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Welcome Shop by health concern Care of joints, bones and muscles Bone Health + Vitamin D3 5000
Bone Health + Vitamin D3 5000
Bone Health + Vitamin D3 5000
Care of joints, bones and muscles
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Vitamin D3 5000 IU
Vitamin D3 5000 IU is a bioavailable form of vitamin D for optimal absorption.
  • Corrects widespread deficiency in vitamin D.
  • Promotes good cardiovascular health.
  • Strengthens bones, optimising of bone health.
Bone Health
Bone Health is a 100% natural formulation for rebalancing bone modelling and preventing bone loss.
  • Helps maintain the structural integrity and biomechanical quality of bones.
  • Supports the bone formation phase and helps reduce the resorption phase.
  • Helps balance bone metabolism.
  • Contains natural ingredients (phytoestrogens) that mimic the action of oestrogens.
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Person with inflammed knee and pink flower in the background

Bone Health is a 100% natural supplement aimed at strengthening the bones. It contains four plant extracts in vegetarian capsules, traditionally used for their benefits in combatting bone loss: Astragalus membranaceus root, Cuscuta chinensis seeds, Eucommia ulmoides leaves and Rehmannia glutinosa root standardised to 2% flavonoids.

Research has shown that these four plants naturally help reduce the activity of osteoclasts (the bone resorption phase) and support that of osteoblasts (the bone formation phase).

Bone Health is the perfect complement to the bone function formulation Super Bone formula, which contains vitamins and minerals.

Who is Bone Health aimed at?

Bone Health is recommended for the following groups of people:

  • Those aged over 40 (bone mass starts to decline by 1%-2% a year at this age).
  • Menopausal women (during the post-menopause decade, bone loss speeds up by 2%-3% a year due to the fall in oestrogen production).
  • Those with a family history of osteoporosis-related fractures.
  • Women who do little or no exercise.
  • Those suffering from inflammatory bowel disease (Crohn’s).

What’s the reason for this bone loss?

Primarily linked to ageing, osteoporosis is a natural process characterised by a decrease in bone mass and bone density. It makes bones more ‘porous’ and vulnerable to fractures from even simple falls. As bone loss does not normally produce any symptoms prior to a fracture, it is known as ‘the silent disease’. But why does this bone loss occur?

Our bones undergo constant remodelling throughout life via a two-fold process:

  • A resorption phase during which specialised cells called ‘osteoclasts’ eat away at existing bone structures. This leads to the development of holes in the bones (called Howship lacunae).
  • A new formation phase during which other specialised cells called ‘osteoblasts’ make new bone structures to compensate for the ‘holes’ and restore bones to a healthy state. Minerals then accumulate in the new matrix to optimise the bones’ mechanical resistance.

This dual process allows the body to be in constant harmony with its environment. In this way, damaged bones are quickly rebuilt and the body is even able to make stronger bones if environmental factors change (such as when we engage in a new physical activity). However, it’s important that this two-fold process remains in balance: if the resorption phase gains the upper hand, the ‘holes’ are never filled in and bones become dangerously fragile. This is exactly what happens in osteoporosis.

A number of factors affect the balance of this bone remodelling (1):

  • Sex hormones. Oestrogens are the main regulators of bone tissue remodelling. They target osteoblasts and are powerful inhibitors of bone resorption by osteoclasts. The fall in oestrogen caused by the menopause leads to an enduring imbalance in bone renewal: gains start to be outweighed by losses and osteoporosis develops rapidly.
  • Mechanical constraints. Bones are able to adapt according to the level of physical restraint to which they’re subjected. When you suddenly stop exercising, following an injury for example, physical stimulation stops, which increases the resorption phase and reduces the rebuilding phase. Physical inactivity is therefore a cause of osteoporosis over the long term.
  • Bone Morphogenetic Proteins (BMPs). These are proteins which promote the bone formation phase.
  • Insulin Growth Factors (IGFs). These stimulate osteoblast activity.
  • Transforming Growth Factor (TGF). This is a group of messengers that significantly influence the two phases of bone remodelling.
  • Vitamin D. This vitamin plays an essential role in bone renewal: it stimulates intestinal absorption of calcium and phosphate (which are used to mineralise new bones) and inhibits parathormone, a protein that stimulates bone resorption.

What does the supplement Bone Health contain? What makes it so good for supporting bone remodelling?

Bone Health contains a blend of four plant extracts traditionally used for combatting bone loss.

Eucommia ulmoidesleaves

This is one of the most commonly prescribed natural treatments in China for treating osteoporosis (2-3). According to the theory of traditional Chinese medicine, Eucommia ulmoides (which is also called Du-Zhong in Asia) optimises the health of the kidneys which nourish and support bone tissue.

