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Alcohol Detox Supplement
Alcohol Detox Supplement
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Alcohol Detox
Liver and detoxification
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Description
The cutting-edge formulation for beating a hangover and other harmful effects of alcohol
  • Rich in standardized extracts of milk thistle and Picrorhiza kurroa, with hepatoprotective properties.
  • Contains the cells’ favourite sulphur derivatives (N-acetyl-cysteine, sodium R-lipoate…).
  • Contains thiamine, which supports normal nervous system function.
  • Contains vitamin C, deficiency in which is common in cases of chronic alcohol consumption.
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Hangover man in bed, with hands on his head

Alcohol Detox Supplement - Innovative Formula to Restore Liver Health

Alcohol Detox is a dietary supplement combining the best active substances for reducing the adverse effects of excessive alcohol consumption. Containing plant extracts targeted at liver health, it also provides vitamins, the uptake of which can be impaired by metabolising ethanol. Its synergistic formulation also acts at a cellular level to support the processes of detoxification.

What is in Alcohol Detox, the perfect supplement for alcohol-fuelled evenings and that ‘morning after misery’?

The anti-hangover supplement Alcohol Detox brings together exceptional active principles to help the body recover following heavy alcohol consumption :

  • N-acetyl-cysteine (NAC). This derivative of the amino acid cysteine is attracting considerable scientific interest due to its direct link with glutathione synthesis and its effect on levels of acetaldehyde (1-2) ;
  • vitamin C. This helps protect cells against the oxidative stress triggered by drinking alcohol. Some studies also point to a link between significant alcohol consumption (> 80g a day) and the development of scurvy (3) ;
  • sodium R-lipoate. A sodium salt of alpha-lipoic acid, an important sulphur-containing compound, it appears to play a key role in recycling glutathione (4) ;
  • thiamine. This water-soluble form of vitamin B1 helps maintain normal energy metabolism and nervous system function (5). It is combined here with benfotiamine, a fat-soluble derivative of thiamine, for enhanced efficacy (6) ;
  • asparagine. A study conducted with control groups suggests a plausible link between decreased serum levels of asparagine, a proteinogenic amino acid, and subsequent diagnosis of an alcohol-related disease (7) ;
  • extract of milk thistle (Silybum marianum), standardised to 80% silymarin. A plant originating from the Mediterranean region, milk thistle was much-prized by the Greeks for relieving liver problems. Helping to maintain normal liver function, it seems to exert a regenerating and protective effect on hepatocytes via its main active principle, silymarin (8) ;
  • extract of kutki (Picrorhiza kurroa). A plant that grows at high altitudes on Himalayan mountainsides, it is similar to Indian gentian in Ayurvedic medicine. Its root promotes normal liver function, offering remarkable hepatoprotective activity (9) ;
  • extract of kudzu (Pueraria lobata). The adaptogenic properties of this climbing vine are attracting scientific interest, with one study showing promising prospects in its examination of the plant’s effects on dependency in heavy drinkers (10).

Note: the supplement Alcohol Detox is not designed to reduce blood ethanol levels.

How is ethanol eliminated from the body?

With the chemical formula C2H5OH, ethanol (or ethyl alcohol) is the psychotropic molecule common to all alcoholic drinks. Partially captured by the stomach, its reabsorption takes place primarily in the gut. It then reaches the liver, via the portal vein, where it is degraded (up to 80%).

Alcohol metabolism involves three major enzymes: alcohol dehydrogenase (ADH), cytochrome P450 and catalase. These are responsible for converting ethanol into acetaldehyde, which is itself converted into acetate by a fourth enzyme, aldehyde dehydrogenase (ALDH). These mechanisms remain largely effective depending on age, weight, ethnicity and medication.

What are the consequences of excessive alcohol consumption on the liver and brain?

Excessive alcohol consumption usually results in a series of short-lived but unpleasant symptoms: headache, intense thirst, fatigue, nausea, dizziness, intolerance to light or noise, irritability ... collectively known as a hangover (11). These variable symptoms peak when blood alcohol levels fall to zero, and can persist for 24 hours. Though often made light of, they should be taken seriously as they are likely to compromise alertness, decision-making or physical coordination.

