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Welcome Shop by health concern Heart and circulation Horse Chestnut Extract 250 mg
Horse Chestnut Extract 250 mg
Horse Chestnut Extract 250 mg Horse Chestnut Extract 250 mg
Horse Chestnut Extract 250 mg
Heart and circulation Customer reviews
18.00 €(20.03 US$) is available

Horse chestnut extract for improved leg comfort (higher quality)

  • 100% natural venotonic
  • Supports good circulation
  • Helps reduce leg circumference
  • Higher content of active principles (20% aescin compared with the normal 3-6 %)
60 Veg. Caps
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Horse chestnuts

Horse Chestnut Extract 250 mg

Who should take Horse Chestnut Extract?

Horse chestnut extract is for anyone who suffers, either regularly or occasionally, from the following symptoms:

  • the sensation of heavy legs;
  • pain in the legs or feet;
  • swollen calves or thighs (especially in the evening);
  • day or night cramps;
  • itching of the lower limbs;
  • frequent oedema;
  • pins and needles in the legs ;
  • recurrent tingling.

It’s estimated that 25% of women, and around 10-15 % of men are regularly affected by at least one of these symptoms.

What is horse chestnut?

The horse chestnut tree which bears the fruit originated in the Balkans (especially in Bulgaria and Albania) and is now found throughout Europe.

Traditionally, the whole seed was used (and sometimes even the leaves and bark), but since it was discovered that it contained an anticoagulant called aesculin, producers of natural extracts are required to remove this molecule.

However, Horse Chestnut Extract’s content of the active substance aescin has been increased as it is responsible for the supplement’s beneficial effects on the circulation . Our supplement also contains other active compounds responsible for its synergistic effect:

  • Flavonoids (particularly quercetol and kaempferol), which give the horse chestnut fruit its pigmentation (1).
  • Saponosides (the most active principles of which are aescin and b-aescin).
  • Tannins.
  • Coumarins.
  • Essential oils.
  • Proteins (globulin and hippocastanin).
  • Polysaccharides.

Horse chestnuts are often confused with chestnuts because they are morphologically very similar.

What is venous insufficiency?

Venous insufficiency is characterised by changes to the vein wall (leading to the development of varicose veins), hormonal fluctuations (resulting in increased elasticity of the vein wall) and dysfunctional valves.

It manifests in poor blood flow in the veins. It’s mainly the legs which are affected – they become heavy, painful and swollen as blood accumulates. It eventually leads to the permanent formation of unsightly varicosities: damaged veins that are blueish, twisted and prominent.

What are horse chestnut’s mechanisms of action in relation to blood flow?

The aescin it contains maintains the permeability and tone of the vein wall (venotonic effect) (2), which helps blood return to the heart, particularly in the superficial capillary vessels (3).

These effects are due to three distinct mechanisms:

  • Increasing levels of the energy molecule ATP (decreased levels of which are associated with venous insufficiency).
  • Reducing the activity of phospholipase A2, an enzyme which releases inflammatory mediators in blood vessels (4).
  • Also reducing adherence of neutrophils (immune cells which are immobilised and aggregate on the inner surface of blood vessels) and inhibiting the activity of an enzyme called hyaluronidase which breaks down capillary walls (5).

A number of studies have shown additional effects for aescin:

  • anti-inflammatory (activation of leukocytes).
  • antioxidant (increases in reduced glutathione) (6).
  • anti-haemorrhoidal

What does science have to say about horse chestnut?

The large number of trials conducted on horse chestnut in people with venous insufficiency include the following:

  • Neiss et al demonstrated alleviation of leg pain and oedema in individuals supplementing with 300mg of horse chestnut extract (7).
  • Lorh et al showed a decrease in leg volume with the same type of supplement (8).
  • Pilz et al obtained similar results (9).
  • Diehm et al showed aescin to have a similar effect to that of compression stockings (10).
  • Koch et al demonstrated positive effects for aescin and pycnogenol (a molecule found in French maritime pine bark) on venous insufficiency (11).

Frequently-asked questions

Are there any risks associated with taking horse chestnut?

Horse chestnuts are sometimes described as poisonous. This is because of a toxin called aesculoside which has been carefully removed from the supplement Horse Chestnut Extract.

Apart from this, the only other change is the increase in aescin, a thoroughly well-tolerated molecule.