While modern science has demonstrated the anti-osteoporosis properties of Eucommia ulmoides, the mechanism of action is not yet clear. Several studies have shown that the plant’s non-steroidal polyphenolic lignans (4) behave in the same way as oestrogens. These ‘phytoestrogens’ may also bind to ‘oestrogen receptor alpha’ (5-7), potentially upregulating the activity of a number of genes central to osteoblast function (8).

It is this mechanism which may explain their ability to stimulate the phase of bone formation by osteoblasts (9) and thus increase bone mineral density, without causing any side-effects (10).

Astragalus root

Astragalus is well-known for its adaptogen properties but this traditionally used plant has other strings to its bow. With a high content of flavonoids, particularly isoflavones (11), it has been used for thousands of years to counteract osteoporosis (12).

Research has shown that it acts on two factors involved in bone remodelling (13-14):

  • It increases levels of TGF-β1, a growth factor which actively supports bone formation. This factor enables the recruitment, differentiation and proliferation of osteoblasts necessary for bone formation (15-16).
  • It also reduces levels of TGF-α, another growth factor that plays an important role in bone resorption and strongly promotes bone destruction by osteoclasts. After the menopause, levels of TGF-β1 fall (17), contributing to the imbalance in bone remodelling.

Scientists believe that the isoflavones in Astragalus also interact with oestrogen receptors. Like oestrogens, they increase the absorption of calcium which is vital for bone remineralisation.

Cuscuta chinensis seeds.

Cuscuta chinensis is a parasitic plant that has been used in traditional medicine for thousands of years for supporting bone function. It is also known as Dodder and Tu-Si-Zi. Its mechanism of action appears to be very similar to that of Astragalus: Cuscuta chinensis also contains a number of flavonoids (18), the most active of which are kaempferol, quercetin, hyperoside, astragalin and lignans (19).

Studies show it supports osteoblast differentiation and proliferation while inhibiting osteoclast activity (20-21).

Extract of Rehmannia root

Rehmannia glutinosa is an edible plant commonly known as Dihuang, used for at least 3000 years in traditional medicine. Modern research has revealed the presence of numerous bioactive compounds including flavonoids and monoterpenoids (22). Catalpol appears to be the most effective of the monoterpenoids (23) for supporting bone function, though the precise mechanism has yet to be established.

Five good reasons to opt for Bone Health

  1. Most of the drugs used for treating osteoporosis (biphosphonates, calcitonin, oestrogens, fluoride, etc) cause problematic side-effects in the long term (osteonecrosis of the jaw, increased risk of certain cancers and several cardiovascular problems) (24-28). There is thus significant demand for natural products that are free from such side-effects.
  2. Recent research shows it’s no coincidence that these four plant extracts are traditionally used to support bone function. They are all rich in phytoestrogens, molecules that mimic oestrogen activity and thus control several factors involved in bone remodelling.
  3. This trademarked blend has been the subject of one in vitro and two in vivo studies. In all three cases, researchers observed a significant increase in biomarkers of bone formation as well as an improvement in resistance to fracture.
  4. Bone Health acts synergistically with vitamins and minerals scientifically recognised as beneficial for bone health. While these substances are the elements needed for bone remineralisation, Bone Health enables the body to choose the right specification and help implement it effectively.
  5. It contains only natural and safe texturing agents – rice flour and acacia fibre.

How and when should Bone Health be taken?

For significant long-term effects, supplementation should continue for a period of several months, at a dose of two capsules a day.

A number of additional measures can be taken:

  • Supplementation with vitamin D, with calcium, or with other relevant substances available to buy at Supersmart (orthosilicic acid, and BMPs…).
  • Frequent exposure to sunlight.
  • Reducing consumption of caffeinated drinks (as they encourage calcium loss and thus the bone resorption phase).
  • Taking up, or returning to, regular exercise (at an appropriate level for your physical condition).

The blend is very well-tolerated and is completely non-toxic.

Updated: February 2019.


This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

Buy Bone Health for bone remodelling benefits.

CompositionBone Health
Daily dose: 2 vegetarian capsules
Number of doses per pot: 30
Amount per dose
Osteosine™, a patented blend of extracts of Astragalus membranaceus root, Cuscuta chinensis seeds, Eucommia ulmoides leaves, Rehmannia glutinosa root standardised to 2% flavonoids. 250 mg
White rice flour, acacia gum.
Osteosine™, NuLIV science, USA
Directions for useBone Health
Adults. Take 2 capsules a day. Each capsule contains 125mg Osteosine™.
Light orange softgels

Vitamin D3 5000 IU is an exceptional supplement containing 5000IU of vitamin D3 (the most bioavailable form) per softgel. It is enriched with sunflower oil to maximise its absorption.