Repeated consumption of alcohol disrupts fat and sugar metabolism. This manifests in excess triglycerides in liver tissues, causing a condition known as steatosis. What’s more, the accumulation of acetaldehyde leads to free radical generation and protein glycation, while at the same time impeding the production of glutathione, a cell-protective tripeptide. It thus creates an environment conducive to chronic inflammation of the liver and digestive tract (12-13).

Ethanol damage also affects the central nervous system, particularly the frontal cortex (inhibition, self-control, etc.), the hippocampus (memory), the cerebellum (balance) and the brainstem medulla (autonomic functions such as heart rate, blood pressure …) (14). This explains the wide range of physical and behavioural symptoms experienced after a night of heavy drinking.

What effect does alcohol have on vitamin absorption?

Excessive alcohol intake also increases the risk of vitamin deficiency, with several studies suggesting this is particularly the case for vitamins A, B1, B9 and C (15).

While the mechanisms at work here are not yet clear, a number of theories have been suggested:

  • a change in the absorption, storage or metabolism of vitamins;
  • theft of the vitamins’ by the alcohol itself, to satisfy its own, or induced, metabolic reactions;
  • replacement of all or part of the daily calorie intake by the ‘empty’ calories of alcohol (remember that 1g of ethanol = 7 kcal).

How do you ‘cure’ a hangover?

While the relative merits of traditional hangover remedies are the subject of debate, few have actually demonstrated genuine efficacy. Time remains the best healer in enabling the body to break down the ethanol and eliminate its harmful by-products.

There are, however, a few steps you can take to prevent your symptoms from getting worse:

  • stay well-hydrated. Alcohol inhibits vasopressin, the hormone governing fluid retention in the kidneys (16), and thus increases urination. To prevent dehydration, you should regularly drink plain water, as well as broth or vegetable juices rich in mineral salts to maintain a good electrolyte balance;;
  • go easy on the paracetamol. Interactions between alcohol and paracetamol are particularly complex and are the subject of much scientific debate. However, severe cases of hepatotoxicity have been reported in alcoholics, making the case for exercising caution (17-18). As for analgesics based on aspirin or ibuprofen, they are likely to irritate an already weakened gastric mucosa.
  • eat light. To detoxify, rather than overload the liver, choose easily-digestible foods such as poached eggs, lean fish or steamed vegetables. Remineralising foods, such as bananas or honey, can also provide a welcome ‘shot in the arm’ (19). Avoid citrus fruits, however, as they can aggravate heartburn.

Which other supplements can be combined with Alcohol Detox?

To help ease a hangover and get you back on your feet after a night of excess, you could also try:

  • Dihydromyricetin, a natural supplement containing dihydromyricetin, the no. 1 flavonoid for ‘the morning after the night before’ (20) ;
  • LIV 52®, a concentrate of 8 detoxifying Ayurvedic plants supported by 180 clinical studies.
Composition
Daily dose : 1 capsule
Number of doses per box : 120
Amount per dose
N-acetyl-cysteine 125 mg
Ascorbic acid 125 mg
Sodium R-lipoate 50 mg
Thiamine HCl 50 mg
Asparagine 50 mg
Milk thistle 80 % silymarin 50 mg
Picrorhiza kurroa 4 % Kutkin 50 mg
Kudzu 40 % isoflavones 50 mg
Benfotiamine 25 mg
Other ingredients:Acacia gum, rice flour.
Directions for use
adults. Take one capsule with each glass of alcohol.
Attention : Alcohol Detox will not prevent you from getting drunk nor affect your blood alcohol levels. However, Alcohol Detox can significantly reduce alcohol’s harmful effects: hangover, malnutrition, oxidative stress, liver and brain toxicity.
4.5
4.4 /5 5 reviews
Description
5
5.0 / 5
Quality
5
5.0 / 5
Value for money
4
3.6 / 5

Reviews 5
Excellent
60 %
Great
20%
Average
20%
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0%
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MESSADI Samir
5
Réduit réellement les effets désastreuses de la consommation excèssive d'alcool..