What are other measures can be combined with horst chestnut supplementation?

If you suffer from circulation problems, particularly in the legs, it’s important to be aware of risk factors to avoid and positive steps to take to boost the action of venotonics:

Factors to avoid:

  • Wearing anything too tight on your legs or around the abdomen.
  • Sitting with your legs crossed.
  • Prolonged standing.
  • Excess abdominal weight.
  • Wearing unsuitable shoes (very high heels).
  • Very high temperatures.
  • Engaging in intense sports (such as volleyball, handball or football).

Measures to adopt:

  • Regularly stand on tiptoes.
  • Keep flexing your feet when sitting for prolonged periods.
  • Wear special orthopaedic insoles.
  • Take a cool shower at the end of the day, beginning at the ankles and moving up to the thighs).
  • Engage in regular, gentle exercise, such as walking, swimming or gymnastics.
  • Wear compression socks or stockings: they help stimulate venous return and prevent blood from pooling.
  • Eat a diet high in plant fibre (fruits and vegetables).

Can Horse Chestnut Extract be combined with any other supplements?

Horse Chestnut Extract combines well with other natural venotonics such as Lympathonic, a sweet clover extract with a high coumarin content, and VeinoMax, a natural formulation containing several plant extracts good for circulation problems.

How should Horse Chestnut Extract be taken?

A number of scientific studies show that the aescin in horse chestnut offers excellent bioavailability, particularly when the natural extract is taken outside of mealtimes.

It is therefore advisable to take Horse Chestnut Extract in the morning, and again in the evening before bed.

Updated: 30/05/2018


This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the directions for use, the recommended daily dose and the ‘use-by’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of reach of young children. Store in a cool, dry place.

Daily serving: 2 capsules
Number of servings per bottle : 30

per serving

Horse chestnut extract standardised to provide 20% escin 500 mg
Other ingredients: Acacia gum, rice bran.
Directions for use
Take one capsule morning and evening on an empty stomach.
  1. KAPUSTA I., JANDA B. & SZAJWAJ B. (2007) Flavonoids In Horse Chestnut (Aesculus hippocastanum) seeds and powdered waste water byproducts. J. Agric. Food Chem. 55 : 8485-90
  2. DUDEK-MAKUCH M., STUSZINSKA-SROKA E. Horse chestnut – efficacy and safety in chronic venous insufficiency : an overview. Revista Brasileira Revista de Farmacognosia 2015, 26 (1) : 9 p
  3. Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res. 2001 Sep;44(3):183-93.
  4. ARNOULD T., JANSSENS D., MICHIELS C. & REMACLE J. (1996) Effect of aescine on hypoxia-induced activation of human endothelial cells. Eur. J. Pharmacol. 315 : 227-33.
  5. FACINO R.M., CARINI M., STAPHANI R., ALDINI G. & SAIBENE L. (1995) Antielastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Arch. Pharmacol. 328 : 720-4.
  6. KUCUKKURT I., INCE S., KELES H., AKKOL E.-K, AVCI G., YESILADA E. & BACAK E. (2010) Beneficial effects of Aesculus hippocastanum L. seed extract on the body’s own antioxidant defense system on subacute administration. J. Ethnopharmacol. 129 : 18-22.
  7. Neiss A, Böhm C. [Demonstration of the effectiveness of the horse-chestnut-seed extract in the varicose syndrome complex]. MMW Munch Med Wochenschr. 1976 Feb 13;118(7):213-6.
  8. Lohr, E., Garanin, G., Jesau, P., Fischer, H., 1986. Ödempräventive Therapie bei chronischer Veneninsuffizienz mit Ödemneigung. Munchen. Med. Wochen. 128, 579-581.
  9. Pilz, E., 1990. Ödeme bei Venenerkrankungen. Med. Welt 41, 1143-1144.
  10. Diehm, C., Schmidt, C., 2001. Venostasin retard gegen Plazebo und Kompression bei Patienten mit CVI II/IIIA. Final Study Report. Klinge Pharma GmbH Munich, Germany. Reported in: Ottillinger B et al. BMC Cardiovasc. Disord. 1, 5.
  11. Koch, R., 2002. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother. Res. 16(Suppl. 1), 1-5.

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Horse Chestnut Extract 250 mg
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