Daily or twice a week supplementation with Vitamin D3 5000 IU produces a rapid increase in circulating levels of the vitamin, as confirmed by blood tests, and has a positive effect on cardiovascular, endocrine, nervous system, immune and cognitive function.

Who is Vitamin D3 5000 IU aimed at?

The latest studies show that between the months of October and April, almost everyone (1-4) living at a high latitude has an inadequate level of vitamin D (5-6). March sees levels reach their lowest point (7-8).

Vitamin D3 5000 IU is thus aimed at anyone living in France, Italy, Germany, Spain, the Netherlands, Portugal, Poland, the UK, Canada and the United States throughout autumn and winter.

Vitamin D is produced by the body on exposure of the skin to the sun’s ultra-violet rays (UVB). However, in temperate regions of the Northern Hemisphere, the conditions are not conducive to this process, both because of the sun’s angle of elevation and the weather during these seasons, as well as urban lifestyles: at this time of year, we tend to stay indoors and cover ourselves up too much to maintain adequate vitamin D production. Peak production rapidly plummets from November onwards and reserves are quickly exhausted.

Vitamin D3 5000 IU can also be used in the spring and summer by many groups of people (40% of individuals have inadequate levels even during these periods):

  • Those with dark skin who live at high or middle latitudes, because they need more sun than a fair-skinned person to produce the same amount of vitamin D.
  • Those who are less mobile or who do not get much exposure to the sun.
  • Those who are overweight, because vitamin D produced from the sun’s rays is sequestered by the fatty layers under the skin.
  • Those over 50 (9), both due to less exposure to the sun (delicate skin) and less efficient conversion of vitamin D precursors into vitamin D in the superficial epithelial layers of the skin.
  • Those suffering from bone disease.
  • Those with malabsorption problems and inflammatory bowel disease because this makes absorbing fats more difficult.
  • Those following specific diets (excluding meat, fish, eggs or products fortified with vitamin D).
  • Those living in areas of high pollution, as CO2 absorbs UV rays.
  • Those who regularly use UVB-blocking sunscreens (with an SPF above 15) as these can prevent up to 99% of UVB from penetrating the skin.

For all these groups of people, Vitamin D3 5000IU is often the safest way of quickly increasing their levels of vitamin D and of maintaining them throughout the year, now available to buy at Supersmart.

What are the effects of too little vitamin D?

Vitamin D is not really a vitamin: it should actually be thought of as a hormone. It performs many functions in the body, the best-known of which are its key roles in the intestinal absorption and binding to bones of dietary calcium, in muscle function, in maintaining cognitive function, in supporting the immune system and in tissue cell renewal.

The effects of a lack of vitamin D may go unnoticed for years but in the long term, they can be serious: softening of bones (osteomalacia), osteoporosis, bone pain, muscle weakness, joint pain (particularly in the wrists, ankles and shoulders), migraines, increased risk of depression, insomnia, hair loss (10) …

Conversely, optimal vitamin D levels bring numerous benefits for our health:

  • Optimisation of bone health (11-13).
  • Reduced risk of cardiovascular disease and stroke (at doses of at least 600IU a day (14)).
  • A decrease in blood pressure (at doses of at least 2000IU a day (15)).
  • Improved blood cholesterol levels (at doses of at least 2000IU a day (16)).
  • Increased strength and muscular balance (at doses of at least 800- 1000 IU a day (17)).
  • Reduced risk of neurocognitive problems and auto-immune diseases.
  • Potential reduction in fibromyalgia pain (at doses of at least 2400 IU a day) (18).

What is the optimal intake for vitamin D?

There is still debate about which vitamin D blood levels produce benefits. The very latest evidence suggests that circulating levels in excess of 50 nmol/L, or even 75 nmol/L, may be optimal for overall health. Those below 30 nmol/L, on the other hand, are associated with adverse effects on health.

Achieving a blood concentration of 75 nmol/L often requires supplementation with at least 2000IU a day. In the same vein, taking 3000IU a day for eight weeks has been shown to result in a concentration of more than 75 nmol/L of 25(OH)D (19-20).

In 2010, more than 40 international scientists called for greater awareness among doctors of the importance of vitamin D in preventing osteoporosis and cardiovascular disease. They recommended that the entire Western population (living at middle latitudes) should supplement with 1000-2000IU, especially from October to March.

What about dietary intake?

There are very few sources of vitamin D in the diet. They are mainly restricted to animal-sourced fats, particularly those from oily fish, and fortified foods such as dairy products, and some vegetable oils and plant-based drinks.

According to the French SUVIMAX study, the diet may only provide an average of 136IU of vitamin D a day. It is thus the body’s endogenous production from UV-B which is primarily responsible for circulating levels.

How does Vitamin D3 5000 UI differ from other such supplements?