Christian Chevalier
3
Produit vraiment très cher. Une alternative moins sophistiquée mais quand même efficace serait la bienvenue
VLIEGHE Emmanuelle
5
Product beantwoordt totaal aan verwachtingen,
GOREUX Anne
5
Cela me convient
GOREUX Anne
4
comme je bois de l'alcool je le prends !
References
  1. Šalamon Š, Kramar B, Marolt TP, Poljšak B, Milisav I. Medical and Dietary Uses of N-Acetylcysteine. Antioxidants (Basel). 2019;8(5):111. Published 2019 Apr 28. doi:10.3390/antiox8050111
  2. Vasdev S, Mian T, Longerich L, Prabhakaran V, Parai S. N-acetyl cysteine attenuates ethanol induced hypertension in rats. Artery. 1995;21(6):312-6. PMID: 8833231.
  3. Lim DJ, Sharma Y, Thompson CH. Vitamin C and alcohol: a call to action. BMJ Nutr Prev Health. 2018;1(1):17-22. Published 2018 Dec 5. doi:10.1136/bmjnph-2018-000010
  4. Pirlich M, Kiok K, Sandig G, Lochs H, Grune T. Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells. Neurosci Lett. 2002 Aug 9;328(2):93-6. doi: 10.1016/s0304-3940(02)00415-9. PMID: 12133563.
  5. Langlais PJ. Alcohol-Related Thiamine Deficiency: Impact on Cognitive and Memory Functioning. Alcohol Health Res World. 1995;19(2):113-121.
  6. Manzardo AM, He J, Poje A, Penick EC, Campbell J, Butler MG. Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug Alcohol Depend. 2013;133(2):562-570. doi:10.1016/j.drugalcdep.2013.07.035
  7. Kärkkäinen O, Klåvus A, Voutilainen A, Virtanen J, Lehtonen M, Auriola S, Kauhanen J, Rysä J. Changes in Circulating Metabolome Precede Alcohol-Related Diseases in Middle-Aged Men: A Prospective Population-Based Study With a 30-Year Follow-Up. Alcohol Clin Exp Res. 2020 Dec;44(12):2457-2467. doi: 10.1111/acer.14485. Epub 2020 Nov 2. PMID: 33067815.
  8. Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y
  9. Rastogi R, Saksena S, Garg NK, Kapoor NK, Agarwal DP, Dhawan BN. Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Med. 1996 Jun;62(3):283-5. doi: 10.1055/s-2006-957882. PMID: 8693047.
  10. Penetar DM, Toto LH, Lee DY, Lukas SE. A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm. Drug Alcohol Depend. 2015;153:194-200. doi:10.1016/j.drugalcdep.2015.05.025
  11. Swift R, Davidson D. Alcohol hangover: mechanisms and mediators. Alcohol Health Res World. 1998;22(1):54-60.
  12. Patel R, Mueller M. Alcoholic Liver Disease. [Updated 2022 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546632/
  13. Lieber CS. Metabolic effects of acetaldehyde. Biochem Soc Trans. 1988 Jun;16(3):241-7. doi: 10.1042/bst0160241. PMID: 3181606.
  14. Nutt D, Hayes A, Fonville L, et al. Alcohol and the Brain. Nutrients. 2021;13(11):3938. Published 2021 Nov 4. doi:10.3390/nu13113938
  15. Hoyumpa AM. Mechanisms of vitamin deficiencies in alcoholism. Alcohol Clin Exp Res. 1986 Dec;10(6):573-81. doi: 10.1111/j.1530-0277.1986.tb05147.x. PMID: 3544907.
  16. Madeira MD, Sousa N, Lieberman AR, Paula-Barbosa MM. Effects of chronic alcohol consumption and of dehydration on the supraoptic nucleus of adult male and female rats. Neuroscience. 1993 Oct;56(3):657-72. doi: 10.1016/0306-4522(93)90363-k. PMID: 8255426.
  17. Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol. 2000;49(4):291-301. doi:10.1046/j.1365-2125.2000.00167.x
  18. Mofredj A, Cadranel JF, Darchy B, Barbare JC, Cazier A, Pras V, Biour M. Toxicité hépatique du paracétamol à dose thérapeutique chez le sujet éthylique chronique. A propos de 2 cas d'hépatite mortelle chez des patients cirrhotiques [Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis]. Ann Med Interne (Paris). 1999 Oct;150(6):507-11. French. PMID: 10615538.
  19. Shi, Peiying et al. “Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models.” BMC complementary and alternative medicine vol. 15 225. 14 Jul. 2015, doi:10.1186/s12906-015-0766-5
  20. Shen Y, Lindemeyer AK, Gonzalez C, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390-401. doi:10.1523/JNEUROSCI.4639-11.2012

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