croissance osseuse alors que j’étais en plein accès douloureux d’ostéoporose. Mon état s’est stabilisé en quelques jours puis les douleurs ont diminué régulièrement. Je pense continuer ce remède pendant quelques mois puis 1 gélule par jour et une pause etc..
Françoise Delfour
72 Days
Rapidité de livraison avec prestataire fiable ! Toujours impeccable.
Virginie
72 Days
Siempre buenas experiencias y cada vez más rápidos los envíos
Elsje Fokkelman
72 Days
Livraison rapide et en parfait état. Jamais d'erreur.
WUILLEMIN Sylvie
72 Days
J'ai trouvé rapidement sur le site le complément qui m'était nécessaire et la livraison a été très rapide. Merci.
Client
72 Days
Facilité pour passer les commandes. Délais de livraison tenus. Produits de qualité. Je suis cliente depuis longtemps et très satisfaite.
Alexandre PUBERT