Vitamin D3 5000 UI is an exceptional supplement that you can choose to buy for at least three main advantages:

  1. It contains vitamin D3, which is more effective than the vitamin D2 form found in plant-sourced products (23). The two forms were long thought to be equivalent but recent trials have shown this is not the case.
  2. It offers a powerful dose of 5000IU per supplement. It is designed to be taken every day (in which case it’s best to check your 25-hydroxyvitamin D status), twice-weekly, or weekly. Several studies have confirmed supplementation with 1000-10,000IU a day to be effective (24-27).
  3. It comes in the form of softgels and contains sunflower oil to maximise the absorption of the vitamin D. Comparative studies have shown that this form is better absorbed than the dry form and that it produced a more significant increase in 25(OH)D levels.

Frequently asked questions from internet-users

How often should you take Vitamin D3 5000 IU?

As vitamin D is fat-soluble, the body is able to store it in fats when intake exceeds requirements.

In theory, therefore, you could take mega-doses of vitamin D (100,000-500,000IU) each month or even each year. However, it has been demonstrated that daily ingestion is closer to what our bodies naturally prefer. High doses of vitamin D are also linked with several adverse effects, such as an increased risk of falls and fractures, respiratory infections (28), and hypercalcaemia (too much calcium in the blood, producing symptoms such as constipation) as well as a fall in the natural production of melatonin (a mediator of sleep).

It’s, therefore, better to opt for a supplement like VitaminD3 5000IU which can be taken every day (5000IU a day), every other day (2500IU a day), twice a week (around 1400IU a day) or weekly (around 700IU a day).

I’ve spent a lot of time in the sun this summer. Could my vitamin D levels be high already?

No. Spending long periods in the sun will not increase your vitamin D levels beyond a certain limit. Excessive exposure to the sun degrades pre-vitamin D3 (which is converted into D3 in the skin) and vitamin D3 itself. Lengthy sun exposure over the summer will therefore not be enough to maintain adequate levels over the winter months.

Does ageing reduce the ability to produce vitamin D?

Those over 50 are still able to produce vitamin D from the sun’s rays but for several reasons, production is less effective, and levels of circulating vitamin D tend to be lower.

What effects does vitamin D have on cognitive problems?

Research has demonstrated the presence of vitamin D hormone receptors (VDRs) in neurons and glial cells in the hippocampus, hypothalamus, cortex and subcortex, all areas of the brain involved in cognitive function (29).
In binding to these receptors, vitamin D triggers mechanisms which protect against the processes involved in neurocognitive problems (30). Vitamin D also exerts an antiatrophic effect by controlling the production of neurotrophic agents such as Nerve Growth Factor (NGF) and Glial cell line-Derived Neurotrophic Factor (GDNF) (31).

These properties may explain why low vitamin D levels in older people have been associated with cognitive problems (32-33) and Alzheimer’s disease (34).

The cohort analysis InCHIANTI established a link between hypovitaminosis D and cognitive problems, and showed that elderly people lacking in vitamin D (< 25 nmol/L) had a significantly increased risk of overall cognitive decline compared to those with higher levels (> 75 nmol/L) (35). This finding has been confirmed by other prospective studies, particularly the analysis of the MrOS (36) and SOF (37) cohorts. One study even showed that taking in excess of 800IU of vitamin D a day reduced the risk of Alzheimer’s disease by a factor of 5 after 7 years (38).

Most elderly people are deficient in vitamin D but not all will develop Alzheimer’s disease. It is therefore unlikely that a lack of vitamin D is the only factor responsible for the onset of the disease and that supplementing with vitamin D alone will be enough to prevent it (42).

How should Vitamin D3 5000 IU be taken?

Vitamin D3 5000IU should be taken alongside the meal of the day with the highest fat content. Doing so will increase the supplementation’s efficacy by 30%-60%. Fats encourage bile secretion which increases the absorption of vitamin D.

You can check how effective Vitamin D 5000IU is by asking your doctor for a 25-hydroxyvitamin D test (40) before and after supplementation. It’s the best biomarker of vitamin D (41).

Updated: January 2019

CompositionVitamin D3 5000 IU
Daily dose : 1 softgel
Number of doses per box : 60
Amount per dose
Vitamin D3 5000 IU
Other ingredients : sunflower oil
Directions for useVitamin D3 5000 IU
adults. Take one softgel a day or as advised by your therapist.
Warning : At doses above 2000 IU a day, a 25-hydroxyl vitamin D analysis should be carried out. If you suffer from kidney disease, do not take vitamin D3 without consulting your therapist. Do not exceed 10,000 IU a day, all sources combined, without the advice of your therapist.

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Bone Health + Vitamin D3 5000
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(61.64 US$)
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