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Nattokinase is a dietary supplement containing nattokinase, an enzyme which has been attracting significant scientific interest since its discovery in a traditional Japanese food (natto) and the confirmation a few years later of its exceptional properties.
What is fibrinolysis?
Fibrinolysis is a normal, breakdown process in which clots of fibrin (a filamentous protein) are broken down by the enzyme plasmin. This reduces the amount of fibrin in the blood, and as a result, helps to protect the body against thrombosis, the process in which a blood clot forms in and obstructs a blood vessel.
Plasmin is an enzyme produced by the liver, initially in an inactive form, plasminogen. This binds to fibrin, and if a clot forms, the plasminogen becomes activated and cuts the fibrin in different places.
This normal reaction is facilitated by activators such as urokinase and Tissue Plasminogen Activator (t-PA) secreted by the vessel wall following a trauma. These activators work primarily by converting the plasminogen into plasmin (2).
What causes thrombosis?
Thrombosis is defined as the obstruction of a blood vessel by a clot. It can be venous (phlebitis, pulmonary embolism) or arterial (heart attack, stroke …).
Most of the time, thrombosis occurs after damage to a vessel wall following gradual hardening and loss of elasticity. This is called atherosclerosis.
Atherosclerosis is normally seen in those over 40 but there are certain groups of people at higher risk:
- smokers;
- those who are overweight;
- diabetics;
- those who do no daily exercise;
- those who suffer with bleeding disorders;
- those with a long history of poor dietary habits;
- those who’ve been subjected to daily stress for several years.
What is in Nattokinase
Any questions?
Our team of nutrition experts and scientists has the answers.
Natto is a food made from soya beans fermented with the bacteria Bacillus subtilis. It has been traditionally consumed in Asian countries for over 2000 years, particularly Japan where it’s thought to be a factor in the exceptional longevity of the Japanese people (3).
In 1987, a team of scientists discovered that this food contained a potentially fibrinolytic enzyme called nattokinase (NK). A large number of studies have since been conducted on this enzyme (4-6), the ingredient in our dietary supplement.
We recommend taking 2-4 capsules a day or as advised by your therapist.
Each capsule contains 50mg of nattokinase, which corresponds to 650 FU (fibrin degradation units). Studies show that nattokinase can be absorbed in the gut when administered orally.
Traditional consumption of natto and the numerous clinical trials conducted on it over the last 30 years have shown nattokinase to be safe, including in supplement form (7). However, it is not recommended for those who have suffered an ischaemic stroke, peptic ulcer or coagulation disorders, or anyone receiving anticoagulant treatment, as well as people due to have, or who have had surgery. Nattokinase appears to act as an anticoagulant and may therefore aggravate bleeding disorders.
We also recommend following the steps below throughout the supplementation period to help lower your risk of thrombosis and/or atherosclerosis:
- maintain a healthy weight;
- ensure any diabetes is well-controlled;
- take regular exercise;
- eat a healthy, balanced diet with plenty of fruit and vegetables;
- don’t smoke;
- control your blood pressure.
november 10 2025
In progress.
Translated by SuperSmart
october 21 2025
The maintenance of arteries and other blood vessels is not easily quantifiable.
Translated by SuperSmart
october 15 2025
Dynvéo offers Nattokinase at a much lower price, and 1 capsule per day during the meal... whereas it's 2 with Smart and on an empty stomach!
I am doubtful about continuing with Smart for this dietary supplement.
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october 2 2025
For irrigation and the heart
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january 26 2025
ok as per my expectations
Translated by SuperSmart
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