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NAD+ Booster Formula
Dietary supplement supporting NAD+, the pillar of cellular longevity
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NAD+ Booster Formula is a dietary supplement that combines the 3 most effective nutrients associated with the production of NAD+, a coenzyme essential to cellular vitality and longevity.
It has been designed to support people who want to maintain their NAD+ levels, which start to decline from their thirties and may fall by as much as 20% by their sixties.
This innovative product is listed in our longevity category.
Composition and benefits of our NAD+ 'booster' food supplement
Role of NAD+ in cell energy and longevity
Nicotinamide adenine dinucleotide (NAD) is a coenzyme present in all the body's cells.
In its oxidised form, called NAD+, it is known to:
- participate in the production of ATP, the main source of energy for cells, by transferring electrons during cellular respiration;
- activate sirtuins, enzymes involved in cell longevity;
- be essential for PARP enzymes, which repair DNA (1-2).
With age and oxidative stress, the activity of sirtuins and PARP increases to repair cells, while the level of the CD38 enzyme, which degrades NAD+, rises sharply.
This process reduces NAD+ levels.
When NAD+ is insufficient, and energy production (ATP) remains the priority, sirtuins and PARP enzymes function at a slower pace, accelerating cellular senescence and ageing (3-6).
Benefits of the 3 ingredients in NAD+ Booster Formula
Our exceptional supplement contains a trio of ingredients studied for their link with NAD+ production:
- nicotinamide riboside (NR): NR is a form of vitamin B3 (niacin) that contributes to normal energy metabolism, fatigue reduction and normal nervous system function. Nicotinamide riboside is reputed to be one of the most effective precursors of NAD. In addition to being particularly bioavailable, it disperses minimally into other metabolic pathways, unlike simple nicotinamide. More specifically, our supplement uses nicotinamide riboside chloride, the most stable and pure form of NR. Numerous studies suggest that consumption of nicotinamide riboside increases NAD levels in various tissues (7-18);
- Apigenin: apigenin is a flavonoid naturally present in certain plants, such as parsley, oregano and tea. Here, it comes from a celery leaf extract standardised to 42% apigenin. Several studies have found that this compound could inhibit the activity of CD38, the enzyme primarily responsible for breaking down NAD+ (19-20);
- BluNAD Booster™, a proprietary botanical blend of pomegranate fruit rind extract (Punica granatum) and tagetes flower extract (Tagetes erecta): this innovative botanical combination was the subject of a randomised, double-blind, placebo-controlled clinical study conducted on 140 subjects for 60 days at 1,000 mg/day. The study revealed the possible efficacy of the compound in neutralising CD38 activity (-18%) and increasing NAD+ levels (+26.3%). BluNAD Booster™ is even more effective at increasing NAD+ levels than NR or other precursors taken alone. Its combination with NR (500 mg/per day of BluNAD Booster™ and 500 mg/per day of NR) has also been judged to be the most promising synergy for increasing the amount of NAD+ in the body (+31.4%) (21).
4 strong points of the pro-longevity NAD+ Booster Formula
NAD+ Booster Formula has 4 key strengths:
- an exclusive synergy: our formula is the only one to combine these 3 super-powerful ingredients, extensively studied in the field of cellular energy and longevity, with NR, celery apigenin and the innovative BluNAD Booster™ blend;
- an exceptional dose of nicotinamide riboside: we have increased the dose of nicotinamide riboside chloride to 300 mg per day to guarantee optimal effects;
- a cutting-edge compound that has been the subject of clinical studies: the particularly innovative BluNAD Booster™ brand ingredient has had its properties clinically tested, with remarkable results;
- vegetable capsules with natural excipients: the vegan capsules used are made from hypromellose (HPMC), a compound derived from cellulose, and contain acacia gum, a vegetable ingredient, as their sole excipient.
What is in NAD+ Booster Formula
Any questions?
NAD+ is a molecule that occurs naturally in cells and is not found directly in food.
However, its levels can be increased by providing precursors that the body converts into NAD+ via:
- foods rich in vitamin B3 (niacin & nicotinamide): lean meat, salmon, tuna, poultry, mushrooms, peanuts, etc.;
- foods rich in tryptophan, an indirect precursor: eggs, milk, turkey and other poultry, pumpkin seeds, etc.;
- oral supplements providing higher intakes: niacin, nicotinamide or nicotinamide riboside (NR) capsules.
We also recommend that you optimise your lifestyle to stimulate endogenous production, with regular physical activity, moderate calorie restriction and good sleeping habits.
It is not recommended to supplement directly with NAD+, as it is a bulky molecule that does not easily pass into the bloodstream and is therefore poorly assimilated.
On the other hand, its direct precursors (nicotinamide riboside, for example) are much more easily absorbed and converted into NAD+ by the body, with bioavailability demonstrated by several studies.
It should be noted that some people also inject NAD+ intravenously, but this remains a more marginal practice, the effects of which are still poorly documented by research.
NAD, or more precisely its precursors such as NR, is generally extremely well tolerated (22).
The possible side effects sometimes mentioned (digestive problems, redness, temporary tiredness, etc.) are temporary, mild and very rare.
Precursors of nicotinamide adenine dinucleotide, such as NR, can be taken both in the morning and later in the day.
Due to the complete composition of our formula, we recommend taking our NAD+ Booster Formula product with meals (3 capsules a day, for example, one capsule at breakfast, one at lunch and one at dinner).
In addition to taking NAD+ Booster Formula, you can also support the health of your mitochondria, your cellular energy reserves. For example, consider urolithin A, a metabolite studied for its potential capacity to support mitophagy, or mitochondrial recycling (see Urolithin A). You can also combine it with a dedicated complete formula rich in PQQ (such as Mitochondrial Formula).
And don't overlook the power of 'senolytics', compounds tested for their ability to eliminate senescent cells, the 'zombie' cells that accumulate in the body, increasing inflammation and accelerating ageing and the onset of chronic disorders. One of the most prominent potential natural senolytics is called fisetin, a flavonoid found in small quantities in strawberries and onions (see Fisetin). There are also synergistic formulas that combine fisetin, quercetin, bromelain, etc. (such as Senolytic Complex).
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