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What’s the difference between vitamin D2 and vitamin D3?

Are you wondering what the difference is between vitamins D2 and D3? And which of them is better? Supersmart has the answers.
Vitamin D softgels
Vitamin D capsules
Rédaction Supersmart.
2020-06-02Comments (0)

There are two forms of vitamin D in the body – D2 and D3: their empirical chemical formulae differ by a single carbon atom. We get them from different sources: D2 is found primarily in plant-based foods, while D3 is obtained from animal-origin foods, and is also produced when our skin is exposed to the sun’s rays.

What are vitamin D3’s characteristics?

Vitamin D3, or cholecalciferol, is synthesised from a sterol (complex lipid) called 7-dehydrocholesterol, naturally present in the body. When this sterol is exposed to the sun’s UVB rays, it is converted into vitamin D. Most of the vitamin D circulating in the body is produced in this way (1). That’s why we’re advised to expose our skin as much as possible to natural light. Vitamin D3 is also obtained from the diet, in particular from oily fish and egg yolk.

What are vitamin D2’s characteristics?

Vitamin D2, or ergocalciferol, is a derivative of ergosterol, a sterol naturally present in the cell membranes of certain plants and fungi. Vitamin D2 is obtained by exposing ergosterol to the sun’s UVB rays. It is found in mushrooms (especially those exposed to UVB rays) as well as in vitamin D-fortified foods like margarine.

Which form of vitamin D should I choose?

Vitamins D2 and D3 are both metabolised in the liver into calcifediol and then converted in the kidneys into calcitriol, the active and usable form of vitamin D (2). However, research has shown that vitamin D3 increases the level of calcitriol in the body to a greater degree (3). It is also less sensitive to heat and humidity than D2 and thus more stable (4).

As a consequence, if you wish to take a vitamin D supplement, vitamin D3 is the better choice. You have three options to choose from:


  1. Thomas Ernandez, Catherine Stoermann-Chopard : Vitamine D et insuffisance rénale chronique : regain d’intérêt pour une vitamine oubliée. Rev Med Suisse. 2012, Vol. 8, pp 2140-2145.
  2. Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppönen, Jacqueline Berry, Reinhold Vieth, and Susan Lanham-New : Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012, Vol. 95(6), pp 1357–1364.
  3. Glendenning P, Chew GT, Inderjeeth CA, Taranto M, Fraser WD : Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol. Bone. 2013, Vol. 56(2), pp 271-5. 
  4. Lisa A Houghton, Reinhold Vieth : The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006, Vol. 84(4), pp 694–697. 


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